(Updated 7/17/20). Have you heard of the anti-aging supplement Protandim? Maybe you saw a YouTube video of when Protandim was featured on ABC's PrimeTime? Protandim called an “Nrf2 activator” has been said to be the “only supplement clinically proven to reduce oxidative stress in humans by an average of 40 percent in 30 days.” That’s fancy talk for Protandim is a type of antioxidant supplement. Unlike other products, Protandim is said to work by helping the body increase its own natural antioxidant enzymes. Sounds good, but does Protandim work, or is it a scam? These are some of the questions I will address in this review. The good news is there are clinical studies on Protandim. I will use that research in this review and help you understand it. By the end of this review, you'll have a better idea if Protandim is right for you.
Other Anti-Aging Supplement Reviews
What Is Protandim?
Protandim might sound like a drug but it's really a dietary supplement. It's said to combat free radical damage (oxidative stress) by stimulating the production of the body's own natural antioxidant enzymes such as catalase, superoxide dismutase (SOD), and glutathione.
The idea goes like this: instead of taking individual antioxidant supplements (like vitamins C, E, etc.) in the hopes they will battle free radicals and combat aging and disease, Protandim is supposed to augment or ramp up your own naturally occurring free radical defenses.
It's a novel concept to be sure.
The supplement website (LifeVantage.com) says the supplement is “clinically proven to reduce oxidative stress to levels of that of a 20-year-old.” Oxidative stress refers to the stress (cellular damage) caused by free radicals.
What Does The Name Mean?
My guess is the name was chosen because the ingredients are supposed to “pro-actively” work in “tandim” to help defend us against aging and disease.
Who Makes Protandim?
Protandim is a product of a company called LifeVantage Corporation. LifeVantage is actually a publicly traded stock on the NASDAQ. Its stock symbol is LFVN.
The company is located at 9785 S. Monroe Street, Suite 300 Sandy, UT 84070. If you google this address you will see a building with “LifeVantage” at the top. That is good. It tells us the company has a physical location.
Contact LifeVantage
Call the company at 866-460-7241.
The Better Business Bureau gave LifeVantage an A- rating when this review was updated. See the BBB file for updates and more information.
Protandim Ingredients
According to the product's website, there are 5 ingredients in each caplet of Protandim which add up to 625 mg:
| Amount Per Serving (1 caplet) | Percent Daily Value |
|---|---|
| Calcium (as dicalcum phosphate & calcium carbonate) 77 mg | 8% DV |
| Proprietary Blend Consisting of the following | 675 mg |
| Milk thistle extract (Silybum marianum) seed. | |
| Bacopa extract (Bacopa monnieri) whole herb | |
| Ashwagandha extract (Withania somnifera) root | |
| Green tea extract (Camellia sinensis) leaf | |
| Turmeric extract (Curcuma longa) rhizome |
Notice in the table above they tell us the source of each ingredient:
- The milk thistle extract is derived from the seeds of the plant
- The bacopa extract is derived from the whole plant
- The ashwagandha extract is derived from the root of the plant
- The green tea extract comes from the leaves of the plant
- The turmeric extract is derived from the underground stems (rhizome) of the plant
Other Ingredients
The supplement label also tells the supplement has these other ingredients:
- Microcrystalline Cellulose
- Croscarmellose Sodium Silica
- Modified Cellulose
- Stearic Acid
- Magnesium Stearate
- Maltodextrin
- Medium Chain Triglycerides
These other ingredients play no role in the effects or benefits of the product. They make up the caplets and/or help with the delivery of the ingredients into the body.
I want to commend the LifeVantage company for sponsoring much of the research below. It's rare to find a product with so many clinical studies.
Protandim Research
Protandim is different from a lot of supplements because there really is clinical research on this product. Below is a summary of the Protandim research with links to the studies for those who want to see them for themselves.
Because scientific studies can be wordy and complicated for most people, I will summarize the study and put the research in the proper context to make it easier to understand.
2016 Protandim Research
Study
The Effect of Protandim® Supplementation on Athletic Performance and Oxidative Blood Markers in Runners.
Study summary: In this investigation, researchers tested if taking Protandim (675 mg/day) for 90 days would improve 5K running performance and reduce TBARS. The study involved 38 runners who were randomly given either Protandim or a placebo.
Results: After 90 days, those taking Protandim (1x/day) showed no improvement in running performance compared to those taking the placebo. In addition, Protandim did not reduce TBARS or alter levels of antioxidant enzymes superoxide dismutase (SOD) or glutathione peroxidase (GPX) during resting periods. The researchers report however that in those over age 35, Protandim improved SOD twice as much as those taking the placebo.
See the full review of this study
Study
Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or an Nrf2-inducer.
Study summary: Here, researchers sought to determine what effect various compounds had on extending the life of mice. Protandim was one of the compounds tested. The other compounds tested in the study were fish oil, ursodeoxycholic acid (a bile acid, used to dissolve gall stones), and the diabetes drug, metformin. Different mice received the different compounds for their entire lifespan.
Beginning at 10 months of age, mice received Protandim at a dosage of 600 parts per million (ppm) in their food. This amount was chosen because it was similar to the Protandim dosage used by people. When the mice were 17 months old, the dosage was increased to 1200 ppm because this was thought to be better.
Study results: researchers noted male mice getting Protandim had a 7% increase in average lifespan. The supplement did not lengthen the life span of female mice. The researchers also point out that while the average lifespan was increased, the maximum lifespan did not increase. Regardless, this was a mouse study.
2013 Protandim Research
Study
Study
Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress
Study results: Researchers noted that mouse heart cells treated with Protandim increased the production of an antioxidant/anti-inflammatory enzyme called Heme oxygenase 1 (HO-1) as well as Nrf2. This was a test-tube study using isolated mouse heart cells.
This investigation is derived from a Masters's Thesis in 2010. The title of the MS Thesis is “UPREGULATION OF HEME OXYGENASE-1 AND ACTIVATION OF NRF2 BY THE PHYTOCHEMICALS IN PROTANDIM .” It is not unusual for a quality MS thesis or other graduate work to go through the peer-review process and be published.
2012 Protandim Research
Study
Antioxidants for the Treatment of Patients with Severe Angioproliferative Pulmonary Hypertension? Published in the journal, Antioxidants in Redox Signaling.
Summary: This is a rat study. Protandim increased antioxidant enzymes in rats, protecting the hearts from damage.
Study
Phytochemical activation of Nrf2 protects human coronary artery endothelial cells against an oxidative challenge published in the journal, Oxidative Medicine and Cellular Longevity.
Summary: This is a test tube study. Human coronary (heart) artery cells were treated with Protandim (20 micrograms per milliliter) or placebo (ethanol). All cells were then treated with hydrogen peroxide (H2O2) to induce free radical damage. Cells treated with Protandim showed less cell death than those getting the placebo.
Study
Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.
Summary: This investigation showed the supplement did not work. To be fair, this was a strange study. Researchers looked at 30 alcoholics . The researchers stuck tubes down the throats of the subjects to take fluid samples from their lungs. They randomly gave the people 1350 mg of Protandim per day or a placebo, for a week. They tested for various things to see if Protandim helped the people. It didn’t.
I don't know how relevant this study is to whether Protandim works or not. I mentioned it because it was a human study. For a much more in-depth review of this study—written by a doctor—see the review posted on ScienceBasedMedicine.org.
2011 Protandim Research
Study
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
Summary: This is a test tube study. Essentially, Protandim altered cellular pathways involved in antioxidant enzyme production and colon cancer, cardiovascular disease (heart disease), and Alzheimer's disease. This is encouraging, but, humans are more complicated than isolated cells. This study doesn’t prove the supplement reduces the risk of any of these diseases.
Study
The role of manganese superoxide dismutase in skin cancer.
