Last Call Hangover Supplement Review: Does It Really Work?

Last Call is a hangover supplement promoted as a natural way to help your body recover after drinking. Marketed as an alcohol recovery supplement and “hangover pill,” it claims to reduce next-day fatigue, headaches, and nausea. Its key ingredient, DHM (dihydromyricetin), is advertised as the compound that helps the liver clear alcohol faster. But is there any proof it works? In this evidence-based Last Call supplement review, we’ll examine its ingredients, clinical research on DHM, and what science actually says about whether it prevents hangovers or just sounds good in marketing.

🧠 Does the Last Call Hangover Supplement Really Prevent Hangovers?

A: There’s no human clinical evidence proving that Last Call or DHM (dihydromyricetin) prevents hangovers or speeds alcohol recovery. Some animal studies show that injected DHM helped rats sober up faster, but oral supplements like Last Call haven’t been proven effective in people.

🍻 Last Call Supplement Ingredients (Nutrition Facts)

Each serving (2 capsules) of Last Call contains the following ingredients:

Ingredient	Amount per Serving (2 Capsules)	% Daily Value
Thiamin (Vitamin B1)	13 mg	1111%
Riboflavin (Vitamin B2)	2 mg	102%
Vitamin B6	9 mg	549%
Vitamin B12	66 mcg	2279%
Magnesium	10 mg	2%
Selenium	36 mcg	66%
Copper	0.3 mg	66%
Manganese	1.2 mg	37%
Chromium	66 mcg	58%
Potassium	10 mg	190%*
Sodium	3 mg	<1%
DHM (Dihydromyricetin)	633 mg	N/A
L-Cysteine HCl	633 mg	N/A
L-Theanine	66 mg	N/A
Alpha Lipoic Acid	53 mg	N/A
Milk Thistle	33 mg	N/A
Prickly Pear	33 mg	N/A
BioPerine (Black Pepper Extract)	3 mg	N/A

N/A percent daily value not established.

Other ingredients: vegetable cellulose, microcrystalline cellulose, and magnesium stearate

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🔍 Why Last Call Uses Dihydromyricetin (DHM)

Dihydromyricetin (DHM) is a flavonoid extracted from the Japanese raisin tree (Hovenia dulcis). It’s been used in traditional Asian medicine as a liver tonic and anti-intoxication remedy. The Last Call company calls DHM their “MVP ingredient.” That tells us it's important.

Here’s what the actual science says:

Does Dihydromyricetin in Last Call Reduce Alcohol Intoxication

In one of the key research papers on DHM, rats were injected with large amounts of alcohol. Some received DHM injections, others didn’t.

Alcohol-only rats were unconscious for about 110 minutes
Rats injected with DHM woke up in around 30 minutes
Blood alcohol levels stayed the same, meaning DHM didn't change metabolism. Rather, it affected the GABA-A receptors in the brain

➡️ This is where the “DHM sobers you up” story comes from. But it was injected DHM, not oral capsules.

Dihydromyricetin and Liver Function (NALFD)

In a Chinese clinical trial, 60 adults with non-alcoholic fatty liver disease (not heavy drinkers) took 600 mg DHM daily for 3 months.

Results showed:

Lower AST and ALT (liver enzymes)
Improved triglycerides and insulin resistance

➡️ But these were non-drinkers with liver disease, not people recovering from hangovers. This study doesn't prove DHM prevents hangovers. Instead, it only reveals that it may help support healthy liver function.

How DHM In Last Call Affects Alcohol Metabolism

In a follow-up study, researchers tested oral DHM in rats after they had consumed high amounts of alcohol. Result: it didn't work. DHM didn’t reduce blood alcohol or acetaldehyde. This led the researchers to conclude: “The proposed positive effect of DHM during alcohol intoxication has not been proven.”

How Much DHM Does Last Call Contain?

According to the Supplement Facts label, each serving of Last Call (2 capsules) provides 633 mg of DHM.

That's about 30 to 60 times higher than the amounts used in animal research.
DHM’s oral absorption is poor, meaning all of it may not reach the bloodstream.
Proof that 633 mg of DHM stops hangovers cannot be located

🧩 What About Last Call's Other Ingredients?

L-Cysteine: Often included to boost glutathione, but human hangover data are weak. (glycine and NAC are better options)
Milk Thistle: Popular for liver support, but inconsistent clinical results.
Prickly Pear: Some small studies show reduced hangover symptoms, but results vary.
B-Vitamins and Minerals: Helpful if you’re nutrient-deficient from chronic drinking, but they don’t neutralize alcohol.

Bottom line: most of the formula consists of standard hangover-pill ingredients seen in other products. None has strong human proof for actually preventing hangovers.

