Update 12/6/22. At one time, Anatabloc was a SUPER popular anti-inflammation supplement. It was sold online and at GNC and elsewhere. It was touted to help reduce pain, help joints and arthritis pain, and reduce chronic inflammation. Anatabloc was unique. It contained an ingredient not found in any other supplement I've EVER seen in over 20 years of investigation. This unique ingredient also contributed to its own downfall. In this unbiased, updated review, I reveal everything you need to know about Anatabloc, from its rise – and fall – to the research and proof and the company which made it. I'll also shed light on other anatabloc supplements too.
What Is Anatabloc
Before we talk about Anatabloc (sometimes misspelled Anatablock), I need to tell you about Anatabine (also called anatabine citrate). Anatabine is the active ingredient in Anatabloc. Anatabine is a chemical found in
- eggplants
- potatoes
- green tomatoes
as well as tobacco and tobacco smoke (remember this).
Chemically, anatabine “looks” like nicotine. Because of this, it was also used some anti-smoking supplements. Anatabine has a longer half life than nicotine, so it stays in the body longer. That's why it was thought it might help people quit smoking.
How Does Anatabloc Work?
Here is the way Anatabloc was supposed to reduce chronic inflammation:
1. Anatabine enters the cells of the body where it…
2. Deactivates a protein called NFkB.
3. When NFkB is deactivated, it can't enter the nucleus of the cell (the brain center of the cell) to cause excessive cellular inflammation.
Inflammation is thought to play a role in MANY diseases, such as:
and many others.
So, if Anabloc worked, it might have disease-modifying benefits. If you read the comments below, you will see some people have said some pretty amazing things too.
Anatabloc Ingredients
Anatabloc contains these ingredients
| Anatabine | 1 mg |
| Vitamin A | 500 IU |
| Vitamin D3 | 40 IU |
This review will focus only on Anatabine because this is “secret sauce” in Anatabloc.
Other Ingredients
These other ingredients are also found in this supplement: Mannitol, natural and artificial mint flavors, sucralose, silicon dioxide, stearic acid, hydroxypropyl methylcellulose, magnesium stearate, titanium dioxide (color), natural glaze, methylparaben, propylparaben, triethyl citrate, citric acid, BHT, mono and diglycerides, and polysorbate 80
These ingredients played no role in the results or benefits of Anatabloc.
Anatabloc Research
When this review was originally created, the proof for Anatabloc was mostly on lab animals. There is now human proof. This review will focus only on human research. Much of the research is on Anatabine, which is an active ingredient in Anatabloc. Still, proof for anatabine is proof for Antabloc.
Rock Creek Pharmaceuticals (more on them below) supports and plays a role in much of the research.
Studies On Anatabloc
In one report, researchers in the US gave Anatabloc or a placebo to 146 people with Hashimoto's disease – the most common form of hypothyroidism. People were given 9-24 mg of anatabine in the form of lozenges. Those taking Anatabloc saw a significant reduction in thyroid autoantibodies.
Some people saw over a 20% decrease in thyroid autoantibodies. This means better working thyroid glands.
One small study (10 people) noted a face cream containing anatabine improved skin appearance, reducing redness and blotchy skin appearance. This does make some sense. Niacin, which looks a little bit like anatabine has been used in skin creams for years.
Niacin is also VERY popular in the anti-aging world. See the Niagen review for more on this.
Anatabine cigarettes have been shown to reduce nicotine levels in smokers significantly. This study reflects the interest in using anatabine to help people quit smoking.
Because inflammation follows exercise, researchers were interested in seeing if anatabine would reduce inflammation after people worked out. In this study, 18 men were given either a placebo or 6-12 mg of anatabine per day for 10 days. They also performed an intense exercise program.
Unfortunately, this noted anatabine did not reduce pain, or swelling or help muscle strength. This is noteworthy, given TV commercials featuring pro golfers John Isner and Fred Couples.
In another exercise study, researchers gave Anatabloc or a placebo to 17 men. The dosage of Anatabloc used was 6-12 mg. While these researchers saw that Anatabloc did not reduce exercise-induced muscle damage, it did appear to reduce markers of inflammation such as C reactive protein (CRP). That is interesting.
Preliminary research suggests anatabine activates NFR2, a substance that raises naturally produced antioxidant defenses such as superoxide dismutase (SOD). This is at the heart of some proposed anti-aging supplements, such as Protandim and PB125.
There are also several lab animals and test-tube studies involving Anatabloc/anatabine. I won't cover them here because we are people and not mice, rats or test tubes.