Summary: This is a mouse study. Here, researchers reported the supplement reduced tumor growth in mice. For the most part, this appears to be a review of previous research relating free radical damage to the development of skin cancer.
Study
Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway.
Summary. This is a test tube study. Basically, a blood vessel was bathed in Protandim. Researchers noted the supplement reduced the thickening of vein cells.
2010 Protandim Research
Study
The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice.
Summary. This is a mouse study. Mice were genetically created to have muscular dystrophy. They were given Protandim at a dosage similar to what is recommended for humans. After 6 months, the mice given Protandim showed a 46%reduction in the free radical breakdown of fat (TBARS). TBARS stand for ThiobarBituric Acid Reactive Substances.
The greater the TBAR level, the greater free radical damage. Thus, reducing TBARS is taken to be a good thing. This doesn't prove Protandim helps muscular dystrophy. People with muscular dystrophy should discuss this with their doctor for greater insights.
Study
The chemopreventive effects of Protandim: modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesis.
Summary: This is a mouse study. Protandim reduced damage to the mitochondria of mouse cells. of this study. The mitochondria, often called the “powerhouse” of the cell, make energy —and makes free radicals in the process. The mitochondria are a major area of anti-aging research.
Study
Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure.
Summary. This is a rat study. Researchers tested if the supplement helped pulmonary blood pressure. After 6 weeks, Protandim did not reduce pulmonary artery blood pressure or the number of lung lesions. These researchers did say “our data point to a cardioprotective effect of Protandim.” But, this is a vague statement.
2009 Protandim Research
Study
Protandim, a fundamentally new antioxidant approach in chemoprevention using mouse two-stage skin carcinogenesis as a model.
Summary: This is a mouse study.
Study
Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim.
Summary: This is a test tube study. Cells treated with supplements showed significant increases in glutathione, an antioxidant compound. This is the study LifeVantage lists as “proof” Protandim increases glutathione levels by 300%. It may raise glutathione 300% – in a test tube – but does the same effect occur in people?
2006 Protandim Research
Study
The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy.
This is a human study. 39 healthy men and women, age 20-78 years were given Protandim (675 mg per day) between 30 and 120 days.
Study Summary:
1. Protandim caused a significant increase in the antioxidant superoxide dismutase (SOD) in red blood cells.
2. TBARS declined by 40% after 30 days
3. SOD in red blood cells increased by 30% after 120 days
4. Catalase decreased by 40% after 120 days
5. There was a non-significant rise (4.9%) in uric acid.
6. No change in CRP levels was seen.
7. No change in HDL, LDL or triglycerides were seen.
Protandim Research Summary
Here is a quick summary of the research:
| Study Year / Title | Study Type (Human, mouse, etc.) |
| 2016 Research | |
| The Effect of Protandim Supplementation on Athletic Performance and Oxidative Blood Markers in Runners | Humans |
| Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer | mice |
| 2013 Research | |
| Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress | Mouse heart cells |
| 2012 Research | |
| Antioxidants for the treatment of patients with severe angioproliferative pulmonary hypertension? | Rats |
| Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge | Test tube study |
| Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. | Humans |
| 2011 Research | |
| Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. | Test tube study |
| The Role of Manganese Superoxide Dismutase in Skin Cancer | Mice |
| Protandim attenuates intimal hyperplasia in human saphenous veins cultured ex vivo via a catalase-dependent pathway | Test tube study |
| 2010 Research | |
| The Dietary Supplement Protandim® Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress in Muscular Dystrophy Mdx Mice | Mice |
| The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis | Mice |
| Chronic Pulmonary Artery Pressure Elevation Is Insufficient to Explain Right Heart Failure | Rats |
| 2009 Research | |
| Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model | Mice |
| Synergistic induction of heme oxygenase-1 by the components of the antioxidant supplement Protandim. | Test tube study |
| 2006 Research | |
| The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy. | Humans |
To be fair, it's possible I may have missed some research. I'll update this table as I become aware of new research.
My Thoughts On The Research
While Protandim has been the subject of several clinical investigations, only 3 of them involved humans. They are:
- The 2006 study (click to see study)
- The 2012 study (click to see study)
- The 2016 study (click to see the study)
Protandim And Weight Loss
Can Protaindm help you lose weight? There is no good evidence for this. None of the above clinical investigations was about weight loss. To the credit of LifeVangage, they do not market this supplement for weight reduction.
Protandim And Multiple Sclerosis
Is this supplement worthwhile if you have Multiple sclerosis (MS)? Some have put forth the idea that disruption of free radical stress – via stabilizing Nrf2 (the stuff this supplement is supposed to improve) – might help MS. So, is there any proof? There was an investigation presented in 2011 at the 5th Joint triennial congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis Amsterdam, The Netherlands.
The title of the presentation was: Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis? Here, researchers treated rat and human oligodendrocytes with several compounds ― one of which was Protandim ― and then exposed the cells to a chemical to create free radical damage.
These researchers noted Protandim was seen as “the most potent inducer” of Nrf2 antioxidant enzymes defenses. In other words, Protandim helped the most.
This is intriguing, but it's not the same as giving it to people with MS to see if their symptoms improved.
There is also some evidence that stimulating Nrf2 might reduce cellular inflammation via inhibition of NFkb. Inhibition of NFkb is also something another supplement – called Anatabloc – was supposed to do. Currently, though there is little human proof for Protandim improving quality of life in those with MS.
See the Anatabloc review.
Protandim And ABC Primetime
In 2005, this supplement was featured on ABC's Primetime news show. In this segment, ABC correspondent John Quinones met with Dr. Joe McCord, a respected researcher whose name appears on many of the Protandim clinical studies. According to his Wikipedia page, as a grad student, Dr. McCord was involved with the discovery of Superoxide Dismutase, an important free radical savaging enzyme. Here is the ABC Primetime segment :
Basically, John Quinones gets a blood test to measure his TBAR level (an indicator of oxidative stress). He's given Protandim for 2 weeks and then returns to the lab where he has his blood tested again.
Dr. McCord tells John Quinones the supplement caused a “45% reduction” in oxidative stress and goes on to say this is the level seen in a “newborn baby”. The ABC Primetime segment is often used as proof the supplement really works. But, as I see it, one problem is John Quinones doesn't have is blood tested by an independent lab. This is bad science in my opinion.
Of course, the Primetime segment is interesting. But it's been over a decade since this segment aired. You'd think such an impressive result would warrant a follow-up. I wish Primetime and John Quinones would do a follow-up story.
Update. Dr. McCord is now involved with the PB125 supplement.
Protandim And The FDA
In 2017, the FDA reached out to LifeVantage to inform them they considered Protandim to be a drug and not a supplement based on claims made about it as an NRF2 Synergizer. Basically, the FDA was saying the claims being made at the time, made people think the supplement could treat disease. This is something not allowed under US supplement regulation. This may be the reason for the dramatic change in the LifeVantage website and marketing. There are no more claims about the effects of the supplement. Instead, the company now calls itself “a wellness and personal care company” and makes references to “bio-hacking.”
Do Doctors Endorse Protandim?
While the supplement is not endorsed by the American Medical Association (they don't endorse any supplement), I'm sure some physicians believe in it – and others who don't.
Does Protandim Have Caffeine?
According to the product website, each tablet has 1.8mg of caffeine. That's much less than in a cup of coffee and most energy drinks. I don't think this small amount would keep people up at night, but because we are all different it might be wise to not take it close to bedtime.
Is It Kosher?
No. this supplement is not kosher or organic. It is however made in the US. That is good.
