Update 8/1/19. If you have ringing in the ears – a medical condition called tinnitus – you may have heard of a supplement called Lipoflavonoid which, has been “used extensively for decades for the treatment of Meniere’s syndrome and tinnitus.” That's what the company says. I became curious about this supplement after I started getting ringing in my left ear. So, I decided to try lipoflavonoid and see if it helped. What follows is not only my review of LipoFlavonoid but also the results of what happened when I used it. Hopefully, what you will read will help you better decide if LipoFlavonoid is right for you.
Other Tinnitus Reviews
For this review, I looked at Extra Strength Lipo-Flavonoid Plus. According to the product box, a serving is 3 caplets. Each serving (3 caplets) has the following ingredients:
|Vitamin C (ascorbic acid)||200 mg||334% DV|
|Vitamin B1 (thiamine mononitrate)||0.67 mg||44% DV|
|Vitamin B2 (riboflavin)||2 mg||118% DV|
|Niacin (niacinamide)||0.67 mg||34% DV|
|Vitamin B6 (pyridoxine HCL)||0.67mg||34% DV|
|Vitamin B12 (cyanocobalamin)||3.33 mcg||56% DV|
|Pantothenic acid (calcium pantothenate)||3.33 mg||34% DV|
|Calcium (dicalcium phosphate)||58 mg||6% DV|
|Exclusive Tisina Complex composed of the following:||1000 mg||N/A|
|1 Choline bitertrate|
|3 Lemon bioflavonoid complex|
In this table, % DV= percent daily value, mcg = micrograms, and N/A = no daily value has been established
Tisina is the name the company calls the 3 ingredients in their proprietary blend. This blend contains the active ingredients in Lipoflavonoid.
Previously, the supplement label contained another ingredient – eriodictyol glycoside. As you will see below, eriodictyol glycoside is the active ingredient in Lipoflavonoid.
Lipoflavonoid Other Ingredients
Heres a list of the other ingredients in this supplement
|microcrystaline cellulose||stearic acid||partially hydrogenated vegetable oil (soybean, palm or cottonseed)|
|polyvinyl alcohol||magnesium stearate||silicon dioxide|
|titanium dioxide||hypromellose||ethyl vanillin|
The label also tells us Lipoflavonoid may also contain
- Hydroxyl methyl-cellulose
- Polyethylene glycol
- Soy lecithin
- FD&C red #40
- FD&C red #40 lake
- FD&C Yellow #6 (sunset yellow)
- Xantham gum
- FD&C blue #1 lake
- FD&C blue #1
- Lipoflavinoid also contain soy
These other ingredients play no role in the benefits of Lipoflavonoid.
Lipoflavonoid Active Ingredient
I don't think the vitamins and minerals play any role in helping tinnitus. So I won't cover them. Instead, let's just focus on the research on its active ingredient. As you read the research below pay attention to the word eriodictyol glycoside. This is the active ingredient.
Lipoflavonoid Tisina Complex
3 caplets of Extra strength Lipoflavonoid contains 1000 mg (it used to be 1500mg) of the following ingredients called the Tisina complex:
- Choline bitartrate
- High potency lemon bioflavonoid complex
OK, lets cut to the chase. The active ingredient in Lipoflavonoid is called eriodictyol glycoside. This is what they refer to as “lemon bioflavonoid complex.”
Eriodictyol glycoside is a phytonutrient called a bioflavonoid. It's found in lemon peels. This compound is mentioned in the tinnitus /min
The Lipoflavonid website discusses surveys from 2010 and 2014 ENTs. The surveys revealed 84%-90% of ENTs recommended Lipo-Flavonoid to patients with ear ringing and Meniere’s disease. While these surveys are not peer-reviewed studies, I believe them.
Both my primary doctor and ENT were aware of this supplement when I saw them for my tinnitus. Surveys aside, there are no clinical studies on Lipo-
Flavonoid itself to see if it works.