Summary Of Anatabloc Research
Here is a summary of the Anatabloc human research:
- Anatabine reduced thyroid antibodies in people with hypothyroidism
- Anatabine lowers nicotine levels in smokers
- Anatibine did not reduce muscle damage, pain, or swelling but may lower CPR levels
Anatabloc Questions
Let's now answer some common questions people have asked me about this supplement.
Can Anatabloc help muscle soreness?
Muscle soreness after exercise (DOMS) is very common. Currently, the proof seems to show Anatabloc doesn't reduce muscle soreness, swelling or muscle damage. It may reduce a blood test marker of inflammation called CRP. I think we need more exercise research.
Can Anatabloc Help Concussions?
There is brain inflammation when someone gets a concussion. But there is no proof that taking Anatabloc:
- reduces the risk of getting a concussion
- improves recovery time after getting a concussion
- reduces brain damage from concussions
I cannot find any research involving anatabine and concussions.
In December 2013, the FDA sent a warning letter to Star Scientific – makers of Anatabloc – telling them to remove references on their websites which gave people the impression the supplement might help concussions and other forms of traumatic brain injuries (TBI).
For more on concussions and TBI see these reviews:
Can Anatabloc Help Multiple Sclerosis?
The proof that Anatabloc can help MS is in its infancy. There is some mouse evidence it may help, but no human studies have been conducted yet.
What About Anataboc and Weight Loss?
Websites might discuss how anatabine/Anatabloc can help people lose weight or reduce weight gain, which sometimes happens when people quit smoking. But there is no good proof for this. No study has looked at reducing gaining weight after quitting smoking.
What is CigRx?
This is the anti-smoking product Star Scientific was developing before it began researching anatabine for arthritis pain and other health problems. CigRx contains anatabine too.
Anatabloc Dosage
The general recommendation is to take 2 lozenges per day. Do not use more than 6 lozenges per day. Another dosage recommendations= take your body weight into consideration. Here the Anatabloc dosages would be:
- 100-120 lbs: 2 lozenges 3x per day
- 121-170lbs: 2 lozenges 4x per day
- 171-220lbs: 2 lozenges 5x per day
- over 220lbs: 2 lozenges 6x per day
I've never seen this dosage regimen used in human studies. So, I'm not sure how accurate this is.
Who Makes Anatabloc?
Anatabloc is a product of a company called Rock Creek Pharmaceuticals. Another name for this company is Star Scientific. Star Scientific was the original name of the company. When the research changed directions from looking at Anatabine as a cure for smoking to helping arthritis pain, the company changed its name to Rock Creek Pharmaceuticals.
The phone number for the company was 800-778-2031. The company website was Anatabloc.com (the website no longer works). When this review was originally created, the Better Business Bureau listed the company address as 4470 Cox Rd Ste 110, Glen Allen, VA 23060.
There is also a connection to another company called the RosKamp Institute, located in Florida. Some of the research on Anatabloc has been conducted by this company too.
The company has since filed for bankruptcy and is no longer making Anatabloc supplements.
Should I Invest In Rock Creek Pharmaceuticals?
Star Scientific formally changed its name to Rock Creek Pharmaceuticals in 2014. Its stock symbol is RCPI. It's a publicly traded company. Regardless of what you invest in, do your homework.
Be careful with “gurus” who talk stocks up on websites, as you don't always know who you are dealing with. Sometimes unscrupulous people say things about a company to create interest so they can pump the stock price up so they can dump it for a profit. This trick is sometimes called “pump and dump.” Unless you’re an investing pro (think Warren Buffett), I recommend you talk to a financial advisor before risking any money.
Anatabloc And The FDA
Many people think the FDA does not regulate supplements. Anatabloc is proof it does. Almost from the start, the FDA claimed anatabine contained a new dietary ingredient (NDI). A new dietary ingredient is any substance that was not sold as a supplement before 1994.
Products containing new dietary ingredients need to prove to the FDA they are safe. There is also the issue that anatabine is found in tobacco. Tobacco cannot be called a dietary supplement. I think this may also have played a role in the demise of Anatabloc.
Rock Creek pharmaceuticals state that because anatabine is found in things like peppers and eggplants, it is not new and can be sold as a supplement. In the end, the FDA won, and Rock Creek stopped making Anatabloc.
Calls To Bring Back The Sale Of Anatabloc
Problems with the FDA have not stopped people from hoping for the return of Anatabloc.
This has not stopped people who loved Anatabloc from continuing to hold out hope. Former customers have launched a petition at Change.org to petition the FDA to reverse their decision and let Anatabloc be sold again.
