For the longest time, I thought Nerium was a skin care company. I had no idea Nerium had supplements too – until I became aware of a brain formula supplement called Nerium EHT. This supplement is VERY different from other memory supplements I've seen and reviewed here. In this unbiased review (I don't work for the company), we will look the science, research and ingredients on Nerium EHT. Does it improve memory, help concussions reduce the odds of getting dementia? These are some of the questions I'll address. Does it really work? Is it the real deal or a scam? Let's see what we can discover. See the Prevagen review for more on that memory supplement.
What Is Nerium EHT?
From the website of the company that makes this supplement, we learn EHT for the brain it is “a mixture of bioactive molecules isolated from coffee that helps strengthen neural connections and promote optimal brain health.”
What does that mean?
That description is pretty vague but it sounds like Nerium EHT is supposed to help the brain work better. They used to call this a “mind enhancement formula” although that wording has since been removed from the company website. Anything that could help the brain work better, might – in theory – lead to several health benefits ranging from improved memory to protection against dementia.
We'll address some of these issues in sections below.
Nerium EHT Ingredients
According the product website (Nerium.com) a box contains a 30 day supply. Taking 1 tablet of Nerium EHT has the following ingredients:
|Nutrient||Amount Per Serving||Percent Daily Value|
|Vitamin D (cholecalciferol)||2000 IU||500% DV|
|Vitamin B6 (pyridoxine HCL)||1.6 mg||80% DV|
|Vitamin B12 (methylcobalamin)||10 mcg||167% DV|
|Magnesium (from 100 mg mag citrate)||16 mg||4% DV|
|Selenium (selenomethionine)||70 mcg||100% DV|
|Alpha lipoic acid||50 mg||N/A|
|EHT (proprietary coffee blend)||35 mg||N/A|
In the table above, “N/A” means there is no daily value for that particular nutrient.
While the product website says the product also contains, sodium hyaluronate, this ingredient is not listed on the Supplement Facts label.
While vitamin B12 was originally present as cyanocobalum, this has been changed to methylcobalamin. This is a trendy ingredient but for most people, I don't see an advantage to it.
Nerium EHT also has the following “other ingredients” listed. I’ve put them in order as they appear on the label:
- Dicalcium phosphate
- Microcrystalline cellulose
The tablet coating of the product is composed of :
- Polyvinyl alcohol
- Titanium dioxide (color)
- Vanillin (extract of vanilla bean)
- Croscarmellose sodium
- Stearic acid
- Magnesium sterate
These other ingredients likely play no role in any benefits from the product.
Now, let's see if Nerium EHT supplement – itself – has any research showing that it improves memory in people. After that, we'll look the research on its ingredients.
Nerium EHT Research
Does Nerium EHT have any proof that it really improves memory?
I was curious if it did, so I first searched Google for:
- Nerium EHT Research
- Nerium EHT Clinical Trials
No clinical studies could be located.
I then went to Pubmed.gov, which is the National Library of Medicine, a repository of millions of clinical studies. I searched Pubmed for:
- “Nerium EHT”
No studies showed up.
I then went to ClinicalTrials.gov to see if there might be any studies in the pipeline that were on going
I searched for “Nerium EHT.”
No relevant investigations showed up.
- I then searched the website NeriumEHT.com. No studies were found there either.
- I searched the Nerium.com website too. No clinical trials on Nerium EHT were present.
All this says to me that despite the hype, no clinical evidence appears to exist for this supplement.
Summary of Search Results:
- Pubmed.gov: no studies located
- ClinicalTrials.gov: no studies located
- Google search: no studies located
- Nerium.com: no studies located
- NeriumEHT.com: no studies located
If there are clinical research studies on Nerium EHT and memory, they cannot be found.
That doesn't necessarily mean the product doesn't work. Rather, it just means nobody has tested it – yet. And that includes the Nerium company too. When those studies are conducted and published, I will update this review as I become aware of them.
To be clear, there is research on EHT – which is part of this supplement. The research on EHT will be summarized below.
Let's look at the research on the ingredients in the Nerium EHT.
Nerium EHT Ingredient Research
From the Ingredients list above, we can see that 1 tablet of Nerium EHT contains:
- Vitamin D 2000IU
- Vitamin B6 1.6 mg
- Vitamin B12 10 mcg
- Magnesium 16 mg
- Selenium 70 mcg
While these are all fine nutrients, for healthy people, I'm not convinced they contribute anything significant to helping memory, dementia or the immune system etc. beyond what we might get in the diet naturally or in a regular multivitamin.
Of course, those who are not so healthy might benefit from these nutrients, but for the most part, a multi vitamin and vitamin D supplement will cover these bases. As such, I won't cover the vitamins or minerals in this review.
If Nerium EHT really works, I think the answer lies with its other ingredients.
Let's look at those now.
Each tablet of Nerium EHT has 50 mcg of Huperzine. The scientific name for this herb is Huperzia serrata. It is sometimes also called Chinese club moss or “Hup A.” Another name for Huperzine A is Selagine.
There have been several studies noting that Huperzine A may be of benefit to people with Alzeheimers disease and dementa. It might do this because Huperzine A appears to prevent the breakdown of acetycholine, (say, uh-see-tul-co-lean) a chemical involved in memory. It does this by inhibiting an enzyme (called acetylcholineesterae) that is involved in the breakdown of acetylcholine.
In other words, by knocking out the enzyme that breaks down acetylcholine, the levels of acetylcholine in the brain rise and the chemical stays around longer. Theoretically, this might help boost memory.
Nerium EHT does appear to contain an amount of huperzine A (50 micrograms) that has been used in clinical trials. That is encouraging. Studies show that it may take 2-8 weeks before differences are noticed. This is a general rule and I'm sure this would vary according to how bad the memory problems were, medications people take and other factors.
It should be said that not all studies show Huperzine A works. This may be due to issues involved in purifying the Huperzine A compound and extracting it from the plant. Remember, plants contain thousands of different chemicals. Huperzine A is only one of them.
If the proper methods of extraction are not followed, perhaps this may be a reason for some studies showing Huperzine A doesn't work.
Several of the studies I saw appear to come from China and while they do appear to show Huperzine A may work, at least one study notes that because of problems with how some of the studies were conducted, caution and more research is needed. WebMd.com has a nice write up on Huperzine A that includes potential side effects.
Sometimes Huperzine A is touted to improve memory in healthy people without memory problems. But, I can only find one study – dating back to 1999. For me, one study is not enough evidence – yet – to say healthy people need it.
Huperzine A has been in other memory supplements too suchas:
See those reviews for more information.
Alpha Lipoic Acid
I usually see alpha lipoic acid in diabetes and weight loss supplements. There does appear to be a connection between getting diabetes / insulin resistance and getting dementia. I've even seen Alzheimer's disease called “Type III diabetes” to drive this message home. Thus, adding this alpha lipoic acid to a memory supplement does, in theory, make some sense. If we can reduce blood sugar levels, we might also reduce dementia.
That said, I'm hard pressed to find evidence that alpha lipoic acid helps memory. A review of alpha lipoic acid dementia research conducted in 2001 found no good proof it helped people with memory issues.
I did locate one study noting that alpha lipoic helped, but this study had problems with how it was conducted. Also, that study used 600 mg. Nerium EHT only has 50 mg- a lot less than that study used.
When I searched Pubmed.gov (The National Library of Medicine) for the words “alpha lipoic brain,” a good amount of the research I saw involved mice and rats. That's not to say alpha lipoic acid is useless.
I do think it has some benefits. But for the brain, memory and dementia, at this point, I think we need more research to make a better judgment.
Alpha lipoic acid is also in the memory supplement Procera AVH. See that review for more information.
The EHT molecule is an ingredient in the Nerium EHT supplement. The EHT molecule is derived from coffee and is a mixture of several different compounds. What does EHT stand for?
Thats easy – if you can pronounce it.
EHT stands for “Eicosanoyl-5-HydroxyTryptamide.”
Now, you know why they call it EHT.
It's said that researchers at Signum Biosciences noticed that people with severe memory decline had a disruption of a regulator protein called PP2A. The PP2A protein regulator is said to help keep the connections between brain cells “robust and healthy.”
Theoretically, anything that could help increase the PP2A, might let brain cells talk to each other better. This might help memory and other things that PP2A helps regulate.
This does sound interesting. So, is there any research on EHT? Yes, there is.
