Gray Hair Supplements: Do They Work? Review of Research

Update 9/5/20. One of the first signs that we may be getting older is that our hair slowly starts to turn gray. Each year people spend billions of dollars on dyes and creams to help hair keep its youthful appearance. But what about supplements? Yes, there are indeed pills touted to turn back the clock and restore hair to its natural color. One product I quickly ran into as I wrote this review is called Catalase Hx. The word – catalase – is a reference to what's said to be the active ingredient in most of these supplements. But do they work? In this review, I want to look at Catalase Hx and in doing so, try to see if it has any evidence showing that it stops gray hair. If we can figure this out, we can understand all of these products.  By the end of this review, you'll have a better idea of whether these “no gray hair” supplements are right for you.

Other Gray Hair Reviews

• Amla Fruit Review
• Pseudocatalase review
• PHYTO Re30 Review
• SeroVital Hair Regeneres Review

Who Makes Catalase Hx?

Invite Health is the name of the company.  According to the Better Business Bureau file, Invite Health is located at 900 Shames Drive , Westbury, NY 11590. As can be seen from the link, this building does indeed display “Invite Health.” On the bottle of Catalase Hx I have, there is another address listed: 1645 Jericho Tpk, New Hyde Park NY 11040.

An online search of this address also shows that this building is next door to “Hickey Chemists.” Jerry Hickey, a pharmacist, is the Chief Scientific Officer of Invite Health. He also hosts Invite Health Radio, on local radio stations.

The About page of Invite Health states that Hickey Chemists merged with Invite Health in 2001. The BBB gives Invite Health a rating of “B+” when this review was created. Do check the file for updates and additional information.

How To Contact Invite Health

Their website lists a hotline number of 800-349-0929. According to the Better Business Bureau File, Invite Heath can also be reached at 718- 325-1100. The contact number listed on the bottle of Catalase Hx I have is 800 437 8090.

Catalase Hx Ingredients

According to the product label, 1 bottle of Catalase Hx contains 30 capsules. In 1 capsule there are the following ingredients:

Catalase	600 mg
Picrorhiza	100 mg

Let's look at these ingredients separately

Catalase

Catalase is an enzyme, and a lack of it is involved in hair turning gray. As we get older, we make less catalase. To summarize the explanation listed on the Invite Health website, lack of catalase causes the buildup of hydrogen peroxide, which in turn “bleaches” the hair and skin by blocking the production of the pigment melanin, which gives skin and hair its color.

They go on to say that adding catalase can aid in “helping to prevent discoloration.”

This is an intriguing notion.

Could taking the catalase enzyme:

1. prevent gray hair?

2. restore the natural color to already gray hair?

As I looked over the Invite Health website, one thing that occurred to me is where they said catalase might help “prevent discoloration.” That is not necessarily the same thing as saying catalase would reverse grey hair to its normal color.

Even so, is there any evidence that the catalase enzyme helps prevent gray hair? Unfortunately, I didn’t see any studies on the Invite Health website to show it did. So I searched the National Library of Medicine for:

• Catalase gray hair

• Catalase melanin

I wanted to see if anyone ever tried to give catalase to people to see if it actually reversed gray hair. While I did see a few studies showing catalase and hydrogen peroxide are involved in the graying process, I saw no studies attempting to see if giving catalase to people would return hair to its normal color or slow down the graying process.

What's up with that?   Studies related to catalase and gray hair I did locate include:

• A 2014 study titled Premature Graying as a Consequence of Compromised Antioxidant Activity in Hair Bulb Melanocytes and Their Precursors
• A 2009 study titled Senile hair graying: H2O2-mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair.

Neither of these studies show that catalase supplementing stops or reverses gray hair. I provide them in the hopes that they will help others who are investigating this topic.  

Picrorhiza Kurroa

According to the Invite Health website Picrorhiza is “helpful in boosting the body’s Catalase production.” So, I searched the National Library of Medicine for:

• Picrorhiza catalase

• Picrorhiza  gray hair

Oddly, no human studies showed up, although I did locate 2008 study titled Antidiabetic and antioxidant effects of Picrorhiza kurrooa rhizome extracts in diabetic rats, where picrorhiza improved catalase production in diabetic rats. What about people?   I then Googled these words to see if anybody else online might list research.

While I saw websites that discuss picrorhiza and its role in helping gray hair, nobody showed ANY research studies. It's like everybody repeats what everybody else says about this stuff. Where's the human evidence?

As an aside, I also saw references to cosmetics giant, L’Oreal, and how they were coming out with a pill that will stop gray hair (as long as you keep taking it) from occurring in the first place.

Based on my inability to find any published, peer-reviewed proof showing that supplementation with either catalase and/or picrorhiza  helps gray hair, I can't say if it works.

Other Gray Hair Supplements

Catalase Hx isn't the only grey hair pill out there. Another supplement, called Go Away Gray, made by a company called Rise-n-Shine LLC was featured in this 2013 Chicago Tribune article titled Can a supplement reverse graying hair?

