Update 1/6/20. Zyflamend Whole Body is touted as a natural herbal response to inflammation. The supplement is said as being able to benefit many conditions related to inflammation most notably arthritis, cancer osteoporosis, and back pain. But, does Zyflamend really work or is it a scam? Unlike many natural healing supplements, Zyflamend has several clinical studies published in medical journals. In this review, we'll look at the research and try to figure out if it works. Possible side effects will also be addressed. Does it really work? Let's see what we can discover.
Zyflamend Benefits
The product website states that Whole Body was designed to provide:
Zyflamend Ingredients
According to NewChapter.com, the company that makes this supplement, the Whole Body formula has the following ingredients in 2 soft gels:
Rosemary (Rosmarinus officinalis) | 150 mg | % DV |
Turmeric (Curcuma longa) | 110 mg | NA |
Ginger (Zingiber Officinalis) | 100 mg | NA |
Holy Basil (Ocimum sanctum) | 100 mg | NA |
Organic Green Tea (Camellia sinensis) | 100 mg | NA |
Hu Zhang (Polygonum cuspidatum) | 80 mg | NA |
Chinese Goldthread (Coptis chinensis) | 40 mg | NA |
Barberry (Berberis vulgaris) | 40 mg | NA |
Organic Oregano (Origanum vulgare) | 40 mg | NA |
Chinese Skullcap (Scutellaria baicalensis) | 20 mg | NA |
NA=daily value not established
Other Ingredients Listed
The Whole Body supplement label also lists these additional ingredients:
- Extra-virgin olive oil
- maltodextrin
- hypromellose (capsule)
- organic yellow beeswax
- candelilla wax,
- organic sunflower oil
- organic olive oil
These ingredients likely play no role in the benefits of the product.
Zyflamend Research
The NewChapter.com website states that “Zyflamend has been studied at leading research institutions and has been shown to benefit multiple areas of health including joint health, skin health, bone health, and normal tissue growth.” There is indeed research on Zyflamend with many of these studies involving the effects of Zyflamend and prostate cancer.
This supplement has several clinical studies – more than I see for most dietary supplements. Below is a summary of each investigation broken down by date to help you better make sense of them.
2016 Research
In a report titled Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series, researchers note 4 cases of men with prostate cancer that were helped by the supplement.
2012 Research
A test-tube study titled Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells reported the supplement affected prostate cancer cells.
In the study titled Zyflamend, a combination of herbal extracts attenuates tumor growth in murine xenograft models of prostate cancer researchers noted that mice, given the human-dose equivalent of the supplement, reduced prostate cancer cell growth. It's pretty interesting that they gave the mice the amount used in the supplement. I don't see that often.
Researchers published a test-tube study titled Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis which noted the supplement (and carnosol, one of the compounds in the product) inhibited expression of two types of cancer-causing genes and their related cell mutations.
Researchers released the results of a test-tube study titled, Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway, which reported that the supplement improved the death of cancer cells by making them more sensitive the immune system.
The results of another test-tube study titled, Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets, indicated that the supplement, could inhibit the spread of pancreas cancer cells. The effect was greater when the supplement was combined with anti-cancer medications. The supplement was also noted to reduce NFKB, a protein that is related to cellular inflammation.
NFKB is a hot topic in research because of the link between inflammation and diseases like cancer, heart disease and maybe even aging. Other supplements touted to reduce NFKB include Protandim and Anatabloc so see those reviews for additional information.
Another test-tube study titled, Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutamide to inhibit prostate cancer cell growth, indicated that the supplement inhibited the spread of prostate cancer cells and that this effect was greater when combined with prostate cancer medications.
2011 Research
Researchers released the results of a test tube study titled Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer, which indicated the supplement could decrease the growth of prostate cancer cells.
Another test-tube study titled Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells, indicating the supplement inhibited the growth of skin cancer cells.
2010 Research
In a review article titled Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis, the authors noted that they could not recommend the supplement for osteoarthritis or rheumatoid arthritis because there are no human trials showing that it helped those conditions.
2009 Research
Researchers released the study Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial. This study consisted of 29 men (age 40-75) at risk for prostate cancer. Of these, 23 men completed the 18-month study. Every 3 months, blood was taken and analyzed for various things including PSA, CRP, NFKB, and testosterone. Men took Zyflamend gel caps 3 times per day.
