ASEA, a cell signaling supplement, contains trillions of stable, perfectly balanced Redox Signaling Molecules suspended in a pristine saline solution. From the moment I first heard of this supplement, I was intrigued because “redox” is a word which takes me back to college chemistry class and, honestly I've never heard of it being used to promote supplements before. In this ASEA review, I'll look at the research and science on ASEA and help you figure out if it's right for you. I'll also address some of the things people say this supplement can do too. This is an unbiased review. I don't work for the company. I just want to help you understand this supplement better.
1 What Is Redox Signaling?
OK, so how does ASEA work? At the heart of this supplement (pronounced “ah see ah”) is something called Redox Signaling. Let's talk about what Redox signaling is. 
The word Redox refers to two words – reduction and oxidation.
- “Red” is a reference to reduction
- “Ox” is a reference to oxidation
In the world of science, reduction and oxidation are used to refer to things that transfer electrons (negatively charged particles).
- Electrons carry a negative electrical charge.
- When a molecule or atom receives an electron, it's overall electrical charged REDuced (it's becoming more negatively charged).
- When a molecule or atom has electrons removed from it, it's said to be OXidized. (it becomes more positively charged)
So, Redox signaling is about using electrons to transfer signals (information) between molecules and atoms. This information can result in good stuff or bad stuff happening.
2 Rexox Signaling In Plain English
Redox signaling is a way for atoms and molecules to talk to each other by way of transferring electrons. They communicate by way of antioxidants and free radicals. Here's how it works:
- Free radicals remove electrons. This is also called Reduction
- Antioxidants donate electrons. This is also called Oxidation
It's from reduction and oxidation we get the term RedOx reaction. During redox reactions, electrons are transferred from one thing to another. This transfer of electrons also transfers information. Basically, this helps atoms/molecules “talk” to each other.
simply put, redox signaling is accomplished by the interaction between antioxidants and free radicals.
3 ASEA Ingredients
The product website has said the supplement is made of “trillions of stable, perfectly balanced Redox Signaling molecules suspended in a pristine saline solution.”
The saline solution is a reference to salt water. This is why some people online say that ASEA is just expensive salt water. I'll let others make that judgment as I'm primarily interested in the research on this stuff.
They say the redox signaling molecules are grouped into two types:
- Reactive Oxygen Species (ROS)
- Reduced Species (RS)
Let's translate these names:
- Reactive oxygen species are basically free radicals
- Reduced Species are basically antioxidants
4 ASEA Research
The ASEA company commissioned a genetic testing company called Taueret Laboratories to perform a study. It was called “Initial Gene Study Showed ASEA REDOX Affected Important Signaling Pathway Genes.” The science is complicated so let's just summarize it:
ASEA Genetics Study Summary
This investigation lasted 2 months and involved 60 people who were split into 3 groups:
- ASEA group (25 people). They drink ASEA
- Placebo group (25 people). They drink salt water
- Control group: (10 people). They didn't drink ASEA or salt water
From the summary of the investigation, we learn, most of the people were white women with an average age of35.
Study Results
Researchers noted that 5 genes, involved in cell signalling changed their expression by 20-31%.
This is very interesting but I noticed a couple of problems:
- Results showed 5 genes changed their expression but they didn't say how they changed. I assume it was in a good way.
- The study doesn't seem to be published in a medical journal.
Why isn't this investigation published in a medical journal? Watch this ASEA video below:
At 55 seconds into this video, Dr Jeffrey Mocny of the ASEA science counsel states “ASEA is dedicated to performing the highest quality science in the field.” To me, “highest quality science” means publish your research in a medical journal.
ASEA Exercise Study
Prior to this, in 2012, researchers at Appalachian State University published the results of an exercise study. The title of the study was Influence of a redox-signaling supplement on biomarkers of physiological stress in athletes: a metabolomics approach. Let's summarize this research and the results:
Study Summary
In this 1 week long study, 20 people rode a stationary bike as fast as they could for 46 miles (75 km). They were given either 4 oz ASEA or 4 oz of a placebo drink per day for a week before the cycling test and 16 oz of ASEA (or placebo) during the test.
Blood samples were taken before, immediately after exercise and 1 hour after exercise to see what happened.
