Updated 12/21/24. For the longest time, I thought Neora (formally Nerium International) was a skincare company. I had no idea Neora had supplements, too – until I became aware of a brain formula supplement called EHT. This supplement is VERY different from other memory supplements I've seen and reviewed here. In this unbiased review (I don't work for the company), we will look at the science, research, and ingredients of Neora EHT. Does it improve memory and help concussions reduce the odds of getting dementia? These are some of the questions I'll address. Does it really work? Is it the real deal or a scam? Let's see what we can discover. Also, see the Neora Fit Review
What Is Neora EHT Brain Formula?
From the website of the company that makes this supplement, we learn EHT for the brain it is “a mixture of bioactive molecules isolated from coffee that helps strengthen neural connections and promote optimal brain health.”
What does that mean?
That description is pretty vague, but it sounds like Neora EHT is supposed to help the brain work better. They used to call this a “mind enhancement formula” although that wording has since been removed from the company website. Anything that could help the brain work better might – in theory – lead to several health benefits ranging from improved memory to protection against dementia.
We'll address some of these issues in the sections below.
Neora EHT Brain Formula Ingredients
According to the product website (Neora.com) a box contains a 30-day supply. Taking 1 tablet of Neora EHT has the following ingredients:
| Nutrient | Amount Per Serving | Percent Daily Value |
|---|---|---|
| Vitamin D (cholecalciferol) | 2000 IU | 500% DV |
| Vitamin B6 (pyridoxine HCL) | 1.6 mg | 80% DV |
| Vitamin B12 (methylcobalamin) | 10 mcg | 167% DV |
| Magnesium (from 100 mg mag citrate) | 16 mg | 4% DV |
| Selenium (selenomethionine) | 70 mcg | 100% DV |
| Huperzine-A | 50 mcg | N/A |
| Alpha lipoic acid | 50 mg | N/A |
| EHT (proprietary coffee blend) | 35 mg | N/A |
In the table above, “N/A” means there is no daily value for that particular nutrient.
While the product website says the product also contains sodium hyaluronate, this ingredient is not listed on the Supplement Facts label.
While vitamin B12 was originally present as cyanocobalamin, this has been changed to methylcobalamin. This is a trendy ingredient, but I don't see an advantage to it for most people.
Other Ingredients
Neora EHT also has the following “other ingredients” listed. I’ve put them in order as they appear on the label:
- Dicalcium phosphate
- Microcrystalline cellulose
The tablet coating of the product is composed of :
- Polyvinyl alcohol
- Titanium dioxide (color)
- Macrogol
- Vanillin (extract of a vanilla bean)
- Talc
- Croscarmellose sodium
- Stearic acid
- Magnesium stearate
- Silica
These other ingredients likely play no role in any benefits from the product.
Now, let's see if the EHT brain formula supplement has any memory research. After that, we'll look at the research on its ingredients.
Neora EHT Research
Does Neora EHT have any proof that it really improves memory?
Searching clinical databases for studies revealed none.
No relevant investigations showed up.
- Likewise, the company website shows no studies either.
All this tells this reporter that no clinical evidence exists for this supplement.
Summary of Search Results:
- Pubmed.gov: no studies located
- ClinicalTrials.gov: no studies located
- Google search: no studies located
- Neora.com: no studies located
If there are clinical research studies on Neora EHT and memory, they cannot be found.
That doesn't necessarily mean the product doesn't work. Rather, it just means nobody has tested it – yet. And that includes the Neora company too. When those studies are conducted and published, I will update this review as I become aware of them.
To be clear, there is research on EHT – which is the namesake ingredient in this supplement. The research on EHT will be summarized below.
Let's look at the research on the ingredients in the Neora EHT.
Neora EHT Ingredient Research
From the Ingredients list above, we can see that 1 tablet of Neora EHT contains:
- Vitamin D 2000IU
- Vitamin B6 1.6 mg
- Vitamin B12 10 mcg
- Magnesium 16 mg
- Selenium 70 mcg
While these are all fine nutrients for healthy people, I'm not convinced they contribute anything significant to helping memory, dementia or the immune system etc., beyond what we might get in the diet naturally or in a regular multivitamin.
Of course, those who are not so healthy might benefit from these nutrients, but for the most part, a multivitamin and vitamin D supplement will cover these bases. As such, I won't cover the vitamins or minerals in this review.
If Neora EHT really works, I think the answer lies with its other ingredients.
Let's look at those now.
Huperzine A
Each capsual of the EHT Brain Formula contains 35 mg of Huperzine. This is less than the 50 mg it origionaly contained. The scientific name for this herb is Huperzia Serrata. It is sometimes also called Chinese club moss or “Hup A.” Another name for Huperzine A is Selagine.
Several studies have revealed Huperzine A may be of benefit to people with Alzheimer's disease and dementia. It might do this because Huperzine A appears to prevent the breakdown of acetylcholine (say, “uh-see-tul-co-lean”) a chemical involved in memory. It does this by inhibiting an enzyme (called acetylcholinesterase) that is involved in the breakdown of acetylcholine.