The researchers noted Zylamend alone ―and in combination with other supplements:
- reduced PSA levels
- reduced CRP (a marker for inflammation)
- reduced NFKB (a marker for inflammation)
No changes in testosterone were noted. Researchers saw no significant changes in the COX 2 enzyme. This is opposite the findings of the 2012 study mentioned above.
This study appears to be the first human trial of Zyflamend. While interesting, this study did not include a placebo group (that's a problem). Also, the study makes no mention of the other supplements used.
2008 Research
Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model. Here, researchers noted that the topical application of the supplement to the cheeks of hampers reduced chemicals associated with cellular inflammation and mouth cancer.
2007 Research
Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. In this investigation, researchers noted the supplement reduced the formation of osteoclasts (bone-eating cells involved in osteoporosis) as well as the inflammation protein called NFKB. This was a test-tube study.
The role of Zyflamend, an herbal anti-inflammatory, as a potential chemopreventive agent against prostate cancer: a case report. Researcehrs report the results of one person involved in the 2009 human Zyflamend study summarized above. I'm not sure why the researchers decided to release the results of only 1 person? This makes no sense to me.
Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation Here, researchers reported noted the supplement inhibited the growth of prostate cancer cells in a test tube.
2005 Research
Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity induces apoptosis of prostate cancer cells that lack COX-2 expression, Researchers noted that the supplement caused the death of prostate cancer cells in a test tube.
Zyflamend And Cancer
Several clinical studies of this supplement involve cancer, with an emphasis on prostate cancer and to a lesser degree, pancreatic cancer. That's pretty rare as dietary supplement research goes.
The research is interesting but, for the moment, most evidence is limited to lab animal and test-tube studies. I only found 1 human study of Zyflamend and prostate cancer.
Note. When I say “test tube study” I'm making a general statement regarding research that is not conducted in either lab animals or humans.
The supplement may reduce PSA levels, something men may be interested in. One study mentioned above has noted the supplement can lower PSA levels. Currently, there is no evidence the supplement reduces the risk of prostate cancer. Whether the supplement can help breast cancer needs more study.
Zyflamend And Osteoporosis
One test-tube study noting the supplement suppressed the formation of osteoclasts, a type of bone-eating cell that plays a role in the formation of osteoporosis and osteopenia.
Theoretically, this might hint the supplement may offer protection against osteoporosis and/or osteopenia but since there are no human studies of this, it is difficult to tell how much help it would be at this time. The best defense against osteoporosis is exercise.
Zyflamend And Arthritis
There is some research noting the supplement may reduce the COX2 enzyme as well as the protein, NFKB, both of which might play a role in arthritis. This is interesting, but I have not seen any studies on the question of “Zyflamend and arthritis pain.” In other words, does the supplement help people with arthritis feel better?
In a review of previous research, conducted in 2010, researchers did not recommend the supplement. This contrasts with many of the positive reviews on Amazon by verified purchasers of the product. There is even praise by some who have fibromyalgia, a form of arthritis.
See the Ribose and Fibromyalgia review for more on this topic.
Zyflamend And Back Pain
A lot of websites mention this supplement can help back pain. It might, but no conclusive evidence on back pain could be located. If Zyflamend reduces inflammation, it might indeed have an effect on helping to heal some types of muscular back pain but as or now, other than testimonials, there isn't any good proof either way.
Zyflamend Research Summary
Here is a summary of the Zyflamend research I was able to locate:
Study Name | Type of Study |
---|---|
2016 Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series, | Case report of 4 men with prostate cancer |
2014 Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells | Test tube study |
2012 Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer | Mouse study |
2012: Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis | Test tube study |
2012: Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway | Test tube study |
2012: Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets | Test tube study |
2012: Zyflamend inhibits the expression and function of androgen receptor and acts synergistically with bicalutimide to inhibit prostate cancer cell growth | Test tube study |
2011: Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer | Test tube study |
2011: Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells | Test tube study |
2010: Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis | Review article of various supplements |
2009: Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial | Human Study |
2008: Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model | Lab animal study |
2007: Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products | Test tube study |
2007: The role of Zyflamend, an herbal anti-inflammatory, as a potential chemopreventive agent against prostate cancer: a case report | Case report of 1 person |
2007: Zyflamend-mediated inhibition of human prostate cancer PC3 cell proliferation: effects on 12-LOX and Rb protein phosphorylation | Test tube study |
2005: Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression | Test tube study |
I personally discount the results of the 2007 human report because it's a report of only 1 person involved in the 2009 human study. As such, that person has already been included in the 2009 human study. Let's group the 2007 human case report with the 2009 human study because these are basically the same thing.