Study Results:
- ASEA did not help people ride the bike any faster compared to placebo.
- ASEA did not reduce exercise-induced inflammation compared to placebo.
- ASEA did not reduce exercise-induced oxidative stress compared to placebo.
- ASEA did not alter exercise-induced changes in immune function compared to placebo.
The study does note “ASEA supplementation caused a significant shift in 43 metabolites” before exercise occurred ―especially free fatty acids and vitamin C. While this is interesting, I'm not sure how this relates to improving exercise performance. Remember, the supplement didn’t seem to help people ride the bike any faster.
These researchers also note free fatty acids and vitamin C were made more available before exercise. That is interesting too, but what about during exercise? There is no mention on fatty acid availability during exercise. That’s too bad because if fatty acid availability were increased during exercise, it might mean ASEA could improve exercise endurance.
I hope this study is replicated to determine fatty acid use during exercise.
Study Problems:
While this investigation, is listed in a science journal, it appears as an abstract. Abstracts are summaries of research which do not necessarily have to go through the peer review process. The lack of peer review decreases the significance of abstracts in my view.
Why wasn't the entire study published? When the study first came out, it was highly touted on the company website but today, it cannot be located.
ASEA Mouse Study
In this investigation, mice were force-fed ASEA or a placebo for 7 days prior to running to exhaustion. Basically the mice getting supplement ran about 29% longer than the mice getting the placebo. This is very interesting but it’s a mouse study.
5 Other ASEA Research
The Science page of the product website, used to list additional evidence. While they no longer appear to be available, there used to be 9 downloadable pdf files. Below is a summary of each along with my opinions of them.
1. ASEA Safety Studies Summary
This paper is also titled: ASEA Ingestion, Safety, Summary from Human Studies North Carolina Research Campus Human Performance Laboratory.
This study looked at how the supplement was tolerated in 106 overweight people who drank 4 oz per day for 12 weeks compared to placebo.
Results. There were no side effects reported compared to the placebo group. ASEA had no effect on cholesterol levels, blood sugar levels or CRP levels, all of which were high in this group of overweight people. There was no mention if people lost weight.
Possible Problems
- This does not appear to be a published, peer reviewed study.
2. PNNL Safety Report. This paper is actually titled “Data from an In vitro Study Relating to Product Safety (PNNL stands for Pacific North West National Laboratory)
This was basically a test tube study. ASEA did not result in any toxicity when cells were exposed to it. That's good.
Possible Problems
- This does not appear to be a published, peer reviewed study.
3. Reactive Molecules Verification
This paper is also titled “Verification Procedure for Reactive Molecules in ASEA.”
This is just a paper that talks about quality control of ASEA. I'm happy they have quality control measures in place. That says a lot about the company.
4. ASEA Antioxidant Efficiency
This paper is also titled “Report For ASEA on Experimental Results-In Vitro Antioxidant Enhancement and Oxidative Stress Reduction.
This paper relates how cell cultures treated with ASEA showed improvements the antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX).
Possible Problems
- This does not appear to be a published, peer reviewed study
- This is test tube study
- Effects in cell cultures do not necessarily mean the same thing occurs in humans
5. Athletics
This paper is also titled “Report to ASEA on VO2max Athletic Endurance Enhancement Testing.”
I located a summary of this study online. In this investigation 17 athletes were tested for aerobic capacity before and after 2 weeks of taking the supplement each day.
Results
Athletes improved aerobic capacity after taking the supplement.
Possible Problems
- This does not appear to be a published, peer reviewed study
- They don't tell us what kind of athletes these were
- There was no placebo group to compare the results to
- Study speaks of “significant trends” but without a placebo group we don know if the improvements were clinically significant.
6. ASEA Metabolite Findings FAQ
This is a FAQ paper summarizing the results of an exercise study of 20 people conducted at Appalachian State University. I summarized this study above, in the Research section.
Possible Problems
- This does not appear to be a published, peer reviewed study.
7. ASEA Research Summary Presentation
This is titled “ASEA Metabolomics.” This is the human exercise study I summarized above.