Protandim Side Effects
Are there any Protandim dangers out there? I don't think so. I believe this supplement is pretty safe. I am not aware of any side effects. That said, here are a few general things you might want to think about if your not healthy. This list is not complete:
- Start with less than the recommended dosage for the first week to see how you respond
- Speak to your doctor/ pharmacist if you are pregnant or breastfeeding
- Stop taking the supplement at least 2 weeks before having surgery
- Speak to your doctor /pharmacist if you take any prescription drugs like blood thinners
One study noted the supplement might raise uric acid levels (by 4.9%). Would this be bad for those who suffer from gout? Currently, there is no direct proof gout pain is increased by Protandim. See the review of Tart Cherry Juice for more info.
While allergic reactions are likely uncommon, LifeVantage does mention this possibility in some people. Specific symptoms mentioned on the LifeVantage website include:
- gastrointestinal disturbances (i.e., stomach ache, diarrhea, vomiting)
- sometimes as a headache or rash on the hands or feet
Stop taking the supplement if you experience these symptoms.
The company website warns against using the supplement if you are undergoing chemotherapy or radiation therapy for cancer. This is likely because of the unknowns of combining antioxidants with some cancer therapies. If you have cancer or are getting treatment for it, ask your doctor. I'm glad the LifeVantage company informs people about this.
LifeVantage also stresses the importance of talking to a doctor if you have any autoimmune disease like arthritis or Type I diabetes. I'm not aware of any problems in anyone but I appreciated the company mentioning this.
How To Measure Your TBARS
Remember TBARS are a measure of free radical damage (oxidative stress) of cells. Protandim is said to reduce TBARS. The TBAR test is also called a Lipid Peroxidase test. Ask your physician about this test. For those who really want to know if Protandim is working, getting this test done first—and a month later— might be a good idea. I'm not sure if insurance covers the test or not. Talk to your doctor for more information on this.
Aged Garlic Extract also has some evidence it might reduce TBARS (click to see review)
TrueScience Brand
True Science is a brand name under which various beauty products made by the company can be identified. Products offered under the True Science brand include:
- Shampoo
- Scalp serum
- Facial cleanser
- Eye serum
What is PhysIQ?
PhysIQ is the brand name associated with various fitness-related products. This brand includes:
- Fat burn supplements
- Prebiotics
- Whey protein
- Appetite suppressants
Protandim For Dogs
Protandim Dogs (formally called Canine Health) is for pets. According to the LifeVantage website, this supplement contains 150 mg of the same ingredients as Protandim – as well as omega 3 fatty acids and collagen. The website goes on to say: “Reducing oxidative stress in dogs may reduce many of the disorders associated with aging in canine.” To support this, the organization states a 3rd party animal health company has found the supplement reduces oxidative stress in dogs.
Protandim vs. PB125
PB125, by Pathways Bioscience, is another supplement whose makers claim can reduce TBARS and activate NrF2. PB125 is the supplement by Dr. Joe McCord and associates. Recall Dr. McCord used to be associated with the LifeVantage company.
While PB125 is said to be the next generation of NrF2 activators, no studies have yet compared these supplements to each other to see which is better. The ingredients in both products are different for the most part.
See the PB125 Review for much more information.
Protandim vs. Tru Niagen
The Tru Niagen supplement boasts research showing it can raise NAD+ levels in humans. Tru Niagen is based on nicotniamide riboside a form of niacin (vitamin B3).
The idea of slowing aging by raising NAD+ is different than Protandim. So far no clinical studies have compared these supplements to each other. While the original Protandim does not contain nicotinamide riboside, the Life Vantage company does offer another version called the “NAD Synergizer” which contains niacin.
Protandim vs. Elysium Basis
Basis by Elysium is a popular anti-aging supplement that contains very different ingredients than Protandim. Like Tru Niagen, Elysium Basis also is an NAD+ booster supplement. So, which is better? Unfortunately, there are no head-to-head studies yet.
See the Elysuim Basis Review for more insights.
Protandim vs. SeroVital
You've probably seen TV ads for SeroVital. How does Protandim compare to SeroVital? Both supplements contain different ingredients and are touted to work differently.
While Protandim is said to help boost our bodies antioxidant enzymes, SeroVital is marketed to raise human growth hormone (HGH).
If we just look at the research, Protandim wins hands down. The makers of Serovital only have one study.
Where To Buy Protandim
This supplement is not sold in stores like Walmart, Target, Cosco, CVS, Walgreens, Kmart, or BJs. It's also not sold at GNC or Vitamin Shoppe. Rather, it's mostly purchased from LifeVantage independent distributors.
It is also available online as well although when using a distributor, you may get the individualized attention you might not get by buying it yourself.
Protandim Price
According to the LifeVantage website, a one-month supply (30 capsules) costs $59.99 retail. If you order it through a LifeVantage distributor, it costs $49.99 – and that is on a monthly basis. In other words, that means auto-shipments. If you want to purchase one month only to test drive it first, speak to your LifeVantgage independent distributor.
Protandim Yearly Cost
Let's round the price up to $50 a month. In one year, the supplement would cost you $600. Shipping and tax may be extra. If you only want to order 1 bottle to try yourself, you can get it on Amazon too.
My Suggestions
If you can afford it, go ahead and give it a try for a month or so and see if you feel any better. If you really want to know for sure, get your TBARS measured first.
Remember, exercise will also reduce TBARS too.
Protandim Pro & Con
Here's a quick summary of what I liked and didn't like. These are my opinions. Yours may be different.
| Pro | Con |
|---|---|
| There are clinical studies on Protandim | Not all the studies are on humans |
| Company has been around a long time | Not available in stores |
| Company sponsors research on Protandim | Expensive |
| Lots of hype about benefits |
Does Protandim Work?
While I'm intrigued at the prospect of slowing down aging, I'm can't say for sure if Protandim works or not. The research is intriguing but in my opinion three's not enough human research yet to draw conclusions. So, does Protandim really work? Let's just say I'm looking forward to more human clinical studies.
Here is it is on Amazon If you want to check it out/see what others are saying
I was activated 11-1-22 I had IBS. I paid at First $1,400 For Medication that cost one dollar back then which only took the pain away and I was in bed for 3 months. when I started Protandim NFR 2 it took 3 month to work with my DNA I was able to do the things I loved to do. yes protandim NFR2 is the best and it cost me less than $1,400
Thanks for sharing, Lillian. I’m glad to know Protandim is working well for you.
I tried Protandim for 3 months. I didn’t feel any different. Do you think I’d have better luck with their NAD supplement?
Confused, Honestly I’m not convinced NAD booster supplements really work. In tried one of those supplements for a month (not the protandim NAD supplement) and I didn’t feel any different. No better and no worse. Ive written much about NAD supplements here are some of my reviews
Nestle Celltrient Review
Video Tru Niagen Review
I tried True Niagen for 30 days. This is what happened
Why Im skeptical about Tru Niagen
If you try it let me know what happens.
The consistent reports of reduced anxiety and enhanced sense of well-being associated with taking Protandim have been (together with aggressive MLM recruiting and sales) key to its market acceptance. The pharmacology underlying these reports has not received much attention.
Ashwagandha (Withania somnifera or WS) has been revered for centuries in Ayurvedic medicine as an anti-depressant / anti-anxiety treatment. It has also been touted as an aphrodisiac. This combination caught the attention of a few Asian researchers because neurotransmitter agonists are well known for having the opposite effect on libido.
Experiments have demonstrated that (contrary to traditional beliefs), WS extract does indeed cause sexual dysfunction, at least in male rats, much like benzodiazepine GABA agonists (e.g. Xanax). Further experiments have shown the effects of WS extract on anxiety are virtually indistinguishable from lorazepam.
Given the well-documented side-effects of anti-depressant and anti-anxiety medications, would it be worthwhile to wait for a study of the pharmacology of the key alkaloids in WS extracts? Also, we noticed that Dr. McCord has removed WS extract from his new PB123 marketed south of the border. The explanation for this decision would be of interest.