To be fair, let's also leave out the 2010 review article on Zyflemend and antioxidants for arthritis because it's not a study on Zyflamend alone.
Zlyflamend Nighttime
There is another version of this product that is supposed to be taken at night. It is called Zlyflamend Nighttime. Here is a side-by-side comparison of the Zlyflamend nighttime and Zlyflamend Whole Body:
Zyflamend Nighttime (2 capsules) | Zyflamend Whole Body (2 capsules) |
---|---|
Holy Basil (Ocimum sanctum) (leaf) 150 mg | Rosemary (Rosmarinus officinalis) 150 mg |
Turmeric (Curcuma longa) 100 mg | Turmeric (Curcuma longa) 110 mg |
Chinese Skullcap (Scutellaria baicalensis) (root) 100 mg | Ginger (Zingiber officinale) 100 mg |
Lemon Balm (Melissa officinalis) (leaf) 85 mg | Holy Basil (Ocimum sanctum) 100 mg |
Chamomile (Matricaria recutita) (flower) 75 mg | Organic Green Tea (Camellia sinensis) (leaf) extract 100 mg) |
Hops (Humulus lupulus) 75 mg | Hu Zhang (Polygonum cuspidatum) (root and rhizome) 80 mg |
Ginger (Zingiber officinalis) (rhizome) 75 mg | Chinese Goldthread (Coptis chinensis) (root) extract 40 mg |
Valerian (Valeriana officinalis) (root) 40 mg | Barberry (Berberis vulgaris) (root) hydroethanolic extract 40 mg |
Organic Oregano (Origanum vulgare) (leaf) | |
Chinese Skullcap (Scutellaria baicalensis) (root) extract 20 mg |
Valerian root is well known for its sleep-inducing effects.
Other Ingredients
Other ingredients also listed in the PM version of Zyflamend are
- Extra-virgin olive oil
- hypromellose (capsule)
- organic olive oil, maltodextrin
- organic yellow beeswax
- candelilla wax
- silicon dioxide
These additional ingredients likely play no role in the effects of the nighttime version of the product
Who Makes Zyflamend?
The supplement is produced by a company called New Chapter Inc. Their address is 90 Technology Drive Brattleboro, VT 05301. To contact New Chapter their phone numbers are:
- 800-543-7279
- (802) 257-0018
The Better Business Bureau gives New Chapter a rating of “A+” when this review was created. Here is the BBB file on New Chapter. According to the BBB, New Chapter was created in 1983.
In March 2012, Proctor and Gamble bought New Chapter.
Zyflamend vs. Anatabloc
The supplement appears to reduce an inflammation protein called NFKB. The reduction of NFKB is something that the makers of Anatabloc also claim. There is research that Anatabloc can reduce NFKB as well. Because of this, some might wonder:
- Is Zyflamend better than Anatabloc?
- Are both supplements better together?
Sadly, I don't think we will get an answer on this anytime soon. Anatabloc is no longer sold in the US.
For more information see the Anatabloc review.
Zyflamend vs. Protandim
Protandim is touted as an anti-aging supplement and is quite popular in some circles. The people who sell Protandim claim that it can reduce cellular inflammation. One of the ingredients in Protandim is Tumeric. Tumeric also happens to be in Zyflamend.
Could the Tumeric be the common denominator between these supplements? Head-to-head comparisons of Zyflamend and Protandim cannot be located,
See the PB125 review for more insights
Questions And Answers
Does Zyflamend contain caffeine?
No, the supplement is caffeine-free and has no stimulants.
Does it raise blood pressure?
Clinical studies don't show this. Some of the ingredients may lower blood pressure, however. See the side effects section below.
Does it cause people to gain weight?
No study has noted people gain weight while taking Zyflamend. Likewise, no clinical studies show weight loss either.
Does Zyflamend cause constipation?
