Episode 17 of Joe Cannon Health. This week we dive into BPC 157. Body Protecting Complex 157 (BPC 157) is a molecule isolated from the stomach which is touted to help heal injuries to tendons and ligaments as well as many other things such as depression and ulcers. What does the research say? Does it really work? Does it have any side effects? In this health podcast episode, you will learn the research on Body Protective Complex. If you know the research on the Body Protection Complex, this will help you better decide if its right for you. If you have any questions, leave them below in the comments.
Myth of the week:
- do you need a sports drink when you exercise?
What is BPC 157?
- Its also called penta-deca-peptide BPC 157 AND PL 14736
- It's a peptide that's 15 amino acids long
- Research started showing up in the early 1990s
What does it do?
Some claims include:
- Heal tendons and ligament injuries
- Decrease muscle soreness (DOMS)
- Help depression
- Help ulcers
- Help inflammatory bowel syndrome (IBS)
- Protecting the heart
How does Body Protection Complex Work?
- producing new blood vessels (angiogenesis)
- Ramping up nitric oxide production
- increasing receptors for growth hormone
Likely multiple targets of action
Body Protecting Complex Tendon Injury Research
- Most studies limited to lab animals
Does it help delayed muscle soreness
- what is delayed muscle soreness (DOMS)
- Human evidence is lacking
Does it help depression?
Human evidence for reducing depression is lacking
What about BPC 157 dietary supplements
- Touted to speed healing from injuries
- Human clinical evidence for dietary supplements is lacking
Is it legal in sports?
- Will it cause a red flag on drug tests?
- Check with WADA and USADA for their position statements
Body Protecting Complex dosages
- Dosages may be derived from amounts used in animal research
Any side effects
- Not according to lab animal research
Quote of the week
- Original Review of BPC 157
- BPC 157 and blood vessels.
- BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing
- The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration
- Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts
- Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone.
- Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.
- Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.
- Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro
- The antidepressant effect of an antiulcer pentadecapeptide BPC 157 in Porsolt's test and chronic unpredictable stress in rats. A comparison with antidepressants.
- Accelerated healing of excisional skin wounds by PL 14736 in alloxan-hyperglycemic rats.
- FDA alerts health care professionals and patients not to use drug products intended to be sterile from Promise Pharmacy
- Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability.
- The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides