Written by Joe Cannon, MS. Update 6/4/22. Omega XL, touted on TV as a “natural solution for arthritis and joint pain,” is a product you may have seen in TV commercials featuring Larry King. The benefits of Omega XL are said to be derived from an extract of the green-lipped mussel. The questions I get asked most are: “Does Omega XL work? and “Is Omega XL just a fish oil supplement?” Are there any side effects? Let's see what the research says.
Omega XL Health Claims
This dietary supplement is touted to reduce joint pain by reducing inflammation. The key ingredient comes from the green-lipped mussel (Perna canaliculus). This is different than other fish oil supplements.
How Does Omega XL Work
The key active ingredient in Omega XL is a compound called “PCSO-524.” This name refers to fatty acids that come from the green-lipped mussel (Perna canaliculus) in New Zealand.
This fatty acid extract (PCSO-524) is said to reduce pain and inflammation by working on pain pathways called the COX (cyclooxygenase) and LOX (lipoxygenase) pathways.
By reducing inflammation in the body, the pain might we experience can be reduced.
Who Makes Omega XL & Company Contact Information?
Omega XL is distributed by Great HealthWorks, whose address is 4150 SW 28th Way, Fort Lauderdale, FL 33312-5201.
According to the Better Business Bureau, the company was started in 2003.
To contact Great Health Works, customer service, call 800-488-8082.
Better Business Bureau Rating and Customer Complaints
Great Health Works has been in operation since 2003. The BBB gives Great HealthWorks an A+ rating with 4.61 out of 5 stars. When their site was last checked, there were 99 complaints listed with the Better Business Bureau. To their credit, the company responds to customer complaints and issues refunds when requested. The company has been accredited by the BBB since 2010.
What Is Pharmalink International?
What is called Omega XL is really a product by a company called Pharmalink International Limited. They are located at
In the US, their distributors are:
- Great HealthWorks
- Lyprinol.com
Therefore, Great HealthWorks is the US distributor of Omega XL. There's nothing wrong with this. This information is provided for those doing their own research.
Larry King TV Commercial
What Is Lyprinol?
Lyprinol is another name for Omega XL. They are the same thing. Lyprinol is the name of the supplement sold internationally by Pharmalink International. Much of the research you see below will be on Lyprinol. Remember Lyprinol research = Omega XL research.
Quick Reference: Omega XL Names
These four names all refer to the same thing:
- Omega XL
- Lyprinol
- PCSO-524
- Green-lipped mussel extract
Omega XL Ingredients
From the bottle, we see 2 soft gel capsules have 300 mg of the following ingredients:
- Green-lipped mussel extract (PSCO-524)
- Olive oil
- Vitamin E
The key ingredient is green-lipped mussel extract (PSCO-524). Neither olive oil nor vitamin E significantly contributes to the supplement's benefits.
There is also an Omega XL Sport, which contains 600 mg per two soft gels.
Omega XL Research
The OmegaXL.com website says the “Patented green lipid extract found in Omega XL has been the subject of 25 years of multiple published clinical studies. Some of that research involves animals. However, in this review, we will only review the human clinical trials.
Omega XL Human Clinical Studies
Here's a review of human research.
2018 Studies
Study Title: The Effects of PCSO-524®, a Patented Marine Oil Lipid derived from the New Zealand Green Lipped Mussel (Perna canaliculus), on Pulmonary and Respiratory Muscle Function in Non-asthmatic Elite Runners.
Study Summary:
16 runners who did not have asthma were given either 8 capsules of Omega XL or a placebo (olive oil) for 12 weeks.
Results:
Omega XL did not improve lung functioning.
2015 Studies
Study Title: The effects PCSO-524®, a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green-lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle-damaging exercise in untrained men: a randomized, placebo-controlled trial.
Study Summary:
This study involved 32 untrained young men (average age was 22) who exercised on a treadmill (downhill running) to cause delayed muscle soreness (DOMS) and muscle damage. The men were randomly given either a placebo or 1200 mg of PCSO-524 for 26 days before they exercised and for 96 hours afterward.
Results:
Omega XL significantly reduced various measurements of muscle damage compared to the placebo. Those taking the supplement also had significantly less reduction in muscle strength after exercise. While the study was funded by Pharmalink International, the maker of the supplement, the researchers report no conflicts of interest and the company played no role in the study.
2013 Studies
Study Title: Marine lipid fraction PCSO-524™ (lyprinol(®)/omega XL(®)) of the New Zealand green lipped mussel attenuates hyperpnea-induced bronchoconstriction in asthma.
Study Summary:
The aim of this study was to determine if the supplement could reduce breathing problems during exercise in people with asthma. Basically, researchers wanted to see if the supplement would help exercise-induced asthma symptoms. This study lasted 8 weeks and involved 20 college-aged men and women with mild to moderate asthma symptoms. Students were randomly given either a placebo or 1200 mg of Omega XL (8 capsules) per day.
