If you have ringing in the ears – a medical condition called tinnitus – you may have heard of a supplement called Lipoflavonoid which, according to its website, has been “used extensively for decades for the treatment of Meniere’s syndrome and tinnitus.” I became curious about Lipo-Flavonoid after I started getting ringing in my left ear. So, I decided to try it and see if it helped. What you will read below is not only my review of LipoFlavonoid but also the results of what happened when I tried it. Hopefully, what you will read will help you better decide if LipoFlavonoid is right for you. See my tinnitus supplements review also.
For this review I looked at Extra Strength Lipo-Flavonoid Plus. According to the product box, a serving is 3 caplets. Each serving (3 caplets) has the following ingredients:
|Ingredient||Amount Per Serving||Percent Daily Value|
|Vitamin C (ascorbic acid)||300 mg||500% DV|
|Vitamin B1 (thiamine mononitrate)||1 mg||67% DV|
|Vitamin B2 (riboflavin)||3 mg||177% DV|
|Niacin (niacinamide)||10 mg||50% DV|
|Vitamin B6 (pyridoxine HCL)||1 mg||50% DV|
|Vitamin B12 (cyanocobalamin)||5 micrograms||83% DV|
|Pantothenic acid (calcium pantothenate)||5 mg||50% DV|
|Calcium (dicalcium phosphate)||87 mg||9% DV|
|Extra Strength Proprietary Blend||1500 mg||N/A|
|High potency lemon bioflavonoid complex|
Looking at these ingredients, I just don't think the vitamins and minerals play any role in helping tinnitus. I say this because:
1. These same vitamins and minerals are found in many other supplements – and the makers of those products don't claim they help ringing in the ears.
2. I don't think most people are deficient in these vitamins or minerals. If you eat lean
meats, fruits, vegetables, you are getting all of these things.
If Lipoflavoind really works, then it's because of the stuff in the proprietary blend. Let's look at those ingredients now.
Proprietary Blend Ingredients
Three caplets of Extra strength Lipoflavonoid contains 1500 mg of the following ingredients:
- Eriodictyol glycoside
- Choline bitertrate
- High potency lemon bioflavonoid complex
They don't tell us how much of each of these 3 ingredients contributes to this 1500 mg but, we can assume that the first ingredient contributes the most and the last ingredient contributes the least.
As an aside, eriodictyol glycoside refers to a phyto-nutrient called a bioflavonoid that is found in lemon peels. I mention this because the last ingredient in the proprietary blend above, is a “high potency lemon bioflavonoid complex.”
That sounds a lot like Eriodictyol glycoside to me.
So, does that mean eriodictyol glycoside is listed 2x in the ingredients list? I'm not sure. Either way, I believe eriodictyol glycoside is the main active ingredient in Lipoflavonoid.
Instead of trying to locate research on each of the ingredients in the proprietary blend, let's just look at the research on Lipoflavonoid and eriodictyol glycoside as it pertains to tinnitus (ringing in the ears).
I searched the Lipoflavonoid website (lipoflavonoid.com) as well as the National Library of Medicine (PubMed.gov) to find clinical studies on this product. While I did not see any studies conducted on Lipoflavonoid itself, the Lipoflavonoid website does list a few clinical trials on their “history of lipoflavonoid” page.
The studies are on eriodictylol glycoside, the lemon bioflavonoid mentioned above. This is another reason why I think eriodictylol glycoside is the main active ingredient.
Oddly, the studies they cite date back to the 1960s. Both of the studies were done by Dr. Henry Williams, an ENT doctor (ears, nose and throat doctor) who first proposed that eriodictyol glycoside might help ringing in the ears. Here are the studies:
While both of these studies note that the eriodictyol glycoside bioflavonoid helped ringing in the ears, unfortunately I can't find the full text of either study, so I can't see how the studies were done. I'll assume they were both well done studies that used a placebo.
Wikipedia reports that in 1965 Walter Reed Hospital conducted a study of citrus bioflavonoids in people who had hearing loss that was not related to Meniere's Disease. Those researchers however found no improvement in hearing.
