Update 2/16/20. Can SeroVital raise human growth hormone (HGH) by 682%, reduce wrinkles, decrease body fat or increaase your bone density? Can it make you look –and feel- DECADES younger? You've seen the SeroVital commercials on TV and you may have wondered if it really worked. In this review, I'll help you better understand SeroVital by breaking it down into questions and answers. I'll show you the research and the pros and cons and help you figure out if SeroVital is right for you.
1. What Is Growth Hormone?
Human growth hormone (HGH) is a hormone made in the brain. It's also called somatotropin (so-mat-to-tro-pin). By whatever name you call it by, HGH does a LOT of things such as:
- Helping muscles grow
- Helping fat loss
- Helping collagen formation
- Helping the immune system
- Helping brain functioning
We tend to make less HGH as we get older and this is why people are interested in this hormone as a way to turn back the clock of aging and help us grow younger again. Some people might even take HGH injections too. SeroVital is not the same thing as HGH injections you may get from your doctor.
2. What Is A Secretagogue?
This very complicated word is pronounced “se-kreet-a-gog.” It's a science term and refers to anything that makes your body secrete something. SeroVital contains secretagogues (amino acids and herbs) which, are supposed to help your body secrete (produce) more growth hormone.
3. Don't Confuse HGH With HCG
HGH – human growth hormone – is not the same thing as HCG. HCG refers to a pregnancy hormone called human Chorionic Gonadotropin. People sometimes use HCG to help with weight loss.
See the HCG review for more on this.
4. Who Makes SeroVital?
The company is called SanMedica International. They hold the patent on SeroVital too. It's US Patent Number 8,551,542 Here is the US patent if you want to read it.
5. Contact SeroVital
The company address is 5742 W Harold Gatty Drive Salt Lake City, UT 84116-3777. Two other companies are also at this address:
- Basic Research LLC (BasicResearch.org)
- LimitLess WorldWide LLC (LimitlessWorldWideLLC.com )
To contact SeroVital by phone call 801-517-7007
6. Better Bureau Ratings
When this review was last updated,
- The BBB rating for SeroVital
- The BBB rating Basic Research LLC
- The BBB rating Limitless Worldwide LLC
See the BBB files for updates and more information.
7. The SeroVital Box Controversy
Depending on where you purchased this supplement, you may or may not see “HGH” on the box. Most boxes of SeroVital contain the letters HGH – which stands for human growth hormone. But some -like the box I have – do not. Why?
While it's hard to know for sure, in the comments below someone had mentioned that SeroVital purchased from Costco does not contain the HGH reference. So whether or not you see HGH may be related to where you purchased it from.
Does SeroVital really raise HGH 682%? Well, the box does say “Clinically Tested 682% Mean Increase” – but if you look closely, it doesn't say a 682% increase in HGH.
8. SeroVital Research
There is clinical research on this dietary supplement. The SeroVital study title is Elevated Growth Hormone 120 Minutes a Single Low Dose of Amino Acids in Healthy Subjects.” This investigation was presented at an Obesity Society meeting in 2012.
This investigation involved 16 people (12 men and 4women) in their 30s. The study lasted 2 weeks. During one week, people took SeroVital, and the next week, they received a placebo. Researchers tested growth hormone levels were measured at 15, 30, 60, 90 and 120 minutes after taking the supplement or placebo.
Results: These researchers found HGH levels were higher 120 minutes after taking SeroVital compared to placebo. Levels of IGF-1 were also noted to be higher 8 hours later. IGF-1 is the molecule that is actually responsible for many of HGH effects.
Another study was presented at the 2019 Endocrine Society Conference (ENDO 2019). This investigation contained 45 people (mostly women) with low HGH levels. The presented study noted SeroVital raised IGF-1 levels and HGH levels. The study sounds fascinating but it may not yet be published. When the study is published, this secion will be updated.
9. SeroVital Study Problems
The SeroVital research study does show it raises HGH levels. Here are my thoughts on the study:
1. The study doesn't seem to be peer-reviewed. It was presented at the Obesity Society as an abstract (an abstract is a summary of research). The study is listed with ClinicalTrials.com and was completed in 2012.