Study Results:
Those taking Omega XL saw a significant reduction in average asthma symptom scores as well as a significant reduction in the use of asthma medication use.
Study Title: Perna canaliculus Lipid Complex PCSO-524™ Demonstrated Pain Relief for Osteoarthritis Patients Benchmarked against Fish Oil, a Randomized Trial, without Placebo Control.
Study Summary:
This investigation involved 50 older men and women (44 women, 6 men; their age was about 65 years). All people had knee or hip osteoarthritis. For 12 weeks, people were randomly given either:
- 1200 mg of fish oil per day or
- 1200 mg Lyprinol per day (containing 400 mg of PCSO-524)
Study Results:
Those who received the Omega XL extract (PCSO-524) reported significantly less pain and more mobility than those who were given fish oil. No side effects were reported and no change in blood pressure or liver enzymes was reported.
Study problems:
This study had no placebo group. Researchers also did not measure changes in inflammation enzymes, the stuff green-lipped mussel extract is supposed to inhibit.
Study Title: Marine oil dietary supplementation reduces delayed onset muscle soreness after a 30 km run.
Study Summary:
Investigators were testing if PCSO-542 could reduce muscle soreness after exercise (see this for more on DOMS). In this study, 32 runners performed a 9-mile run (15 km) on an asphalt course at 70% of their maximum aerobic ability. The runners were given either Omega XL or a placebo for 11 weeks.
The amount of Omega XL used in the study was 1200 mg per day (this provided 400 mg of the PCSO-524 active ingredient in Omega XL). After 11 weeks, people ran the same 9-mile run again, at the same speed. Blood samples and pain levels 3 days later were recorded for comparison.
Study Results:
Researchers noted runners who received PCSO-542 (OmegaXL) have significantly less delayed muscle soreness (DOMS) than those who took the placebo. The effect was “slight but significant” which, to me means, the effect might not be noticed by most people. Interestingly, Omega XL seemed to reduce muscle soreness more in runners who were less fit. In the more advanced runners, there was less of an effect.
Study problems:
This was a single-blinded investigation so the researchers knew who was getting Omega XL and who was getting the placebo. These types of studies open the possibility that researchers might inadvertently/unconsciously influence the outcomes of the study.
Interestingly, there were no significant reductions in the muscle damage enzyme, creatine kinase levels (CK). Theoretically, if the supplement reduced muscle soreness, it makes sense that it might reduce CK levels. But no reduction was seen.
2012 Studies
Study Title. “Treatment of children’s asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstructive asthma” published in the Internet Journal of Asthma, Allergies and Immunology.
Study Summary:
71 kids with moderate asthma (age 6-13) were randomly given either 4 placebos per day or 4 capsules (600 mg) of Lyprinol per day for the 16-week study (4 months).
Study Results:
There were no differences in the number of asthma symptoms between those taking Omega XL and placebo. Those taking the supplement saw no changes in wheezing or breathlessness, chest tightness or lost sleep. The supplement did reduce the use of astha medications either.
2011 Studies
Study Title: Measurement of pain relief resulting from administration of Perna canaliculus lipid complex PCSO-524™ compared with fish oil for treating patients who suffer from osteoarthritis of the knee and/or the hip joints.
Study Summary: 50 men and women over 55 years of age who had osteoarthritis of the knee and/or hip. Most of the people in the study were women. People were randomly given either 1200 mg of fish oil or 1200 mg of Lyprinol (Omega XL) for 12 weeks.
Study Results:
Those who received the supplement showed a “statistically significant reduction in pain, improved levels of mobility and activity” with “no noted effects.” No significant changes were seen in those who received fish oil.
People in this study did have access to acetaminophen (Tylenol). Those taking Lyprinol reported using less acetaminophen than those who received fish oil.
Study problems:
People were able to use pain medications. Theoretically, this may have masked the effects of the supplement.
Study Title: The effects of Lyprinol(®) on delayed onset muscle soreness and muscle damage in well-trained athletes: a double-blind randomized controlled trial.
Study Summary:
Researchers tried to see if Omega XL could reduce muscle soreness after exercise. In this 2-month-long investigation, 20 well-trained college-age males were randomly given 200 mg per day of the supplement or a placebo.
Study Results: Lyprinol did not reduce muscle soreness after exercise.
Study problems:
Researchers tested CRP levels. CRP is a marker for cellular inflammation. The higher the CPR, the more inflammation. Since the supplement is marketed to be anti-inflammatory, it should reduce CRP levels. But, it didn't. This is one of the few studies that measured CRP levels.
2006 Studies
Study Title: Systematic review of a marine nutriceutical supplement in clinical trials for arthritis: the effectiveness of the New Zealand green-lipped mussel Perna canaliculus.
Study Summary:
This is a review of the research previously conducted on the green-lipped mussel (Perna canaliculus). The authors concluded there was “little consistent and compelling evidence” (up until 2006).
Study Problems:
These researchers were looking at freeze-dried green-lipped mussel powder supplements. This is not the same thing as Omega XL. The review also mentions other similar green-lipped mussel supplements such as “Seatone.”
