Update 1/31/21. Real Dose Weight Loss Formula No. 1 is a weight loss supplement that claims its ingredients are “based only on the results from human studies.” That statement alone made me want to review Formula 1! Furthermore, Real Dose also says that their products use the exact same amount of the ingredients that are used in research. Both of these are bold statements that I don't see many supplement companies making, so let's review Real Dose Formula 1 and see what we can find out.
Who Makes Real Dose Formula No 1?
Real Dose Weight Loss Formula No. 1 is a product of Real Dose Nutrition LLC located at 2031 16th Street Boulder, CO 80302. To contact Real Dose Nutrition, call (800) 928-5580 if inside the US (or if outside the US,
+1-307-222-6725). In my review I found 2 different websites for the company:
According to the Better Business Bureau, while Real Dose Nutrition is not a BBB accredited business, the company has a BBB rating of “A.” It appears that the person in charge of the company is Dr. Steven Sisskind. While he is listed as the “Chief Medical Officer” on both the BBB website and the Real Dose website, in a press release, dated June 10th 2013, Dr. Sisskind is called “the creator” of Real Dose Nutrition Formula No 1.
Real Dose Formula No.1 has also been sold on Amazon but it may be unavailable.
Real Dose Weight Loss Formula No 1 Ingredients
According to the product website (Realdose.com), 1 capsule of Formula No 1 has these ingredients:
|Proprietary blend||300 mg||N/A|
|Dolichos biflorus (seed) extract|
|Betel (Piper betle) (leaf) extract|
|Decaf green coffee bean extract (Svetol)||133.33 mg||N/A|
|Siberian Rhodiola rosea (root)||113.33 mg||N/A|
|Pepper (Piper nigrum) (fruit)||5 mg||N/A|
N/A = Not applicable. No daily value established.
Real Dose Formula No 1 is non-GMO and free of gluten, dairy, eggs, or soy.
Real Dose Formula No 1 Research
As far as I can see from the Real Dose website, Formula No. 1 has no published peer-reviewed research to show that it helps people lose weight. Also, I'm not aware of any published research that used the entire unique blend of ingredients that are in Formula No 1 weight loss pills.
That said, as I understand the premise behind this supplement, the idea here is that because there is weight research on 2 of the ingredients ―and Real Dose Formula No. 1 uses the same ingredients, in the same amounts used in research―that the same weight loss benefits should be seen with this product. It's an interesting idea. Let's now take a look at the research on the ingredients in the product and see what that research says.
To their credit, RealDose.com not only lists the research on the ingredients, it also links to those studies also, so I will list those studies for each ingredient below.
Dolichos Biflorus (Seed) Extract
There are 2 studies listed in support of Dolichos biflorus. They are:
1. Study title: Efficacy of an Herbal Formulation LI10903F Containing Dolichos Biflorus and Piper Betle Extracts on Weight Management. This was an 8-week study involving 50 overweight people. The participants were put on a 2000 calorie per day diet and exercised 30 minutes per day.
The people received either a placebo or 300 mg of a supplement called “LOWAT” ― a product of Interhealth Neutraceutical Inc. LOWAT is a blend of both Dolichos biflorus seed extracts and Piper betle leaf (which is also in Real Dose Formula No 1). If you read the study in the link above, they call LOWAT “LI10903F” so don't be confused.
Results. Those who received the LOWAT supplement lost significantly more weight (an average of 5 lbs) compared to those who didn't get the supplement. Significant decreases in ghrelin and increases in adiponectin (hormones that play a role in how much we weigh) were also seen in those who received the LOWAT supplement.
2. Study title. Efficacy and Safety Evaluation of a Novel Weight Management Herbal Formulation LOWAT. The Real Dose website states that this study was presented at the 51st meeting of the American College of Nutrition in October 2010. This is a study of the effects of the LOWAT supplement in rats. It may be a fine study but since it's not peer-reviewed (and a rat study), I'm inclined to discount it.
Real Dose Formula No 1 contains 300 mg of the proprietary blend of both Dolichos biflorus seed extracts and Piper betle leaf. I believe the proprietary blend used is the LOWAT supplement. The LOWAT blend is in other products and is a standalone supplement itself. For example, here is the LOWAT supplement on Amazon.
Decaf Green Coffee Bean Extract
The Real Dose website references 2 studies to support the use of green coffee bean.
1. A study titled: Svetol, green coffee extract induces weight loss and increases the lean to fat mass ratio with overweight people.
2. A study in French which is the same study as study #1. This is likely the original investigation that was also translated into English. I'm not sure why the Real Dose website lists the study in both English and French.
The keyword in this study is “Svetol” which is a specific extract of green coffee bean. There is some weight loss research on Svetol although it's less than I'd like. See the review of Green Coffee Bean and weight loss,
For those who want to compare prices, here is Svetol on Amazon.