Let's look at that research now.
Sigmun Biosciences had an EHT supplement called ME Sports, which was marketed to athletes. That product website – MeSports.me – redirect people to NeriumEHT.com.
They say that “ME™ sports has been shown to be beneficial in in vivo models of cognition, memory and motor function.” The phrase “in vivo” basically means conducted in animals/not in a test tube. While that's good, it's not the same thing as human studies.
On the website of Signum Biosciences, several clinical studies are listed. I’m gong to link to the studies below so you can see it as you conduct your own research. This research is complicated. Even the titles of the studies sound complicated.
So, instead of getting bogged down in trying to explain the research (which I admit is over my head too), I'll just list the study name and give a quick breakdown as to whether it involved people, lab animals or was test tube research (which I define as research not occurring in living animals).
By breaking the research down this way, people can get a better idea as to how far along the research on EHT currently is. As more research is published, I'll update this section.
Here are the studies listed in support of the EHT compound.
|Study Title||Type of Study|
|EHT™ coffee extract: A neuroprotective agent and modulator of PP2A methylation with anti-inflammatory and antioxidant properties (S16.006) (2015)||Test tube study|
|Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. (2014)||Rat study|
|Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's diseasedisease. (2013)||Mouse study|
|Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. (2011)||Mouse study|
|The structural basis for tight control of PP2A methylation and function by LCMT-1 (2011)||Test tube study|
|Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease (2011)||Review paper of previous research|
|Protein carboxyl methylation and the biochemistry of memory. (2009)||Study involving isolated cells.|
|Mechanisms of tau-induced neurodegeneration. (2009)||Review paper of previous research|
|From promiscuity to precision: protein phosphatases get a makeover. (2009)||Test tube study|
|Protein carboxyl methylation and the biochemistry of memory. (2009)||Test tube study.|
|Structural mechanism of demethylation and inactivation of protein phosphatase 2A. (2008)||Test tube study|
|Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.(2008)||Test tube study of mouse and human cells|
|Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. (2008)||Test tube study|
|Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation (2007)||Mouse study|
|Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.(2004)||Test tube study|
|Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. (2004)||Test tube study. Appears similar to previous study. Same authors.|
|Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. (2002)||Test tube study.|
As can be seen from the table above, there is a need for human research on EHT.
Some may have also heard of a study Princeton University. This investigation A undergraduate senior thesis on EHT. The title of the thesis is “The Neuroprotective Effects of Eicosanoyl-5-hydroxytryptamide in an in vitro Model for Parkinson’s Disease.” This is not a human study.
Essentially, human cells were treated with Signum EHT to see what happened. This investigation showed the EHT molecule has a cell-protective effect. While the investigator did use human cells, isolated cells -even if they are from humans – are not the same as testing EHT in humans.
Let me be clear: I listed the studies like this not to slam the product or deprecate any company. Rather, the goal was to make it easier for people to better understand this very complicated research. As more research becomes published, this section will be updated.
EHT vs. EHT 0202
If you read the comments you will see Nerium Brand Partners arguing with me about how I am wrong and there is evidence for this supplement. But, the proof they are referring to is for a compound called EHT 0202. This is not the EHT in Nerium. It is not Signum EHT.
EHT0202 is an Alzheimer's drug and there are clinical trials on it.
As I was writing this review, I came across clinical trials for an Alzheimer’s drug It is not the same thing as the EHT. The reasons for this are because:
- EHT is a product of Signum Biosciences located in New Jersey. The EHT 0202 drug developed by a French company called Diaxonhit (formally called Exonhit).
- When I goggled “Signum Biosciences and Exonhit (or Diaxonhit) I didn’t see anything that made me think their compounds were the same thing.
Because of this, Brand Partners should not confuse research on EHT0202 with Nerium EHT. I admit the names of both compounds are very similar so it's easy to confuse them.
Does Nerium EHT Have Caffeine?
I think the answer is yes and no. Nerium EHT is decaffeinated but I've also seen it said that it has a small amount of caffeine. They say the amount of caffeine is less than is in a decaffeinated cup of coffee. That's very little caffeine. I don't think most people would notice it. Some people have left comments below saying that they had trouble sleeping. Whether or not this is related to caffeine, I can't say.