In other words, by knocking out the enzyme that breaks down acetylcholine, the levels of acetylcholine in the brain rise and the chemical stays around longer. Theoretically, this might help boost memory.
Neora EHT appears to contain an amount of huperzine A (50 micrograms) that has been used in clinical trials. That is encouraging. Studies show that it may take 2-8 weeks before differences are noticed. This is a general rule, and I'm sure this would vary according to how bad the memory problems were, the medications people take, and other factors.
Do All Studies Say Huperzine Works?
No. Some research says huperzine may not work. This may be due to issues in purifying the Huperzine A compound and extracting it from the plant. Remember, plants contain thousands of different chemicals. Huperzine is only one of them.
Several of the studies appear to come from China. While they do appear to show Huperzine A may work, at least one study notes that because of problems with how some of the studies were conducted, caution and more research is needed.
Sometimes, Huperzine A is touted to improve memory in healthy people without memory problems. However, I can only find one study. For me, one study is not enough evidence – yet – to say healthy people need it.
Supplement makers think Huperzine A works because its been has been used in other memory supplements, such as:
See those reviews for more information.
Alpha Lipoic Acid
Alpha-lipoic acid may be in some diabetes and weight loss supplements. There does appear to be a connection between diabetes/insulin resistance and dementia. I've even seen Alzheimer's disease called “Type III diabetes” to drive this message home.
Thus, adding this alpha lipoic acid to a memory supplement does, in theory, make some sense. If we can reduce blood sugar levels, we might also reduce dementia.
But does alpha lipoic acid improve memory? More research is needed. One review of alpha lipoic acid dementia research found no good proof it helped people with memory issues.
One study has noted alpha lipoic helped memory, but this study seems to have problems with how it was conducted. Also, that study used 600 mg. Neora EHT only has 50 mg.
Alpha-lipoic acid is also in the memory supplement Procera AVH. See that review for more information.
Here's alpha-lipoic acid on Amazon
EHT
The EHT molecule is an ingredient in the Neora EHT supplement. The EHT molecule is derived from coffee and is a mixture of several different compounds. What does EHT stand for?
EHT stands for “Eicosanoyl-5-HydroxyTryptamide.”
Now, you know why they call it EHT.
It's stated that the researchers at Signum Biosciences noticed that people with severe memory decline had a disruption of a regulator protein called PP2A. The PP2A protein regulator is said to help keep the connections between brain cells “robust and healthy.”
Theoretically, anything that could help increase the PP2A, might let brain cells talk to each other better. This might help memory and other things that PP2A helps regulate.
This does sound interesting. So, is there any research on EHT? Yes, there is.
Let's look at that research next.
EHT Research
Previously, Sigmun Biosciences had an EHT supplement called ME Sports, which was marketed to athletes.
It was stated that that “ME™ sports has been shown to be beneficial in vivo models of cognition, memory and motor function.” The phrase “in vivo” basically means conducted in animals/not in a test tube. While that's good, it's not the same thing as human studies.
On the website of Signum Biosciences, several clinical studies are listed. I will link to the studies below so you can see them as you conduct your own research.
Neora EHT Research Summary
Instead of getting bogged down in explaining the research, I'll just list the study name and give a quick breakdown as to whether it involved people, lab animals or was test tube research (which I define as research not occurring in living animals).
By breaking the research down this way, you can get a better idea of how far along with the current research on EHT.
Here are the studies listed in support of the EHT compound.
| Study Title | Type of Study |
|---|---|
| EHT™ coffee extract: A neuroprotective agent and modulator of PP2A methylation with anti-inflammatory and antioxidant properties (S16.006) (2015) | Test tube study |
| Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. (2014) | Rat study |
| Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's diseasedisease. (2013) | Mouse study |
| Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. (2011) | Mouse study |
| The structural basis for tight control of PP2A methylation and function by LCMT-1 (2011) | Test tube study |
| Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease (2011) | Review paper of previous research |
| Protein carboxyl methylation and the biochemistry of memory. (2009) | Study involving isolated cells. |
| Mechanisms of tau-induced neurodegeneration. (2009) | Review paper of previous research |
| From promiscuity to precision: protein phosphatases get a makeover. (2009) | Test tube study |
| Protein carboxyl methylation and the biochemistry of memory. (2009) | Test tube study. |
| Structural mechanism of demethylation and inactivation of protein phosphatase 2A. (2008) | Test tube study |
| Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.(2008) | Test tube study of mouse and human cells |
| Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. (2008) | Test tube study |
| Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation (2007) | Mouse study |
| Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.(2004) | Test tube study |
| Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. (2004) | Test tube study. Appears similar to previous study. Same authors. |
| Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. (2002) | Test tube study. |
As can be seen from the table above, there is a need for human research.
What About The Princeton University Study?
Some may have also heard of a study at Princeton University. This investigation was an undergraduate senior thesis on EHT. The title of the thesis is “The Neuroprotective Effects of Eicosanoyl-5-hydroxytryptamide in an in vitro Model for Parkinson’s Disease.”
This is not a human study.
Essentially, human cells were treated with Signum EHT to see what happened. This investigation showed the EHT molecule has a cell-protective effect. While the investigator used human cells, isolated cells -even from humans – are not the same as testing EHT in humans.
Let me be clear: I listed studies like this not to slam the product or deprecate any company. Rather, the goal was to help you better understand this very complicated research. As this reporter becomes aware of more evidence, this section will be updated.
EHT vs. EHT 0202
EHT0202 is an Alzheimer's drug. It is not the same thing as EHT, the supplement.
The reasons for this are because:
- EHT is a product of Signum Biosciences located in New Jersey. The EHT 0202 drug was developed by a French company called Diaxonhit (formally called Exonhit).
- Performing online searches for “Signum Biosciences and Exonhit” (or Diaxonhit) does not reveal anything showing these compounds are the same.
Because of this, Brand Partners should not confuse research on EHT0202 with Neora EHT. Their names are very similar so it's easy to confuse them.
Does Neora EHT Brain Formula Have Caffeine?
I think the answer is yes and no. The EHT brain formula is decaffeinated, but I've also seen it said it has a small amount of caffeine. They say the amount of caffeine is less than is in a decaffeinated cup of coffee.
That's very little caffeine. I don't think most people would notice it. Some people have left comments below saying they had trouble sleeping. Whether or not this is related to caffeine, I can't say.
Neora and Dementia
Can the EHT brain supplement reduce risk of dementia or Alzheimer’s or improve memory if it were taken long-term? It's a tantalizing idea to be sure. There is just not enough evidence to say yes or no to this question.
For those who have dementia or are thinking about EHT for their family members who already have cognitive insufficiency problems, the best advice is to show the ingredients this supplement to their doctor.
Food for thought: Evidence suggests regular exercise can preserve brain health.
Does Neora EHT Help Concussions?
In the past, the Sigmun Biosciences website used to contain an EHT supplement called “Me Sports” where “Me” stands for “Mind Enhancement.” They used to say that Me Sports “provides the best protection for your brain.” References to Me Sports no longer appear on the Sigmun website. It has been replaced by Neora EHT and may be discontinued.
Does Neora EHT Brain Formula help with concussions? There is a lack of proof showing the supplement helps recovery from traumatic brain injuries or reduces their risk of concussions.
Neither Neora or the Sigmond Biosciences websites make any health claims that supplement helps traumatic brain injuries.
Can EHT Brain Formula Help Parkinson's
Can EHT help Parkinson's disease? For now, the proof is lacking.
There are references to Neora EHT being endorsed by the Michael J. Fox Foundation. But, according to the website Truth in Advertising, this is not true. While the Michael J. Fox Foundation does seek a cure for Parkinson's, it does not endorse any specific treatments.
The Michael J Fox Foundation has awarded grants to Signum Biosciences to investigate PP2A as it relates to Parkinson's.
Neora EHT Brain Formula and ADHD
Does EHT help people with attention deficit disorder or attention deficit hyperactivity disorder? It may or may not. There is not enough research on either of these conditions to provide a verdict either way. No research on either condition is known.
Neora EHT Brain Formula and Exercise
The company that invented the EHT molecule has a paper titled ” EHT® Age-Defying Supplement: Scientific Rationale for Boosting Workout and Post-Workout Recovery.” This paper (which can be found by doing an online search) is not a peer-reviewed clinical study. Rather, it discusses how the ingredients in EHT might reduce inflammation that occurs after intense exercise and improve recovery.
No doubt, there is human research on the vitamins/ minerals in the product. The EHT molecule also might hold promise in theory.
But, whether or not Neora EHT Brain Formula would benefit people who do CrossFit, Zumba, Tabata or any other exercise program is speculation until the research is published.
Is Neora EHT Brain Formula FDA Approved?
The FDA doesn't technically “approve” supplements. This is part of the US law that regulates supplements, called DSHEA, which is short for the Dietary Supplement Health and Education Act. In the US, supplement companies do not have to tell the FDA that they are making a new supplement or get FDA approval before a supplement is marketed to the public.
Who Makes Neora EHT Brain Formula?
There are two different companies involved with this dietary supplement:
- Neora
- Signum Biosciences
Let's look briefly look at each company separately.
The Neora Company
According to the company website (Neora.com / formally Neurium), the company is a “relationship marketing company.” That means they offer a variety of products that are sold via distributors, called “Brand Partners.” In other words, Neora is a multi-level marketing company. There is nothing wrong with that. It's how they do business.
The address on file with the Better Business Bureau is 4201 Spring Valley Road, Farmers Branch, Texas 75244-3631. This is less than 3 miles from their previous home, 4006 Belt Line Road Addison, TX 75001.
While the company was not accredited by the Better Business Bureau; it did have an A+ rating when the BBB website was checked.