2. The study involved 16 people, mostly men.
3. The study showed HGH levels were higher 120 minutes after taking SeroVital.
4. This investigation did not measure:
- body fat
- testosterone levels
- muscle strength
Grated some of this will take longer to see a difference.
5. This study involved people in their 30s. Since this is an anti-aging supplement, it would have been nice to involve older people.
10. What Are Normal HGH Levels?
According to Medline Plus, normal HGH levels for men and women are:
- Men: 1 – 9 nanograms per milliliter (ng/ml)
- Women 1 – 16 nanograms per milliliter (ng/ml)
11. SeroVital Benefits
The company says HGH is associated with:
- Reduced body fat
- Improved mood & energy
- Heightened sex drive
- Stronger bones
- Increased lean muscle mass
- Reduced appearance of wrinkles
Remember, the benefits of HGH do not necessarily mean SeroVital has the same benefits.
12. SeroVital Ingredients
SeroVital contains 5 amino acids and 1 herb. According to the box I have, 4 capsules of SeroVital have the following ingredients:
|Amount Per Serving||Percent Daily Value|
|Proprietary Blend Containing||2.9 grams|
|L Lysine HCL||N /A|
|L Arginine HCL||N /A|
|N-Acetyle L Cysteine||N /A|
|L Glutamine||N /A|
|Schizonepeta (arial parts) Powder||N /A|
Other ingredients that are also listed in SeroVital are:
- Steric Acid
- Magnesium Stearate
- Titanium Dioxide
- Rice Flour
- Microcrystalline Cellulose
- Candurin Silver Fine
- Yellow # 5
- Silicon Dioxide
- Yellow #6
These other ingredients play no role in the benefits of the supplement.
If we look at the 6 main ingredients (4 amino acids and 1 herb) we see 4 capsules of SeroVital has a total of 2.9 grams for all of the ingredients.
Let's look at the HGH research for the ingredients in SeroVital.
Lysine makes up most of the ingredients in the supplement. Lysine is an essential amino acid (essential means we don't make it ).
In a 1981 study, lysine alone did not raise HGH levels – in young men – when it was combined with the amino acid, arginine. The amount used in this investigation was 1200 mg of lysine and 1200 mg of arginine.
In a 1993 study, the combination of lysine and arginine did not raise HGH levels in older men compared to placebo. This study used 3 grams of lysine and 3 grams of arginine used 2x per day for 2 weeks.
Researchers in Finland noted 2 grams of lysine did not raise HGH levels in weight lifters who were 19-35 years of age.
Arginine is a non-essential amino acid (we can make it). It's the second most abundant ingredient in Serovital.
In one study, researchers noted the combination of 1500 mg of arginine and 1500 mg of lysine, raised HGH levels. Ironically, the amino acids did not raise HGH levels when people exercised. That's odd.
Another study reported that both 5g and 9g of arginine raised growth hormone levels in young men more than a placebo. In another investigation, 6 grams of arginine did not raise HGH levels (or other hormones) in 15 runners compared to a placebo.
In a 2007 study, arginine used for 7 days didn’t raise HGH or IGF-1 in adults. These people took 7 grams of arginine per day.
In this paper, the researcher states while both arginine and exercise increased HGH levels. But, when combined together, the rise is less than seen with exercise alone.
In another paper, it was noted arginine, given before strength training reduced HGH levels. These researchers gave people 0.075 mg of arginine per kilogram of body weight
Translation: there are 2.2 pounds in a kilogram. So, if you were 180 lbs (82 kg), you’d get 0.075 x 82 =6.15 grams of arginine.
Oxyproline, also known as pyroglutamic acid is a type of amino acid. Evidence for oxo-proline raising HGH in people cannot be located.
Another name for this stuff “NAC”. N-Acetyl-Cysteine is a version of the amino acid cysteine. In supplements, NAC is often used to increase glutathione, a powerful antioxidant.
Here's NAC on Amazon
Glutamine is a non-essential amino acid. In a study from 1995, researchers noted 2 grams of glutamine, raised HGH levels in 8 of 9 healthy men (32-64 years of age). SeroVital contains only 1 mg of glutamine in 4 capsules.
See the review on glutamine for more insights.
