By Joe Cannon, MS
MS Exercise Science | BS Chemistry & Biology
Investigating dietary supplement research since the 1990s
Updated September 2026
Restorin NR is a new NAD+ booster from Seragon Biosciences that uses a proprietary form of nicotinamide riboside called nicotinamide riboside fumarate. A 2026 study reported that Restorin NR raised blood NAD+ levels more than conventional nicotinamide riboside (NR) or NMN. In this Restorin NR review, I examine that research, explain what the study actually found, look at how the Restorin NR ingredient differs from regular NR and NMN, and investigate whether the evidence supports the anti-aging and longevity claims associated with RESTORIN supplements. I also include information provided by RESTORIN customer support.
Quick Answer: Restorin NR: Better than NMN and NR?
Restorin NR is a new form of nicotinamide riboside called nicotinamide riboside fumarate. In a 2026 mouse study, it raised blood NAD+ levels significantly more than nicotinamide riboside chloride and NMN when equivalent doses were used.
The study has several limitations, including that it lasted only 7 days, involved mice rather than people, measured NAD+ only in blood, and did not reveal whether Restorin NR improved energy, memory, muscle function, skin, disease risk, lifespan, or any other meaningful health outcome.
I also could not locate any published human clinical trials of Restorin NR. So, at this point, the evidence suggests Restorin NR may be a more efficient NAD+ precursor in mice. But, it does not yet show that Restorin NR works better than NR or NMN in people or that raising NAD+ more produces better health.
Important distinction
Throughout this review, Restorin NR refers to the nicotinamide riboside fumarate ingredient tested in the 2026 mouse study. RESTORIN refers to the commercial multi-ingredient supplement sold at Restorin.com. They are not the same thing.
Prefer video? Here's my breakdown of the Restorin NR study
Update After recording this video, RESTORIN confirmed to me that its supplement contains nicotinamide riboside, but the company would not disclose the amount or confirm that it is the Restorin NR fumarate form discussed in the study.
What Is Restorin NR?
The Restorin NR ingredient is a proprietary form of nicotinamide riboside fumarate developed by Seragon Biosciences.
Most nicotinamide riboside supplements use nicotinamide riboside chloride, sometimes abbreviated NR chloride. Restorin NR replaces chloride with fumarate, creating a different crystalline salt form of NR.
The researchers suggest this new form may help explain why Restorin NR raised NAD+ more effectively in their mouse study. They also propose that fumarate itself could contribute to the effect. However, that proposed NR-fumarate synergy remains a hypothesis. The study did not test or prove that such a synergistic effect actually occurs.
In other words, we know the Restorin NR ingredient raised NAD more than NMN and nicotinamide riboside, but we don't yet know exactly why.
The 2026 Restorin NR Study
The study was titled “Restorin NR is a Highly Efficient NAD+ Precursor” and was published in Drug Design, Development and Therapy.
The study compared Restorin NR ingredient with regular nicotinamide riboside (NR chloride) and NMN.
They tested Restorin NR in 53 older mice, and it lasted 7 days. The mice were divided into groups and given either:
- Restorin NR at a lower or higher dose
- Regular NR at a lower or higher dose
- NMN at the higher dose
The results were interesting.
The Restorin NR ingredient increased blood NAD+ by about 28% at the lower dose and 31% at the higher dose.
By comparison, the higher dose of regular nicotinamide riboside increased NAD+ by about 18%, while NMN increased it by about 19%.
Furthermore, Restorin NR raised NAD+ more than regular NR or NMN, and it took less Restorin NR to achieve those results.
Did Restorin NR Raise NAD+ More Than NMN?
It appeared to.
The Restorin NR ingredient produced significantly higher blood NAD+ than NMN.
Something else: it took less of the Restorin NR ingredient to raise blood NAD+ as much as the higher dose of NMN or NR
The authors describe this as approximately a threefold improvement in NAD+ per dose.
Be aware that this doesn't necessarily mean Restorin NR is 3 times more effective than NMN or NR.
Restorin NR Study Limitations
The study just described suffers from some problems such as:
First, these were mice. Raising NAD+ in mice doesn't necessarily mean it raises NAD+ in humans.
Second, the experiment lasted only seven days.