The name Lipoflavonoid was first used in a 1964 study. So, based on this fact, this supplement has research dating back over 50 years. The active ingredient in Lipoflavonid is said to be a compound called eriodictylol glycoside.
While this ingredient may not be listed on the supplement label, it is present. They call it “lemon bioflavonoids.”
The research on eriodictylol glycoside dates to the 1960s. I located 2 clinical studies. Both investigations were conducted by an ENT named Dr. Henry Williams. Here are the studies:
In the 1964 study, 197 people with tinnitus and Meniere's were given 9 caplets of Lipoflavinoid for 6 months. The majority of them showed improvements in hearing after using the supplement.
In another investigation, Walter Reed Hospital, in 1965, conducted a study of citrus bioflavonoids in people with hearing loss that was not related to Meniere's Disease. Those researchers found no improvement in hearing. This study may not be relevant to Lipoflavinoid because those in the military may suffer from hearing loss for other reasons.
In an effort to find more recent research, I then searched clinical databases for these words:
- eriodictyol glycoside hearing
- eriodictyol glycoside tinnitus
- eriodictyol glycoside Ménière's
I also searched for these words too:
- Lipoflavonoid tinnitus
- Lipoflavonoid Menieres
I located a study published in 2016, where researchers gave 40 people with tinnitus either:
- Lipoflavonoid + manganese
- Lipoflavonoid Plus by itself
The people took Lipoflavoind 3 times a day by itself or in combination with 8 mg of manganese. Manganese was included because some previous research suggested it might help tinnitus too.
This study lasted 6 months.
After 6 months, researchers concluded that neither Lipoflavoind Plus or the combo of Lipoflavonoid with manganese – helped reduce tinnitus symptoms.
Summary Of Research
Research in the 1960s has shown Lipoflaviniod might help some people with Meniere's disease. A smaller study from 2016 noted Lipo-Flavinoid did not work.
How Does Eriodictylol Glycoside Work?
Recall from above that eriodictylol glycoside – the lemon bioflavonoid -in this supplement, is seen as the likely active ingredient. So how does it work? While this is not fully known, it is speculated eriodictylol glycoside somehow affects histamine levels. Excess histamine is thought to be a reason for ear ringing /tinnitus and plays a role in Meniere's disorder.
There is a nighttime version of this supplement. Here is Lipoflavonoid Plus vs. LipoFlavonoid Nightside by side:
|LipoFlavonoid Plus||LipoFlavonoid Night|
|Vitamin C 300 mg||Vitamin C 200 mg|
|Vitamin B1 1 mg||Vitamin B1 0.67 mg|
|Vitamin B2 3 mg||Vitamin B2 2 mg|
|Niacin 10 mg||Niacin 6.67 mg|
|Vitamin B6 1mg||Vitamin B6 0.67 mg|
|Vitamin B12 5 mg||Vitamin B12 3.33 mcg|
|Pantothenic acid 5 mg||Pantothenic acid 3.33 mg|
|Calcium 87 mg||Calcium 58 mg|
|Tisina Complex 1000 mg||Tisina Complex 1000 mg|
|1. Choline bitartrate||1. Choline bitartrate|
|2. Inositol||2. Inositol|
|3. High potency lemon bioflavonoid complex||3. High potency lemon bioflavonoid complex|
|Melatonin 5 mg|
As can be seen, both versions contain 1000 mg of the Tisina complex. In addition to this, Lipoflavonoid Night contains 5 mg of melatonin. Melatonin is a hormone which studies show may help us fall asleep faster.
Sometimes both supplements are sold together as a combo pack too.
Who Makes LipoFlavonoid?
The company is called Clairon Brands LLC. The company is located at 27070 Miles Road Suite A Solon, Ohio, 44319. The contact phone number is : (844) 454-7632. This address (minus the “suite A”) is the same for other products including Absorbine Jr and even something called “Anti-Monkey Butt Powder.”
Another company name located is DSE Health Solutions located at 164 Northfield Drive, Edison NJ 08837. This address corresponds to to Garden State Fulfillment as well as another supplement company called Numark Laboratories also called Numark Brands.