No studies show constipation as a side effect. To reduce constipation, make sure to maintain enough fluids and fiber in the diet.
Does Zyflamend prevent cancer?
There is preliminary evidence that Zyflamend may help prostate cancer, but it's too soon to know how much. There's no proof taking the supplement will reduce the risk of prostate cancer or extend the lives of those who have cancer either.
Zyflamend Side Effects
Zyflamend appears safe in the vast majority of people. I'm not aware of any serious side effects. There are over 2000 comments on a Zyflamend supplement on Amazon, with most of them positive.
That said, for those who want to try Zyflamend, here are some things to consider. This list is not complete.
- Start with less than recommended for the first week to see how you respond
- Speak to your doctor first if you are pregnant or breastfeeding
- If you take any medications like blood thinners, speak to your doctor/pharmacist
- Stop taking Zyflamend at least 2 weeks before having surgery
- One human study noted mild GI discomfort from Zyflamend (this is common for many supplements)
- One study noted the supplement may reduce PSA levels. This may have an impact on PSA blood tests.
- At least one study noted that Zyflamend reduces COX2, an enzyme involved in many things such as arthritis. This might mean Zyflamend is a natural COX2 inhibitor. How Zyflamend interacts with other COX2 inhibitors such as aspirin or prescription arthritis medications is not known.
- Tumeric may interact with blood thinner medications
- Ginger may interact with blood thinner medications and reduce blood pressure. People with heart disease should talk to their doctor before using Zyflamend.
Does Zyflamend Work?
There is a growing body of clinical research suggesting Zyflamend may be an effective natural reducer of inflammation. It might also have benefits for people with prostate cancer too. The research is interesting, and the combination of ingredients in Zyflamend seems logical. Zyflamend is also less expensive than many other natural pain remedies. There are several lab animal test tube studies – and some human studies – that seem to show this supplement is doing something. Did it work for you? Leave a comment below and let me know.
Toni Carr says
Does this interact with aspirin, cholesterol med, or beta blocker? My friend had a heart stint put in and was told not to take Aleve anymore, he’s. had a hip replacement on both sides has achey joints also. Would love for this to help him be pain free. He also takes magnesium. Yeah I know it’s an awful lot. I’m trying to get him more on the natural kick. Oh I just got him started on Hawthorn Berry supplement, his Dr was ok with this. Thanks for all your researching.
Joe says
Hi Toni, while I’m not a doctor/pharmacist, my guess is its probably ok. That said, If I were your friend Id show it to his pharmacist and see what she/he thinks about it. Let us know what happens. You are a good friend Toni. Im glad your friend has you in his corner helping him 🙂
Sarah says
Your state that you should stop taking Zyflamend before surgery. Why is that and how soon can you begin taking it afterwards? Asking because my partner is recovering from hernia surgery a week ago and wants to try Zyflamend to see if it will help with healing, as well as his other inflammation issues. Do you think he can try it now, or should he wait?
Thank you and thanks for your helpful review.
Joe says
Hi Sarah, That is a good question. I often give the caution of stopping supplements at least 2 weeks before surgery because so many dietary supplements can have blood thinner properties. This increases the chances of bleeding problems during surgery.
As for when your partner can take zyflamend again after surgery, that is something I am not sure of. My hunch is 1 week is not enough. I’d wait longer. I cant give you an absolute time though. I’m not aware of anything about Zyflamend helping recovery from surgery. When he goes back to the doctor for a follow up Id ask that question. Let me know what they say.
Sarah says
Thank you. I called New Chapter and they said there’s no reason he can’t take it a week after surgery. But we will wait at least 2 weeks. Thanks for your input.
S.
Joe says
Hi Sarah, I think 2 weeks is good. Glad you were able to get through to New Chapter 🙂
Bill James says
Considering taking Zyflamend for lumbar spinal stenosis. Please recommend dosage and advise if any conflict with Eloquis. My wife takes it and it works for her. Thanks. Bill
Joe says
Hi Bill, I recommend you show it to your wife’s pharmacist about the Eloquis. With all new supplements I feel its best to start with less than is recommended to see how you react.