2004 Studies
| Study Title: Treatment of knee osteoarthritis with Lyprinol®, lipid extract of the green-lipped mussel – A double-blind placebo-controlled study.
Study Summary: 67 completed the study with knee osteoarthritis were either given Lyprinol or a placebo for 6 months. Study Results: Those who received Lyprinol had no difference in pain perception than those who received a placebo. Study Problems: This study does not tell how much Lyprinol people used. Those who took a placebo showed improvements. Also, people in this study were allowed to use acetaminophen for pain. This could have masked the effects of OmegaXL. |
Study Title: Efficacy and tolerability of a combination of Lyprinol and high concentrations of EPA and DHA in inflammatory rheumatoid disorders.
Study Summary:
50 people with rheumatoid arthritis were given a combination of Lyprinol and fish oil supplements for 12 weeks.
Study Results:
62% of the people were able to reduce their arthritis medications by the end of the study.
Study Problems
This study didn't use Omega XL. It used a different supplement called which has 35 mg of the green-lipped mussel extract as well as 458 mg of fish oil per capsule. Omega XL has 50 mg of the green-lipped mussel extract per capsule. Also, there was no placebo group.
2003 Studies
Study Title: Clinical efficacy and safety of Lyprinol, a patented extract from New Zealand green-lipped mussel (Perna canaliculus) in patients with osteoarthritis of the hip and knee: A multi-centre two-month clinical trial.
Study Summary:
60 people with osteoarthritis of the hip and knee (54 people completed the study) were given 4 capsules (600 mg) of Lyprinol per day for 8 weeks.
Study Results:
Researchers report that 80% of people said they experienced significant pain relief and improved joint function. No side effects were reported.
Study problems:
There was no placebo group.
2002 Studies
Study Title: Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomized clinical trial.
Study Summary:
46 people with mild asthma were studied for 8 weeks. People were randomly given either a placebo or Lyprinol twice a day.
Study Results:
Those who received the Lyprinol reported less wheezing, less exhaled hydrogen peroxide (a marker for airway inflammation and free radical stress) and an increase in peak expiratory flow, compared to those who received a placebo. In other words, their asthma got better.
2000 Studies
Study Title: The effect of a lipid extract of the New Zealand green-lipped mussel on three cases of arthritis.
Study Summary:
This is a report on the effects of Omega XL on 3 people who had rheumatoid arthritis. I am unable to locate the results of these case studies.
Study Title: Anti-inflammatory effects of a stabilized lipid extract of Perna canaliculus (Lyprinol®). The link goes to a pdf of the study.
Study Summary:
This is a review article that covers several other investigations that have noted positive results with Lyprinol.
1998 Studies
Study Title: The treatment of arthritis with a lipid extract of Perna canaliculus: a randomized trial.
Study Summary:
30 people with arthritis (osteoarthritis and rheumatoid arthritis) were given either freeze-dried green-lipid mussel powder (1150mg/day) or Lyprinol (210 mg/day) for 3 months.
Study Results:
Both supplements decreased pain, swelling, and stiffness in people. Researchers noted that 70% of those with osteoarthritis benefited from the treatments and 76% of those with rheumatoid arthritis also benefited.
Study problems:
While the results are impressive, neither supplement improved handgrip strength. You'd think if arthritis pain was less, then people should be able to grasp things tighter (because they were in less pain). But this did not happen. Also, there was no placebo group in this study.
1983 Studies
Study Title: Perna canaliculus in the treatment of rheumatoid arthritis. I can't find the results of this investigation.
1980 Studies
Study Title: Perna canaliculus in the treatment of arthritis.
Study Summary:
66 people were followed for 3 months. People with osteoarthritis and rheumatoid arthritis were given either a placebo or 1050 mg of a green-lipped mussel supplement, called Biolane, a product by the New Zealand company, Vitaco. This was not OmegaXL but I'm adding it because it's a study of green-lipped mussel.
Study Results:
76% of the rheumatoid and 45% of the osteoarthritis group reported improvements in pain/ stiffness. Researchers also noted that 40% of all participants in the study did not notice any benefits.
Study problems
This study did not use Omega XL/Lyprinol. While the researchers state that a large percentage of people with osteoarthritis and rheumatoid arthritis showed improvements, the researchers did not say these results were “significant.”
Also, grip strength did not improve. If arthritis pain got better, then grip strength should improve also. I believe this may be the very first study performed on green-lipped mussel extract.
Summary Of Omega XL Arthritis Research
Kudos if you made it through all those studies! Here is a quick review of the human Omega XL arthritis research to date. To be fair, I will say “it works” or “it does not work” based only on research that found statistically significant results.
