Supplement Clarity

Neora EHT Brain Formula Review: Does It REALLY Work? Ingredients & Proof.

Nerium-eht-review

Updated 12/21/24. For the longest time, I thought Neora (formally Nerium International) was a skincare company. I had no idea Neora had supplements, too – until I became aware of a brain formula supplement called EHT. This supplement is VERY different from other memory supplements I've seen and reviewed here. In this unbiased review (I don't work for the company), we will look at the science, research, and ingredients of Neora EHT. Does it improve memory and help concussions reduce the odds of getting dementia? These are some of the questions I'll address.  Does it really work? Is it the real deal or a scam? Let's see what we can discover. Also, see the Neora Fit Review 

What Is Neora EHT Brain Formula?

From the website of the company that makes this supplement, we learn EHT for the brain it is “a mixture of bioactive molecules isolated from coffee that helps strengthen neural connections and promote optimal brain health.”

What does that mean?

That description is pretty vague, but it sounds like Neora EHT is supposed to help the brain work better. They used to call this a “mind enhancement formula” although that wording has since been removed from the company website. Anything that could help the brain work better might  –  in theory – lead to several health benefits ranging from improved memory to protection against dementia.

We'll address some of these issues in the sections below.

Neora EHT Brain Formula Ingredients

According to the product website (Neora.com) a box contains a 30-day supply. Taking 1 tablet of Neora EHT has the following ingredients:

NutrientAmount Per ServingPercent Daily Value
Vitamin D (cholecalciferol)2000 IU500% DV
Vitamin B6 (pyridoxine HCL)1.6 mg80% DV
Vitamin B12 (methylcobalamin)10 mcg167% DV
Magnesium (from 100 mg mag citrate)16 mg4% DV
Selenium (selenomethionine)70 mcg100% DV
Huperzine-A50 mcgN/A
Alpha lipoic acid50 mgN/A
EHT (proprietary coffee blend)35 mgN/A

In the table above, “N/A” means there is no daily value for that particular nutrient.

While the product website says the product also contains sodium hyaluronate, this ingredient is not listed on the Supplement Facts label.

While vitamin B12 was originally present as cyanocobalamin, this has been changed to methylcobalamin.  This is a trendy ingredient, but I don't see an advantage to it for most people.

Other Ingredients

Neora EHT also has the following “other ingredients” listed. I’ve put them in order as they appear on the label:

The tablet coating of the product is composed of :

  1. Polyvinyl alcohol
  2. Titanium dioxide (color)
  3. Macrogol
  4. Vanillin (extract of a vanilla bean)
  5. Talc

These other ingredients likely play no role in any benefits from the product.

Now, let's see if the EHT brain formula supplement has any memory research. After that, we'll look at the research on its ingredients.

Neora EHT Research

Does Neora EHT have any proof that it really improves memory?

Searching clinical databases for studies revealed none.

No relevant investigations showed up.

All this tells this reporter that no clinical evidence exists for this supplement.

Summary of Search Results:

If there are clinical research studies on Neora EHT and memory, they cannot be found.

That doesn't necessarily mean the product doesn't work. Rather, it just means nobody has tested it – yet. And that includes the Neora company too. When those studies are conducted and published, I will update this review as I become aware of them.

To be clear, there is research on EHT – which is the namesake ingredient in this supplement. The research on EHT will be summarized below.

Let's look at the research on the ingredients in the Neora EHT.

Neora EHT Ingredient Research

From the Ingredients list above, we can see that 1 tablet of Neora EHT contains:

While these are all fine nutrients for healthy people, I'm not convinced they contribute anything significant to helping memory, dementia or the immune system etc., beyond what we might get in the diet naturally or in a regular multivitamin.

Of course, those who are not so healthy might benefit from these nutrients, but for the most part, a multivitamin and vitamin D supplement will cover these bases. As such, I won't cover the vitamins or minerals in this review.

 If Neora EHT really works, I think the answer lies with its other ingredients.

Let's look at those now.

Huperzine A

Each capsual of the EHT Brain Formula contains 35 mg of Huperzine. This is less than the 50 mg it origionaly contained.  The scientific name for this herb is Huperzia Serrata. It is sometimes also called Chinese club moss or “Hup A.” Another name for Huperzine A is Selagine.