They created the website BringBackAnatabloc.org where you can share your testimony of how the supplement helped you, sign an FDA petition to bring Anatabloc back, and read news about the supplement.
How To Buy Anatabloc: Can You Still Purchase It?
While this supplement was once VERY popular and sold at GNC and other stores, it is no longer permitted to be sold in the US. The FDA forced Rock Creek Pharmaceuticals to stop the production of Anatabloc.
Anatabloc Supplements
While Anatabloc is no longer able to be purchased in the US, I did notice other companies selling supplements said to contain anatabine.
One such company is HydraPharm (PredatorNutrition.com). They sell a supplement literally called “Anatablok” which they say contains “pure anatabine.” Predator Nutrition is not based in the US. I am not sure if they are allowed to ship their Anatablok supplement to the US.
The supplement is marked as an anti-inflammatory nootropic (brain enhancer) used to support memory and attention.
The Va Governor Controversy
As if things could not get worse, Rock Creek Pharm found itself at the center of a very public controversy involving the former Virginia governor, Robert McDonnell, and his wife. It's alleged Rock Creek gave $165,000 in gifts to the former Va governor and his wife in exchange for helping Rock Creek's development of Anatabloc.
Anatabloc Side Effects
Anatabloc is probably safe for healthy people, at least for short-term use. Human research shows no significant negative side effects. Mild to moderate side effects reported have included:
- Dizziness
- Nausea
- Headache
- Tingling feelings
- Insomnia
In the comments section below, one person reported feelings of depression. This has not been observed in clinical studies.
Does Anatabloc Work?
Despite the problems with the FDA, several people swore Anatabloc worked. I never experimented with it when it was being sold and the only person I knew who did try it told me it did not reduce his pain. Pain is complicated and its possible others may have had better results.
Unfortunately, Anatabolc supplements are no longer available in the US. While, in the past, I have been rather hard on this supplement and Rock Creek Pharmaceuticals, I was sad it was taken off the market. I am happy to see some human research on anatabine, look forward to more and hope one day to see it sold once again.
Joe
“John, I just spoke to the person today I know who tried anatabloc. he said tried 2 bottles and it didn’t help him. I know the investors in this product don’t want to hear it but more human arthritis research for glucosamine sulfate than anatabloc. Glucosamine isnt perfect either but there is research.”
Joe, I’d (for example) be pretty stupid if I was scared of someone saying any biological product didn’t work for his/her particular body/condition. You yourself say glucosamine isn’t perfect either. Anatabloc is not going to work for everyone’s particular need.
My knowledge indicates to me that about 60-70% of those who try it for good reason (a real inflammatory problem) will have significant success with it. It amazes me when people post or review “it didn’t work for me so it doesn’t work” in speaking of biologically active agents. Such things just don’t work that way because of our thank-goodness diversity.
As far as “more research” for glucosamine, do you realize (or have you already forgotten?) the inflammatory property of anatabine has only been KNOWN for 3 years now? The research is just getting underway. I’m very puzzled by your neglecting facts of comparison and neglecting research to, so eagerly it seems, reach negative conclusions you, I must opine, seem to cherish.
This is not new to me/us. There is (always) a community of people (thanks to our diversity) who will resist new thought and that is not entirely unhealthy. I remember when (thanks to my 69 years) people were ridiculed for proposing continental drift. Not just doubted. Ridiculed. Despite the then-recognized 95+% match up between the eastern continental margins of the Americas and the western margins of Africa/Europe. However, I’m betting the farm that this matter has the inevitability of continental drift … not out of hope but out of really deep research (thanks to the help of many others who willingly share).
Oh, the original anatabine patents did NOT specify just an antidepressant property, and, in fact, in the amounts now taken only a few of us will get that benefit. READ THE PATENTS. If you (really) want to know what they say, READ THE PATENTS.
(Your friend got it wrong. It has never been “tested” AS an antidepressant by the present developers, although one can speculate with considerable assurance that it would have such property at some level, and indeed a few report getting that benefit. Likely heavy smokers receive such benefit to a degree, although nicotine apparently tends to “beat out” anatabine at the receptor quest in tobacco users … by about 95:3 )
And I will quickly add that informal C-RP lowering has already been shown in a clinical trial that concentrated on another variable, but no, not peer reviewed. That’s what’s going on now, but no, just three years into this discovery that test has reported successful “1/2 way through” results, but not of course yet peer reviewed. It’s coming.
I hope it is not too much to add this about the clinical trials (all of them), with more on the way.