2013 study: it works (12-week study. 1200 mg/day used)
2011 study: it works (12-week study. 1200 mg/day used)
2004 study: it does not work (6-month study. Unknown amount used)
2004 study: it works (12-week study. 4 capsules per day)
2003 study: it works (8-week study. 600 mg/day used)
1998 study: it works (3-month study. 1150 freeze-dried and 210 mg mussel extract/day)
1980 Study: it does not work (3-month study. 1050 mg/day study did not use Omega XL)
Of the 7 studies, 5 noted it worked. Keep in mind several of the Omega XL arthritis studies had problems with how they were conducted. See the summaries above for more information.
Omega XL Asthma Research Summary
OmegaXL is also touted to improve asthma. Here is a quick review of asthma research. As before, I will classify whether “it works” or “it does not work” based only on research that noted statistically significant results.
2013 study: it works (8-week study. 1200 mg/day used)
2012 study: it does not work (4-month study 600 mg used)
2002 study: it works (8-week study. 300 mg/day)
Based on the asthma research above, I'm not sure if the supplement helps asthma or not. From these 3 studies, it looks like Omega XL works at 300 mg a day and 1200 mg per day but not at 600 mg per day?
Omega XL And Heart Disease
During one of the Omega XL infomercials, Larry King asks Dr. Sharon McQuillan, who also appeared on the infomercial this question:
“How can omega XL reduce the risk of heart attacks?” She responds :
“30 years of studies have shown the benefits of omega 3s.” She goes on to say that ” I recommend Omega XL to all my patients to help protect their hearts, preserve their heart and vascular health.”
But, as far as I can tell, Lyprinol/Omega XL ―itself ―has never been proven – via clinical studies – to improve heart disease or reduce the risk of heart attacks.
It's possible it may help ―since it contains omega-3 fatty acids, like EPA and DHA. But until somebody tests the product, it's speculation. Also, notice this claim is about omega 3 fats (EPA and DHA) and NOT the green-lipped mussel.
Later in the infomercial, Dr. McQuillan says Omega XL is “the most potent anti-inflammatory that exists.” But, as far as I can tell, there are no studies comparing Omega XL to other natural anti-inflammatory supplements. Also, if the supplement is so potent, why did people in several of the studies still need to take Tylenol?
Read this book to see how to reverse heart disease.
Omega XL And Back Pain
I'm not aware of any back pain studies.
Omega XL For Fibromyalgia
I have not seen any studies involving people with fibromyalgia who took this supplement.
Does Omega XL Help IBS?
Can this supplement help irritable bowel syndrome (IBS)? So far, clinical research on IBS cannot be located. Likewise human research on inflammatory bowel disorder (IBD) The evidence I located involved lab mice.
Omega XL And Cancer
There is internet chatter about Lyprinol helping cancer. This hype appears to be traced to a 2005 rat study. I am not aware of any published clinical proof in humans showing Omega XL/Lyprinol helps any type of cancer.
See the side effects section for more information if you have cancer.
Omega XL And Muscle Soreness
There are 3 studies of Omega XL and DOMS. So far, two studies have noted it helps while one study shows the supplement does not work. From the studies showing it reduces muscle soreness, its effects seem to be best in those who are beginners.
Omega XL Pros And Cons
Here's a quick review of what I liked and didn't like about the supplement. These are my opinions.
| Pro | Con |
|---|---|
| Lots of studies | Many studies have problems |
| Available at Amazon & Ebay | Expensive |
| Few side effects | Over the top claims |
How Much PCSO-524 is In Omega XL?
Most studies use a patented product called Lyprinol (another name for Omega XL). Studies note that 150 mg of this product contains 50 mg PCSO-524. This is what is in 1 gel cap. Scroll up to the ingredient breakdown for more information.
How Long Until Omega XL Works?
The severity and the type of arthritis would likely play a role in how long before effects were noticed. If OmegaXL is going to work, studies of arthritis, generally note 4-8 weeks is typical. As for others how long it might take to help other health issues, I can't say.
Omega XL For Dogs
There is some research noting that Omega XL may help dogs with arthritis. The product sold is called Mussel Dog although there are MANY green-lipped pet supplements. One study has noted the supplement may not reduce pain or inflammation better than the anti-inflammatory medications. From the research, if it's going to work, it may take 6 weeks until the effects are noticed by your pet.
Omega XL Side Effects and Health Reactions
None of the human studies report any significant side effects. Some studies have even noted no interaction with blood thinner medications, which is interesting since Omega XL contains low amounts of EPA and DHA, (natural blood thinners). That said, here are some general considerations if taking this supplement. This list is not complete:
As with all supplements not prescribed by your doctor:
- Stop taking at least 2 weeks before having surgery
- If you take blood thinner medications, speak to your doctor/pharmacist first
- Speak to your doctor first if you are pregnant or breastfeeding
- Speak to a qualified medical specialist if you take any medicines
There is a report of a 76 year old woman who developed liver problems shortly after she started taking Lyprinol for arthritis. After she stopped taking Lyprinol, her condition improved.
There is a report datelining how people with breast cancer and prostate cancer tolerated green-lipped mussel lipid extract. In this preliminary investigation, 17 people received 260 mg of the green-lipped mussel extract 2 times per day (510 mg total). While the extract was well tolerated in most people, 2 of the people in this trial developed liver problems. This doesn't prove Omega XL causes liver problems. For those with cancer, speak to your oncologists about the supplements you take.