🚫 What the Science Says About Last Call and Hangovers

So far:

No human clinical trials show that Last Call or oral DHM reduces hangover severity in people.
Injected DHM may help intoxicated rats recover faster, but that doesn’t mean capsules will.
One human study on DHM supports liver health, not hangover recovery.
The 2020 animal study found no change in alcohol metabolism when DHM was given orally.
Clinical trials showing the Last Call supplement works cannot be located.

Even the Last Call label itself admits:

“Last Call does not treat alcohol intoxication.”

That’s honest and accurate.

Last Call Customer Testimonials

In a Reddit post, people who've used the supplement say

👍 Positive/hopeful experiences

Some users say they feel a milder hangover after using Last Call.
A few mention less grogginess or a lighter headache than usual the next day.

👎 Skepticism & negative reports

Many report no noticeable effect at all. It didn’t reduce their hangover symptoms.
A few mention gastric upset or mild digestive discomfort.
Some question whether the perceived benefits are just a placebo effet or due to drinking less.

Overall, it seems people are willing to try it but are unsure how well it works.

Frequently Asked Questions About the Last Call Hangover Supplement

What is the main ingredient in the Last Call supplement?

The key ingredient in Last Call is DHM (dihydromyricetin), a plant compound extracted from the Japanese raisin tree (Hovenia dulcis). It’s often promoted in hangover pills for its potential to support liver health and reduce alcohol’s effects. However, most studies on DHM were done in animals, not humans.

Does DHM actually prevent hangovers?

There’s no human clinical research proving DHM prevents hangovers or speeds up alcohol recovery. In one rat study, injected DHM helped the animals wake up faster after being given alcohol, but oral supplements like Last Call haven’t shown the same effect in people

Is Last Call safe to take after drinking?

For most healthy adults, Last Call appears safe when taken as directed. It mainly contains vitamins, minerals, antioxidants, and herbal extracts like milk thistle and prickly pear. However, its long-term safety hasn’t been studied, and people with liver disease or who take medications should check with their doctor first.

When should I take the Last Call hangover supplement?

The instructions are a bit vague. The label recommends taking two capsules before, during, or after drinking alcohol. There’s no research verifying the best timing or dose, but taking it close to when drinking alcohol is similar to how DHM was used in some studies.

Does Last Call really support liver health?

One human study found DHM improved liver enzymes and blood lipids in people with non-alcoholic fatty liver disease. That suggests possible liver-support benefits. But that trial did not include drinkers or test hangover recovery. So, any liver health benefit from Last Call remains unconfirmed for alcohol users.

What do customer reviews say about Last Call?

User feedback is mixed. Some say they feel less groggy or nauseated the next morning, while others report no noticeable effect. A few users mention mild digestive discomfort. Overall, most reviews show uncertain or minimal results — consistent with the lack of human clinical data.

Are there better-studied hangover remedies?

Yes. While no supplement completely prevents hangovers, evidence supports hydration, rest, eating before drinking, and moderation. Nutrients like glycine and N-acetylcysteine (NAC) have stronger research support for alcohol detoxification than DHM-based supplements.

Bottom line: Does the Last Call hangover supplement work?

At this point, there’s no solid scientific proof that Last Call or DHM supplements prevent hangovers. It might support liver health over time, but results for hangover prevention are anecdotal. The safest and most effective way to avoid hangovers is still drinking less alcohol and staying hydrated.

Last Call Hangover Pill Pros & Cons

Pros	Cons
Contains liver-supporting nutrients (B-vitamins, milk thistle, selenium)	No human trials showing hangover prevention
DHM studied for liver health	Animal studies only; injected, not oral
Transparent label	Expensive compared with generic vitamins
Generally safe for healthy adults	May cause mild stomach upset in some users

🧠 Final Verdict: Should You Try Last Call Hangover Supplement?

If you’re curious, Last Call is unlikely to hurt most healthy adults. It’s mainly vitamins, minerals, and antioxidants.
But if you expect it to eliminate hangovers or sober you up, the science just isn’t there yet.

The strongest evidence on DHM so far comes from rats injected with the compound, not humans taking pills.
Until proper human trials on hangover recovery are published, skepticism is warranted.

🗣️ Final Thoughts: My Evidence-Based Last Call Hangover Supplement Review

Claim: Prevent hangovers and speed recovery.
Evidence: Weak (no human hangover studies).
Key Ingredient: DHM (dihydromyricetin).
Dose: 633 mg per serving (oral).
Result: Possibly helpful for liver enzymes, not proven for hangovers.

If you want to reduce hangovers, the best evidence-based options remain:

Drink less alcohol.
Stay hydrated.
Eat before drinking.
Get adequate sleep.

Or for the best results, just don't drink at all.