########## 12 12 03
===== SUMMARY ====
1 ALZHEIMER’S NCT01669876
Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer’s Disease
=====
2 THYROIDITIS NCT01551498
Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)
=====
3 SMOKING NCT01428310
Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers’ Urge to Smoke (ALSO c-rp was done and reported in Jan of 2012). This was a comparison between Anatabloc and the predecessor CigRx.
=====
4 INFLAMMATION INDICATOR C-REACTIVE PROTEIN NCT01607619
Effect of Anatabine on Elevated Blood Levels of C-reactive Protein
=====
5 ROSACEA ANATABLOC CREME NCT01740934
A Study to Evaluate the Safety, Tolerability, and Effects of Anatabloc® Crème in Rosacea
===== DETIALS =====
1 Recruiting
Study to Evaluate Dietary Supplementation With a Version of Anatabloc(R) in Subjects With Alzheimer’s Disease
Condition:
Alzheimer Disease
Interventions:
Dietary Supplement: Anatabloc(R); Dietary Supplement: Placebo
2 Active, not recruiting
Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention)
Condition:
Thyroiditis, Autoimmune
Interventions:
Dietary Supplement: Anatabloc Supplement; Dietary Supplement: Placebo
3 Completed
Study to Evaluate the Safety and Efficacy of Dietary Supplement Anatabloc in Reducing Daily Smokers’ Urge to Smoke
Conditions:
Tobacco Use Disorder; Tobacco Dependence; Smoking
Interventions:
Dietary Supplement: Anatabloc(TM); Dietary Supplement: CigRx(R)
4 Recruiting
Effect of Anatabine on Elevated Blood Levels of C-reactive Protein
Condition:
Inflammation
Intervention:
Dietary Supplement: Anatabine
JustMe, appreciate you listing those preliminary studies. I will be looking for them when they finally are published and will update my review with their results. As of right now, they do not have the same weight as the published research I linked to in my review because they are not yet finished and published. Patents and unpublished clinical trials don’t hold as much weight for me. That said, I am glad that Star Scientific is investing some effort and money to support research on their products.
Glucosamine sulfate is not perfect however it does have a LOT more human published research than anatabloc – and glucosamine sulfate is a lot cheaper also. I mentioned it as an alternative for those who may want to try a cheaper alternative first before experimenting with anatabloc.
Just because continental drift was found to be fact does not mean the same will one day be said about anatabloc.
what you say about anatablc only being around for 3 years is true – its a very short time. Yet the TV commercials make anatabloc out to be the best thing since sliced bread. As I’ve mentioned, the research just isn’t there yet.
Joe
I don’t understand. Why don’t you go to google and use their patent search and simply search the term “anatabine”. From what you know so far you should be amazed. The single patent I cited for a particular reason is NOT “THE” PATENT. Reread what I wrote … why I cited that OLD patent. Then if you’re really interested do the google search and read the newer patents for the new Anatabloc type supplements (also search for apps). I will try to finish a lengthy response later, but one big problem you have is that you have assumed, wrongly, that you (initially) found much of the information available on this subject. You did not. The patents are lengthy it’s true, but that’s where you’ll begin to (with an open mind) get the idea of what this is all about.
John
Try reducing your dose to 3 and then 2 tabs a day (latter less than $30/mo) and see if you still don’t get the relief you need. Remember this product will help you with other things, or prevent them, as well as many instances of “joint pain”. It is a general anti-inflammatory not specific to “joint pain”. The unusual thing is that it can be taken continuously by most people.
All
If you try this, you will greatly reduce your chance of any of the mild side effects by starting slowly and work up to a therapeutic dose. I suggest 1/2 tab for 4 days, 1 tab for 4, etc. You may also find this way that you do not need the max dose for your particular body/problem. There are strong rumors that the product will reformulate after the 1st of year to in effect lower the cost (and presume they will actually lower cost on old formula), perhaps by 33% or so.
JustMe, I searched the library of medicine and listed the studies I found. If you know other studies – esp those on humans -I would appreciate it if you would email them to me. I would have LOVED to look at evidence on the anatabloc website on the page that is for “health care professionals” but as I said in my review, they won’t let me see it as I do not have a medical license.
I’m really not interested in patents on anatabloc because patents don’t get to real question – has it been proven to reduce joint or muscle pain / stiffness in published peer reviewed human research. As I write these words today, the answer seems to be no, it hasn’t. I’m intrigued by the inflammation aspect of anatabloc but again, the claim right now is based on preliminary evidence and not human trials.