Omega XL Customer Negative Testimonials
Amazon has over 19,000 ratings for this supplement with 66% of those giving it a 5-star rating. Since nothing will work for everyone, it should also be known that 21% of people gave Omega XL between 1 and 3 stars.
Chief customer complaints include:
- the price (it's overpriced)
- caused gout flair-ups and raised uric acid levels
- it didn't work after a month
- it works but the results are not dramatic
- the supplement smells bad
- package does not specify if it is free of mercury, PCBs, and other toxins
- caused a steep rise in PSA levels
- supplement caused intense abdominal pains
- bottle contains fewer pills than listed on the label
Buy Omega XL
The supplement is very popular and can be found at Walmart, GNC, and many other locations. You can order it directly at GreatHealthWorks.com.
It is available on Amazon too.
Contact Omega XL
To contact Great Health Works, call 800-609-4818
Omega XL Price
On the GreatHealthWorks.com website, the supplement costs $129.95 for a bottle containing 120 soft gels for $129.95.
The supplement comes with a 90-day money-back guarantee. Returns after 90 days will not be eligible for refunds. For more information about these people should call customer service at 1-800-609-4818.
Other Green- Lipped Mussel Supplements?
Green-lipped mussel extract is getting popular. Even Plexus Slim has added Lyprinol one of their supplements. As far as I can tell, only Lyprinol/Omega XL appears to have been studied clinically, and so, that is an advantage this product has over others.
That said, quality-made dietary supplements containing the same dosage, might in theory work similarly to each other.
Does Omega XL Work?
There is no doubt that Omega XL (Lyprinol) has a LOT of clinical research dating back several years. The majority of these studies appear to show the active ingredient in (called, PCSO-524) may have pain-relieving benefits. That said because some of the studies have problems with how they were conducted, I feel better investigations need to be done.
Hi Joe!
Couldn’t sleep because the pain in my hands was keeping me awake. Turned on the TV to see Larry King’s infomercial. Got online to research and your unbiased review was exceedingly helpful! Thank you so much for all the work compiling this research in one well-explained document. 🙂
I think I will give a similar less expensive product a try, and hopefully sleep better afterwards.
Now I just have to talk myself out of buying the Power Pressure Cooker XL….
Six Kids, really glad you found my review helpful. I liked yoru website by the way and congrats on your MS degree. Have a wonderful 2016! 🙂
It’s sold on an infomercial, how good can it be?
Why does this product have to be so expensive? The recommended usage is 6 capsules per day, which utilizes a bottle in 10 days. You will have to purchase 3 bottles per month to get everyday use. Is everyday use necessary?
Barry, Well, my guess is paying Larry King and for all the TV advertising plays a role in the price. The fact that there is some research on Lyprinol also likely plays a role too. I did try to break down how much researchers used in the studies. Go back to my review and see if that lines up with what they are recommending. Have you tried other products to see if they work as well as Omega XL? Is Omega XL helping you?
Vey useful review Joe, and certainly appreciate the links to research. I must admit that I worry that these positive reviews and comments posted here and elsewhere could easily be from people paid to do so (which sadly is quite common). For me when I read the research summaries you have provided it seems clear the effects while statistically significant are likely to be modest, however, the supporters who post make claims of wild improvement which the research does not seem to suggest should be possible.
I do know that due to genetic differences some people may experience more or less benefit so that is a confounding factor. I am going to continue to research this and similar problems as at 47 I am myself suffering from joint pain (as well as asthma and back issues). Thank you again for your efforts.
Mark you are welcome. I do try to weed out spammers but anything is possible. I do feel there is value to what people say as thus can bring up stuff I missed. I like to put the emphasis on the studies as this can help put some comments in another light.
This product is the best I can live comfortable now I can clean my own house I can do my own shopping I can bend, lift, stand for longer periods of time.
I use to be in sooooooooo much pain. My life has changed. I know this because when i ran out and had to wait to get my next order i was felling the pain again come back gradually. This is a great product for me
Andrey, great! Really glad to hear it’s helping you!
Excellent article and excellent summary. Your reviews were very thorough and easy to follow. It looks like you covered everything. I feel better already as you have saved me hours of research on this product. I don’t think this product is for me as my joint pain in minimal.
Have you written any articles on Prevagen to improve memory with aging? This is my first time coming across your page, but I am going to make you a favorite.
Thanks again for you easy to follow article.
I just found your article on Prevagen. Again, you have saved me a lot of time (and money). Thanks!
SueZin glad you found me and thanks for the nice words. Always appreciated.
After reading all of this so called information….I still have one question for the author…DOES IT WORK???/ You have talked about whats in it what’s it all about but never have you said if it works. When you review leave something for the consumer to understand. I see nothing so it must work because you have avoided the RIGHT QUESTION. Waste of time!!!