Kody, just curious, where did you hear ashwagandha was removed from PB125? I checked the PB125 website and they are still listing ashwagandha as an ingredient. Ashwagandha is also mentioned in the first PB125 study which was published in may 2019. Here is a link to that study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563026/
In my review of PB125 I noticed ashwagandha is not in the version of the supplement sold in South America.
Here is the PB125 review which goes into more detail
Hi Joe,
Yes, I knew ashwagandha was still used in PB125. I was commenting on its effects being so similar to benzodiazepines and the evidence for similar side as indicated by several studies. This seems a little disconcerting and I was asking if you had any information on why it was removed from PB123 for sale in South America.
Thanks!
–Kody
Kody, I looked at the chemical structure of both ashwagandha and benzodiazepines. They do not look similar to me. I did see one paper discussing how they may have similar effects in lab animals https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270108/ I didn’t see anything in humans. its possible future studies are in the pipeline.
Unfortunately, Pathways Bio Science doesn’t have a contact number so I can’t ask them why some countries don’t include ashwagandha in their PB125 formula.
Hi Joe, Thanks for your work on this. I think there’s been a little confusion with the similar product names. It appears the formula identified as “PB125” includes ashwagandha; it was removed from their formula “PB123”. Regardless, the real reason for pointing this out was I was hoping to discover whether anyone has looked into the pharmacology of the well-known sedative and anti-depressive drug effects of ashwagandha, or raised any concerns about it.
Most scientists would want to understand how their product works before it is recommended for long-term chronic use. Dr. McCord seemed a possible candidate since he made the decision to remove it from one of his products.
Several authors point out that there is no nutritional resource (e.g. serotonin metabolic precursor) to account for the effects. The research I’ve seen comparing ashwagandha to GABA agonists seems to be based on physiological effects (anxiety and sexual dysfunction), but only in rats and mice as you say.
In your review of the ashwagandha alkaloids (I know there are a lot of them), were you able to find any research that identifies the primary neurotransmitter agonist? I noticed the abstract of a paper that appears to do so, but the paper itself was behind a pay-wall. You probably would have access.
Kody, ahh ok yes PB123. I coverd that in the PB125 review. Correct PB 123 has no ashwagandha. PB123 has Carnosol Ginger extract (6-gingerol) and luteolin.
If you tell me the name of the paper you are looking for I can try to find it and email it to you if that helps.
Do not you think we could reduce oxidative stress by changing our life style?
Changing eating habits, changing attitude to life and people, do some exercise, walk in the woods, get closer to nature etc.
https://cathe.com/4-ways-to-reduce-oxidative-stress-and-cell-damage/
Thank you for sharing your thoughts.
Judit
Judit, there is no doubt eating better can reduce free radical damage (oxidative stress). Im glad the article you linked to mentioned advanced glyccation end-products (AGEs). These are compounds formed when sugar combines with fat and protein. AGEs increase free radical stress on the body. Slow cooking, eating more fruits and veggies reduces AGEs.
Does protandim or other supplements reducing AGEs? You just gave me an idea for a new review 🙂
New study you could look into reviewing: Differential effects of vitamin C or protandim on skeletal muscle adaptation to exercise
https://www.physiology.org/doi/abs/10.1152/japplphysiol.00277.2018
Kyle, thanks for this. I looked at the study. While its a rat study, Im glad to see LifeVantage is still letting others look at their product (looks like they only provided Protandim but did not take part in the study). I noticed they said the study lab was supported by DARPA – the top secret think tank of the US gov. Thats intersting.
I saw the researchers thanked Dr. Joe McCord too. Dr. McCord no longer seems to be associated with LifeVantage/Protandim. Hes actually got his own NRF 2 supplement now, called PB125
Heres the PB125 Review
Hi everyone, PB125 is the new supplement by Dr. Joe McCord. In this review I breakdown its ingredients and research as they pertain to Nrf2 and TBARS and compare it to Protandim
http://supplementclarity.com/pb125-review/
Feel free to share with your friends 🙂
Hi Joe, found you via researching nrf2. A friend who uses it asked me to take a look at their site & science. I’m not overly impressed with my findings, and most of my negative views have been nicely covered by you & other sites I have visited.
My friend maintains she is enjoying benefits re her anxiety issues.
As I have not tried it, and to be honest will probably not. My personal layman evaluation suggests it is not for me.
The reason I won’t embark on a trial of the product (I am very open to looking at health protocols outside big pharma) is that for the past 8yrs I have been using a glutathione precursor with excellent health & well being benefits. Over the 8yrs I have witnessed many that have gained significant benefit, be it for a health challenge, sporting enhancement (energy / recovery ) & general well being.
I am certainly not advocating a cure or be all end all product, other than a very effective & significant product.
I would like your opinion on the science of initially Dr Robert Keller, and now world renown scientist & medicinal chemist Dr Herbert Nagasawa, who is the foremost authority on glutathione. Both these fine gentlemen have their products marketed via MaxInternational a MLM company. Yes I am involved with the company but more so the sharing of the science & value of what the products offer the human body.
The beauty of Dr Nagasawa’s invention Cellgevity (25 yrs in the making) is that his research was funded by the NIH. There are also a number of world class scientists & doctors, conducting peer reviewed human studies in their field using riboceine, Dr Nagasawa’s invention.
These studies range from Atherosclerosis, post stroke, wound healing (already tabled), migraine (already proven but trying to speed up the bio availability) to name a few.
If you have come across this company or more importantly, the scientists & their inventions, I would welcome your thoughts.
The product is costly, but I firmly believe prevention is a lot cheaper & beneficial than fighting disease.
For me as a 57yr old builder who used to live on anti inflammatories & pain killers (due to my industry & playing state grade squash) and my wife who suffered with arthritic hands, the protocol has been significant.
Thank you for your research into such companies and, I look forward to any response you may care to share.
Kind Regards
Michael Spadaccini
Northam, Western Australia
Hi Michael, I dont think I’ve heard of Cellgevity (or Dr Keller or Dr Nagasawa) but I did just add Cellgivity to my list of things to circle back and take a look at. I am familiar with glutathione. Here is my glutathione review.
What is the glutatione precursor in Cellgevity? Is it NAC?
Hi Joe, thank you for your response.
Dr Nagasawa’s invention Cellgevity has riboceine at its core. Dr Kellers MaxGxl had NAC at its core. Cellgevity has been proven to be 300% more effective than any other means of raising intracellular glutathione.
As you would be aware, glutathione is a tri peptide with cysteine being the rate limiting factor for our cells to produce glutathione.
As cysteine is an extremely fragile molecule it is destroyed in the gut before it can offer any real benefit, thus rendering any glutathione supp useless. Dr Nagasawa over 25 yrs of research & development, has formulated that wrapping the fragile cysteine molecule in Ribose protects it thru the gut, whereby it can enter the blood stream, into the cell where the cysteine remains to produce glutathione & the ribose passes into the mitochondria to produce energy.
There are other supporting ingredients in cellgevity, or those with allergies to the supporting ingredients can just have the pure riboceine product.
Sorry for the layman terminology, but I can share privately links for you to peruse Dr Nagasawas science & peer reviewed studies.
I notice in your “about me” references, you have worked with nasa, so has Dr Nagasawa. He is also the inventor of the 3 minute cyanide antidote, has 165 peer reviewed studies behind him, and has been revered by his colleagues as one of the top ten scientists on the planet.
Just a quick note re nrf2 activation. Cellgevity has a broccoli seed extract that is the best available, and stated by Dr Scott Nagasawa (son) is a key activator of the nrf2 pathway.
As I stated in the last post, Dr Nagasawa is the foremost authority on glutathione.
Thank you again for taking a look, and I think you will enjoy the science behind cellgevity.
I look forward to your feedback.