I know my words do not sit well with some anatabloc investors (I noticed that I’ve been mentioned me on some investing websites about this) and while I mean no offense to anybody it really is about the research. As a scientist, I know you can appreciate my position.
Started taking the recommended dosages 12-17-12.
No negative side effects at this time.
Cronic pain in both shoulders and right ankle is reduced but @ $100 per month, not to the point where I would be a repeat buyer at this time.
John, I just spoke to the person today I know who tried anatabloc. he said tried 2 bottles and it didn’t help him. I know the investors in this product don’t want to hear it but more human arthritis research for glucosamine sulfate than anatabloc. Glucosamine isnt perfect either but there is research. Here is a small review of glucosamine sulfate that might help you.
Justme, come back! We want you to expound further on this subject, given your professional background and your “near insider” information.
Thanks to Thomas Delackner who did some research for me last night about Patent 6,569,470 that JustMe mentioned, it appears that anatabine may have been originally tested as an antidepressant. It seems to have mono amine oxidase inhibitory (MAO inhibitor) activity. So the patent is for MAO inhibition, not arthritis or joint inflammation.
Joe:
As one with a great deal of experience with this product, and one who has thoroughly researched the companies and research organizations behind it, I have reams to say but, alas, only moments right now to comment.
Let me take two things to address quickly (guess it turned into three).
First I would like to comment on your continuing comments to the effect …
++++++++++ quote
i find it ironic that they would release a supplement to the market based on 2 mouse studies an an as of yet not complete human trial.
but when TV commercials say it works for joints and muscles – but have no evidence to base those claims – then you need to know that
Ben, the only way to truly know something is to look at the research conducted on the product. Anatabloc TV commercials are saying that its proven to reduce inflammation in joints in muscles but I see none of that proof they are talking about.
++++++++++ end quote
I think you are overlooking (or unaware of) the route to discovery of the anti-inflammatory effect of anatabine. Those many hundreds of us “first adopters” of an anatabine supplement, made by the same company prior to Anatabloc and intended for another purpose NOT RELATED to issues of inflammation and pain resulting therefrom, were “the ones” who discovered the property (along with the researchers who tried the substance and had the same kinds of results at the same time).
They and we all began comparing notes (in online forums), with a feeling of embarrassment for many of us who were not really sure whether to believe, or not, what we experienced, and thus were we glad to hear others report and confirm the same.
After much preliminary research on dose and safety with a totally new direction in mind for a new product based on this evidence, the research staff at Rock Creek, in cooperation with the researchers, brought the product to market as a supplement based on THAT evidence … the reports of hundreds of individuals, many thousands by now (but we first adopters had NO reason to expect any such result), who on their own initiative reported that a new supplement marketed as an aid to reduce smoking was actually doing wonders for a very wide variety of “inflammatory issues”.
“The evidence” is that, probably more than anything else, we reported results from helpful to dramatic (but NOT “curative”) for arthritic and other joint pain. The only thing I know of that we experienced to a similar degree was rapid chronic sinusitis help, and the company apparently thought the joint pain relief to be something more solid or significant.
That said as to what we most reported, many many of us reported help not only with joint pain and sinusitis but with (likely number 3) asthma, benign prostatitis (BPH) … on and on, with some reporting relief of such serious things as, especially, Crohn’s and RA.
Again I emphasize that none of us had any reason to expect any such results. However, the researchers involved took the matter seriously, and as soon as their subsequent research began to leak out about why this may be, “things” began to come together to complete the picture. It turned out that this may be the first almost side-effect-free substance that avoids the mixed bag of results caused by “shotgun” anti-inflammatories like NSAIDS and even steroids because it much more directly works on a major inflammatory mechanism called NF-kB.
And so it turns out that what all these conditions have in common is NF-kB … and, if one thinks about it, “autoimmunity”. Another of these is Hashimoto’s thyroiditis … but the promise here would be (in my estimation) one of prevention, as this long term illness develops over decades (usually) due to attack of one’s thyroid by one’s own antibodies. Thus the thyroid studies.
But the significance here is how what I just reported unfolded: in reverse order from the usual “drug development path”. It was not that a pharmaceutical company looked for an NF-kB modulator because of the connection of that with a host of disorders, found it, and then tested it for efficacy, etc. The significance is that this all happened in reverse order. Thus there was no (initial) impetus for a drug company to get benefit from millions of dollars of research (having found an NF-kB modulator) by crafting carefully designed (and limited) studies to prove benefit, all the while hoping that the side effects would prove to not be “too bad”.