Signum Biosciences
Signum Biosciences is the biopharmaceutical company that discovered the EHT molecule. They are a privately held biotechnology company founded in 2002. This company is located at 11 Deerpark Dr Monmouth Jct, NJ 08852. The former company address was 133 Wall Street, Princeton, NJ 08540.
Their contact phone number is 732.329.6344. While not an accredited company, the BBB gives Signum an A+ rating.
Contact Neora
The company can be reached at these phone numbers:
- USA: 855-463-7486
- Canada: 888-304-6046
Where Can You Buy Neora EHT Brain Formula
The supplement is not sold in stores like Target, Walmart, CVS, Walgreens, Costco, RiteAid, Sames Club, Kroger or Food Lion. To purchase any Neora supplement, most people go through a Neora Brand Ambassador. Another option is to purchase directly from Nora.com.
How Much Does EHT Brain Formula Cost?
When I checked the company website, for a 1 month's supply (non-returning customer), the cost varried between$65 and $85 per month, depending on where you purchased it from and if you opted for autoshipments.
Yearly Cost
If buying directly from the Neora website or an annual cost of the Brain Formula is:
Monthly delievery: $65/month: $780
One-time purchase: $80/month: $960
How To Take Neora EHT Brain Formula
The company website says to take 1 tablet per day with food in the morning, preferably with some food that has healthy fats. This is likely to increase absorption. A box contains 30 tablets, which is a month's supply.
Neora EHT Brain Formula Side Effects
I believe the EHT Brain Formula supplement is safe for healthy people. I’m not aware of any side effects from the product at the time this review was created. There is also a lack of human research on this product as well. That said, here are a few things worth mentioning. Speak to your doctor if you think any of this applies to you. This list is not complete:
- Start with less than suggested for the first week to see how you respond.
- Stop taking the supplement at least 2 weeks before surgery.
- Speak to your doctor first if you are pregnant or breastfeeding.
- If you take ANY medications, speak to your doctor or pharmacist first.
- Huperzine A might slow down the heart rate. This may be a problem for people taking some medications, such as those for heart disease and/or high blood pressure.
- If the product contains a little bit of caffeine, this might interfere with sleep if taken close to bedtime especially in those very sensitive to caffeine. Some people, in the comments below, stated they had trouble sleeping after starting the supplement.
Neora EHT Brain Formula Pro and Con
Here is a quick rundown of what I liked and didn't like about this supplement. These are my opinions. Take them for what they are.
| Pro | Con |
|---|---|
| Been around a long time | Expensive |
| Company is respected | No human clinical proof |
Does Neora EHT Work?
While preliminary research hints the EHT molecule, might have benefits, I think it's too soon to tell. This supplement has been out for a few years now, and the company has not published clinical studies to back up its claims. While the ingredients in Neora Brain Health Formula appear to make sense on paper, they need to be tested in people with clinical results published in medical journals. So, is it a scam? Many people say it's not. Many have said it's the real deal. Stay tuned for more research.
Here it is on Amazon
Any Questions or Comments?
As a scientist (geologist) I thought your review was very well done.Joe. The amount of EHT in the supplement (amount per serving) is listed as 35 mcg. That is different to the company and other reviews listing it at 35mg. Quite a difference. Can you confirm actual amount? Thanks!
Jim, yes you are correct. it is 35 mg not 35 mcg. I have corrected my mistake. Thanks so much for bringing this to my attention and also thanks for the kind words.
Christina, I had a chance to look over the link to the White Papers you were nice enough to pass along to me this morning. There are 29 links on the site you provided to me. I did look through them all but saw no human study on either the EHT molecule or Nerium EHT supplement.
While there are many peer reviewed studies listed, the majority of the links on the page you provided to me were either animal studies, test tube studies (which I define as those not conducted on either people or animals) or review articles.
I did see one autopsy study on PP2A from 2004 which is interesting. Id like to see more like that.
Those links that had human studies pertained to B vitamins (folic acid, B6 and B12) and their benefits to senility by their ability to lower homocysteine.
Again, I sincerely do hope you will keep me posted on new research involving humans. I am looking forward to seeing it.
at what age can a teen try it if at all? Is it safe? I am confused as hell reading all this stuff
Hi Macc, Most supplement makers I’ve seen recommend that teenagers (under 18) not take dietary supplements. That’s likely because of how little dietary supplement research involves kids. I recommend you ask your doctor about this. Show her /him the ingredients and see what they think. Even though some here have said they are giving Nerium EHT to kids, because we are all different, I believe in asking your health care provider first.
Nerium brand partners were also given this document to pass along as a resource to medical savvy people. I have not read it (I don’t have a medical background so it wouldnt make sense to me). Thanks https://drive.google.com/file/d/0B6PWFq94qRpGZmU3dVBOVzhYdVk/preview?pli=1
Christina, thanks for that. I glanced at it and while I did not see any human research, I’m going to take a closer look at it. If I see anything new/interesting or a human study, I will update my review. I do appreciate you showing me this.
There are no human studies to date. Please read our FAQ sheet for more information. Thanks http://uploads.nerium.com/upcontent/US-EN_EHT%20FAQs_4-15.pdf
Christina, with respect, you are reading marketing stuff. If you can show me a human study on either EHT or Nerium EHT I will gladly add it to my review.
Nerium did not compile the information disclosed. Signum Bioscience Labs out of Princeton University compiled them and handed to us for distribution to people like you who ask. With respect, I actually thought you would take an interest in the information provided by a scientist who has been in the field for 30 years. Sorry! I have nothing further to add. Thanks
Christina, I do have an interest in what you showed me and I WILL look it over closely. I have already glanced at it and pledge to you that I WILL be looking closer at it later today.
Why are you so fixated on having a Human study??
The studies and tests being done are on a molecular level. PP2A is PP2A in both Humans and Rats.
Why do you want the PP2A extracted from a Human??
Maybe you do not understand the science you are reading?? And what EHT does to PP2A and then how it effects the Tao, and therefore supports the Neuronal Networks of the Brain??
Also, WHY if you amended your Blog to now include some EHT studies, do you not amend the top part of your article where you state “you are forced to conclude that no studies exist” ???
Clearly they do, and many of them. You seem to be fixated on the Human/Rat difference but Scientists have been using Rats for decades because they share many similarities in structure and function to Humans.
http://www.chrcrm.org/en/rats-and-research
Tenille, Let me address your questions in order you asked them:
1. I am “fixated” as you say, on a human study of Nerium EHT because I believe we should know about any side effects before the the supplement is released to the public. Nerium EHT contains Huperzine which may have some side effects. I’d like to know what they might be. I feel you deserve knowing this.
2. I am not asking for PPA “extracted” from a human. Rather, I’d like to see a human study showing EHT alone (without huperzine or the other ingredients in Nerium EHT) improves memory/concentration/focus in humans or delays senility in older adults who take it. The evidence Ive seen is very interesting and I’m curious if they carry over to people. Wouldn’t you like to to know this too?
3. I freely admit I’m not an expert on EHT/PPA. I don’t have to be an expert in EHT/PPA to ask rational questions like this.
4. When I said I was “forced to conclude” Nerium EHT had no published peer reviewed studies, that is correct. At this time the product has no human studies. I believe you are confusing EHT (which has research) with Nerium EHT which has no research yet. Remember Nerium EHT contains many ingredients which I showed you in my review.
Tenille, let me ask you this question; if the EHT molecule was so good that it was put in the name of the product, why did Nerium add other ingredients into their product? Why didn’t they just give people the EHT molecule and call that product “Nerium EHT?”
I know as a Nerium ambassador you are likely angry at what I wrote. That was not my goal. I have no ill will to any company or person and I’m quite intrigued by what the EHT science shows so far and am looking forward to human research on EHT and/or Nerium EHT.
The link posted in my last comment was for the studies published at the Journal of Neuroscience.
there are more studies done and published in other MEDICAL Science based outlets.
This is a direct quote from the Signum Biosciences website regarding EHT.
“Studies have been published in The Journal of Neuroscience, Neurobiology of Aging and Neurotherapeutics.”
Please help yourself to those studies. I have more than enough info on this Breakthrough Molecule. And a Global Patent is a BIG deal.
For the readers that don’t know this: in order to obtain a patent for anything one has to PROVE that it does what they say it does. So this molecule has been PROVEN GLOBALLY that it does what they say it does.
I personally am very excited for the array of people it can help, and is Already helping!!
I would hate for someone to NOT choose to potentially help a loved one based on a shady blog review by a NON scientist.
Namaste
Dori, I obtained the EHT studies in my review directly from the signum website. I linked to all of the studies too. I believed the best and most relevant studies would be there. I didn’t find a human study. If you can find me a human study on EHT, I will be more than happy to add it to my review.
Dori, are you a scientist?
Well thank you very much gmail for burying this review in my “promotions” folder. I am just now seeing it. Thank you for your candid and clearly thoroughly researched review. I sent you a lengthy email before it came out in the prelaunch offering asking you to review it and never heard back or saw a review.
In my personal experience with those who have tried it, surprisingly the biggest response has been in the area of an increase in energy levels (from a man with multiple sclerosis and a woman coming off of chemo).
You are correct. There are no human trials and peer reviewed published studies. I believe this will come down the road. Nerium has been criticized for 3 years for not having PUBLISHED studies/clinical trials on their skin care products. They have finally been published. It is a long process and am sure they are moving toward that goal with EHT.
Thank you again for reviewing this product.
Catherine
Catherine, . I’m glad you found me -even if I did wind up in the promotions founder lol. I checked my gmail and I dont see anything from you.. odd but that may explain why you did not hear back from me. That’s gmail for you… Im looking forward to the research too. Do let me know when it comes out.
If EHT did indeed boost the immune system, it could be quite detrimental to people with multiple sclerosis. They have an overactive immune system. Many conventional treatments for MS work by SUPPRESSING the immune system. A boost of energy would be a very small benefit compared to the risk of causing more nerve and brain lesions.