Schizonepeta is an herb. Other names for this include Jing Jie and Japanese Catnip. Does schizonepeta raise HGH levels? Evidence cannot be located. Preliminary evidence suggests this herb may have anti-inflammatory properties. There is speculation cellular inflammation may reduce HGH levels.
13. Ingredients With Evidence
Based on the research which could be located, ingredients with the most HGH research are:
To be fair, it is possible the unique blend in the product may work better than any single ingredient.
14. SeroVital And Fertility
Growth hormone (HGH) is involved in both female and male fertility. So it makes sense some might wonder if SeroVital can help a woman get pregnant. Research linking Serovital to pregnancy cannot be located.
15. SeroVital And Birth Control Pills
There is no evidence SeroVital interferes with birth control pills. Women who are concerned about this are encouraged to speak to their pharmacist for more insights.
16. SeroVital And HIV
People with HIV/AIDS may be interested in natural ways to boost growth hormone levels. Can SeroVital help? No evidence can be located. For now, the best advice is to show the ingredients to a doctor/pharmacist and see what they say.
17. How To Take SeroVital
The company recommends taking take 4 capsules of SeroVital on an empty stomach, either 2 hours before meals or about 2 hours before going to bed. Taking the capsules on an empty stomach, however, appears necessary.
Do not take more than SeroVital 4 capsules per day.
These same directions also hold true for the liquid concentrate version too. SeroVital Liquid has the exact same ingredients as the capsules.
18. What's Growth Factor 9?
Growth factor 9 (GF9) is another supplement touted to raise HGH. Growth Factor 9 has the same ingredients as Serovital. The Growth Factor 9 package mentions SeroVital.
19. What's Thrive HGH
Thrive HGH is a supplement by the company called Limitless World Wide LLC. Thrive HGH contains the same ingredients as SeroVital.
20. SeroVital vs. Growth Factor 9 vs. Thrive HGH
Here are the ingredients in all 3 supplements side-by-side
|SeroVital||Growth Factor 9||Thrive HGH|
|Blend 2.9g made of||Blend 2.9 g made of||Blend 2.9g made of|
|L Lysine||L Lysine||L Lysine|
- 3 different supplements
- 3 different names
- Same Ingredients
21. SeroVital vs. GenF20?
GenF20 is another supplement reported to improve HGH levels. No studies could be located which compare these supplements to each other. GenF20 other ingredients like Tribulus Terrestris. For more information see the GenF20 review.
22. Where Can You Buy SeroVital
This supplement is very popular and can be purchased at many locations such as Vitamin Shoppe, GNC, Target, Walmart, Khols, Bed Bath and Beyond, CVS, Rite Aid, Walgreens, Costco, Ulta Beauty, and many online retailers.
23. SeroVital Cost
When purchasing from SeroVital.com a bottle costs $99 for a one-month supply. If you go on their Preferred Customer Program (auto-ship program), the price is $79.20. Both prices include free shipping.
24. The Preferred Customer Program
The SeroVital preferred Customer Program is their auto-ship program. If you choose this option, the company will send you a new shipment of the supplement every 28 days. Your credit card will be charged $79.20 per month.
25. How To Return SeroVital
SeroVital is sold at many local stores so returning it to where you purchased it is the fastest way to get a refund. If you bought it from the its website, the company lists this address for returns:
Attention Returns Department: 5742 Harold Gatty Drive Salt Lake City, UT 84116. They also list this phone number: 1-800-898-5153 where people can get more specific information. I recommend you call the company before sending it back so you know exactly how to do it.
26. Is SeroVital FDA Regulated?
All dietary supplements are regulated. Many don't know this but it is true. While the FDA does not test supplements, there is a regulation. The supplement law is called The Dietary Supplement Health and Education Act (DSHEA). It's been in effect since 1994.
27. Is It Made In America?
Yes, the company which makes it is located in Utah.
28. Can SeroVital Change The Microbiome?
Does SeroVital impact gut health? While clinical studies cannot be located, preliminary research shows arginine can alter the bacteria in the mouth. So, while it's possible SeroVital may positively impact the microbiome, the best way to ensure a healthy gut is to eat lots of fruits, veggies, beans, and seeds.