Third, researchers measured blood NAD+. They did not determine whether the supplement raises NAD+ in other tissues like muscle, brain, etc.
Fourth, they did not measure health outcomes. It's unknown if Restorin restores memory, lowers blood sugar, improves muscle strength, or helps people live longer.
Fifth, it appears that there was no “older mice + placebo” group. If there were, the study would have been better in my opinion.
Who Funded the Restorin NR Study?
The research has connections to the company developing the Restorin NR ingredient. They are called Seragon Biosciences.
Several of the researchers were employed by or affiliated with Seragon-related companies; the study received support from Seragon; and one researcher reported a leadership role and ownership of Seragon stock or stock options.
This doesn’t mean the results are wrong, and I personally like seeing companies invest in research on the supplements they sell. That said, some people may feel more confident in the results if they are eventually confirmed by researchers with no ties to Seragon.
Has Restorin NR Been Tested in Humans?
I couldn't find a published human study on Restorin NR ingredient.
Multiple clinical trials have studied regular nicotinamide riboside and NMN in people. Both appear capable of increasing NAD+ or NAD metabolites, but whether that leads to meaningful health benefits still remains unanswered.
This is at the heart of my criticisms of these supplements: simply raising NAD+ does not automatically mean better health.
Restorin NR vs RESTORIN: What's The Difference?
During my investigation, I discovered the website Restorin.com, which sells a supplement called RESTORIN. The website describes it as containing NAD+ precursors, senolytics, sirtuin activators, and polyphenols.
The Who Are We” page of the website redirects to the Seragon website, which strongly suggests the RESTORIN supplement is affiliated with Seragon Biosciences. However, the Restorin.com website did not list an actual Supplement Facts label.
When I contacted the company, they confirmed that nicotinamide riboside is contained in the supplement, but that it is part of a proprietary blend and would not disclose the amount. They also did not say whether the supplement contains nicotinamide riboside fumarate, the form of NR tested in the study I summarized above.
The RESTORIN supplement (there is an AM and PM version) contains a proprietary blend that, in addition to nicotinamide riboside, also contains other ingredients including urolithin A, icariin, alpha lipoic acid, spermidine, L-theanine, ergothioneine, and PQQ.
Most of these ingredients are interesting; however, they were not tested in the original Restorin NR mouse study discussed above.
How Much Restorin NR Was Used (In Human Amounts)?
The dosages used in the 2026 mouse study (0.33 mmol/kg and 1.0 mmol/kg) don't help us much. But if we do some math and convert from mouse to human dosages, this works out to about 700 mg to 2100 mg/day for a person who weighs 154 lb (70 kg). The table below offers approximations for people of different body weights.
| Body weight | body weight (lbs) | HED from 0.33 mmol/kg mouse dose | HED from 1.0 mmol/kg mouse dose |
|---|---|---|---|
| 70 kg | 154 lb | ~693 mg/day | ~2,100 mg/day |
| 80 kg | 176 lb | ~792 mg/day | ~2,400 mg/day |
| 90 kg | 198 lb | ~891 mg/day | ~2,700 mg/day |
| 100 kg | 220 lb | ~990 mg/day | ~3,000 mg/day |
I approximated Human Equivalent Doses (HEDs) using the table in this article.
Remember these are approximate human estimates. They are NOT recommended amounts people should take. The Restorin NR ingredient has not yet been tested in people.
However, because RESTORIN customer support would not disclose how much RN the supplement contains – or confirm that it contains nicotinamide riboside fumarate – we cannot directly compare these estimates to the RESTORIN supplement.
Will Restorin NR Help You Live Longer?
The original mouse study lasted only 7 days so it can't prove mice or people will live longer.
Interestingly, Seragon has also published another mouse study on what they call a “novel longevity drug.” This compound, which they call SRN-901, was a combination of quercetin, urolithin A, alpha lipoic acid, and a proprietary Seragon compound called SRN-820, and nicotinamide riboside.
This combination of ingredients resembles some of the ingredients shared with me by RESTORIN customer support.
However, if you read the study, they do not indicate whether they used nicotinamide riboside fumarate or “regular” NR.
Even if we set aside that this is another mouse study, this investigation can't prove the Restorin NR ingredient extends life because it also used other ingredients.