Jo, I know I wrote a lot in this review but did you read the very last section called “Does It Work?” I think I made my thoughts clear there.
I think the answer to does it work, is not so cut and dried. I think the answer is it depends, and there appears to be no definitive answer. For me, I tried the stuff religiously for about 8 months and found no noticeable improvement in my overall well being. But for every one of me, there is another that swears by it. There may be no better solution to simply trying it out to determine if it works for you or not.
I have suffered for almost 10 years with Fibromyalgia, osteoarthritis and chronic pain. Most days I could hardly get outta bed and walk without severe pain all over my body . it started gradual then gotten worse over the years . I finally have a dr.to treat me but he doesn’t truly understand my pain and daily challenges. I take a couple prescriptions for pain control, but I started taking omg xls,a few days ago to see if it might help with all of my stiffness and inflammation.
Too soon to say it’s working 100% But im going to keep trying them,crossing my fingers i may get some relief from this horrible disease!!
Sandra, I can only imagine what you must be going through. I am happy that you have found a doctor who is taking an interest in trying to find the causes of your pain. I do hope omega XL helps you. do keep me updated.
Here is my review of a supplement called Ribose. It has some preliminary evidence that it might help fibromyalgia pain. Some people have said it’s helped them. If you try this, let me know what happens.
I will say a prayer for you today that you become pain free again.
Great article and helpful summary of effectiveness. My personal experience supports some pain relief from an old knee injury when running. I was given a starter subscription and took 600mg of Omega XL for about a year. I noticed less aches and pains in my knee which had an ACL replacement and partial meniscectomy and usually ached with any rigorous exercise.
Because of the cost, I decided to cancel my subscription and just try over the counter Fish Oil. I did that for a year and noticed an increase in aches in my knee. I have returned to Omega XL and, over the past year, feel the same positive effects in my knee.
Just my personal story and your results may vary. Good Luck!
John, thanks for sharing. I’m happy Omega XL is helping you.
I have been using Omega XL for the past 2 months. My overall well-being is improved as I was ill for the year 2014. I feel so much more alive. I also noticed that my blood sugar is regulated now. I intend to stay with this product for a while.
Mernell, thanks for the feedback. I am happy that Omega Xl is helping you.
very informative,I have tried Omega XL for 30 days and been relieved from pain in the back,hands,and muscles behind the legs and thighs.
F, thanks for the feedback and I’m really glad Omega XL has helped you.
The patent that Pharmalink / Lyprinol have is coming off very soon and then the price will almost certainly drop as there are a number of companies waiting in the wings and will hit the ground running when the protection expires. The only problem with Lyprinol (apart from price and a preacher selling it from the pulpit) is that the oil is mainly in triglyceride form because of the manner of extraction. Krill oil is much richer in phospholipids, a much more bio-available form.
When you consider that every cell in your body ( all 34 trillion of them) has 50% of a Phospholipid ( phosphatidylcholine) in the outer wall, and these cells are dying at an great rate, it becomes important to replace these phospholipids. We produce a green lipped mussel oil that is also rich in phospholipids simply because we use an ethanol extraction but krill oil has certainly taken the world by storm. A lot of it is hype but it is a good oil.
Joe, I see you sell your own version of green lipped mussel extract (Tripernol). Have you published any clinical trials on your product (published, peer reviewed studies) to prove to people that it is better than Omega XL or any other green lipped mussel product? I didn’t see any when I looked at your website.
HI Joe, I am 60 yrs old, 10 years ago I had to practically had to drag my right foot to walk I think because of hip arthritis. I used ground provisions (cassava,yams etc.) for 14 days, it can be eaten with any other food 3 times per day. 5 yrs. ago same thing happened to a lesser extent repeated the treatment I am good as gold today. I tell every one about this and yet to see some one try it. Maybe because it’s free.
Charlie, that’s interesting. Ive never heard of it but Im glad it helped you.
Joe, I agree with the other comments above that this is a very thorough review and it saved me quite a bit of time trying to research the information myself. My grandmother had taken the Omega XL and did find that it was helpful; however, being on a fixed budget, she was looking at other options that may be beneficial to help with joint pain.
I will pass along the information from your review and may suggest that she try the Lyprinol. Thanks again and I wish you much success with your site.
mairmcninja, thanks, Im happy I was able to help you. I’ll say a prayer for your grandmother tonight too.
I have been using Omega XL for the past 14 weeks. During that time, I have taken no less than 3 capsules per day and up to six capsules per day, with four being the norm. I am healthy, in pretty good shape and 46 years old but I have some arthritic type pain in several joints. I also have suffered from allergies my entire life.
During the time I have taken OmegaXL, I have seen zero benefits. It is also quite costly as they have recommended I double my dosage so now my monthly bill runs about $100.
I would hate to disuay people with problems from using this product if it will actually work for you, I can only speak from my own personal experience having used the product religiously over an adequate time to receive the benefits.