29. SeroVital Hair And Skin?
Some people have reported, SeroVital HGH has lead to better-looking skin (see comments). This is interesting but no clinical studies so far have looked at this.
30. Is SeroVital Gluten-Free?
I'm not sure. The website did not say either way when this review was updated. Rice flower is part of the “other ingredients” but according to the Celiac Disease Foundation, rice is naturally gluten-free.
The best way to know for sure is to call the company. You can reach them at 801-517-7007.
31. What Happens If you Stop Taking It?
In theory, if you were seeing benefits from and stop taking SeroVital, you'd likely go back to where you were to begin with. How long this might take to happen I can't say. If you combined it with exercise and eating a better diet, how far you might slide downhill would likely be less. There are no clinical studies showing what happens to people after they take SeroVital for several months and then stop taking it.
32. Do You Have To Take It Forever?
If you are happy with SeroVital HGH and stopped taking it, in theory, you might go back to where you started. How long this might take to occur is not known.
33. Can Teenagers Take SeroVital?
Teenagers are teeming with growth hormone so there is no reason for them to take this supplement. The supplement website says not to take it if you are younger than 18.
34. Is SeroVital Better With An NAD Booster?
This supplement is touted to be an anti-aging. Some of the most popular anti-aging supplements today are things like Tru Niagen, Niacel and Elysium Basis. These supplements are said to slow aging by raising a compound called NAD levels our cells. Whether or not SeroVitalHGH would work better with a NAD supplement is unknown. No study has looked at this (yet). For more information see these reviews:
35. SeroVital And Weight Loss
While growth hormone may be associated with reduced body fat, there is no evidence SeroVital burns fat or helps people lose weight. If you are taking it for weight loss, any effects would be magnified If you combined the supplement with exercise and eating fewer calories.
36. Does SeroVital Contain HGH?
No. There is no human growth hormone in this supplement. The ingredients in the supplement are supposed to help your body to make more of its own HGH naturally.
37. Does It Have The Side Effects Of HGH?
While HGH is a necessary hormone, too much HGH associated with some bad things such as:
- Carpal tunnel syndrome
- Joint pain
- Fluid build up causing swelling
SeroVital will not produce the same side effects as too much HGH.
38. Can It Help Me Grow Taller?
Growth hormone therapy is sometimes prescribed by doctors to help kids grow taller. That said, there is no proof this supplement would help a child or adult grow taller. When in doubt, ask your doctor or pharmacist.
39. Is Powdered SeroVital Better?
The Rapid Dissolve Crystalline Powder version of SeroVital contains the same ingredients and amounts as the capsules. The big advantage of the powdered version is if you did not like swallowing pills.
40. Is Maximum Strength Better?
When I looked into this, I noticed some websites selling “Maximum Strength” SeroVital but the ingredients – and amounts of ingredients – are identical to “regular strength.”. I did not see Maximum Strength listed on the supplement's official website. Could the max strength product be counterfeit? When in doubt, call the company and ask them.
41. Can Men Use SeroVital?
Yes, you can. Remember, even though the product is advertised to women, the SeroVital study mostly consisted of men.
42. SeroVital Side Effects
I think SeroVital is safe in healthy people. While there isn’t a bunch of any single ingredient, here are a few things to keep in mind and ask your doctor about if you think they apply to you. This list is not complete:
- Start with less than recommended for the first week to see if you have any side effects
- N-Acetyl-Cysteine and arginine may reduce blood pressure. Consider if you take high blood pressure medicine
Stop taking SeroVital at least 2 weeks before surgery
- Talk to your doctor if you are pregnant or breastfeeding also
- If you have a history of cancer, speak to your doctor. Remember, HGH causes things to grow.
- Schizonepeta contains a compound called pulegone which might damage the liver in high amounts. Schizonepeta is the last ingredient listed, so there is not much in the supplement. If you have liver problems, speak to your doctor first.
- If you take any medications like blood thinners, speak to your doctor and pharmacist
On the plus side, some people -in the comments below – have said their skin looked better after taking SeroVital
Some online reports -which cant be confirmed -suggest the supplement might cause:
The odds of any of these happening is unknown. These may be isolated incidents not likely to occur in most people. Like many things in the supplement world, results – and side effects- may vary.