Neora EHT Brain Formula Supplement Facts (source: Neora.com)

Several studies have revealed Huperzine A may be of benefit to people with Alzheimer's disease and dementia. It might do this because Huperzine A appears to prevent the breakdown of acetylcholine (say, “uh-see-tul-co-lean”) a chemical involved in memory. It does this by inhibiting an enzyme (called acetylcholinesterase) that is involved in the breakdown of acetylcholine.

In other words, by knocking out the enzyme that breaks down acetylcholine, the levels of acetylcholine in the brain rise and the chemical stays around longer. Theoretically, this might help boost memory.

Neora EHT appears to contain an amount of huperzine A (50 micrograms) that has been used in clinical trials. That is encouraging. Studies show that it may take 2-8 weeks before differences are noticed. This is a general rule, and I'm sure this would vary according to how bad the memory problems were, the medications people take, and other factors.

Do All Studies Say Huperzine Works?

No. Some research says huperzine may not work. This may be due to issues in purifying the Huperzine A compound and extracting it from the plant. Remember, plants contain thousands of different chemicals. Huperzine is only one of them.

Several of the studies appear to come from China. While they do appear to show Huperzine A may work, at least one study notes that because of problems with how some of the studies were conducted, caution and more research is needed.

Sometimes, Huperzine A is touted to improve memory in healthy people without memory problems. However, I can only find one study. For me, one study is not enough evidence – yet – to say healthy people need it.

Supplement makers think Huperzine A works because its been has been used in other memory supplements, such as:

See those reviews for more information.

Here is Huperzine on Amazon

Alpha Lipoic Acid

Alpha-lipoic acid may be in some diabetes and weight loss supplements. There does appear to be a connection between diabetes/insulin resistance and dementia. I've even seen Alzheimer's disease called “Type III diabetes” to drive this message home.

Thus, adding this alpha lipoic acid to a memory supplement does, in theory, make some sense. If we can reduce blood sugar levels, we might also reduce dementia.

But does alpha lipoic acid improve memory? More research is needed. One review of alpha lipoic acid dementia research found no good proof it helped people with memory issues.

One study has noted alpha lipoic helped memory, but this study seems to have problems with how it was conducted. Also, that study used 600 mg. Neora EHT only has 50 mg.

Alpha-lipoic acid is also in the memory supplement Procera AVH. See that review for more information.

Here's alpha-lipoic acid on Amazon

EHT

The EHT molecule is an ingredient in the Neora EHT supplement.  The EHT molecule is derived from coffee and is a mixture of several different compounds. What does EHT stand for?

EHT stands for “Eicosanoyl-5-HydroxyTryptamide.”

Now, you know why they call it EHT.

It's stated that the researchers at Signum Biosciences noticed that people with severe memory decline had a disruption of a regulator protein called PP2A. The PP2A protein regulator is said to help keep the connections between brain cells “robust and healthy.”

Theoretically, anything that could help increase the PP2A, might let brain cells talk to each other better. This might help memory and other things that PP2A helps regulate.

This does sound interesting. So, is there any research on EHT? Yes, there is.

Let's look at that research next.

EHT Research

Previously, Sigmun Biosciences had an EHT supplement called ME Sports, which was marketed to athletes.

It was stated that that “ME™ sports has been shown to be beneficial in vivo models of cognition, memory and motor function.” The phrase “in vivo” basically means conducted in animals/not in a test tube. While that's good, it's not the same thing as human studies.

On the website of Signum Biosciences, several clinical studies are listed. I will link to the studies below so you can see them as you conduct your own research.

Neora EHT Research Summary

Instead of getting bogged down in explaining the research, I'll just list the study name and give a quick breakdown as to whether it involved people, lab animals or was test tube research (which I define as research not occurring in living animals).

By breaking the research down this way, you can get a better idea of how far along with the current research on EHT.

Here are the studies listed in support of the EHT compound.