Jeff says
I have recently been hit with severe joint pain. Was recommended I try Xyflamend taking 3 in the morning and 3 at night for 5 days and then cut back to 2 daily. When I started taking it, within 2 days the inflammation was gone and I felt good again. But when I went down to 2 a day, pain and inflammation returned. When it got bad enough, I went back to 6 a day and now feel good again. I don’t know how long I can continue to take 3x the recommended dosage…But my own experience is showing a vast improvement.
Robin says
I’ve used Zyflammend for years. Not only is it effective on my arthritis pain but it also got rid of my chronic gum disease (dentist says I don’t need the $4K worth of laser surgery anymore) and it also has been effective on my eczema (my feet and hands are no longer covered with a blistering rash that I used to have all year around). This is a product I never run out of and never stop using.
Lorraine Best says
I left for a 7 day trip and forgot to pack my zyflamend….by the time I got home the spinal pain was searing from osteoarthritis, especially in the cervical area. I had forgotten how bad the condition really is without the Zyflamend! When I take the Zyflamend, I’m good as new!
Apple Wellness has recently recommended that I consider switching to Curamed. Any input on how the two compare? I’ve been battling threats of ovarian cancer, breast cancer, and ulcerative colitis for a number of years now, so I also take glutathione regularly, along with spirulina, vital greens with bluegreen algae, and magnesium.
I use COQ10 to keep the heart healthy and use beet juice to keep the blood pressure normal. Besides that, I eat whole foods (organic when I can afford it), avoid red meat & nitrates, and minimize corn, wheat, and soy because of pesticides, and of course, I entirely ban all forms of HFCS, MSG, food coloring, preservatives, additives and processed foods.
Joe says
Hi Lorraine, It looks like Curamed is a curcumin supplement (it has 750 mg). Curcumin is an extract of the spice called Turmeric. Curamed uses a trademarked brand of curcumin called BCM95. If you search my site for BCM95 you can see other products that have contained it and the research I turned up on it.
Several supplements have BCM95. Here is some I found on Amazon.
I personally wonder if turmeric itself might be a better way to go. Thats because turmeric contains curcumin. You can get turmeric at any grocery store and here it is on Amazon too.
Im not sure if we can absorb glutathione itself. “NAC” is a supplement that is converted to glutathione. That might be a better way to go for raising glutathione levels. If you have cancer, speak to your pharmacist /oncologist about glutathione first though. Its use is a little controversial in people who have cancer.
Catherine says
It’s a bit hard to tell who paid for those studies and whether there are any conflicts of interests by the researchers ( i.e., are they connected to the company that produced zyflammend). That makes it difficult to assess the results and value of the studies. But thanks for the independent review.
Joe says
Hi Catherine, Thanks so much. Oftentimes, it’s the company that pays for a study to be done. Generally, I don’t hold that against a company, because if they dont pay for studies, they might not get done. If there is a conflict of interest, I do consider that. We can often tell if there are conflicts if we read the entire study. Many studies have, at the bottom, a section called “conflicts of interest.” Study authors often also now tell us if the company had any role in how the study was performed. Hope that helps 🙂
Kristos says
The problem with Zyflamend is Proctor and Gamble own it now, that is not a trust worthy company, all New Chapter products will be ruined they have already gotten rid of Zyflamend PM, and they have taken out the Holy Basil out of the Zyflamend.
Joe says
Kristos, thanks for letting me know about proctor and gamble. Ive updated my review. I did look at Zyflamend on Amazon and I still saw holly basill listed.
pati says
i also see pm available
Joe says
Hi pati, you are correct! I have updated the review to include Zyflamend Nighttime. I also added in some new research on Zyflamend too. Thanks so much for bringing this to my attention 🙂
Dee says
Have used the Zyflamend softgels for 12 years would not be without them!
John Corsiglia says
I’ve had lower back pain and an arthritic knee for 10+ years. N-saids were working, but stomach objected and I tried Zyflamend and Zyflamend PM. It has worked very well––there is adequate pain relief and no stressing of digestive system.
Cindy says
I have been taking Zyflamend for several years. I was diagnosed with spinal stenosis on the vertabrae in my neck and had pain for several years. I also have arthritis in both knees. Since I started Zyflamend I have not taken a single anti-inflammatory drug and remain mostly pain free.
Joe says
Cindy, that is great and I’m glad Zyflamend is working for you.