More NAD+ Doesn't Automatically Mean Better Health (or Longer Life)
This is the part of the review most people will gloss over – but it's very important.
NAD+ plays essential roles in energy metabolism, DNA repair, redox reactions, and several other cellular processes.
So increasing NAD+ sounds desirable.
But people who buy these supplements don't care about just raising NAD. We care about what matters: does that mean we will move better, sleep better, stay independent longer, develop fewer diseases, or live longer?
Existing human research on NAD+ precursors hasn't consistently shown those kinds of benefits.
What About Claims of More Energy and Better Skin?
The RESTORIN website states that users may begin noticing improvements in energy, skin health, and overall well-being within a few weeks.
How do they know that? I couldn't find human clinical research on the RESTORIN supplement supporting those statements.
Interestingly, the same company FAQ acknowledges that there are no published human studies evaluating RESTORIN's effects on athletic performance.
Can You Take RESTORIN Forever?
The company says RESTORIN capsules are intended to be taken indefinitely and says they are most effective when used daily over an extended period.
But, I could not locate long-term human research showing that the RESTORIN supplement is safe to take indefinitely. In fact, I couldn't find a published human clinical trial of RESTORIN at all. I also couldn't find a human trial of the Restorin NR ingredient.
Because NAD+ metabolism is involved in cancer biology, people with cancer should discuss NAD+ booster supplements with their oncologist before using them.
What Does Harvard Have to Do With RESTORIN?
RESTORIN repeatedly mentions technologies licensed from Harvard University, Mayo Clinic, and Scripps Research
The RESTORIN website lists U.S. Patent 7,977,049 among the patents associated with the product.
The patent is titled Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms.
But licensing university technology does not mean Harvard, Mayo Clinic, or Scripps Research tested the RESTORIN supplement or endorses it.
Who Makes RESTORIN?
RESTORIN is associated with Seragon Biosciences, based in Irvine, California.
Seragon describes itself as a research-based biotech and pharmaceutical company involved in areas including aging metabolism, gene therapy, immunology, and nutraceuticals.
How Much Does RESTORIN Cost?
When I checked Restorin.com, regular RESTORIN was listed at $270 for a single pack. Six packs were listed at $1,450.
RESTORIN PRO and RESTORIN SP are even more expensive.
Supplement Facts labels were not listed on the website when I checked.
For a supplement costing that much, I think customers deserve to know exactly how much nicotinamide riboside they're getting and whether it is the Restorin NR form used in the published mouse study.
What Is the RESTORIN Refund Policy?
RESTORIN has a 30-day return policy, but returned products must be unopened.
The company may also charge up to a 15% handling and processing fee, and return shipping costs are deducted from the refund.
Restorin NR: Pros & Cons
The positive side is that Restorin NR isn't just another NAD ingredient with no research behind it. There is a published study and the investigators directly compared it to conventional NR and NMN.
But this is just one short-lasting mouse experiment that only looked at NAD+ in the blood. There's no proof yet that the increased NAD+ produces better health outcomes, and so far there is no independent research.
As for the RESTORIN supplement, it contains several ingredients in addition to nicotinamide riboside. The company combines them in a proprietary blend, so the amount of nicotinamide riboside is not disclosed, and their customer support did not disclose to me whether the supplement contained the Restorin NR ingredient (nicotinamide riboside fumarate) or nicotinamide riboside chloride (the regular form). At about $270 per pack, the supplement is also more expensive than many other NR and NMN supplements.
My Bottom Line. Does Restorin NR Work?
Right now, I don't believe the science justifies choosing nicotinamide riboside fumarate over less expensive supplements like nicotinamide riboside chloride or NMN, which have been tested in humans over multiple clinical trials.
As for the RESTORIN supplement, we don't know how much nicotinamide riboside it contains or whether it even contains the Restorin NR form tested in the published mouse study. I also couldn't find a human clinical trial of the RESTORIN supplement itself.
Mind you, I'm not endorsing either NR or NMN because I have not been impressed with the results of those studies. If you want my opinion, if your goal is to raise NAD+ while also getting the most overall health benefits, exercise is a very effective way to do both.
What Do You Think About NAD+ Supplements? Comment Below
Further Reading
Nicotinamide Riboside Human Research Summary
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