Jim, That is a theoretical possibility. I think we would need some studies to confirm/refute this. Let’s see what happens.
Great review, thank you!!
I too am a Nerium Brand Partner who was very skeptical of the EHT. I have suffered a number of concussions that have left me with short term memory loss and nerve damage. I have been taking EHT for almost 2 months (3 months is optimal for seeing proper results of any supplement if I’m not mistaken), since I have been on EHT I have found that I am able to recall things from my short term memory better than before. I have also noticed faster cognitive processing and word retrieval which were both major issues for me.
My overall focus is better to the point that people who have known me most of my life and were unaware of my use of EHT use have made comments regarding my mental acuity. I honestly thought it was a placebo effect because I wanted it to work so badly, but even my neurologist made mention of the difference at my last visit this past Friday (7/10/15).
I’m sure it works differently for everybody, but from what I have felt, and have seen in my husband and fellow EHT takers it is very promising. Hopefully we will see some white papers on human trails soon.
I read many of your reviews and find them very sound and just. You are a plethora of information.
Kris, I’m very happy that it is helping you and thank you much for the kind words 🙂
If you have a doctor who has access to a clinical trial database, there are over 400 studies. This article is completely ignorant. He doesn’t even mention what the medical name of EHT is…
Teresa, I actually did say that EHT stands for “Eicosanoyl-5-hydroxytryptamide.” If you re-read my review you’ll see that I did. Here you say 400 studies. In your other comment you said 500 studies.
Please show me 10 clinical studies of Nerium EHT. I’d love to add some to my review.
As usual thorough unbiased review by Joe Cannon. Primary research with those results published in peer reviewed medical journals should be the standard we all look for from any product, whether a supplement or whole food concentrate. Too many grey areas, plays on words, etc…..
Hold these companies accountable to provide you the consumer with all the information needed to make an educated decision based on the facts. Keep it up Joe. I for one appreciate your reviews.
Thanks Jim!
Another study at Pubmed.com
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292348/
ALL very easily found, via the usual routes of research for clinical studies?!!
Tenille, This is a review article. I addressed this in your previous comment. Thanks for sharing this with me.
Joe, You have an admirable amount of patience with Tenille, who obviously does not understand that animal research needs to be followed by controlled safety and efficacy studies in humans. Signum’s focus on protein phosphatase 2A can only be called interesting at this point. Compare that to the animal and HUMAN research on plain old caffeine, where consumption of 2 to 5 cups a day (12 to 30 oz) was associated with a 65% reduced risk for Alzheimer’s Disease. REF: J Alzheimers Dis. 2009;16(1):85-91. doi: 10.3233/JAD-2009-0920.
Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study.
Eskelinen MH1, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M.
Openmind108, that’s very nice of you to say. I believe rational discourse is the best way to get to the bottom of things.
Another study easily found at Pubmed.com
http://www.ncbi.nlm.nih.gov/pubmed/25034344
Tenille, This is a rat study. I addressed this in your previous comment. Thanks for sharing this with me.
Hi Joe.
So I clicked on the link to the your study in your FIRST ingredient up above called: Huperzine A
It took me to the US National Library of Medicine. And yes your study was there.
INTERESTINGLY, while at this site I searched EHT. And low and behold there was a study for EHT!!!
I am curious Joe why your shady research choices when looking for studies on EHT were somehow considered sufficient, and yet you actually researched properly to present evidence for all your other ingredients in review?!
This is EXACTLY why silly Blogs done by NON-experts or Scientists need to really be taken with a big dose of Salt!!
The studies are out there, I am not sure why you ‘chose’ not to find them for EHT but easily found them for your other things??
Here is the link to the EHT study found at your coveted site: The Us National Library of Medicine.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557367/
Tenille, Thanks for sharing and yes most of the links in my reviews go to PubMed. I like to be open/honest and let you see the research yourself rather than you take my word for things. If I can, please let me address your questions/concerns about what I wrote.
1. Let’s keep in mind that there is a difference between EHT and Nerium EHT. While there is indeed research on EHT itself, there appears to be no published peer reviewed research on the product “Nerium EHT.” Nerium EHT contains several ingredients of which EHT is one of them. Does Nerium EHT work better than EHT alone? I have no idea either way at this time as I could not find any head-to-head comparisons.
2. As for the EHT research, I am aware that there is research on EHT. When I reviewed the EHT molecule, I choose to look ONLY at the research studies that are listed on the product website (MeSports.Me which redirects people to Nerium EHT) because I assumed that the company would list the most relevant research there. That is not to say other studies do not exist –you found 3 of them which I’ll discuss below – but again, I figured that the company would list the most important/relevant research. I hope that clears up where I was coming from.
Having said that, let’s look at the research studies you linked to in your 3 comments (don’t worry, I’ll post all your comments as well so others can see them).
Study 1. You linked to this study:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557367/ which is titled “Neuroprotective and Anti-inflammatory Properties of a Coffee Component in the MPTP Model of Parkinson’s Disease” This is a mouse study.