Dray, really sorry omega xl hasn’t helped you but I truly appreciate you taking the time to write and share your experiences with the product. I’d agree that if it’s not working after taking it almost 4 months, then upping the amount probably wouldn’t change things.
The good news is you say you are pretty healthy overall so that I am glad for.
I’m curious about Naturenedics’ use of “re-esterified triglyceride” Form said to be more easily absorbed effectively? I’m trying to decide between that and another highly rated one with with the usual Ethyl Esters form. Both are at Amazon. Thanks for any help.
Andrys, I don’t think it makes a difference. If you take it with food you should be absorbing it no matter what form it is. A good book on omega 3 fats that I own that answers a lot of questions about them is The Omega 3 Handbook.
Thanks for that book recommendation and glad it’s in Kindle format. I have one other question.
The other thing I liked about the first-mentioned company’s product is that they submit recent samples for 3rd-party lab testing and post the results on the product page, for whatever that’s worth. Others have IFOS ratings while some don’t and I see one reviewer considers that important. Hard to decide. Thanks for any thoughts (and for this very useful page).
Andrys, glad to help. For me, when I look at evidence That says something is absorbed better or faster, I always wonder if that means it works better. They are not always the same thing. I’d ask the companies for proof that they work better (reduce heart disease risk etc) than lesser expensive brands. The assumption is they would but be but I like to see the proof for myself.
I’m not aware of any but I’m always open to seeing any new research that’s out there. If you ever find any I hope you will let me know.
Because I’m temporarily on high-dose omeprazole, have been concerned about a tendency of some (in studies) of a decreased ability to absorb Vitamin B12. In that case, the results can be disastrous.
But re Omega-3, today’s my first day looking up pages on it (and I don’t like what I read about Omega XL owner’s billing and selling practices) but am intrigued by what some with joint pain (which a friend has) have experienced with some alternatives (whether because of the combo of ingredients or because of faith).
So am interested in the product that uses the triglyceride form for that reason.
You refer us to relevant Amazon pages. The company I mentioned seems newer but has it in triglyceride form, seems more transparent in dealings, and maybe when you have time you could look at what they say about this. They cite studies in certain years but they’ll need to give the citations.
Maybe you could wring it out of them 🙂 I wondered if Dray might benefit from that if it -can- make a difference.
Andrys, since we store vitamin B12 (we have 2-3 years worth stored up), unless your a vegetarian or have trouble absorbing vitamin B12 I dont think you have to worry about that effect of omeprazole especially if you are only on it temporarily. You can always get B2 checked by your doctor if you are on it long term.
I hear ya about companies that say “studies” but dont list them. Ive seen it before and it frustrates me too.If they have a contact # you can always call them and ask for the studies (maybe customer service might be able to direct you?).
Good advice on all of that. Thanks. I had been more worried about the apparent tendency of those over 50 to be more vulnerable to fractures or bone loss with high doses of Omeprazole for even less than a year. Have found your Facebook page and will follow it. I like your balanced approach.
Andrys, That’s interesting. One of the best things we can do to stimulate bone density is some type of resistance training so do consider that if you are not. Even some push ups against your kitchen sink can help. Vitamin D is also involved (get your vitamin D levels checked just in case. Its been my experience that many of us are low in vitamin D). Thanks I appreciate that on FB. I’m always posting stuff there 🙂
Will do. Already doing 5-lb hand weights. Am 75, so some loss is already inevitable. Just curbing it where I can. Will check Vitamin D. Thanks again, Joe. 🙂
Lovely gathering of useful information on Omega XL i appreciate the effort to create a site worthy of the ad sense revenue i hope its creating for you. This site is of real value.
I wanted to add one thing as the vitamin E is useful. It is there to prevent spoilage by oxidation and some other studies speculate that having it bioavalable may help in both absorption and in potentiating the best possible biochemistry in persons with low vitamin E.
The second claim is very contentious but the notion it helps with protection against spoilage due to oxidation is not. Anyway just thought they might be useful to many.
One thing that I wish omega XL would make more clear is how much of the traditional omega 3 acids are included as well. Is that included in their product info?
At any rate thank you for the efforts you make in providing summarized data without drilling down into detail and That often requires far too much jargon unless that jargon is necessary to understand key differences.
I am forever amazed that more “middle ground” Levels of detail are not compiled for smart lay people who perhaps can read studies or technical white papers but would rather not each time. I will be reading several other reviews on your site as a part of my core introductory sources. I Cannot pay a higher complement to you than that.
One last question, ever get any help from people with medical and bio-chemistry back grounds or better yet do you have any expertise in these areas? I know my background as a bio behavioral researcher has been very helpful to me and in understanding various assertions made by doctors, nutritionists, alterna-therapists, and other possible health and wellness providers/experts
Rob, thanks for your very kind words! From what I’ve read elsewhere (consumerlab.com) it was noted that there was 6.3 mg of EPA and 4.9 mg of DHA in each capsule of omega XL.
My background: yes I do have a BS in chemistry and biology. My MS is in exercise science. I mention this on my About Page too.
I would also like to say thank you for all the work you have done researching this product.