“The studies” happened without expectation, regarding a product that had a stated design for an entirely different and unrelated purpose. I believe that we are so unused to such an event happening in short order (rather than in a progression of hundreds or thousands of years of “folk medicine”, such as with the still-amazing properties of salicylates [aspirin, from tree bark]) that we find it difficult to understand the significance of such events.
You are, I believe, tending to dismiss “the evidence” because you are used to not believing individual reports of success with some product that (the success of which for some already-defined purpose) may be EXPECTED by the user … the placebo effect. If you consider how this all happened, I think you will realize that your perspective on this issue is skewed by your normal response and expectations to a different, and usual, set of circumstances. This is “the usual” in, more or less, reverse order, and thus NOT “the usual”.
The epidemiological evidence cited, by the way, has to do with studies done on those exposed to second-hand smoke (which contains about 3% anatabine of total alkaloid content, mostly nicotine). A group wanted to prove that, among other things, such exposure had a negative effect on the thyroids of those thus exposed. Their finding, to their dismay, was the opposite, and it apparently turns out that the anatabine in the smoke is the likely reason.
I must go but I must say quickly that I don’t know where all these strange addresses for Rock Creek came from, but the correct address is on every product: 55 Blackburn Center, Gloucester, MA. It is true that the company is small and has only been there about 3 years. It’s not a big factory, but in their small space Dr. Wright and his small team have done some marvelous things.
I will come back when I have time, but that may be mid spring.
I am not an employee of any company or research organization. I am a retired scientist and a great benefactor of this amazing set of circumstances. It has literally made my life worth living again, having been set upon by what I now recognize was a sudden and vicious rash of autoimmune disorders, probably foretold by my lifelong Hashimoto’s and asthma (a likely hint at an autoimmune tendency, I now realize). By the way I did not start the original supplement in relation to a smoking habit.
I am a stockholder. I hope I do not sound as though I know “too much”, although truthfully, due to my own intensive research, I may know as much as anyone else outside the company about it. I don’t know whether to apologize for that or to celebrate it, in light of some things said in other comments, but I feel more celebratory, personally. I hope my research has not rendered me to be someone to not be taken seriously.
I DO wish I had more time right now.
PS: Another thing, quickly. Those who are tobacco naive especially, but probably all, should start taking this SLOWLY, one tab every day or two (or even a half) and work up over a period of say three weeks. One’s chances of noticeable side effects are hugely reduced in such a case, and very very few should have any serious enough to prevent taking it continuously as a preventive as well as a treatment … another novelty for “anti-inflammatories”.
PPS: For those who may worry about the MAOI property, it is unique (shared with other minor tobacco alkaloids nornicotine and anabasine) in that it, somehow, self-limits to a safe level. One can learn about this by reading the older patents which presumed that the active aspect would be this property (to aid in reducing smoking, for example) … for example Patent 6,569,470. Indeed the now many patents that relate to these developments are very revealing and a good source of information.
JustMe, I appreciate you writing all that you did. I’m curious what the original use for anatabine was? As a retired scientist I’m sure you can appreciate my need for human peer reviewed research on Anatabloc. In the world of supplements there is so much talk of testimonials and vague claims of being “clinically proven.” While I do not discount voices like yours who say anatabloc has helped them, I do, when I can, try to make peer reviewed human research my litmus test for products.
Again, really appreciate you taking the time for writing.
Adam, thanks and i will call that number and see what they have to say, I can handle sleeping less but the sensation in my chest cavity has me concerned. As for my Gums, they feel incredibly awesome now as well. I am excited to see what my dentist has to say about them. My last dentist appt (2 years ago, ha ha) he said that i needed gum graft surgery, and they were receding bad with large pockets, know i look in the mirror and my gums look and feel great.
As for my sex drive, if i only take 1 pill a day i am ok. But for some reason i am super sensitive to any thing that is supposedly good for your prostate ( Tomatoes, Saw Palmetto, Multivitamins, and of course Anatabloc) so thats just me and how my weird body reacts.
To clarify the plant origin of anatabine – anatabine was first isolated from the tobacco leaf. It was of interest because of its similarity to nicotine and was first marketed as a nicotine alternative in a smoking cessation product. Nicotine is a very simple molecule, as is anatabine. It was relatively easy to synthesize it which makes it simpler and cheaper to commercialize.
Anatabine is present in its natural form in tomatoes, eggplant, potatoes, but in low concentration. Anatabine is a central nervous system stimulant, as is nicotine, and its effects will be similar.