43. SeroVital Pro & Con
Here is a quick overview of what I liked and didn't like about this supplement. These are my opinions. Take them for what they are
|Wildly available in stores||Very expensive|
|Been around several years||Lots of hype|
|It has a US patent||Low-quality study|
|Growth Factor 9 and Thrive HGH are the same thing as SeroVital|
|No clinical proof it does what HGH does|
44. Does SeroVital Work?
To be honest, I have my doubts but since I did not try SerVital myself, I can't say for sure if it works or not. To be fair, some people, provided testimonials below, saying this supplement helped them. For those who take this supplement, it's important to remember it's best if you also eat well and exercise. Kudos to the SeroVital company for also saying this too.
Here it is on Amazon
My name is Gina. I’m in my 50’s and i heard lots about this product. I’d love to try it but I have Celiac disease and I’m writing you to ensure the product is gluten free before I consider buying the product. I also have to be aware of cross contamination such as shared equipment as this would also effect me. Thank you so much. I’m excited to hear back!
Hi Gina, I called SeroVital customer service about this to make sure I was giving you the best answer. The customer service person I spoke to told while the product is just a blend of amino acids and herbs, they could not guarantee that it was gluten free.
Their customer service number is 800-435-1409 if you want to call them yourself and ask.
I wish I had a better answer for you on this. If you decide to try SeroVital, one tip is to start with less than recommended for the first week. If there is any gluten, this will reduce any possible interaction with your Celiac issues.
If you try it, let me know what happens.
Has anyone else with Celiac tried SeroVital? Do you have any advice for Gina?
Deb E. says
I just purchased it but wondering about taking it with my antidepressant and thyroid medications? Anyone else take it with other meds and side effects?
Joe Cannon says
Hi Deb, why dont you show it to your pharmacist and get their thoughts on medication interactions. For what it’s worth, I have not heard of any issues with thyroid or antidepressants. Let us know what your pharmacist says. Also keep us posted on how SeroVital is working for you.
Dyan Cutro says
Having a problem finding where I can purchase SeroVital Accelerated Response System capsules. Originally I ordered them through the Bremenn Clinical Customer Service Rep but now I cannot even find it there. Can you give me some assistance in order to make another purchase of this product? Thanking you in advance, Dyan
Hi Dyan, is the product really called “SeroVital Accelerated Response System?” How is it different than SeroVital? I searched online for “SeroVital Accelerated Response System” but didn’t see on it.
Is it possible this is another name for the rapid dissolving serovital powder? I checked the Bremenn clinical website and they dont appear to carry SeroVital.
Both my husband and I have been taking Serovital for a month and a half, the only change we have noticed is that we both started to get acne! I also feel very tired specially in the morning. Has anyone else gotten acne from this? Thanks
Hi Patricia, this is just a wild guess but I have seen unconfirmed reports of acne breakouts from arginine. Arginine is an amino acid in SeroVital. I don’t think I’ve ever seen any clinical evidence arginine causes acne flair ups though. As for being tired, I’m not sure what would cause that.
Has anyone else noticed acne or getting very tired after taking SeroVital?
Hi Patricia, I did a little bit of digging and found some evidence arginine might cause tiredness. I dont think Ive anyone has told me arginine did this to though though so I’m not sure how common this is.
Took my first dose of SeroVital and noticed my well controlled blood pressure spiked. Has anyone experienced blood pressure increases while taking it?
Hi Nugget, what was your blood pressure before and after you took SeroVital? I dont think I’ve heard of SeroVital raising blood pressure. Has anyone else noticed increased blood pressure?
why i feel so tired while having these pills??
Hi Sarocha, really. how long have you been taking SeroVital? I dont think Ive heard of fatigue from it. does the tiredness come on immediately after or does it take time to happen?
I have been taking Serovital for over 4 months now. The cost is not good, I do not experience the result that the product promises.
I am concerned, I am now receiving results from recent lab work, indicating that my Liver Function Test was abnormally high. I am concerned and seeking further testing.
I am not a drinker, never smoked, don’t take ibuprophen, Tylenol or other pain meds.