8. White Paper on the Effect of an Immune-Supporting Supplement, ASEA, on Athletic Performance based on a Pilot VO2max Test
In this paper, the supplement improved aerobic and anaerobic exercise performance in 18 well conditioned men and women who either rode a bike or ran on a treadmill.
Possible Problems
- There is no placebo group.
- This does not appear to be a published, peer reviewed study.
9. White paper: Bioactivity of ASEA™ Related to Toxicity, Glutathione Peroxidase, Superoxide Dismutase Efficacy and Related Transcription Factors
Possible Problems:
- This is a test tube study
- This does not appear to be a published, peer reviewed study
6 Where To Buy ASEA
The redox signaling supplement is not sold in stores like Walmart, Target, Walgreens, or CVS. It can be obtained directly from an ASEA associate. These are people whose business it is to help people obtain this supplement.
One thing I noticed was there didn't seem to be a way for people to order ASEA directly from the company website. I kind of appreciated this because it means they want people to order it from an ASEA association. In other words, the company is not in competition with those who sell it. The supplement can also be found online too.
7 How Much Is ASEA
I think the cost depends on whether your are an associate or not. If you just want to use it yourself (and not sell it), then the price is around $150 per month but that may also depend on enrolling in an auto shipment program. Associates likely get discounts. When in doubt, it's best to ask an associate for the details.
8 ASEA And Exercise
Does ASEA water help people exercise better? Let's just say I'm skeptical right now. Currently we have a mouse study that hints it might work and a human study showing it doesn't work. I'd like to see better human studies on this topic.
For the athletes reading this, ASEA is NSF certified. NSF (NSF.org) is company that ensures supplements contain what they say. Supplements that have the NSF certification are often preferred by athletes who undergo random drug testing. I'm glad this supplement is NSF certified.
9 ASEA And Weight Loss
Can ASEA help weight loss? Other than it being low in calories, I don't think so. As far as I can tell, claims of the supplement helping burn fat appear to mostly come from the human exercise study summarized above. In that investigation, it was noted that people who drank 4 oz of ASEA per day for a week, had a greater release of fatty acids (triglycerides) at rest.
While this is an intriguing finding, this was an exercise study and not a weight loss study. There was no mention of people losing weight. Since that investigation only lasted a week, I doubt if any weight loss occurred.
Researchers at the University of North Carolina have completed a study which tried to see if the supplement would raise metabolic rate. This study was completed in 2013 but no results have released. Since its been over 5 years since the study was completed, my guess is the results were not impressive.
10 ASEA And Cancer
There is no evidence ASEA water can cure cancer or reduce it from occurring. The same thing goes for every other disease out there (heart disease, diabetes, Autism, arthritis, eczema, Acne, Lyme disease, tinnitus, dementia, fibromyalgia, blindness, etc). I'm not aware of any research on this water involving any health condition. People may say it does a lot of amazing things about what this supplement can do but for now, there is no clinical evidence for any of it.
Having lost both parents to cancer (less than 3 months from each other), I know how scary a cancer diagnosis can be. It's normal to look for answers. I don't believe this supplement is a cancer cure. I just wanted to say this in case you have heard otherwise. While I dont believe it will interfere with chemo or radiation therapy, I also don't think it will improve how they work either.
11 ASEA And Scars
No research appears to show if the supplement helps scars heal faster, fade or disappear. There seems to be no evidence either way.
12 ASEA And Glutathione
Glutathine is an antioxidant compound which tends to decline as we get older. Some have said ASEA can raise glutathione levels by over 500%. I can find no evidence in humans for this statement. If anyone has evidence it does this, let me know.
13 ASEA And Hair
If ASEA promotes hair growth or slows hair loss, evidence cannot be located. There is no proof either way.
For more on hair growth see these reviews:
14 ASEA vs. The Competition
Many supplements promise to help us age gracefully. Here's how this supplement compares to some of the more popular supplements out there:
ASEA vs. Nerium
Nerium has a supplement called Nerium EHT. This supplement contains an extract from coffee (called EHT) which is touted to improve memory. No studies have compared ASEA to Nerium EHT to see how they compare to each other. Like ASEA, Nerium also has some research to support it's effects.