Ishi Freeman says
My doctor recommended Zyflamend when I got a mosquito virus from traveling abroad that affected my joints much like arthritis. After taking it two months, I noticed a big difference. The silver bullet was the turmeric.
I think it is unfortunate that not much research has been done because the only people who have money to do extensive research are drug companies. I think that is very sad. There are probably numerous natural products out there that could help people but they can’t afford to do the extensive research that drug companies do.
Drug companies also fund many medical schools which is why most doctors know little or nothing about a more homeopathic approach.
Joe says
Ishi, thanks for sharing and I’m glad Zyflamend helped you.
Rosemary says
I took GCS for years and finally decided it wasn’t doing anything for me, my joints were still becoming more painful. I started taking Zyflamend about 10 years go, the second time I experienced Plantar’s fasciitis. On the recommended dose I noticed that my finger and toe joints were beginning to feel better.
As an herbalist familiar with the ingredients, I decided to double my dosage. The fasciitis went away and has never returned. I can’t say it’s completely eliminated my joint issues, but I definitely notice the difference if I am unable to replenish my supply for a while, and then when I start taking it again. That’s my two cents.
Mary says
I have been taking Zyflamend for about 6 months now and it has greatly reduced my knee and hip pain. However, I have a very weird side effect I’ve not seen mentioned anywhere. I have a very strong “smell” in my nose, for hours every day. I didn’t connect it to the Zyflamend at first, but when I was traveling and put some in a baggie in my purse, I figured it out.
When I opened my purse, I was overwhelmed with the same odor I had been experiencing for months. I actually stopped taking Zyflamend 3 days ago to see if the smell would go away, but no luck so far. I love how my body feels, but the pervasive odor is really annoying. Is anyone else having the same problem? Any ideas for a solution?
Joe says
Mary, I dont think Ive heard about zyflamend causing a smell /odor in the nose before. Has anyone else?
Greg says
Hi Mary
When I first started taking ginger/tumeric combo I got reflux really bad for a while, it was working gangbusters on my old busted joints so I kept taking it, but I know exactly what you are talking about, the reflux was so bad it was like the powder was getting back up into my nose.
Eventually I started having a little blood in the stool, which can happen as inflammation goes down in your intestinal tract really fast, so I backed way off the dosage for a couple of weeks and gradually ramped back up. Happy to say I feel 20 years younger, and both the reflux and bleeding went away.
Ginger/Tumeric is the one supplement that I notice pretty quickly if I forget to take it consistently. Aches and pains start coming back. Really does wonders… should be more research.
Maria says
I took Zyflamend for 4 months, it worked for me, I was able to do the things that I use to do, without pain. I ran out, and I thought I would be okay without it, within 3 weeks, the pain in my left hip came back, and the pain in my back came back. sigh…I just ordered another bottle of Zyflamend again. I wish I could go without it, to me, it is expensive.
Joe says
Maria, as long as its helping I’ll take that as win. have you tried physical therapy? It’s possible that might help too.
Maria says
No, I haven’t tried that, I don’t have insurance right now, at the time. I do gentle yoga, so that helps also. Thank you for asking, and trying to help. Great info, by the way!
Happy New Year!
Sharon says
I am new to this site and found it as I was trying to wade through all the crap reviews that were obviously sales pitches. Frustrating that it is so hard to figure out which are ads in disguise and which ones have real information – even perhaps through some of the comments listed here.
I have osteopenia from chemo a couple of years ago and suffer from arthritis in many joints (yeah, the doctors keep telling me to quit running but swimming just gets so boring after a while!). Gucosamine/Chondroitin with MSM helps some with the pain and inflammation, but I continue to watch for other ideas backed with research. I know that even natural remedies can cause damage if overdone or not used correctly. I also know that there are always personal anomalies – and placebos even work sometimes – but I prefer to stick with the evidence.
(And I am unconvinced that totally removing any one food group can be a magic bullet – especially when it means cutting out my weekend beer 🙂
So I appreciate the time and effort it takes to actually look at the evidence. So, thanks for this site! I just bookmarked it and will work my way through your comments on other products.