Study 2. You also linked to this study in one of your other comments: http://www.ncbi.nlm.nih.gov/pubmed/25034344 This study is titled: “Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease.” This is a rat study. It is a very interesting study and I’m glad you passed it along to me.
Study 3. You also linked to this study in another comment, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292348/ which is titled “Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease.” This is a review article that describes past research on EHT as it pertains to Alzheimer’s. I didn’t see any human research listed when I looked at it.
I’m sorry if I gave you the impression that I was somehow trying to bash the product. I was not. Rather, I wanted to point out that I felt more human research needed to be done. The studies you linked to also appear to reinforce my opinion.
For the record, I think the EHT molecule is intriguing based on the research I’ve seen so far. I also said that in my review. I’m sure eventually human trials will be done on EHT to further clarify its benefits in humans and I hope you will alert me when they occur so I can update my review.
Joe,
What is the difference between Nerium EHT a just EHT??!!
EHT is the molecule. Nerium is the name of the company that markets it.
The ACTUAL Molecule itself would be named as the actual molecule itself when being studied!!?
I finally found some time today to research MORE studies for you. Since a Rat study is perfectly sufficient for cancer and diabetes research I am wondering why it is NOT sufficient for you?? But anyways, I will play along.
So at the very beginning you provided the Signum Biosciences information. I went to their site. Which is what I did many months ago. They have a TONNE of published studies on their site regarding EHT for all the World to See!!!
I am just so mind blown that you would google search “Nerium EHT Research” and “Nerium EHT Clinical Trials” and just assume they would be there waiting for you presented in a nice little package????!!
That is NOT how one finds research studies! And I KNOW that you know that because you have shown that you know how to find other research studies regarding other items of interest. So I find it very suspect that you would present this method as a sufficient way of finding studies on EHT and then present the fact that you didn’t find any as a reason to be concerned with the efficacy of this Globally Patented Molecule, that has made HUGE waves in the Science Community??!
The ONLY way a bunch of studies would show up with a lame google search such as “Nerium EHT Clinical Trials” is if ONE person took it upon themselves to gather ALL the research studies and compile them into a blog, such as what you have done here with all your other supplements that you are advocating for. A seasoned researcher would know that a google search like the one you did would not likely render anything of substance.
I am just beside myself with how people can post a blog like this and everyone reads the words and takes it as an authority on the subject!!?
I am also so disappointed that someone with research skills would purposely misdirect people this way.
Here is a VERY simple link for you to ALL the studies that have been posted at the Signum Biosciences Website.
http://www.jneurosci.org/search?fulltext=eht&submit=yes&x=0&y=0
I hope this clears some things up for you, Sir.
Namaste
Dori, respectfully, EHT and Nerium EHT are not the same thing. Nerium EHT contains other ingredients. For example, as I tried to point out, the first ingredients listed on the label is not EHT but huperzine A. Why does Nerium contain other ingredients if EHT is the only thing mentioned in the name of the product?
I also respectfully disagree that rat and mouse studies are not solely relied on for human cancer/diabetes therapies. Those preliminary studies need to be followed up by human intervention trials.
Did you look at the studies I linked to? I used the studies at Signum in my review. I can tell you are angry at what i wrote. I did write a lot so I invite you to take a closer look.
I hope this clears up some things.
Placebo effect! Your thoughts! Thanks, Tara
Hi Tara, hard to say. There is some research on huperzine. Let’s do some studies on people and see what happens.
Pretty sure you need to Namaste not Joe. Good Lord.
Joe,
I found plenty of clinical trials for EHT. If you Google EHT 0202 clinical trials, you can find them dating back to at least 2009. Nerium is just the seller of the product and will unlikely have anything to do with clinical research. Sigium Bioscience seems pretty legitimate considering all of its funding and partnerships.
I’ll give this product a try for 90 days when it comes out in August. If it works for me, great. If not, then I guess I’m out $210.
Hi Arid, when I was writing my review I saw the research on EHT 0202 but I did not include it because the research came from French company called ExonHit Therapeutics. Here is a link to one of their studies of EHT 0202 : https://clinicaltrials.gov/ct2/show/NCT00880412?term=EHT&rank=1
Notice they are calling EHT 0202 a “drug” rather than a supplement which is what Nerium EHT is marketed as.
When I searched for “EHT vs EHT 0202” I didn’t see anything stating they were the same thing. Also, when I searched for “exonhit therapeutics Signum Biosciences” I didn’t see anything either that made me think they had a working relationship. So that’s why I didn’t mention EHT 002 in my review – At the time, I didn’t think they were the same thing.
Can you confirm that “EHT 0202” and the EHT in “Nerium EHT” are the same thing ? If yes, can you show me something that proves this and can you tell me the relationship between Sigium Biosciences and ExonHit Therapeutics?
I’m totally open to being wrong about this. If you have any information, let me know and I’ll be very happy to update my review with any new information you can show me.