Nerium and Dementia
Would someone who took Nerium EHT long-term (say, several years), have a lower risk of dementia or Alzheimer’s or be able to keep their memory longer? It's a tantalizing idea to be sure. Right now, nobody can say either way. Currently, there is just not enough evidence to say yes or no to this question.
For those who have dementia or are thinking about EHT for their family members who already have cognitive insufficiency problems, the best advice is show the the ingredients this supplement to a pharmacologist.
Food for thought: Evidence suggests regular exercise can preserve brain health.
Nerium EHT and Concussions
The Sigmun Biosciences website used to contain an EHT supplement called “Me Sports” where “Me” stands for “Mind Enhancement.” They used to say that Me Sports “provides the best protection for your brain.” References to Me Sports no longer appears on the Sigmun website. It has been replaced Nerium EHT and so I believe it's been discontinued.
When I see references to sports and the brain, I think concussions So would something like Me Sports or Nerium EHT help reduce the severity of concussions? Would they help athletes at risk of head trauma or traumatic brain injury (TBI)? I can't say because no concussion research seems to exist. It's worth noting that neither Nerium or the Sigmond Biosciences websites make any claims or references that this would help concussions.
Nerium EHT and Parkinsons
Given that the Nerium brain formula is touted to promote optimal brain health, it would be logical to leap to think it might help those with less than optimal brain health. One such disorder is Parkinson's disease. So, does it help people with Parkinson's? I searched for research to shed light on this, but unfortunately could not find any.
There are references to Nerium EHT being endorsed by the Michael J. Fox Foundation. But, according to the website Truth in Advertising, this is not true. While the The Michael J. Fox Foundation does seek a cure for Parkinsons, they do not endorse any specifics treatments.
Thanks to a reader (see comments below) I was informed that the Michael J Fox Foundation has awarded grants to Signum Biosciences to investigate PP2A as it relates to Parkinsons. Stay tuned for what these studies show.
Nerium EHT and ADHD
Does EHT help people with Attention Deficient Hyperactivity Disorder (ADHD). At this time, there does not seem to be enough evidence to say either way if it helps or doesn't. If evidence exists, it cannot be located.
Nerium EHT and Exercise
The company that invented the EHT molecule has a paper titled ” EHT® Age Defying Supplement : Scientific Rationale for Boosting Workout and Post -Workout Recovery.” This paper (which can be found by doing an online search) is not a peer-reviewed clinical study. Rather, it discusses how the ingredients in Nerium EHT might reduce inflammation that occurs after intense exercise and improve recovery.
No doubt, there is human research on the vitamins/ minerals in the product. The EHT molecule also might-in theory- hold promise too.
But, whether or not Nerium EHT would benefit people who do CrossFit, Zumba, Tabata or any other exercise program is speculation until the research is published.
Is Nerium EHT FDA Approved?
The FDA doesn't technically “approve” supplements. This is part of the US law that regulates supplements, called DSHEA, which is short for the Dietary Supplement Health and Education Act. In the US, supplement companies do not have to tell the FDA that they are making a new supplement or get the FDAs approval before a supplement is marketed to the public.
One stipulation about the DSHEA law is that companies are supposed to notify the FDA when a supplement contains something not used before. This is called a “New Dietary Ingredient.” Since the EHT molecule is something “new,” I wonder if this would be considered a New Dietary Ingredient?
On the flip side though, since EHT is derived from coffee – something that has been around for thousands of years – maybe they do not? Either way, when I searched for “Nerium EHT FDA” and “Nerium EHT New Dietary Ingredient” I didn't see anything.
Who Makes Nerium EHT?
There are two different companies involved with this dietary supplement. The supplement:
- Nerium International
- Signum Biosciences
Lets look briefly look at each company separately.
According to the company website (Nerium.com), Nerium International is a “relationship marketing company.” That means they offer a variety of products which are sold via distributors, called “Nerium Brand Partners.” In other words, Nerium is a multi-level marketing company. Nothing wrong with that. It's how they do business.
The Nerium website lists their address as: 4006 Belt Line Road Addison , TX 75001. The address listed with the Better Business Bureau is a bit different than this, but in the same office building: 4004 Belt Line Rd STE 112, Addison, TX 75001-4356.