Joe, thanks for your response. I forgot to mention that I know two people whose CRP came down dramatically after taking Anatabloc. I have had the test once and had a high number which was a surprise since I was already taking Abloc. Will report to you when I take the test again in January. By then data may be out on CRP Flint study and Thyroid.
Lochlan, thanks for the information. hope your CPR goes down!
Randy My gums were killing me the first week of Anatabloc. I had no idea why. Well it was inflammation. They are awesome now and I have been to the dentist several times since starting Anatabloc.
Let me suggest you call the physician with Anatabloc and discuss your other problem 1-800-778-2031 Extension 4
I can tell you I did experience the same thing you describe right after getting the flu shot but it went quickly away. You may be on other meds. I can tell you I have no side effects. Nor have I seen any with others.
BWT everyone it does help to take the last dosage for the day at bedtime.
Joe the anatabine in Anatabloc has nothing to do with any plant. It is synthesized manufacturing product. Not sure how you are tying it to nicotine. I guess I do not understand your reference. Thanks.
Adam, I appreciate your alacrity on this matter however I am correct about nicotine and anatabine. here is a PDF of a file I took right from Anatabloc.com. it shows the chemical structure of anatabine and nicotine. they look a lot a like chemically and they are both in the night shade family of plants. http://anatabloc.com/wp-content/themes/anatabloc/pdf/General_Info_Anatabine_Citrate_201107.pdf
I don’t need to call any researchers because the research is already there. By their research I shall know them (supplements).
I have been taking Anatabloc since it was released. My allergies and sinus condition are much improved and I have gone from weight of 168 to 155. I honestly think it curbs my appetite. A friend swears it has improved his ruddy complexion. Another says he has dramatically less soreness after exercise. Seems to have more benefit the older you are. Human thyroid data is expected this month and peer reviewed by John Hopkins Dr. Paul Ladensen.
Lochlan, thanks I have my eyes peeled for the research. I’ll update my review when its published. Theoretically if it does help reduce joint/muscle stiffness that might lead to weight loss by way of allowing for more physical activity. I’m guessing on this of course. I’m not sure about allergies though.
Is there anyone besides me that is taking this pill that is having side effects? I can only take 1 pill a day because it feels like it increases my heart rate, and therefore have trouble sleeping and it reduces my sex drive. I had the same side effects with Prednisone and other then these concerning side effects it really seems to help just like prednisone did. As a side note, i think my receding gums are growing back ( i am seeing my dentist next week to see if that is true) and my hair seems to be growing back.
Randy, dont remember seeing elevated heart rate in any anatabloc studies but if its related to nicotine I wonder if that might be something some people might notice? Not sure either way. As for it helping your gums, Im at a loss but Im curious what your dentist says.
I’m in my 2nd day taking anablock as directed… Already it has had a positive effect o my left shoulder which has been extremely painful.
I happen to be taking Anatabloc for quite some time and find it somewhat humorous to see so many blog “experts” here. My issues with inflammation are many and Anatabloc has changed my life.
The real experts are the scientists involved with the company and the many clinicals being done. There are numerous scientific papers on Anatabine the main element of Anatabloc.
Here is the company scientist who by the way had a long career at the FDA.
Dr. Curtis Wright, Senior Vice President and Medical/Clinical Director of Star Scientific’s wholly owned subsidiary Rock Creek Pharmaceuticals Inc. Dr. Curtis Wright, IV MD has been Senior Vice President and Medical & Clinical Director of Rock Creek Pharmaceuticals Inc. since February 2008. Dr. Wright serves as Senior Vice President of Star Scientific Inc. Dr. Wright served as Vice President of Clinical and Regulatory Affairs for Adolor Corporation from 1997 to 1998, and Executive Director, Medical Affairs and subsequently Executive Director of Risk Assessment for Purdue Pharma from 1998 to 2004. Dr. Wright served … as an Executive Vice President for Risk Management and Regulatory Affairs at Javelin Pharmaceuticals, Inc. from 2005 to 2008. Dr. Wright’s career at the FDA, from 1989 to October 1997, included multiple senior scientific positions in the Center for Drug Evaluation and Research, including Deputy Director and subsequently Acting Director of that division. Dr. Wright serves as Member of Scientific Advisory Board of Pear Tree Pharmaceuticals Inc. Dr. Wright holds medical degree, with distinction, from George Washington and received a master’s degree in Public Health from the John Hopkins University.
Here is the scientist handling the Thyroid clinical study that is soon to be realized at John Hopkins ( Worlds foremost Endocrinology Research Institute. By the way he was nominated in 2012 by the American Thyroid Association for Doctor of the Year for his work with Anatabine the main element of Antabloc. Do you know how many YEARS he has worked with Anatabine and how many PAPERS he has authored or co-authored on the subject of Anatabine?