ASEA vs. Protandim
Protandim is probably the most well known anti-aging supplement on Earth. Its been around many years and if you count up the research, has more clinical studies than probably any anti-aging supplement on the market. Protandim is said help the body improve its own production of anti-oxidant defenses.
In a way, this is somewhat similar to ASEA but there is no talk of redox signaling with Protandim. There is also no research comparing these supplements to each other.
ASEA vs. Niacel
Niacel, is one of the newest anti-aging supplements. Niacel is a molecule, which comes from the vitamin niacin, called nicotinamide riboside. This compound is said to slow aging by helping our cells make energy better. No research appears to compare ASEA to Niacel which makes saying which would be best, difficult.For more on Niacel see these reviews
15 Is It Approved by the FDA?
In the US, the Food and Drug Administration does not approve supplements. There is a regulation – and penalties -for those who don't follow the rules but, there is no per-approval process before a supplement can be sold to the public.
16 How Do You Take ASEA?
Basally you drink about 4 oz per day. It can be taken on an empty stomach or with food.
17 Who Makes ASEA?
ASEA is a product of ASEA LLC which is located at 6550 Millrock Dr Ste 100, Salt Lake City, UT 84121-6000. The company is located in “Ste 100” which I take to mean “suite 100.” I believe they are one of several companies at this location. For example, Buckner Insurance Company is located at Suite 300 of the same address.
The company website is AseaGlobal.com.
The Better Business Bureau gives ASEA LLC a rating of “A+” when this review was created. the company is a BBB accredited business. See the BBB file for updates and other information.
18 Contact ASEA
The Better Business Bureau lists a contact number of (801) 928-2001. Another phone number is 888-438-5971. For those who are associates, the Associate Support number of 801-973-7499.
19 ASEA Side Effects
My guess is this supplement is pretty safe for most people. I'm not aware of any side effects from using the product. Some people online I saw said it didn't taste good but that is something we all have to decide for yourself. The supplement does have some salt, but it's website states the amount of salt is less than a carrot.
When looking at ASEA testimonials, I saw some people saying some pretty amazing things ranging from the product improving energy levels and reducing arthritis pain to even speeding recovery after a stroke. And then there are those who said the product did nothing for them. As with anything results you experience may vary.
20 ASEA Renew 28
This is a skin cleanser. It contains an ingredient called sodium magnesium fluorosilicate (also called Hectorite) which is scrubbing agent used in various cosmetics. The company states a European dermatology comapny -Dermatest – tested Renew 28. They tested it in 20 women for 28 days. The women said they saw:
- 21% Improvement in wrinkle dept,
- 20% increased skin elasticity
- 23% improvement in overall wrinkles
- 22% improvement in facial skin texture
- 23% improved skin smoothness
- 11% increase in skin moisture
As an aside, notice the women used the product for 28 days. This is where “Renew 28” gets its name from.
In another study, which lasted 12 weeks, improved cellulite.
It is unknown if either of these studies is published in medical journals. If they are, that's great. If they are not, then this reduces their importance in my opinion.
See the review of Joyome by Plexus Slim
21 Does ASEA Work?
For the moment, I'm not going to say ASEA is a rip off or a scam. While I'm skeptical about the ASEA claims and clinical research, I'm going to take the high road and say let's wait for better research. I'm not impressed with the evidence presented so far but willing to look at future clinical studies. If I see better studies, I may change my opinion. For those who want to try it:
Do You Have Any Questions?
I mixed it with moringa, and it worked great. Same goes for Super Beets, ain’t that weird?
Hi Jerry, did ASEA work better when mixed with moringa and/or Super Beets? Can you tell us how it worked great or better than when you just used ASEA alone?
Heres Super Beets Review
Here’s the Moringa Review
I am a “prove it to me” type guy. So, I have a few questions that ASEA won’t or can’t answer. I have asked these questions to the local ASEA sales representative and have written (unanswered) letters to Utah. When I ask the rep, I get “trust me, it works” for an answer or “it’s too technical to explain.” I also get the answers, “The testimonials tell the whole story” and “the scientists at ASEA know more about this than anyone in the world; they are the leaders in this revolutionary ground-breaking science.”