Each address corresponds to the same business center. If you Google the address you can see what it looks like.
While originally, the BBB gave Nerium International a rating of A+ this has been downgraded to no rating. This reason for this is the BBB said they have “received complaints alleging that Nerium products have caused burning of the skin, skin irritation and/or rash.”
Nerium International is has been BBB accredited business since 2014. See the BBB file for updates and more information.
SiteJabber had no review of Nerium at the time this review was created. See the SiteJabber site for more insights.
Signum Biosciences is the company which discovered the EHT molecule. They are a privately held biotechnology company founded in 2002, located at 133 Wall Street Princeton, NJ 08540. Their website (SignumBiosciences.com) lists this contact phone number: 732.329.6344.
There was no BBB file or SiteJabber file for this company when this review was created.
According to the Nerium website, the company can be reached via these phone numbers:
- USA: 855-463-7486
- Canada: 888-304-6046
- Mexico: 01-800-1NERIUM (637486)
Buy Nerium EHT
The supplement is not sold in stores like Target, Walmart, CVS, Walgreens, Costco, RiteAid, Sames Club, Kroger or Food Lion. To purchase Nerium, most people go though a Nerium Brand Ambassador. Another option is to purchase directly from Nerium.com.
When doing this, you have the option to give the name of the ambassador who referred you, but this is not mandatory. In other words, you don't need an ambassador when purchasing from their website. This means the company may be in competition with ambassadors for sales.
The company tells me products purchased through Amazon/Ebay are endorsed and the warranty does not apply. That said, Amazon and Ebay are pretty good with returns. I've returned things to both and never had any issues.
Nerium EHT Price
When I checked the company website, for a 1 month supply (non returning customer), the cost was $89.95 and for autoshippments it was $69.95. These amounts include $9.95 shipping (which I think is a lot). When I checked, it was less expensive on Amazon and Ebay
Supplement companies often have an arbitration clause when purchasing products from their site. This is to protect them from class action lawsuits. It looks like this might be the cause with Nerium.com also. The Terms and Conditions page of Nerium.com states
“The arbitration shall be conducted before a single arbitrator, and shall not be conducted on a class-wide, class-action, or multiple-complaining-party basis. The prevailing party shall recover its attorneys’ fee and costs from the losing party.”
While I'm not a lawyer this looks like people waive certain rights -like jury trial- when purchasing products from their website. Nobody wants to be sued so I understand companies trying to shield themselves from what can sometimes be frivolous legal battles. I bring this up in case it matters to anyone.
How To Take Nerium EHT
The company website says to take 1 tablet per day with food in the morning, preferably with some food that has healthy fats. This is likely to increase absorption. A box contains 30 tablets, so this will last a month.
Nerium EHT Side Effects
I believe the Nerium EHT is safe in healthy people. I’m not aware of any side effects from the product at the time this review was created. There is also a lack of human research on this product as well. That said, here are a few things worth mentioning. Speak to your doctor if you think any of this applies to you. This list is not complete:
- Stop taking the supplement at least 2 weeks before surgery
- Speak to your doctor first if your are pregnant or breastfeeding
- If you take ANY medications, speak to your doctor or pharmacist first
- Remember you don't need to make an appointment to speak to your pharmacist
- Huperzine A might slow down heart rate. This may be a problem for people taking some types of medications, such as those for heart disease and/or high blood pressure.
- If the product contains a little bit of caffeine, this might interfere with sleep if taken close to bedtime especially in those very sensitive to caffeine. A few people in the comments below have said they had trouble sleeping after starting the product.
Nerium Pro and Con
Here is a quick rundown of what I liked and didn't like about this supplement. These are my opinions. Take them for what they are.
|Been around a long time||Expensive|
|Company is respected||No human clinical proof|
Does Nerium EHT Work?
While preliminary research hints the compound EHT, might have benefits, I think it's too soon to tell. This supplement has been out for a few years now and the company still has not published clinical studies to back up its claims. While of the ingredients in Nerium EHT appear to make sense on paper, to know for sure, it needs to be tested in people in clinical studies published in medical jounrals. So, is it a scam? While I am tempted to say if Nerium EHT really works, it's mostly because of huperzine, without proper testing, that would be speculation. Stay tuned.