Arthro-7 is a supplement touted to “relieve joint support” and “promote joint mobility” in “as little as 7 days.” Those are some really interesting words to be sure. That and the fact that the product contained an ingredient that I normally dont see in many arthritis supplements made me want to review it. So, in this review, let's look at the research and ingredients in Arthro-7 and see if it might be right for you.
Arthro-7 does have some arthritis research. Here is a summary of the studies I located.
Effects of Arthro-7® in relieving symptoms of osteoarthritis with mild to moderate arthralgia. This study was published in 2013 in a journal called Nutrition and Dietary Supplements. The study involved 64 people (31 men and 33 women) in China over the age of 50 who were diagnosed with osteoarthritis. The people were randomly given either Arthro-7 or a placebo.
The placebo was corn starch. There were 24 people in the Artho-7 group and 42 people in the placebo group. People filled out questionnaires before and after the study to gauge improvements. The study lasted 12 weeks.
Those getting Arthro-7 took 4 capsules for the first 4 weeks and then 2 capsules after that for the rest of the study.
Both the placebo and Arthro-7 were provided by Robinson Pharma, the maker of Arthr0-7. The study notes that the company took no role in collection or interpretation of the results. That's good.
The study also mentions that 3 of the researchers “are current or previous employees of DRM Resources which sponsored the project.” DRM Resources is a marketing company in California that appears to specialize in the health and wellness industry. Their website is DRMResources.com.
Interestingly, according to Whois.com, the person who registered the DRM Resources website is Tuong Nguyen, the same person who registered both the US Doctors Clinical site and Robinson Pharma site.
This says to me that Robinson Pharma sponsored the study. I see no problems with a company sponsoring research on their supplement. I dont know why they didn't just come out and say this?
Prior to this study, an investigation in 2008 also noted that Arthro-7 might help arthritis. Like before, this study also took place in China. This study used the AR7 Joint Complex, which appears at the heart of Arthro-7s arthritis benefits. I'll cover more on the AR7 Joint Complex Below.
The study involved 100 people (89 completed the study) with arthritis who were randomly given either a placebo or the AR7 joint Complex for 4 months. People getting the AR7 Joint Complex reported less pain and tenderness and better quality of life than those who got the placebo. X-rays however showed no changes in joints between groups.
These were the only studies I located on the product.
Given that they call the company US Doctors Clinical, it's ironic both of their clinical studies occurred in China.
According to the product website, 2 capsules of Arthro- 7 contains the following ingredients
|Ingredient||Amount per 2 capsules||Percent Daily Value|
|Vitamin C||140 mg||234 % DV|
|AR7 Joint Complext (composed of the following)||1170 mg||N/A|
|Collagen (from chicken)||?||N/A|
|Cetyl myristoleate (CMO)||?||N/A|
|Turmeric (curcuma longa extract, root, 95% curcumin)||?||N/A|
|Bromelain (from pineapple,2400 GDU)||?||N/A|
Other ingredients, listed in order as they appear on the label, are:
- Gelatin (since replaced by hypromellose)
- Silicon dioxide
- Magnesium stearate
- Titanium dioxide
With respect to hypromellose (sometimes called “HPMC”), it has replaced gelatin in the product. My guess is this forms the coating of the Arthro7 capsules. Here is its Wikipedia page, for those who want to know more.
These other ingredients likely play no role in any arthritis effects of Arthro-7. Let's now look at the arthritis research on each of its main ingredients
Vitamin C (also called ascorbic acid) does many things in the body including helping the body make collagen. This compound, found in the joints, is broken down in people with osteoarthritis. Two veggie capsuels of Arthro7 contains 140 mg of vitamin C
With respect to arthritis, one study from 2003 noted that 1000 mg of vitamin C helped people feel less arthritis pain.
The AR7 Joint Complex
Arthro-7 contains a proprietary blend of ingredients, they call the AR7 Joint Complex. As mentioned in the ingredients table above, the joint complex is composed of:
- Cetyl myristoleate (CMO)
- Lipase 30
While we are not told how much each of these is in Arthro-7, we are told that all the ingredients add up to 1170 mg (just over 1 gram). We can also assume that the ingredients at the top of the list make up most of the Ar7 Joint Complex, while those at the bottom, make up the least.
Let's take a look at some of the arthritis research for each of these ingredients and see if we can make sense of them
The label tells us that Arthro-7 gets its collagen from chickens. Collagen is a component of cartilage and other connective tissues. The cartilage between joints is what is worn away in osteo-arthritis (the most common type of arthritis). So, on the surface, it might seem logical that eating collagen might help improve (support) the collagen in our joints.
There are indeed some studies on collagen helping arthritis.
In this 2012 study, 80 people with osteoarthritis of the hip and knee were given either a placebo or 2 grams of hydrolyzed collagen from chickens for 70 days.
Hydrolyzed collagen means the collagen was broken down to its individual amino acids. This is to improve its absorption by the body.