Siberian Rhodiola Rosea
The Real Dose website lists two studies for Rhodiola Rosea:
1. Rhodiola rosea: A Phytomedicinal Overview. This is a review article that shows that Rhodiola Rosea may help recovery from exercise and play a role in mood. That is likely why this herb is in Real Dose.
2. Standardized Rhodiola rosea: A Unique Phytomedicine. A Current Phytochemical Quality Overview. This appears to be a paper that was presented at a meeting titled, The Proceedings of the 8th International Congress Phytopharm, in 2004. Phytopharm is a pharmaceutical /nutraceutical company. Since this paper was presented, it may not be peer-reviewed.
Real Dose Formula No 1 contains 113.33 mg of Rhodiola rosea. At least one study noted that 100 mg of this herb helped mental and physical fatigue.
Pepper (Piper nigrum)
The Real Dose website cites 2 studies in support of this ingredient. They are:
1. A study titled, Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. This study showed that 5 mg of Piper nigrum (pepper) increased levels of coenzyme Q10 in healthy males. Real Dose Formula No 1contains 5 mg of pepper.
2. A study titled Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Basically, pepper increased the absorption of beta carotene.
This is why pepper is in the product. It's not because of any metabolism-boosting or weight loss effect, but rather because pepper appears to enhance absorption of other things. Here, the pepper increases the absorption of the 2 active ingredients in Real Dose Formula No 1.
Summary of studies
If I look only at the studies listed on the Real Dose website, here is how they look to me:
- A published human study of Dolichos biflorus and weight loss
- A presented study on Dolichos biflorus and weight loss in rats
- A published human study of green coffee extract and weight loss (listed in both English and French)
- A published review article of the effects of Rhodiola rose (no weight loss effects mentioned)
- A presented paper on Rhodiola rosea and stress levels (no weight loss effects mentioned)
- A published paper on how pepper raises coenzyme Q10 levels
- A published paper on how pepper helps beta carotene absorption
Based on the research presented on the product website, the ingredients in Real Dose Formula 1 that have human weight loss evidence are:
- Dolichos biflorus (specifically, the LOWAT supplement)
- Green coffee extract (specifically, the Svetol supplement)
Here is LOWAT on Amazon and Here is Svetol on Amazon for those who want to compare prices.
It's possible that the unique blend of ingredients in Real Dose Formula No 1 works better than either /both of these ingredients, but since there appears to be no published peer-reviewed research on Real Dose Formula No 1 itself, I can't know for sure.
Real Dose Formula No 1 side effects
I'm not aware of any side effects from using Real Dose Weight Loss Formula 1 and I think in healthy people it's pretty safe. With any new supplement you've not taken before, it's wise to start with less than is recommended to see how you respond. This will minimize any side effects that you, personally, may have.
How to Return Real Dose Formula No. 1
The product website states that Real Dose weight loss supplements have an “Unconditional 365 Day You Must Be Thrilled!” Money-Back Guarantee. Giving people 1 year to return a product is actually quite generous ―and rare.
According to the Real Dose website, people just have to call customer service and ask for a refund. Return the product with a copy of your sales receipt. Customer service can be reached by calling these numbers:
- In the US: 1-800-838-4854
- Outside the US : +1-307-222-6346
To get a refund, the product should be shipped to this address:
RealDose Nutrition LLC
22100 E 26th Avenue #100 Aurora, CO 80019
According to Google, this address corresponds to a company called “At Last Fulfillment” which I assume is the company that actually ships Real Dose products to consumers.
Does Real Dose Formula No 1 Work?
First, let me say that I appreciated the emphasis on research that I saw on the Real Dose website. It's not often I see supplement websites that link to research. I thought that was refreshing.
While there is not a lot of research on the ingredients, it's possible some people may notice weight loss from Real Dose Weight Loss Formula No. 1 especially if they also exercise and eat fewer calories. How much weight loss might occur if someone were to only take the supplement, I do not know.
I personally think that if the product is going to work, that has more to do with its 2 main ingredients ― Dolichos biflorus and green coffee extract― than the other ingredients, but I admit I could be wrong on this. It could be that the combination of ingredients in Real Dose Formula No 1 enhances the weight loss effects of these 2 ingredients but without human trials, I can't say for sure. Real Dose Formula No 1 is expensive with a 30 day supply costing $67 on the product's website.
Here is Dolichos biflorus on Amazon (the LOWAT supplement) and here is green coffee extract on Amazon for those who want to compare prices.
What do you think?
DAWNMARIE WICKETT says
Hello Joe, I have tried this product and it does what it says! Just wish the price would be more affordable price-wise!
Joe Cannon says
Dawnmarie, Im glad to hear Real Dose worked well for you. It sure is expensive. Have you ever tried the Svetol supplement? It costs less and has some research.
Ann Seanor says
Hi, there. I took Real Dose Weight Loss Formula pretty consistently for about 6 months, as well as utilizing the Livestrong app called “MyPlate” for nutrition and activity calculations. During that 6 months, I lost 20 lbs. I stopped using the Real Dose consistently, and have continued using the Livestrong. I did not gain any of the weight back following my titrating down on the Real Dose. I was quite happy with its performance. Upon reading other comments, though (“happier”), maybe I’ll start again! The Denver winter is dragging down my mood!