While I can't be sure, according to the Chicago Tribune article, Go Away Gray appears to have been created in response to the owner seeing the 2009 catalase study I referenced above, which, incidentally doesn't show catalase supplements help.

Go Away Gray contains 5000 IU of catalase as well as folic acid, zinc, biotin and copper, as well as a “synergistic and proprietary blend” of ingredients that are not listed on the bottle. So far, Go Away Gray appears to have no studies showing that it reverses gray hair.

Another product called Get Away Grey, also contains catalase. USA Today posted an article in 2013 titled Can enzyme supplements really keep hair from going gray?   Forbs also posted an article that same year titled A Pill To Prevent Gray Hair – Is It Finally On The Way?

I'm shocked that nobody in the scientific community has published a paper to test whether giving catalase to people orally reverses gray hair or not. In the words of some teenagers today, that's an “Epic Fail.”

Update. In May 13, 2013, the makers of Go Away Gray and Get Away Gray have settled charges made by the Federal Trade Commission (FTC) about claims made pertaining to these supplements. Here is the FTC Press Release.

Can We Absorb Catalase?

When  gray hair pills came to my attention, my first thought was “can we absorb catalase?” “Can it survive digestion ?” Catalase is, after all, an enzyme. Enzymes are basically protein-based machines.

When we eat protein (fish, steak, whey protein), it's broken down into the amino acids that make up the protein. Those amino acids are then absorbed into the body and used to do whatever the body needs them to do, whether it's make more muscle, or repair a cell in your ear lobe.

Since catalase is made of protein, can it make its way through digestion and into the bloodstream as intact, undigested catalase? I can't find any proof we can absorb catalase. If we can't absorb catalase, then all these catalase gray hair supplements might be useless.  

What About Sublingual Catalase?

If we can't absorb catalase via the stomach, what if we put a catalase supplement under the tongue and let it be absorbed that way? This would let it enter the blood undigested and, in theory, help it get to the hair follicle to work its magic. It's a fascinating idea, although I can't find any studies to see if it's ever been attempted. The same thing goes for transdermal patches too.

Sublingual supplements can be found on the web but when I looked, I didn't see any evidence they helped at restoring hair color. If anyone ever tries this experiment, do let me know what happens.

Catalase vs. PseudoCatalase

PseudoCatalase is not the same thing as the catalase enzyme. Rather,  it refers to an effect of a cream that seems to restore skin and hair color when combined with sunlight. There is research on pseudocatalase, which is very interesting.

Read the PseudoCatalase review for more on this product.

How To Naturally Raise Catalase

Is there anything we can do to raise catalase levels naturally? Well, it turns out there might be. One study noted that exercise can raise catalase levels by over 400%. This only involved lab rats though. Ironically, a human study, involving 18 soccer players noted that exercise led to a decrease in catalase levels.

It's thought catalase levels increase to compensate for exercise ramping up free radical production -and that too much exercise might overwhelm anti-oxidant defenses, leading to reduced production of catalase. Regardless of the theory, there doesn't seem to be much research on this -and even less about how this might be related to the loss of hair color.

Lowering homocysteine may also reduce gray hair from developing. Homocysteine contributes to heart disease and generates free radicals by ramping up hydrogen peroxide production. While reducing homocysteine is great from a heart health standpoint, I've never seen any studies linking this to hair color. Does it work?  It can't hurt, but I can't say either way.

Simple ways to reduce homocysteine levels include increasing the intake of folate (or folic acid), vitamin B12 and vitamin B6.

While we are on the topic of diet, one human study noted people with prematurely gray hair had low levels of iron, serum ferritin, calcium vitamin D and vitamin B12. This doesn't prove lack of these nutrients causes gray hair.

If gray hair is-at least – partially related to elevated hydrogen peroixde -then it makes sense to eat foods that contain naturally occurring antioxidants. Any food that is colorful (red, green, orange, purple etc) will have these ingredients.

Basically, I'm talking about fruits, veggies, beans and teas.

Do Anti-Gray Hair Pills Work?

Can catalase supplements restore hair to its natural color again? Well, on the Invite Health Expert Discussion page for Catalase Hx, Jerry Hicky, the Chief Scientific Officer for Invite Health says:

“I've had clients tell me they went on catalase and their hair color came back. How do I test that? How do I know if that’s true? I don't know.”

This would be pretty easy to test. Give people catalase Hx for 4-8 weeks and see if their hair returns to its normal color. Easy-peasy! Because of the ease at which this can actually be tested.

Personally, I feel gray hair is more complex than just a catalase deficiency. Comment below if it has helped you. While we tend to think gray hair is a sign of getting “older” I'm not so sure of this. Rumor has it my grandfather started to go gray at 17. Right or wrong, that, at least, gives me some solace when I look in the mirror.

Here are all the catalase supplements on Amazon.

Any Questions Or Comments?