I work with the Univ of FL biochemical lab, Univ of FL Molecular Biology Lab and FL state forensic lab. I would like to verify some of their claims in the lab or with eager to volunteer students.
I know the answer to some of the questions, but I would like to get an answer from them, not a testimonial from a truck driver in Ohio who claims the product repaired the herniated discs in his back in only three weeks. Again, I have written them letters asking, and I have asked their local rep….no legitimate answers.
1. What process is used to identify, validate and quantify the presence of “Trillions of Balanced Redox Signaling Molecules in the Pristine Saline Solution?” Trillions? Should be easy to find.
2. They claim our cells make fewer and fewer of these molecules as we age, okay. So what is the test used to quantify the “increase of Redox Signaling Molecules in a human body” after using their product?
3. They claim their product “boosts efficiency of the body’s own antioxidants by 500%,” how do they test for antioxidant efficiency and how do they quantity that?
4. They claim the product “decreases free radical damage in the body”–how do they test for that and how do they show their product influenced the decrease in damage?
5. They claim the product “promotes enhanced immune function” in the human body–how is this measured as the result of their product?
Without credible answers, my biochemical receptors and C13H19NO2 levels are telling me this magic water is just that, magic. And everyone knows, magic isn’t real.
Hi Amille, your questions seem logical to me. Can anyone answer these questions?
If you ever get your study done at the Univ of Florida, I’d love to see what you turn up.
You are correct. If this was legitimate, a real miracle supplement, it would be worth billions. It would undergo clinical tests and revolutionize the medical industry while “healing” millions of people. But, this is not the case. It has not real clinical evaluation, no valid studies — nothing but testimonials.
If it were real these testimonials would be front page news…they are not… Many of the testimonials are folks tied up in the MLM operation or their friends. All fake. The company is hiding behind outsiders to “advertise” the benefits of the product.
Their associate brag on the product healing everything from cancer, to kidney failure, to heart disease to acne.
John, thanks for sharing your thoughts.
Hi Joe, I really appreciate the time you have taken to give a very fair and unbiased evaluation of this product. I am an Asea associate and currently work globally (mainly in Europe, USA and Australia) with patients, clinicians and several progressive clinics and whilst I completely agree that it will take some time before the studies have gone through all the appropriate channels, we are truly seeing incredible results with Asea in the field.
In many ways, I feel like we are effectively pioneering the use of RSMs in various therapeutic forms. My core team and I are starting to see some incredible trends, and predictable recovery patterns across many conditions; particularly auto-immune (including cancer, diabetes, arthritis) and neuro-degenerative diseases (Parkinsons, Alzheimers, Dementia).
We are also seeing great results with conditions such as chronic fatigue, fibromyalgia, lupus… I was on the phone with one of our French clinics tonight and we were exchanging very similar experiences witnessing reversal of symptoms in a predictable way.
I am certain that the science will catch up. In the meantime, I am excited to work at this new frontier so that we can help people who don’t have the time to wait. I appreciate that you have made some comparisons with other products, however I do believe that Asea Redox is in a new category of its own.
Unlike other supplements it is not foreign to the body – it is already made by our bodies and because it is native, it is easily used by our own bodies without any guess work or experimentation.
We have spent so long looking for ‘cures’ in far away jungles, and yet our bodies already have the ability to repair, destroy and replace damaged cells with healthy ones – sometimes however, we are simply missing the tools. RSMs are one of important keys of this process that keeps us healthy, and free of disease. When we raise our levels, its amazing what the body can do.
Many thanks again for your article.
Hi Cristina, thanks so much. Its very interesting to learn you have been working with clinics. Has anyone expressed an interest in doing research with ASEA for fibromyalgia,lupus, chronic fatigue etc? I’d think as medical people, they would want to at least write up case reports on the reversal of these issues with ASEA. Has anyone said they would do this?
This should be taken with a clear understanding of what it is and that at the molecular level the science is solid. If you take this product looking for some effect there is no study which can quantify a condition that never developes as a result of of the product. This it helps our bodies ability to help itself
Robert, maybe at the molecular level the science is solid, meaning there is evidence for redox signaling. I just looked again at the research and I’m still not convinced redox signaling evidence is evidence for ASEA. Let’s see what their research shows.