I’ll start by saying that I am a Nerium Brand Partner and love all 3 of their skin products. I was skeptical when they announced EHT, but decided to give it a try and was very interested in seeing how it might improve my husband’s not so great memory and focus. After almost a full month I can tell you that Nerium has another great product that you will want to use!
I feel a greater sense of focus, which I think we can all use in this age of multitasking. But better yet, my sleep quality has drastically improved. I used to take both all natural sleep aids as well as Ambien, and unless I’m traveling now, I need neither. I know it’s REM sleep, too. My dreams are amazing and some of their contents are from years ago!
Like all of their products, EHT has a money back guarantee. I highly recommend everyone try it!
Kelli, thanks for the feedback and glad your husband has been benefiting from it.
The company touts this product as:
• Promotes better cognitive function and overall brain health
• Combats oxidative stress and chronic inflammation
• Fortifies and strengthens natural brain functions
• Protects and supports neuronal networking
• Enhances the body’s natural energy stores
• Boosts the body’s immune system
• Increases focus
your review spoke specifically to Alzheimer’s and memory loss. What about these other effects?
Hi Judy, I looked at memory and Alzheimer’s because that’s how it was first presented to me. While I would not rule anything out yet, if EHT has effects on these other effects, I think we need human studies to know for sure. What they said about that PP2A protein is interesting. I summarized the research listed to support the use of EHT. I really didn’t see much in the way of human trials. As such, I really can’t comment on those other things you mentioned. If you come across any other research, I hope you will let me know so I can keep this review up to date.
I believe caffeine inhibits all of the PDEs. I don’t know why it doesn’t have Viagra-like effects. PDE5 occurs in certain erectile tissue, hence the value of the PDE5-specific inhibitor Viagra in treating erectile disorder.
I don’t know about EHT. The risk reduction for dementia from coffee seems to be entirely from caffeine, which is a nonspecific inhibitor of the phosphodiesterase enzymes. These are the enzymes which break down the intracellular signals cyclic AMP and cyclic GMP. cGMP is the signal which occurs inside the cell when nitric oxide binds to its receptor on the cellular membrane.
Sildenafil (brand name Viagra) is a specific phosphodiesterase 5 (PDE5) inhibitor, and there is some evidence it may be useful against Alzheimer’s Disease. That’s probably for the same reason caffeine is useful. Inhibiting the breakdown of cGMP and perhaps cAMP may amplify the effects of intercellular signals that are diminished in old age.
Mark, interesting point. Does caffeine also inhibit PDF5 inhibitor? I sometimes see caffeine in male performance supplements so wondering if that might be the reason?
Caffeine is a nonselective PDE inhibitor with (at any reasonable dose) insignificant PDE5 activity
Openmind108, that would explain why I feel no different after drinking it 😉
Although I am not a scientist nor researcher, I found this article compelling in knowing that although mice & rat studies aren’t as accurate for things like drug studies, they are more useful in brain studies. http://content.time.com/time/magazine/article/0,9171,1580427,00.html
Jennifer, thanks an interesting article. Thanks for sharing. 🙂
Coffee protects against dementia and Alzheimer’s Disease — about 2/3 reduction in risk for 3 to 5 cups daily.
http://www.researchgate.net/publication/41562356_Caffeine_as_a_protective_factor_in_dementia_and_Alzheimer's_disease/file/d912f5100f5d1ec4be.pdf
http://health.usf.edu/nocms/publicaffairs/now/pdfs/JAD111781.pdf
http://www.researchgate.net/profile/Hilkka_Soininen/publication/23807092_Midlife_coffee_and_tea_drinking_and_the_risk_of_late-life_dementia_a_population-based_CAIDE_study/links/09e4150f4eb442bc40000000.pdf
Mark, I’ve read about the connection between dementia reduction in coffee. Does that carry over to EHT? From what I’ve seen online, distributors say no, saying drinking coffee would not provide enough EHT to work. I say it can’t hurt.
Hello and good evening Joe. Hope all is well. I was Waiting for you to do a review on this product as I have several friends that are distributors. As I know you do unbiased and very thorough reviews. Research based using “primary research” not borrowed is the only credible research in my opinion.
Tested on humans for the specific area being deemed beneficial, not animal tested or test tube either. Upon which peer reviewed research is published, that’s what gold standard testing is all about and the standard we should all hold these companies accountable. Great job as always Joe!
Jim, thanks! I hope it helps your friends who are distributors.
I took EHT for 35 days with breakfast and it affected my ability to sleep. I was down to 4 or 5 hours per night. Since I quit my normal sleeping habits have returned
Curt, that’s interesting. I dont think Ive heard of EHT affecting sleep before. Anyone else have that effect?
Actually, just the opposite. I’ve been taking it since May and now do not have to take Ambien to sleep and sleep much better thah before. Have not heard anyone else who has had this problem.
Lora, thanks for the feedback. I’m glad you are sleeping better since taking it. Anyone else sleeping better?
I had difficulty sleeping as well. I stopped taking it on a daily and switch to every other day instead. That seemed to help
Parent 2, thanks for the feedback!