Kind Regards
Michael Spadaccini
Hi Michael, thanks for that. Does cellgevity have any peer reviewed clinical studies published on the product (not the individual ingredients). I’d be specifically interested in any study which compared the glutatione boosting ability of Cellgevity to just NAC.
https://www.mymaxoffice.com:443/244843/en/au/backoffice/resources/ResourceLauncherPublic?ResourceId=144
Hi Joe, your request will be met via this link. I hope you can access it.
Michael, thanks I was able to download the PDF. I glanced at the studies. I saw several cell/lab animal studies. I will take a closer look for human research later. Thanks so much for this information 🙂
Hi Joe, Interview with the scientists you may enjoy w
https://youtu.be/AlnYdQFITjM
Thanks Michael, I’ll take a look at it.
Hi Joe, whilst your researching cellgevity & if you have time, take a look at our energy drink & pass on your thoughts if your time allows. I enjoy it for sustained energy. No spike or drop, just the ability to produce more without really noticing anything. Works hand in hand with cellgevity for those big days.
https://www.mymaxoffice.com:443/244843/en/au/backoffice/resources/ResourceLauncherPublic?ResourceId=160
Ps: will not send any other product info. Thanks for your time
Michael, thanks the pdf was in Spanish (I think) so I could not read it but will add it to my list of things to circle back and look at.
Geez Joe sorry, I sent the brochure instead of the product sheet I want you to view.
My apologies
https://www.mymaxoffice.com:443/244843/en/au/backoffice/resources/ResourceLauncherPublic?ResourceId=65
Mike, thanks, I took a quick look. I see it has ribose. Ive played around with it for energy but did not notice any difference. Its quite popular with some who have fibromyalgia. Here’s my review of ribose for fibromyalgaia.
Ive added this Pdf for my files. thanks mike.
Thank you for this review! Do you know anything about Pathways Bioscience and their Nfr2 product PB125? Dr. McCord is one of the scientists on the team.
Hi Mandy, I have not heard of PB125 before but I took a quick look at their website. One of the studies shown is actually a Protandim study. I want to take a closer look at the ingredients in PB125. I’m curious how its different than Protandim. Stay tuned.
Hi Mandy, just a heads up that I have reviewed PB125. the review is almost finished. I will probably post it this Monday. Its a detailed analysis of the research and ingredients. Look for it soon.
Thank you! I see it’s posted, and I’m eager to go through it. I’ll comment on the PB125 page. And I’ve shared your site with a handful of friends considering Protandim. They’ve all been greatly appreciative of your unbiased review.
Mandy, thanks so much for sharing my site with others. I really appreciate it 🙂
Thank you so much for this review! I have been in a quandary this last few weeks rather to purchase this supplement. I have been under treatment for Chronic Lyme Disease for several years and have had my financial resources tapped out with all the out of pocket expenses of both treatments and supplements.
It’s so difficult to trust any new product or promise made when so many others haven’t delivered. I have heard about all the research that is behind this product. Thank you for putting it in one tidy place and summarizing it for me.
The research does not impress me so now it’s all up to trusting testimonies. I don’t have issue with supporting MLM’s but I do have issue with spending money on another product that doesn’t work.
It seems that there really is no way to know without forking over the $600.00 to give it a good 6 months to know for yourself it it works for you personally.
Hi Tammy, thanks for sharing and I’m so glad you found my review helpful. I understand your reservations and so very sorry to hear about the financial troubles you have experienced because of your lyme disease. I have known people who have struggled with lyme. It can be a very frustrating disorder to manage.
I agree dropping $600 or so on a supplement without clinical proof is hard to do. While it is possible to experiment by taking the ingredients separately (the review told you how) I have no idea if protandim or its ingredients helps Lyme or not.
Let me do some digging on this to see what I can figure out. Stay tuned. I will try to post a review on Lyme in the near future.
Feel free to share my review with your friends too.
I enjoyed reading your review, I feel is a very fair unbiased review. I will say upfront that I am a Lifevantage distributor. I first heard of Protandim and Lifevantage as a business opportunity in 2013. I completely ignored it for the better part of a year and a half, quite frankly I had no time for “pyramid schemes” and didn’t even bother watching the video that the person who was trying to recruit me kept asking me to watch.
In 2015, I saw an old acquaintance of mine who I had not seen for at least 9-12 months. This person had a very advanced case of arthritis and the last time I had seen him he was in obvious discomfort and pain. He used a walker to move around, his condition had gotten visibly worst in the last two years since I first met him.
As soon as I saw him I realized something had changed. His posture was more erect and the walker was absent. Immediately I asked him what had been the source of such dramatic change, to my surprise he mentioned a supplement called Protandim.
I immediately knew I had heard that name before but not sure where. My friend knowing my history of two motorcycle accidents, and one car accident that left me with a lot of pain and discomfort on my knees, neck, shoulder, and low back pain recommended me to give it a try.
I acted on his recommendation and ordered the product as a customer paying the full retail price, after a month I had not noticed any change at all. My friend kept urging me to keep taking it, he would tell me it was close to 7 months before he noticed a significant improvement.
I kept taking the product and looking at all the information I could find on it. To make a long story shorter, after close to 8 months I told my wife this pill was a “scam” and I had been ripped off of close to $500. Her answered left me speechless. She made me realize that I had gone from a 38-inch waist to a 34.
From a weight of 218 lbs to 188 lbs. From never wanting to walk with her, to not just walking with her but riding my bicycle with the children and working out like I used to before my last accident, my change had been so gradual that I didn’t notice it.
I don’t attribute the weight loss to a metabolic change done by Protandim but to the increased level of physical activity that it allowed me to do as a consequence of more energy and less pain. After realizing this I started studying the business model and although not yet a fan I decided to become a distributor to be able to get the product into the hand of my parents and other family members.
As you said in your review the one thing I don’t understand is why the company doesn’t promote testimonials or human studies, I understand it has something to do with compliance and regulation from the FDA but in my uneducated and layman opinion there is more to this supplement that meets the eye and not having this data is doing a disfavor to people like myself that may be very skeptic.
I consider that it would be important to have data showing at least the reduction of oxidative stress and the increased in glutathione levels claimed by the company after taking Protandim and not leaving it to what someone “feels” or doesn’t “feel”.
Hi Marcos, thanks for sharing and I’m glad to hear you are more physically active than before and able to spend more quality time with your wife and kids. Do you notice any differences in your pain now than before you started taking Protandim?
My guess is the not talking about the studies is as you said, probably related to FDA. They appear to have really changed how they present Protandim to people too. These days it seems to about bio-hacking and not anti-aging.
After 32 months I am in a lot less pain, however, if I go very heavy on my workouts my neck starts getting very tight again but in 1-2 days of rest, I am good again. My knees almost never bother me.
Yes, the company has made a change out of anti-aging into biohacking. A lot of emphasis into always stating that Protandim is not meant to prevent or cure disease, and also sharing testimonials is discouraged by Lifevantage.
The only thing they do allow us to say is that Protandim reduces oxidative stress 40% on average in 30 days. Results may vary.
What’s the difference with Genf20 plus?
Hi Ivo, Here’s the GF20 Review
The GenF20 review takes an in depth review of that product and its research
Also look at the SeroVital Review. Take notice what I discovered about its other names too 🙂
Thank you,Joe. Excellent extensive reviews.
Thanks Ivo, much appreciate you saying that 🙂
Helpful information. Lucky me I found your web site by accident, and I’m stunned why this
twist of fate did not took place earlier! I bookmarked it.
Hi Celia, thanks I’m glad our fates took a twist 🙂 If you have any questions, just let me know.
I have a friend marketing it and would like to know of further studies please.
Hi Daniel, I believe Ive listed pretty much all the research here.
Mr. Cannon,
I read your article and found it very interesting. It is one of the more objective articles I have read. I do have some things I disagree with though. The biggest would be about Dr. McCord and all of the studies that have been done on Protandim.