What Does This Mean: Numark Brands is the company behind LipoFlavonoid. Garden State Fulfillment is probably where the supplement is shipped from.
LipoFlavonoid BBB Rating
Numark Brands, the maker of Lipoflavnoid has an A+ rating with the Better Business Bureau. See the BBB file for updates and more information.
My Lipoflavonoid Experiment
What kind of results can you expect with this supplement? Well, I've had tinnitus in my left ear for some time. After dealing with it for several months, I decided to try LipoFlavonoid to see if it helped.
The first time I used the product, I took 3 caplets before bed. During the night, I noticed that I still had the ringing but when I woke up the next day, the noise in my ear had stopped.
Later that day I actually had an appointment to see my doctor about my ear ringing. When I informed him about my little experiment, he told me he was aware of LipoFlavonoid and from he understands, it appears to work in about 40% of cases.
For a time, I felt fortunate that maybe, I was one of those 40%…until the next day, when the tinnitus in my left ear returned.
As I write these words, I've been using 3 caplets of LipoFlavonoid for about a week and the ringing in my left ear has not stopped, although it does seem to be a tad better than it was before. There are good days and not so good days. It comes and goes.
I'm going to continue to use LipoFlavonoid for the next month or so to see if it needs more time to work and I will update my review to let everyone know what happened.
Update. I've taken LipoFlavonoid for 6 months but it did not reduce my tinnitus symptoms.
This supplement is not very expensive. I have seen it in stores for around $20-$25, sometimes less. Some drug store chains even carry their own version of Lipoflavnoid often costs less. The store versions are often called different names but they can be found on the same shelf.
I've looked at some of these store brands and noticed they often contain the same active ingredients as Lipo-Flavonoid. They often call their key ingredient either citrus bioflavonoids or lemon bioflavonoids.
This is a popular supplement. You can purchase Lipoflavonoid at many familiar stores like CVS, Rite Aid, Walgreens, Walmart, Costco, BJs, GNC, Vitamin Shoppe and Krogers.
The box I have says to take 3 caplets per day. However, on the LipoFlavonoid website they say to take 2 caplets each, 3 times a day (for a total of 6 caplets per day) for 1-2 months, and then to taper off to the maintenance regimen, which I take to be 3 caplets per day.
I didn't see the recommendation of 6 caplets per day when I started taking it. I'll up my dosage to 6 per day for the next two months and report my findings in an update to my experiment, which I outlined above.
Update. After 6 months, I did not see a difference in my tinnitus.
Lipoflavonoid And The Military
On the Lipoflavonoid website, they say that ” Tinnitus is one of the most common service-related disabilities among veterans returning from Iraq and Afghanistan.”
Hearing loss is a significant problem for those in the military. While at least one study has found Lipo-Flavonoid did not work in US service personnel, it was a small study. I'm still curious. Has anyone in the military used lipoflavonoid? If yes, leave a comment below and let me know if it helped you and how long it took to work? Also, let me know if it did not work for you.
LipoFlavonoid Side Effects
I think Lipoflavonoid is safe in healthy people. I'm not aware of any side effects from the product. The product does have vitamin C. Since vitamin C can increase iron absorption, this might be a problem for people with iron overload disease (hemochromatosis ). This is rare though.
Hearing loss, as well as ringing in the ears, can be complicated. In fact, if you start to research the causes of tinnitus, some of them can scare the daylights out of you! So, I think it's best to get checked out by your doctor first to find out what might be causing the problem. If you take any medications, speak to your doctor too.
Does LipoFlavonoid Work?
Research dating back to over 50 years ago hints Lipoflavonoid might work for some people. I wish I was one of them. After taking Lipoflavonoid for several months, it did not reduce my tinnitus symptoms. If it worked for you, leave a comment below and let me know how long it took before it kicked in or anything else you think would help. The good news is the supplement is not expensive and can be found at may local stores.