- eriodictyol glycoside hearing
- eriodictyol glycoside tinnitus
- eriodictyol glycoside Ménière's
I also searched those sites for:
- Lipoflavonoid tinnitus
- Lipoflavonoid Menieres
The following research was revealed:
In a 2016 study, researchers gave 40 people with tinnitus either:
- Lipoflavonoid + manganese
- Lipoflavonoid Plus by itself
More specifically the people took Lipoflavoind 3 times a day alone or in combination with 8 mg of manganese. Manganese was included in this study because some previous research suggested it might help.
Each group contained 20 people and the study lasted 6 months.
By the end of the study, researchers concluded that neither Lipoflavoind Plus or the combo of Lipoflavonoid with manganese – helped reduce tinnitus symptoms.
Who Makes LipoFlavonoid?
On the product website, I found that the company that makes Lipoflavonid is called Clairon Brands LLC. The contact page of Lipoflavonoid.com lists this address: 27070 Miles Road Suite A Solon, Ohio, 44319. Their website lists this contact number: (844) 454-7632.
When I searched online for their address (minus the “suite A”) I found other products having the same address including Absorbine Jr and even something called “Anti-Monkey Butt Powder.”
The product website was registered under another company name, called DSE Health Solutions located at 164 Northfield Drive, Edison NJ 08837. This address also corresponds to Garden State Fulfillment as well as another supplement company called Numark Laboratories. My guess is that Garden State Fulfillment is where these products are packaged and shipped to consumers from.
As I said above, I've had tinnitus in my left ear for sometime. After several months of this, I decided to try LipoFlavonoid to see if it helped or not. The first time I used the product, I took 3 caplets before bed. During the night, I noticed that I still had the ringing but when I woke up the next day, the noise in my ear had stopped.
Later that day I actually had an appointment to see my doctor about my ear ringing. When I informed him about my little experiment, he told me he was aware of LipoFlavonoid and from he understands, it appears to work in about 40% of cases.
For a time, I felt fortunate that maybe, I was one of those 40%…until the next day, when the tinnitus in my left ear returned.
As I write these words, I've been using 3 caplets of LipoFlavonoid for about a week and the ringing in my left ear has not stopped, although it does seem to be a tad better than it was before. There are good days and not so good days. It comes and goes.
I'm going to continue to use LipoFlavonoid for the next month or so to see if it needs more time to work and I will update my review to let everyone know what happened.
Update. I've taken LipoFlavonoid for 2 months but it did not reduce my tinnitus symptoms.
How Much To Take?
The box I have says to take 3 caplets per day. However, on the LipoFlavonoid website they say to take 2 caplets each, 3 times a day (for a total of 6 caplets per day) for 1-2 months, and then to taper off to the a maintenance regimen, which I take to be 3 caplets per day.
I didn't see the recommendation of 6 caplets per day when I started taking it. I'll up my dosage to 6 per day for to the next two months and report my findings in an update to my experiment, which I outlined above.
Update. As stated above, after 2 months, I did not see a difference.
Lipoflavonoid And The Military
On the Lipoflavonoid website they say that ” Tinnitus is one of the most common service-related disabilities among veterans returning from Iraq and Afghanistan.”
I can understand why this would be, so are there any from the military reading this who have used Lipoflavonoid? If yes, can you let me know if it helped you and how long it took to work? Also let me know if it did not work for you.
LipoFlavonoid Side Effects
I think Lipoflavonoid is safe in healthy people. I'm not aware of any side effects from the product. The product does have a lot of vitamin C (500% of the daily value). Since vitamin C can increase iron absorption, this might might be a problem for people with iron overload disease (hemochromatosis ). This is rare though.
Hearing loss as well as ringing in the ears can be complicated. In fact, if you start to research the causes of ringing in the ears, some of them they can scare the daylights out of you! So, I think it's best to get checked out by your doctor first, to zero in on what might be causing the problem. If you take any medications, speak to your doctor too.
Does LipoFlavonoid Work?
After taking Lipoflavonoid for two months, I can say that unfortunately it did not reduce my tinnitus symptoms. If it worked for you, I hope you leave a comment below and let me know how long it took before it kicked in or anything else you think would help.
Here is Lipoflavonoid on Amazon if you want to check it out and see what other's are saying about it.