People reported that after about a month, they had less arthritis pain compered to those who took the placebo. The people in this study used 2 grams of collagen. The people in this study used a product called Biocell Collagen.
While studies like this appear hopeful, not all studies show collagen works.
The product label says it is not a significant contributor of type II collagen. See my review of Frog Fuel for more on type II collagen.
Cetyl Myristoleate (CMO)
This is the ingredient that made me want to review Arthro-7. I don't see it in many supplements although it is an interesting compound. It's pronounced “see-till-mir-is-toll-E-ate.” It is a type of fatty acid that is thought to help lubricate joints.
In a 2002 study, 64 people with knee osteoarthritis were given either vegetable oil (as a placebo) or 350 mg of CMO for 68 days. People who got CMO reported being able to do more knee flexion than those who got the placebo. Neither group though appeared better at extending their knees.
In a study from 2004, 45 people with osteoarthritis of the knees were given either a placebo cream or a cream that contained CMO. People were told to use the creams on their knees twice a day for 30 days. The people who used the CMO-containing cream were able to climb stairs significantly faster than those who got the placebo cream. People getting the CMO cream were better able to walk down stairs too.
[easyazon_link keywords=”Celadrin” locale=”US” tag=”mscscs-20″]This is the product[/easyazon_link]used in both of the above studies. It's available in both pill and cream form.
Some supplements -like Omega XL – contain a different type of fatty acid from the green lipped mussel, thought to help arthritis pain. See my review of Omega XL for more on that compound.
This is a fat digesting enzyme. I am not sure what effect it has on arthritis pain. My guess is it may be present to help breakdown and absorb CMO which is discussed above.
The other name for this is MSM. It's pronounced “methy-sul-phon-el-meth-ane.” The MSM ingredient is popular in arthritis supplements. Products I previous reviewed that also contained MSM include:
- Instaflex (click to read review)
- Australian Dream (click to read review)
- Tissue Rejuvenator (click to read review)
- Joint Juice (click to read review)
Several studies have noted that MSM appears to mildly help osteoarthritis pain. That said, Not all studies show MSM helps arthritis pain. This makes drawing a conclusion – does it work or doesn't it work – difficult at this time. Studies noting that MSM helps have used from 1500- 3000 mg per day.
Tumeric is what gives mustard its yellow color. It's scientific name is Curcuma longa. Turmeric contains a chemical called Curcumin, which has shown some arthritis benefits. That said, curcumin is just one of the chemicals in turmeric. As such, I prefer turmeric over curcumin supplements as I believe it provides a wider spectrum of effects.
As an aside, I sprinkle turmeric on my oatmeal and put it in my smoothies. Give it a try. It doesn't taste bad at all.
In one study from 2014, turmeric was noted to be better than ibuprofen (Advil) in 367 people with osteoarthritis of the knee. In this study, people took 1500 mg of turmeric for 4 weeks.
Some research on a specific turmeric product, called [easyazon_link keywords=”Meriva” locale=”US” tag=”mscscs-20″]Meriva[/easyazon_link], noted that people needed less pain medications after they used the supplement for 2-3 months.
[easyazon_link keywords=”turmeric” locale=”US” tag=”mscscs-20″]Here is turmeric on Amazon.[/easyazon_link]
Some supplements combine turmeric with black pepper. This is to increase the absorption of the turmeric. Turmeric, alone is not well absorbed by the body.
Bromelain is a protein digesting enzyme found in pineapples. The enzyme appears to reduce inflammation and this is likely why it's found in arthritis supplements. That said, since it's an enzyme (which is made of protein), I wonder how much can survive digestion and be absorbed intact?
The label of Artho-7 says that the bromelain contains 2400 GDU. The letters GDU probably refer to “gelatin digestion unit” and likely refers to the strength of the enzyme at digesting gelatin, a protein. Since collagen is also made of a protein, I wonder if bromelain may also be used to better breakdown and absorb collagen?
What Are The Active Ingredients?
The ingredients in the product seem logical for an arthritis supplement. For those, like me, wondering what the main active ingredients might be, my thoughts would be these:
- Cetyl myristoleate (CMO)
Obviously I have no proof either way if I'm correct or not. That would take clinical studies that pitted Arthro-7 to each of these ingredients individually as well as their combination. I base my thoughts just on the research I was able to find.
How Much To Take?
The directions are to take 2 Arthro-7 capsules capsules twice a day for 1 or 2 weeks. When feeling better, it's recommended to reduce intake to two capsules per day as a maintenance dosage.
Who Is Dr. Lisa Pavone?
Lisa Pavone,MD is feathered on a Arthro7 infomercial. According to the University Of Michigan website, she is Co-Medical Director – Livonia Vein Center, Troy Vein Center. According to this YouTube video, shes appeared on several TV shows ranging from Oprah to some previous infomercials.