Dr. McCord has done research on oxidative stress since the late 50’s early 60’s and has published many studies about his discoveries and research. Of all the studies that have been done on Protandim, Dr. McCord only participated in one of the studies you mentioned. His name appears on all the other studies because the researchers that did the study used the research Dr. McCord did on oxidative stress, so they had to give him credit.
I do agree with you in that more human research is needed. It seems that there are more testimonials than science but isn’t that the way it goes with any drug or supplement?
There is one study that was done by a pharmaceutical company (BiogenIDC) on a drug that they created to treat Multiple Sclerosis called BG12. It sounds like you referred to part of it in your article. It was published in the Multiple Sclerosis Journal.
If you would like to see it for yourself go to: https://www.mdpi.com/2076-3921/5/3/30/pdf (PDF Document). The interesting part of this study is that they compared Fumurate Derivative BG-12, tertButylhydroquinone (tBHQ) and Sulforaphanew (SFN) to one supplement, Protandim! How many times have you ever heard of a pharmaceutical company spending their money on a study to compare their drug to a supplement?
On page S367 or page 92, second column under the heading “results” they state “1. BG12, tBHQ, SFN and Protandim are well-tolerated and strongly induce Nrf2-driven antioxidant enzyme production in oligodendrocytes, with Protandim showing the most potent induction.”
They also say in the conclusions “interestingly, Protandim, a dietary supplement consisting of herbal ingredients, was the most potent inducer and therefore may be the most suited as a therapeutic strategy.” All three of those drugs cost between $5100-$5300 a month! BiogenIDC paid somewhere between 3-6 million for this study.
Would you pay that much money for a 230 page study that says that a supplement is better than a drug you spent millions to develop?
That is why I found this study so compelling. LifeVantage had nothing to do with this and it was done on humans. I also disagree with what you said about “making your own Protandim”. I tried to do this. I had no desire to pay a company for something I could do myself. I discovered that I could not make my own supplement cheaper than buying it from the company. Maybe it is just the area I live in.
I have a concern though about the comparisons you did comparing Protandim with weight loss supplements. Why compare Protandim, which is not a weight loss supplement, is not advertised as weight loss supplement with supplements that are for nothing but weight loss?
Why not compare it to other supplements that are just like Protandim? Some may say I am nitpicking but, in all fairness, if you are going to compare something, in this case supplements, you should compare supplements that are similar in what they do.
Now to be fair to you, I am a Navy corpsman with an extensive medical background. I have worked in hospitals, doctors’ offices, ambulance services and personal care facilities. I have also been using Protandim for more than 6 years now. Someone introduced me to it in 2012 because they thought it would do me some good. I pretty much ignored everything I was told about it and checked it out for myself.
I found some of the research you mentioned. I also found a lot of testimonials from people who used Protandim. I also looked up all of the patients it had (6 at the time) currently 9. I have research medications before for the some of the doctors I have worked for and for my own education.
I have never seen a medication not to mention a supplement that has the research behind it that Protandim does. It does not surprise me that most of the science has been done on mice or in test tubes. It’s a matter of cost. The average cost of a study is somewhere between 3-6 million dollars.
While I was on active duty, I was stationed at Bethesda Naval Hosp. where some of the doctors there did research and published their studies. If I wanted to read one all I had to do was go to N.I.H. (at the time N.I.H.S.) That’s where I always go to find valid scientific research. Yes, I do have my own testimonial but there is no science to back up my claims.
From your article I know you do not give much credibility to the testimonials that’s why I have not told you mine and yes, I am also a distributor for LifeVantage. Thank you for your time. I appreciate it.
God Bless,
Michael Henrikson
Hi Michael,
Thanks so much for taking the time to write all you did. I appreciate your well-thought out response to my review of Protandim.
It’s not that I don’t give much credit to testimonials; I do consider them. People have said some amazing things to be sure. I just think Protandim has been around so long that I’m surprised by the lack of human research. It does appear this trend is changing and I welcome seeing more on human studies.
About Dr. McCord and the research. I was not aware of what you said about researchers giving him credit because they cited his previous research. I only went by what I saw on the study. If I was in error on this then I apologize.
I know research can be expensive and that’s why I often advocate seeking out grad students to do research. It would cost much less. Research such as how protandim might impact blood pressure, exercise performance, cholesterol, etc., could be done pretty inexpensively at a University – and it would help a grad student finish their degree. I know at least one protandim study I referenced was a MS thesis by a grad student. I’d like to see more of that type of research.
About protandim and MS, I replaced the link you provided with a PDF of the Protandim MS study you cited. The link you provided did not work. I believe it’s the same study you were referencing “Protandim Protects Oligodendrocytes against an Oxidative Insult”
I’d welcome seeing more on MS and protandim. Given the interest on this topic, I’d like to see a long term evaluation of protandim in people with MS (like a Framingham-type study). I’m sure the company could track this with surveys. That would at least give us some starter-data on whether a clinical trial might be warranted.
When I discussed Protandim for weight loss, I did it because I had been asked if it helped. It was not meant to be a slight against the supplement. I would love to see a comparison of Protandim against other supplements such as nicotinamide riboside, or Elysium Basis which are also marketed for anti-aging.
Here’s my review of Nicotinamide riboside
Heres my review of Elysium Basis
Again, I appreciate you sharing your thoughts on this. You have given me things to think about.
BTW, thanks for serving in the US Navy. I was at a funeral today of a good friend and former Navy vet (from the 50s). It was very nice to see the Navy come to the service. I know my friends family appreciated it.
Mr. Cannon,
I would like to offer my condolences on the passing of your friend. I want to apologies for not double checking the web address I gave you. I didn’t realize it didn’t work until after I posted my comment. The correct web address is: http://journals.sagepub.com/doi/full/10.1177/1352458511422301. I double checked this one! This is the study that I was referring too. If you scroll down to
P826
Nrf2 activators: a novel strategy to promote oligodendrocyte survival in multiple sclerosis?
you’ll see what I was referring to. In my response I said I found this compelling because it was done independent of LifeVantage. The other reason has to do with my own health.
This is where my testimonial begins. Back in 2005 I had become deathly ill and had no idea why. I went to the V. A. Hospital and was diagnosed with Anemia and Multiple Sclerosis. Almost my entire body was numb. Usually when you have a spinal tap done, they numb the area prior to doing the spinal tap because the needle they use is so large. They did not have to do that with me. They did 3 spinal taps on me. The only reason why I know they did 3 is because my wife was watching. That is how numb my body was.
After doing a bunch of test they amended their original diagnosis. They diagnosed me with Transverse Myelitis. This is similar to M.S. in that it strips away the “insulation” from around the nerves. The major difference between the two is that M.S. is reoccurring and T.M. is not.
After being treated, I only got approx. 10% of the feeling back in my body. After speaking with two different neurologist and a few general practitioners they told me that whatever feeling I had was all the feeling I would ever have.
I was never going to get any of the feeling back in my body. That was my life for 7 years until someone told me about Protandim. I told him I would try it just, so I could get rid of him. I didn’t believe much of what he had to say but he believed so strongly that it would help me that he GAVE me a bottle. The only stipulation was that if it did something for me and I decided to continue using it, I would replace the bottle. If it did nothing, I owed him nothing.
After taking it for just a month I started to notice something was happening in my body, but it was so vague I was not sure what was going on. I continued to use it and the more I used it I realized that I was getting the feeling back in my body!
The muscle spasm that I was having started decreasing. Protandim has not cured me of anything but because of me taking it, Protandim has improved my life. I have gotten most (not all) of the feeling back in my body, the arthritis I have in my spine is better. My health improved to the point that I came off disability. It was my honor and privilege to serve in the Navy.