Hi Cd, some preliminary evidence (preliminary meaning not human proof) suggests a compound in one of the ingredients called pulegone may be toxic to the liver. This is a compound in Schizonepeta which is in SeroVital.
I did a quick online search but did not see anyone saying SeroVital caused liver problems or liver failure so that is good. Many things can cause liver enzymes to go up, but why dont you stop taking SeroVital for a month and get another test and see if your liver enzymes go back down.
Here is a reference to the liver issues we are talking about.
Scroll down to the section on “Pennyroyal oil” that is where it discusses pulegone.
If you have any other questions just ask. Do let us know what happens.
Is Sero Vital gluten free? Is it safe for some with Celiac Disease?
Hi Stacy, I went to the SeroVital website and they didnt mention being glutein free. Looking at the ingredients I see rice flower mentioned. When I did an online search I saw some websites saying rice gluten free while others saying to be careful with rice if you are on a gluten free diet. This may be due to flavorings added to processed rice products. The celiac disease website says rice if gluten free https://celiac.org/live-gluten-free/glutenfreediet/food-options/
The main ingredients in Serovital are gluten free buts its in the “other ingredients” where rice flower is found. scroll up in the review to see it. While I’d say show it to your pharmacist to be sure, based on what I saw I believe serovital is ok for someone with Celiac or following a gluten free diet. To be safe, start with only 1 tablet per day to see how you respond.
Does anyone else have thoughts on SeroVital for someone with Celiac?
linda sclafani says
I just started this program, I was a little nervous w/some of the side effects some people mentioned. I am really paying attention to my body while taking it. I take it at night due to the 2 hour empty stomach protocol. I always worked out and eat decent for a 55 yr old menopausal woman LOL – I will check in to let you know how it worked or not worked for me. . I plan on giving it 2 months, provided I escape any bad side effect, to see if it works.
Hi Linda, sounds good. We’ll all look forward to learning what happens 🙂
I would assume that the deletion of the “HGH” wording on the original packaging is an attempt by the manufacturers to get around overseas Customs controls when shipping abroad….HGH is a banned import substance in many western countries….Flagging a supplement with “HGH”wording on the packaging would most likely increase its chance of confiscation by certain overseas border controls.
Dave, that is a good point!
I do really like your review. I think it’s very comprehensive, well researched and balanced. Have you looked at Elysium’s anti-aging supplement? How do you think it compares to Serovital?
Hi Erin, thank you for your nice words. Yes I have looked at Elysium Basis. It has different ingredients than SeroVital. Here is the Elysium Review Also be sure to read the review of its active ingredient – nicotinamide riboside. I linked to it in the Elysium review.
I have taken Serovital for about 2 or 3 years. I take a half dose, just two pills in the morning. I’m a 42 year old female who is very physically active and eats well. Serovital doesn’t work quickly. I reduced my weight by about 15 pounds over a 15 month period and have sustained the weightloss. My body fat is about 13 percent and it gives me great energy. I’d say my skin looks more taught but not a huge change. I notice the difference when I quit taking it. My energy falls off, my appetite increases, I get more irritable.
Hi Erin, thanks for sharing that and I am glad to hear you’re having good overall results with SeroVital.
Art Johnson says
I have now been on Serovital for over a year, thought I’d commented here before, but couldn’t locate it, perhaps it was just an eMail to you.
My desire had been to eliminate (75 year old) thin/weak skin issue, where it is easily ‘sloughed off’ from normal contact with tree bark or similar textured surfaces.
I found complete success in this respect.
As Erin stated above, two capsules a day seems to be plenty. Six months ago, I had cut back to three with no change in results and two months ago to two. This latest dose has increased positive effects, one of which is a reduction in nightly awakenings to visit the bathroom from an average of two times to absolutely zero.
There have been no other changes in my lifestyle or consumption beyond the four/three/two Serovital dose and this urination frequency was sudden and within the past month.
There are also other positive results which are not so easy to quantify but are pleasing nonetheless.
Hi Art, yes it was an email you sent me from back in Feb. I’m glad to hear SeroVital is continuing to work for you. Interesting about how SeroVital is reducing your nighttime bathroom trips. I dont think anybody has reported that yet. Continued success with SeroVital and keep us posted 🙂