Who Is Dr. John Hahn, MD, ND
Like Dr. Pavone above, Dr. Hahn is also featured on an Arthro7 infomercial. He is a foot an ankle surgeon. He is also a doctor of naturopathcic medicine (ND).
What's Arthro7 Sport?
The other version of this supplement is called Arthro7 Sport. As the name implies this product appears to be marketed to people who exercise regularly. Here is a side-by-side comparison of both versions:
|Arthro7 (2 capsules)||Arthro7 Sport (2 capsules)|
|Vitamin C 140 mg||Vitamin C 140 mg|
|AR7 Blend1170 mg composed of the following:||AR7 Blend 1170 mg composed of the following:|
|Collagen (from chicken)||Collagen (from chicken)|
|Cetyl myristoleate (CMO)||Cetyl myristoleate (CMO)|
|Lipase 30||Lipase 30|
|Methylsulfonylmethane (MSM)||Methylsulfonylmethane (MSM)|
|Hyaluronic Acid 100 mg|
As can be seen, the only difference between these supplements is that Arthro7 Sport contains 100 mg of hyaluronic acid. This is a compound we make and its also found in some arthritis supplements.
One study, published in 2012 noted that 200mg of hylauronic acid improved arthritis pain better than a placebo, when it was given to older adults for up to a year. Lower amounts might work too as is mentioned in this 2015 review of hylauronic acid and arthritis.
Is Arthro7 Sport better? At the time this review was created, there doesn't appear to be any studies comparing the effects of regular arthro7 to arthro7 Sport.
What Is Arthro7 Cream?
Arthro7 Fast Acting Cream has different ingredients than the capsules. As is shown on the products website, the active ingredients in Arthro7 cream are:
- Capsicum (0.6%)
- Lidocaine (0.1%)
- Menthol (3%)
All 3 of these ingredients are well known to temporarily relieve muscle aches and pains. They are found in other creams you may have heard of. For example:
- Capsicum is found in Capzaisin arthritis cream
- Lidocaine is the active ingredient in Aspercream
Menthol is found in variety of creams.
Most sports and arthritis creams, temporarily mask (replaces) feelings of pain with either sensations of heat or cold.
Australian Dream, contains a different ingredient than others. See that review for more insights.
Who Makes Arthro-7?
The company name that appears on the packages of Arthro-7 is called US Doctors Clinical. Their website is USDoctorsClinical.com. According to their website, they are located at 15568 Brookhurst St. Ste. 374 Westminster, CA 92683. This is the same address as “Mail Today,” a mailbox company. My guess is that “Ste 374” is their mailbox number.
According to Whois.com the US Doctors Clinical website was registered in 2011. The address listed on file there for the company is 1683 Sunflower Ave, Costa Mesa, CA. If you Google this address, it corresponds to another company called Robinson Pharma.
Robinson Pharma, in turn, is the company that makes Arthro-7. Their website is RobinsonPharma.com. They are located at 3330 S.Harbor Blvd. Santa Ana CA 92704.
If you look at the whois.com files for USDoctorsClincal and RobinsonPharma you see that both websites were registered by the same person -Tuong Nguyen. According to this article at New Hope Network, he is the founder and CEO of Robinson Pharma.
I bring this up because it leads me to believe that US Doctors Clinical is actually a sub-company, of Robinson Pharma. That's not necessary a bad thing because Robinson Pharma is an actual, physical, brick and mortar, supplement company whose website states all products they make are made in the US.
The Better Business Bureau gives Robinson Pharma a rating of “A+” at the time this review was created. See the BBB file for updates and more information.
How to Contact Arthro-7
The Arthro7 website lists this customer service number: 800-914-0594. To contact Robinson Pharma, call 714-241-0235.
Arthro-7 Side Effects
In healthy people, I believe Arthro-7 is safe. The product label states that women who are pregnant or lactating or anyone taking any meditations or dietary supplements should first consult with their doctor. Based on the ingredients, here are a few other things to consider. This list is not complete:
- Stop taking all dietary supplements not recommended by your doctor at least 2 weeks before surgery.
- Speak to your doctor if you take blood thinner medications.
- Turmeric might aggravate gallbladder problems in high doses (more than the product contains).
- People with hemochromatosis (iron overload disease) should speak to their doctor first. Vitamin C can increase iron absorption.
Does Arthro-7 Work?
Arthro-7 does have a couple of studies that suggest it might help reduce arthritis pain in some people. The choice of ingredients in the product appear logical for the most part. I think improvements in pain would vary according to the severity of arthritis as well as the type of arthritis one had. While I could be wrong, based on its ingredients, I feel Arthro-7 appears to be best suited for osteoarthritis. The good news is that the product label says most people will see results in only 1-2 weeks of use.
[easyazon_link keywords=”Arthro-7″ locale=”US” tag=”mscscs-20″]Here's Arthro-7 on Amazon[/easyazon_link]if you want to check it out further.