Joe says
Sharon, so happy you were able to find me (I know it can be a challenge with all the other “review” sites out there). For what its worth, some people do tell me that fish oil (epa and dha) ad well as tumeric helps arthritis pain. Since you mentioned running, my guess is you have arthritis of the knees. exercises to strengthen the quadriceps muscles may also help ease the pain as well. Not sure if you’ve ever considered some physical therapy, to strengthen the quad muscles, but this may also be an option. Strengthening exercises can also help your osteopenia too.
Jim Nichols says
How much MSM are you taking? I was diagnosed by an orthopedic surgeon: oesteoaethritis in my left knee. The pain and instability were nearly disabling. 10 grams each, daily, of both MSM and Omega 3 and all symptoms disappeared.
I’ve stopped the MSM and only take 4 grams of Omega 3.
Practically speaking, there’s no level of toxicity for MSM or Omega 3; you just need to find the therapeutic level for you.
Joe says
Jim, Really glad your pain is gone. Just as an aside, omega 3 fats – EPA and DHA – can have a blood thinning effect when they are used at more than 3 grams per day. That could be an issue for those taking blood thinner meds.
MIGDALIA says
I HAS ONE MONTH USING ZYFLAMEND AND I FEEL EXCELLENT RESULT, MY PAIN HAS LESS
Mia Guerrero says
There is an article in the Cancer Prevention Research AACR Journal ( July 23, 2013) that is using Zyflamend in the study.
Title: “Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice”
Joe says
Mia, thanks for that study. Here is the link for those who are curious http://www.ncbi.nlm.nih.gov/pubmed/23880231
it is study of mice but it is intriguing.
EW says
I was on Zyflammend for a 3 month period last year for general joint improvement. Slight soreness in knees after runs, nothing major.
This stuff gives me super powers… feels like it cuts lactic acid build up in muscles during intense training. My muscles don’t fatigue during short bursts and have much more stamina over longer period too. My brother and a few friends reported the same result after I shared with them.
I started Zyflammend again last week, just 2 pills in the AM, and am having the same great result.
Its certainly a performance enhancer—I don’t mean that in a negative way.
Has anyone had this type of result?
Your review is really top notch. Thx Joe.
Joe says
EW, thanks and I’m glad zyflamend is helping you also.
Greg says
Hi EW – personally there are a few things I take that seem to make a huge difference in both anaerobic and aerobic capacity. Ginger and tumeric are one, but I think red wine is a bigger one. Studies found that it encourages doubling of mitochondria as well as moderate exercise… what compounds are responsible is unknown, I suspect it is a combination.
Even the alcohol could be having some effect, who knows? The ginger and tumeric were found in one study to be as effective as moderate exercise at improving markers of cardiovascular health in postmenopausal women, which is simply incredible. Can’t find that study from 2012 but I’ve seen it, and here’s one from a little ealier that found curcuminoids cut risk of death after bypass by 56%! https://www.ncbi.nlm.nih.gov/pubmed/22481014
If there’s one supplement everyone should take, its ginger and tumeric together.
Alex says
After being hospitalized with non-specific inflammation, extremely high fevers, surgeries to remove fluid from knee, etc… I was finally diagnosed with reactive arthritis due to a bout of food poisoning.
I was on steroids, sulfasalazine, Celebrex, and after 6 months with a considerable amount of remaining symptoms and elevated CRP and Sed rates I was urged to take Enbrel which is a biologic that destroys your immune system.
Needless to say I wasn’t ok with that. I roughed it out and eventuall got to about 90% better.
Fast forward 2 years and symptoms came back. Steroids again, the whole deal. Freaked out. Tried everything under the sun again (both prescription and alternative therapies and herbs). Nothing worked until I bought Xyflamend.
I know this sounds like a commercial but I have stopped taking it an have had inflammation come back in a few days. While taking it my Dr is completely confused at how low my inflammation markers are.
I really hope this works for others. (BTW I was super excited about anatabloc but it did absolutely nothing for me). At the very least if say give it a try. The place I bought it at said they would give me my money back if it didn’t work so go to your nearest health food store and chances are you’ll get the same offer.
Again, this may not work for everyone as we all react differently to different things that we ingest. However, for me it is a life saver.
Joe says
Alex, that’s really great news!
Here is my review of Anatabloc in case you didn’t see it:
https://supplementclarity.com/anatabloc-anatabine-inflammation-review/