Great information – thank you. Do you know if there is any research with regards to autoimmune disorders and Asea helping?
Hi Traecie, I’m not aware of anything specifically dealing with autoimmune disorders. For what it’s worth, I don’t think ASEA will negatively impact conditions. There are many autoimmune disorders out there (thyroid, diabetes, arthritis etc). Is there a specific condition you are thinking of?
I had inflammatory arthritis for four years. I tried many different things. It was gone after three months on ASEA. Miraculous…
Traci, do you have before/after medical documents that prove this? I see from your email you have a medical background so that’s why I ask.
Thank you for all your research on this. Does this article provide any of the science you deem valid?
https://www.redoxproduct.com/files/8515/0743/5279/ASEA-REDOX-Gene-Study-Summary.pdf
Hi Mattie, thank you for sharing this. I read the PDF of the study you provided. It looks very interesting. One thing I did not see though is where – other than ASEA publications – this study is published. I’d like to see this study go through the peer review process so other researchers can take a look at it. I’m sure the study will eventually be published (these things take time occur).
It’s interesting that they say the placebo contained the same saline as ASEA but without the redox signaling molecules. I’d like to know how they removed the redox signaling molecules. What’s that process look like? And, if you can remove those molecules, what is the concentration of redox signalling molecules in ASEA?
Does anyone care to weigh in on this interesting ASEA research summary?
Joe. They did not removed the signaling molecules. They just used a saline solution. Free from signaling molecules. You can use your common sense to understand that.
I suggest to start wondering and doing research on chemiotherapeutic medicines instead. It’s a much deeper subject – did anyone got healed by cancer using them? Or its just another way for the pharmaceutical companies to make money? That’s a serious subject to study.
Asea is a product with the purpose of restoring the body’s functionality and make it more efficient. When such a high tech biological mechanism that human body is – is working properly, there is no room for diseases. A correct lifestyle and wise nutrition- including suplements – will lead to a very good health and quality life. We are better than “Starbucks generation”.
At least there are many testimonials that Asea it’s working. Compare those testimonials with those from chemiotherapeutical medicines. See which one it says it does in the specs but in reality it doesn’t. Cheers.
Augustin, ok so where do the redox signaling molecules come from then?
Hi Joe, I appreciate your willingness to look objectively at the asea studies. I am curious about the efficacy of its claims. Just a couple of thoughts. Studies aren’t peer reviewed. Articles are peer reviewed. I would be interested in knowing if the research studies by asea were written on. Do you know? Also just a point of correction, an abstract is a summary of an article about research studies and not a different type of research.
I think in one of your comments you said the studies were sponsored by holders or investors in the patent(s). How/where did you verify that? Id like to know more about that.
Your article said that asea is NSF certified and that NSF is a company that “ensures supplements contain what they say.” So does that mean asea does in fact contain redox signaling molecules?
Have you looked into the “independent” lab that asea says has verified its product, Bioagilytix? Are they reputable? Are they financially tied to asea or truly independent?
Thanks and look toward to your response!
Laura
Hi Laura, sorry it took so long to reply to you. I appreciate you pointing out studies vs articles. Since I’m usually writing for the general public, I hope you will forgive my interchanging these words.
As far as I can tell, ASEA sponsors the research on their product. That’s not necessarily a bad thing in my book as long as a company takes no role in the research. For example, one of the studies (Effects of ASEA beverage intake on endurance performance in mice) was funded by “Reoxcyn Discoveries Group.” This company shares the same address as ASEA – 6550 Millrock Dr Ste 100, Salt Lake City, UT 84121-6000. and the name of the founder of ASEA -Verdis Norton- is mentioned on this summary of Reoxcyn Discoverys Group too https://www.bizapedia.com/ut/reoxcyn-discoveries-group-inc.html
As for Bioagilytix, they are located in North Carolina. I did not see any formal relationship to ASEA when I looked. Their website appears to show they do a variety of things that dont seem related to ASEA.
You bring up an interesting point about NSF certification. I think all the NSF certification does is test for the presence of banned substances (steroids, etc). While I could be wrong, I dont believe NSF tests products for labeling accuracy.
Hope that helps and thanks again for your very good questions 🙂