God Bless,
Michael
Hi Michael, thanks for sharing your testimonial. Have you ever reached out to LifeVantage about this? I’ve heard people say some pretty interesting things about Protandim. Again, I keep wondering why they don’t track this? I know in the past, Juice Plus (another supplement company) used to send out surveys to some of people who took it to see what benefits people were noticing. These days all that could be done online.
Have you told your doctors about Protandim? Do they have any explanations?
Thanks for your condolences. It was a hard day to get through.
Michael said:
“Dr. McCord has done research on oxidative stress since the late 50’s early 60’s and has published many studies about his discoveries and research. Of all the studies that have been done on Protandim, Dr. McCord only participated in one of the studies you mentioned. His name appears on all the other studies because the researchers that did the study used the research Dr. McCord did on oxidative stress, so they had to give him credit.”
Whoever told you that is lying to you. McCord is listed as an author. You don’t list someone as an author unless they are an author.
All of this has been covered in previous comments.
I enjoyed your research and your article is very well presented.
I would like to point out that the first “peer review” as well as at least one other of the research papers you shared are funded by LifeVantage. There may be more that are as well, but I will leave it at that.
Hi Marti, thank you very much. Its my understanding that LifeVantage supports or has a part in most of the published Protandim studies.
I have been suffering from Graves disease – Hyperthyroid since 2012. Have been on and off Methimazole (a thyroid drug). Even when my doctor said my blood level is fine and reduced the drug and cut it out in time, my side effects were still vivid, esp my heartbeat was bothering me,waking me up from my sleep. In 2016 my doctor recommended to remove my thyroid!!! Terrible, I was devastated.
Coincidentally met Protandim NRF2. It took me 3-4 months to adjust & calm my heart beats down and I have been on it for over a year now.
I am thankful to my friend who introduced it to me. Thankful that I now have no Graves disease symptoms ( anxiety, fatigue, rapid&irregular heartbeat, shaky hands…and many more)
I don’t care what the above comments say about it, knowing that my thyroid is back to normal functioning and as a result I can live a normal life, that’s all it matters to me.
Hi Kelly, did you get tested after using protandim to see if your graves disease had gotten better?
Did you have your thyroid removed?I have graves also and wondering if this is for me
My husband and I started taking this about 3 weeks ago. We have a friend who has had excellent results from taking it this last year and since we were already taking many of the supplements included in this formula, we wanted to give it a try. We even have our 16 year old yorkie taking the pet formula.
While we are not sure we can feel results yet, we are seeing subtle changes in our dog. She is not limping as much and climbing steps again. It’s encouraging. We will keep posting as we see or don’t see results. People who “poo poo” on MLM companies without even trying the products could be missing out on their very own miracle.
Be open minded enough to see what works for you. If you see results, great! If you don’t, at least you did something other than taking another drug and causing even more trauma to your body. Our bodies are created to heal themselves but we have to give it what it needs in order to do that. Nutrition is another HUGE part of this puzzle.
Be blessed and we will share again as we see or don’t see changes 🙂
Hi Pattie thanks for sharing!
I came across your post through a Google search. I am interested in your perspective, would like to see some proper human studies. and while I know one person’s anecdotal story doesn’t constitute a scientific study, I thought I would share mine. This is going to be long, so I can give you the back story. I hope that is okay.
I am 51 years old, in poor shape, and seemingly every joint in my body has some degree of arthritis. This, from a lifetime of joint damage associated with Ehlers Danlos/hypermobility. My first joint dislocation was when I was a toddler. I also have Hashimoto’s; the autoimmune response seemed to have been triggered by an OR infection acquired via surgical repair of a shattered (closed break) humerus; after 18 months of hell, I came close to losing my arm. The infection source was under the hardware that held my arm together, so, with the help of a brilliant surgeon in Baltimore, the hardware was removed, 16 screw holes filled with cement, and I got to keep my right arm.
In short, I am in perpetual pain. I routinely sublux my shoulders in my sleep. I hobble when I first get up and walk, and once I warm up and start moving a little better, my movements look smoother, but I’m still in a lot of pain. I also have three kids, ages 10-14, so I have no time for any of this.
Also, I am a skeptic, I’m married to a skeptic (a scientist for the Federal Govt.), and I loathe and detest MLMs with the fire of a thousand suns. So you can imagine that when a well-meaning family member tried to sell me on Protandim, I was having none of it. They even sent me a bottle to try. I stuck it in a drawer and left it there for two years.
Finally, in honest-to-goodness agony (I refuse to take pain meds, and there are risks with NSAIDs, so I avoid those, too, unless I’m desperate) that nothing seemed to help, I dug out the bottle of Protandim. It hadn’t expired, and on 1/12/18, I figured I had nothing to lose, and took one.
I remained skeptical, expected nothing, but I took one every day until the bottle was empty. In fact, truth be told, I expected less than nothing. I figured it would bother my gut, AND not help me at all. It didn’t bother my gut, so I took it until the bottle ran out. At the end, I didn’t seem to hurt as much, but the replacement bottle (my first one was a gift) was $40 (IF YOU SIGN UP FOR MONTHLY AUTO SHIP), plus $7.99 in shipping, which I frankly think is ludicrous. So I didn’t order.
Within a week, I realized just how much that pill really HAD helped me. With three kids — and, again, expecting nothing — I was too busy to notice that I hadn’t been hurting nearly as much. I was more active because I wasn’t hurting as much. Not “Oh, I will go for a jog” active, but “work on getting caught up with laundry/ go to Costco and stock up on stuff I need” active.
I was functioning better at doing the stuff I had to do. I even lost 4 lbs and didn’t try (and hadn’t had GI problems), which I think had to have been a product of being busier. But it wasn’t an overnight miracle, and I won’t lie and say I felt phenomenal, because I didn’t. But I was feeling functional where I hadn’t been. Within six days of running out, I was hobbling again. I’m not sleeping through the night again. I’m in a lousy mood because I’m hurting. A lot. Again.
I bit the bullet and ordered the stupid bottle. Even though I have to pay a ludicrous amount of shipping, and even though it is a MLM. When it arrives, I am going to start taking notes and really paying attention. If this stuff really did help me feel better, I won’t be without it again. If it doesn’t help in month #2, I will cancel the subscription. If you want me to, I can let you know how it goes.
Hi Mrs J, so sorry to hear all that you have been going through! I’m enough familiar with Ehlers Danlos syndrome to know how debilitating it can be for some people. I think your story would make an excellent topic for future Protandim research. I will look forward to learning what happens as you continue to take Protandim.
Following up here with my progress. I guess I’ve been on Protandim (the Nrf2 activator, not Nrf1, to answer someone’s question) for about 4 months now, without interruption. Vogel said it made no sense that I would try it, given my statement of not trusting MLMs, etc.
I can only say that Vogel must not understand how desperate and willing to try anything true physical pain can cause a person to feel. I do understand. This is why I gave Protandim a shot in the first place.
I still have EDS. I still have arthritic joints. I still have Hashimoto’s. I still have Thyroid Eye Disease (I’m one of the lucky estimated 5% of hypothyroid people who get this disease that is generally reserved for Grave’s Disease patients). I still have Fibromyalgia.
I do have better mobility, and better range of motion, generally speaking. I do have better rest at night. I do notice that hair that was thinning seems to be coming back in. I do have less pain. MUCH less. Do I still have some pain? Yes, I do have some pain. But the joint pain is lessening. As an example, I am better able to open jars now without enlisting the help of my husband, and I am more able to reach the top of my head to style my hair.
It may sound trivial to the likes of Vogel, but it isn’t to me. To me, it is a relief. I also notice that I recover more quickly from injury. I slipped and fell down a flight of stairs and expected that (based on history) I would be nearly unable to move the next day.
However, the next day I was able to hike about a mile and a half with my family. Not without discomfort, but I did it and was okay the day after that, too.