Dr. Paul W. Ladenson, Director of Endocrinology and Metabolism at Johns Hopkins, John Eager Howard Professor of Endocrinology and Metabolism Professor of Medicine, Pathology, Oncology, and Radiology & Radiological Sciences Medical School: Oxford University, Harvard Medical SchoolResidency: Massachusetts General Hospital Fellowship: Massachusetts General Hospital
Board Certification: Endocrinology and Metabolism and Internal Medicine
Please pay attention to the real experts. Do your homework. Thank you.
Adam, I did do my homework when I reviewed Anatabloc and if you clicked on the links in my review you would see that they go to the actual studies that have been done on Anatabloc and anatabine. While I do not say I am as wise in the biochemistry of anatabine as the researchers who are doing the studies, the FACT remains that what the studies listed in my review ARE the studies being used to “prothat anatabloc works. The reduction in inflammation that they say anatabloc causes is based on mouse thyroid glands.
Can you show me 1 study that Anatabloc reduces inflammation in human joints or human muscles? They are saying on TV it does this. Other than people who say it works, where is the proof?
Let me be clear, If you tell me anatabloc is helping you, believe me when I say I’m really happy. However, right now I see no good human proof that it works in humans. Even those researchers you mentioned cant prove it conclusively either until the human studies are done.
Janine,
Thanks for the advice…I am looking into it now…since there is no adverse side effects, I have nothing to lose.
Best Regards,
Ed
Steven,
Thanks for the advice…however, I have been treated by several top rated specialists and yes they all have at first glance thought of the most common..enbrel, Humira ..remicade…however, I have other complications as my disease has adversely effected my Liver and Heart, as well as leaving me with severe colitis…with the high risk of side effects from all three of these drugs, I chose to not try any of them…so to at the very least control the inflammation, predisone is really all that I have been sublected to…unless you have another suggestion.
Best Regards,
Ed
Yep I got one and looked into it, glad to have read this info. I was surprised to see Fred Couples backing this product. We all know about his back problems and I can’t believe this is what he takes. Anything for money!
Thanks for the info
I came here not because I need to cure what this stuff is supposed to cure, but because I’ve been getting spammed big-time by them. I figure that spam marketing = questionable product.
Bill that’s interesting. Anybody else getting the same spam emails?
Thanks for the GREAT review. The first “red flag” that went up for me is the site mentions this “natural occurring compound that comes from plants.” These plants are known as “night shade” vegetables (e.g., potatoes, tomatoes, sweet and hot peppers, eggplant, tomatillos, pimentos, paprika, and cayenne peppers).
If you want to read about these, here’s an excellent web site: http://www.whfoods.com/genpage.php?tname=george&dbid=62. Move down the page and you’ll see a section about the effect on joint health.
I have done a lot of research myself and have always read that “night shades” were not good for a variety of reasons. I may have found this out when I had a diagnosis of Fibromyalgia (and don’t get me started on that topic!).
There is NO WAY I would take this supplement. I would do cortisone shots into my knee before I would waste my money on something like this. I’ll stick with outer approaches that are working for me such as the liquid Glucosamine/Chrondritin along with acupuncture and reflexology.
Best,
Cindy :}
Cindy, thats an interesting point about night shades. Im honestly not sure if there would be any problem or not. I’ll keep that in the back of my mind. As an aside, your liquid glucosamine probably is gllucosamine HCL. if its working for you, great. There is MUCH more proof for glucosamine sulfate though. Here is something you may find interesting
http://supplementclarity.com/glucosamine-4-facts-you-dont-know/
Ed, Before taking a heavy-duty immunosuppressant for ankylosing spondylitis (these are very serious drugs) I would give “low intensity laser therapy” a try. It has no known side effects and has been very successful at treating localized inflammatory conditions. It costs about $1.00-$1.50 per minute so 3 sessions of 20 min would cost less than $100 (not covered by insurance).
There are clinical trials published in peer reviewed medical literature. I cannot say that it is certain that it will work in your case but it has a record of effectiveness in other localized inflammatory conditions and no known side effects.
It is worth a try if there is a chance that it could be an effective alternative to some serious drugs. You can just google “low intensity laser therapy” and locations to find one near you. Make sure the practitioner has certification.
Janine
Methinks Ben doth miss the overall point of why your blog is so valuable…
r walker, no worries. I welcome his questions. 🙂