Ann, thanks for sharing and yes you guys in Denver have some winters. I heard it was 70s yesterday and a blizzard today!
I’m not so convinced ? There are no photos of true consumers and their journey with this product ?
Ann Seanor says
Hi, there. If I could figure out how to post pictures, I’d post a before & after, but if you can tell me how to do it, I’d be glad to.
Hi Ann, currently thats not something possible but its worth me looking into for the future. If it helps, if you have your pictures on your facebook page etc, you can just link to those in the space provided for your website.
I was so desperate to lose weight, I did fall for this scam. Did absolutely ZERO. Even with drinking 80+ oz of water daily, all I got was water-logged and lighter in the wallet.
Good luck to you on your journey.
I have a question to anyone who has tried this, I watched the video then found this website. So far I have seen good results.
My question is after you have lost the weight and achieved your goal weight did you stop taking it and did you gain the weight back, or will this be a life long journey of taking formula 1?
I lost 20 lbs on my own by drinking almost 4 litres of water daily and joining a Nordic pole walking group. I did this in two months but then I stopped going because I am so tired and stressed all the time, then my body started aching, and my feet are killing me. I also decided to join a exercise class next month which I hope I can do.
I see that this has helped people with energy which I clearly need. So any feedback would be great, I am seriously considering trying this.
Michelle, if I can jump in, it sounds like you started doing a LOT of exercise very quickly. My guess is that’s why your feet were starting to hurt. Its difficult to keep up the pace that it sounds like you did. Eventually something is going to give such as the symptoms you described. I’d say do your exercise class but dont do it 6 or 7 days a week. Instead, start out with 2-3 and slowly work up to 4 if you can or go back to that pole walking group. Mix it up. Give the supplement a try but do the other things too. Being healthy is whats really important.
Do let me know what happens.
Thanks Joe, actually the pole walking was only Tuesdays and Thursdays, the exercise class will be on Wednesday and Fridays. My feet have been hurting for awhile and I am sure its from my weight which is why I desperately need to loose some. I will keep you informed if I decide to try this, I just want to know if I have to take them the rest of my life lol
Michelle, sounds good. it sounds like you area already off to a good start. remember, ever 1 pound you lose reduces the weight on your knees by about 4 pounds. I expect that’s on your feet too. So by losing 20 pounds thats 80 less pounds on your knees with each step you take.
Wow, I didn’t realize that. Thankyou for that information Joe 🙂
Michelle, you are very welcome 🙂
Lisa E Rivera says
I have used the Real Dose Weight Loss Formula #1 product. I was able to lose 40 lbs without changing my diet or exercise. I have COPD, so exercising is hard for me. I took 1 pill with a glass of water 30 minutes before every meal. I ate less, which helped me lose weight. I also craved sweets less after about a week, which helped me lose weight. I started having more energy, so I started taking walks which helped me lose weight.
It also helped me feel happier for some reason. After I got to my desired weight, I started taking one pill before breakfast and 1 pill before lunch. I kept the weight off. I slept better because I did more during the day because I had more energy and was happier.
This supplement did not counteract with any of the medications that I was taking. I have now been on this for several years. I take 1 pill a day before breakfast. I still eat what I want, I just want less. No weight gain.
Nancy Barnes says
Hi Lisa, You answered my ultimate concern, medications. I really want to try this to curve my appetite but with my meds I am afraid. I don’t exercise much either but plan to start walking as I have fibromyalgia. Can you email me what you take so I can compare any of mine? It would make me feel better. Thanks!
I have just received my 30-day supply of WLF1 [Weight Loss Formula 1] and noticed on the bottle it is contraindicated if one has bipolar disorder or is on antidepressant medication. I do [Bipolar II], and I am, so I wrote to ask them why the contraindication, and whether there were any studies to back it up.
Replies from RealDose repeatedly mentioned that the product contains “all natural, non-GMO ingredients that are vegan and certified Kosher. It contains No gluten, dairy, eggs, or soy. It is also decaffeinated and does not contain other stimulants.” They have also addressed possible interactions with meds for hypertension, diabetes and cholesterol. All good. But not answering my question.
The best they could tell me re Bipolar and/or antidepressants was to talk to my doctor.
My question: is there anyone reading this that has a bipolar issue and/or is taking antidepressant medication and has gone ahead and tried this product anyway??
Hi Esmee My guess is the Siberian rosea in the product. It has some research on anxiety / depression. Basically the idea is that there might theoretically mean there could be an interaction between it and some meds for depression. check my review I mentioned this.
Does anyone anything else to add to this?
I did see it in your review. It appears to be helpful for physical and mental fatigue, and for anxiety and depression. It sounds like something I need to try! Will check it out with my pdoc and report back. Thank you!
Sounds good I’ll look forward to hearing what they say