For me, Protandim is at least so far a successful experiment. It hasn’t been a miracle cure, but it seems to have done something to help my body function and repair itself, since I recover more quickly, and overall seem to be improving. My skin looks brighter, my hair is filling in, and I’m more energetic as I don’t hurt as much.
I still hate MLMs, and I think — as best as I can tell from research — that the company must be poorly run. I think it is a great product in the hands of a greedy company. I will never sell it for that reason, which is too bad for me since people I know are observing changes in me and ordering it for themselves.
Maybe I’ll still improve with time. I hope so.
Hi Mrs J, thanks for the update. I appreciated your honesty but more than that, am very glad to hear you are seeing some improvements and are not in as much pain. I’m also happy you were not hurt too bad when you fell down the steps. Hopefully you continue to improve. Keep us posted on how you are doing.
Ms J. said: “I am 51 years old, in poor shape…every joint in my body has some degree of arthritis…a lifetime of joint damage associated with Ehlers Danlos/hypermobility…I also have Hashimoto’s… I am in perpetual pain….Also, I am a skeptic, I’m married to a skeptic and I loathe and detest MLMs with the fire of a thousand suns….a well-meaning family member tried to sell me on Protandim, I was having none of it. They even sent me a bottle to try. I stuck it in a drawer and left it there for two years….Finally, in honest-to-goodness agony…I dug out the bottle of Protandim…I remained skeptical, expected nothing, but I took one every day until the bottle was empty. In fact, truth be told, I expected less than nothing. I figured it would bother my gut, AND not help me at all….Within a week, I realized just how much that pill really HAD helped me…I bit the bullet and ordered the stupid bottle.”
That story makes no sense at all. If you were truly skeptical and detest MLMs, why on earth would you resort to trying to alleviate your pain with a product that is not only not advertised as a pain reliever but would not conceivably have any analgesic properties whatsoever.
Wondering if Vogel has found any product for anger. He accuses everyone of deception and cleverness. Seems his anger reduces any consideration of his arguments.
Interesting re: Dr. McCord who created Protandin this month the National Institute on Aging (NIA) of the US National Institutes of Health (NIH) has selected his companies Nrf2 activating dietary supplement PB125TM for study in their Interventions Testing Program (ITP) to evaluate the effects of dietary Nrf2 activation on aging and longevity. And funded a grant for his research.
Selection of test agents for the NIA’s program is competitive, with only a few candidate interventions selected for study each year, based on their potential for beneficial effects on lifespan and healthspan. The candidate interventions include pharmaceuticals, dietary supplements, and other approaches.
The experiments are conducted in the three ITP research laboratories at Jackson Laboratories, the University of Michigan, and the University of Texas Health Sciences Center at San Antonio. His results in extending rats lives with Protandim contributed to their decision.
Gary, why are you continuing to lie about who created Protandim? McCord did not create, or formulate Protandim. This has been well established, and even confirmed by McCord. His name is not even on the patent.
I would very much appreciate knowing your results. I have Rheumatoid arthritis 48 years, looking at this product but cannot afford financially, physically or emotionally to go on another wild goose chase. I am on facebook. Thank you and Good Luck !!
Hi Margie, what supplements for your RA have you tried in the past?
I also have EDS I sublux my shoulders in my sleep and hobble when I get up.
I’d like to hear how you get on with this product. My friends sell it, they think it works they are good people and wouldn’t sell it if they didn’t believe in it.
Karen said: “I also have EDS I sublux my shoulders in my sleep and hobble when I get up. I’d like to hear how you get on with this product.”
That makes no sense. Protandim isn’t a pain reliever and there’s no conceivable reason why it would have any therapeutic benefit for someone with Ehlers-Danlos Syndrome. It’s like expressing an interest in some anonymous stranger’s experiment with treating a disease by eating buttered toast.
Karen said: “My friends sell it, they think it works they are good people and wouldn’t sell it if they didn’t believe in it.”
Best case scenario is that they are unwitting victims with misplaced belief in the product. The worst case scenario is more likely — that they aren’t good people and are knowingly selling fake medicine to people who are ailing.
Hi Ms. J – yes, please let us know on this forum how month #2 goes. Thanks.
Would you mind sharing which one you were taking? Was it NrF1 or NrF2?
Yes, I would like to know!!
Cyndia
My husband and I might both really benefit so I’ll be waiting to hear as well!
Today I went to a presentation by Dr Peter Verdegem. I listened patiently to a pseudoscience lecture given by this snake oil salesman. He invited questions so I pointed out the lack of proper evidence that this expensive rubbish actually has any worthwhile benefits. I suggested that his MLM approach was simple pyramid selling. From his CV I noted that he was the general manager of Amway. This pyramid selling company was kicked out of the UK by our then Board of Trade.
Next thing, was that I was grabbed by the arms by two of his “heavies” and frogmarched out of our village hall. I am 72 years old and not up to scrapping with three guys. I protested but was still forced to leave.
These bunch of shits showed themselves in their true colours. Please don’t be suckered in by LifeVantage or any such charlatans.
Hi Anthony, Until you mentioned him, I’d never heard of Dr. Peter Verdegem. I found his linked in profile https://www.linkedin.com/in/peterverdegem/
I am so very sorry to hear this happened to you when you asked questions.
Wow, so LifeVantage’s new flagship product PhyisIQ is explicitly a laxative according to this home video featuring Peter Verdegem blabbering gibberish live from his Bavarian attic.
https://www.youtube.com/watch?v=g3mhCge8SF8
If you want to waste 10 agonizing minutes watching it, your jaw will drop in disbelief when he shares banal pearls of wisdom like “your gut is an important organ” and “muscles are built up of protein.” He also explains that PhyisIQ works because it’s “complex”. Should have called it PhysLowIQ to better reach their true target audience. He also invokes snakeoil science classics like claiming that the product cleanses toxic buildup from the gut (aka discredited hokum).
Pretty laughable to see the company that was once claimed by its distributors to have a cure for cancer reduced to selling laxatives. Pathetic! Hubris/nemesis.
Another video featuring Verdegem is titled “Doctor’s Series with LifeVantage CEO Darren Jensen 7.5.17”, so apparently this guy is the latest actor LifeVantage has hired to masquerade as an MD. Basically a poor man’s (highly inferior) version of their original science spokes-hack Joe McCord.
https://www.youtube.com/watch?v=1PF2bvz9D3U
That’s the gist of this video introducing Verdegem where the distributor basically describes how Verdegem is stepping into McCord’s shoes to lend an air of credibility; at least enough to fool some dimwits; he’s ridiculously far from credible in reality.
https://www.youtube.com/watch?v=VUlnL9PWcYs
Verdegem has no degree in nutrition or medicine. He has a PhD in organic chemistry. He was also a Brigham Young undergrad, which would explain who he got caught up in Utah’s MLM netherworld. His CV reads like an MLM rapsheet – no less than 4 MLMs, including Amway, LifeVantage, Unicity, and Tahitian Noni.
https://www.youtube.com/watch?v=g3mhCge8SF8
His role at LifeVantage apparently is to make painfully dumb promo videos and participate in distributor training (i.e., BS-ing).
Peter Suffolk said: “Next thing, was that I was grabbed by the arms by two of his “heavies” and frogmarched out of our village hall. I am 72 years old and not up to scrapping with three guys. I protested but was still forced to leave.”
I’m really sorry to hear that. It’s disgusting! I wish I could say it’s surprising but it really isn’t. It reflects the caliber of the people you’re dealing with – con artists. They pretend to be caring but would have no qualms about roughing up senior citizen – and that’s in front of an audience. Just imagine what they do when no one is looking. It’s worse than you can imagine.
Many times it’s not the message but the delivery. After reading the first sentence of your comment, its difficult to believe you were present in order to listen and learn.