I would just like to ask one question which you may be able to answer. Have you any idea why they haven’t done any research studies on back pain? I have spinal stenosis and spondylosis as well as osteoarthritis in my hips, fingers, neck, etc. I am 46 and long for a more active life. I would like to find a product that might improve my symptoms but not sure if omegaxl would benefit me as most of my pain is in my back.
Hi Sharon, I’m not sure why the lack of back pain- omega XL research. it may be because back pain can be challenging to do or it may be because they just have not gotten around to doing it yet. Lack of research does not necessarily mean something doesn’t work and I can empathize with you on your desire to find something that will help. If you do try omega xl, let me know if it helped or didn’t. I’m curious. If you take any blood thinner meds, do ask your doctor or pharmacist about it first. Even thought their research doesn’t show interaction with blood thinners so far, I like to be cautious just in case.
Thank you Joe,
I wanted to let you know that I have been using Omega XL for the last eight months and will never give it up. This product absolutely works for me and I got results in the first two days. I shattered both my tibia and fibula and shredded both of the ligaments that hold the upper and lower leg together, I have titanium plates and pins and lived with constant swelling and unrelenting pain and stiffness for over three years taking ibuprofen every four hours all that time.
Less than a week after starting with the Omega XL I no longer take any ibuprofen. My knee rarely swells anymore and I also have asthma and rarely if ever use my rescue inhaler anymore either or steroids. This product works exactly as advertised and for me it worked even faster than expected.
From what I have seen online as far as reviews go, most of them seems to be from people who think that this product costs too much, my question to them would be, if you would no longer need asthma medications or NSAIDs then this product is not nearly as expensive because of the savings on other products. Also, there are a lot of people out there who aren’t happy unless they are complaining about something. I don’t have the pain anymore and am not ingesting other products that DO have proven side effects and that makes me very HAPPY.
P. Yohn
Patricia, thanks for writing and that sounded like a heck of an injury you had! I’m really glad Omega XL is helping you.
Thank you very much for this review of the research. It is easy to get your hands on rants or raves about different health products but not always easy to get honest, unbiased information. Your summary of the research done for this product is very good and was a valuable read for my wife and I.
I would make one comment though. Though it does not appear that there are consistent reports of side effects or drug interaction I did find it interesting that the only reported problems that you mentioned all involved potential liver complications. Since my wife has had intermittent problems with her liver this information was very important for us.
Daniel, thanks very much! Please share my review with your friends as I wish more people would be able to read it. Yes I also thought the issue with liver problems was interesting and I also thought it was odd/interesting that no interaction with blood thinners were noticed either – even though Omega XL contains fish oils.
Dr.Joe. I appreciate so much all the research you gave us.
Rarely do we find unbiased studies that I consider reading. I’m still on the fence. After trying the product for 2 months it truly seemed to reduce internal inflammation. Some times I wonder if it is psychological with me.Because the product is quite expensive I need more evidence of its value to help me.
Thank you for sharing the study.
S Magee
Sharon you are very welcome, but I’m not a doctor 🙂
Thanks for another very thorough review with lots of great information. I would gather based on your review that one might derive some benefit for arthritis pain at possibly between 600 and 1200 mg per day in particular if you didn’t mind the cost, and that it might be worth a try based upon this research, especially since there are no reported side effects.
I wonder, however, if these are temporary effects or if the supplement indicates any long term improvement. Of course I have not read the links to the papers! Wow, that was a lot of research to summarize in a short paper. Kudos!
Nan, thanks for that! Yes I think its possible based on the research but the Omega XL research also has issues which stopped me from saying it might work for everybody. I tried to list some of the problems I noticed with those studies. Some of the studies showing that “it works” were not as well done as I’d like (one study didn’t even tell how much green lipped mussel extract it used for example). Best I could say is that if Omega XL helps, people should notice a difference in pain in about 1-2 months.
Just a heads up, If you call Great HealthWorks, their customer support is polite but they may say things that are not based in human studies or is extrapolated from what is known about fish oil. I didn’t put it in my review but I called them 2x – and spoke to different reps. Both people said omega xl would help problems that have no research on (back pain, high blood pressure etc). I asked both people if they received commissions for sales. One person would not tell me and the other said they received a salary. I never gave them my phone # but both people called me back a few days later to ask me if I wanted buy the product. After the calls, I thought they either really believe in their product or they might receive commissions.
Whew! Quite the read, but definitely worth it 🙂 Thank you for gathering all the studies with their respective results and weaknesses.
I didn’t realize that Lyprinol has been researched for 30 years… I am hopeful that a proper (double blind) and more extensive study will be conducted in the future with more conclusive results.
Any thoughts on Lyprinol being absorbed topically?
Hey Mel, kudus for getting through the whole review! I know it was long! I saw no human studies on topical lyprinol. I know there are creams that have it (plexus slim has one for example). I’d like to see at least one study on creams. Everything I saw was on orally taken pills of green lipped mussel (lyprinol).