Study Title Type of Study
EHT™ coffee extract: A neuroprotective agent and modulator of PP2A methylation with anti-inflammatory and antioxidant properties (S16.006) (2015)Test tube study
Therapeutic benefits of a component of coffee in a rat model of Alzheimer disease. (2014)Rat study
Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's diseasedisease. (2013)Mouse study
Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. (2011)Mouse study
The structural basis for tight control of PP2A methylation and function by LCMT-1 (2011)Test tube study
Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer’s disease (2011)Review paper of previous research
Protein carboxyl methylation and the biochemistry of memory. (2009)Study involving isolated cells.
Mechanisms of tau-induced neurodegeneration. (2009)Review paper of previous research
From promiscuity to precision: protein phosphatases get a makeover. (2009)Test tube study
Protein carboxyl methylation and the biochemistry of memory. (2009)Test tube study.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A. (2008)Test tube study
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.(2008)Test tube study of mouse and human cells
Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. (2008)Test tube study
Protein Phosphatase 2A Methyltransferase Links Homocysteine Metabolism with Tau and Amyloid Precursor Protein Regulation (2007)Mouse study
Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis.(2004)Test tube study
Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. (2004)Test tube study. Appears similar to previous study. Same authors.
Protein phosphatase 2A methylation: a link between elevated plasma homocysteine and Alzheimer's Disease. (2002)Test tube study.

As can be seen from the table above, there is a need for human research.

What About The Princeton University Study?

Some may have also heard of a study at Princeton University. This investigation was an undergraduate senior thesis on EHT. The title of the thesis is “The Neuroprotective Effects of Eicosanoyl-5-hydroxytryptamide in an in vitro Model for Parkinson’s Disease.”

This is not a human study.

Essentially, human cells were treated with Signum EHT to see what happened. This investigation showed the EHT molecule has a cell-protective effect. While the investigator used human cells, isolated cells -even from humans – are not the same as testing EHT in humans.

Let me be clear: I listed studies like this not to slam the product or deprecate any company. Rather, the goal was to help you better understand this very complicated research. As this reporter becomes aware of more evidence, this section will be updated.

EHT vs. EHT 0202

EHT0202 is an Alzheimer's drug. It is not the same thing as EHT, the supplement.

The reasons for this are because:

Because of this, Brand Partners should not confuse research on EHT0202 with Neora EHT. Their names are very similar so it's easy to confuse them.

Does Neora EHT Brain Formula Have Caffeine?

I think the answer is yes and no. The EHT brain formula is decaffeinated, but I've also seen it said it has a small amount of caffeine. They say the amount of caffeine is less than is in a decaffeinated cup of coffee.

That's very little caffeine. I don't think most people would notice it. Some people have left comments below saying they had trouble sleeping. Whether or not this is related to caffeine, I can't say.

Neora and Dementia

Can the EHT brain supplement reduce risk of dementia or Alzheimer’s or improve memory if it were taken long-term? It's a tantalizing idea to be sure. There is just not enough evidence to say yes or no to this question.

For those who have dementia or are thinking about EHT for their family members who already have cognitive insufficiency problems, the best advice is to show the ingredients this supplement to their doctor.

Food for thought: Evidence suggests regular exercise can preserve brain health.

Does Neora EHT Help Concussions?

In the past, the Sigmun Biosciences website used to contain an EHT supplement called “Me Sports” where “Me” stands for “Mind Enhancement.” They used to say that Me Sports “provides the best protection for your brain.” References to Me Sports no longer appear on the Sigmun website. It has been replaced by Neora EHT and may be discontinued.

Does Neora EHT Brain Formula help with concussions? There is a lack of proof showing the supplement helps recovery from traumatic brain injuries or reduces their risk of concussions.

Neither Neora or the Sigmond Biosciences websites make any health claims that supplement helps traumatic brain injuries.

Can EHT Brain Formula Help Parkinson's

Can EHT help Parkinson's disease? For now, the proof is lacking.

There are references to Neora EHT being endorsed by the Michael J. Fox Foundation. But, according to the website Truth in Advertising, this is not true. While the Michael J. Fox Foundation does seek a cure for Parkinson's, it does not endorse any specific treatments.

The Michael J Fox Foundation has awarded grants to Signum Biosciences to investigate PP2A as it relates to Parkinson's.

Neora EHT Brain Formula and ADHD

Does EHT help people with attention deficit disorder or attention deficit hyperactivity disorder?  It may or may not. There is not enough research on either of these conditions to provide a verdict either way. No research on either condition is known.

Neora EHT Brain Formula and Exercise

The company that invented the EHT molecule has a paper titled ” EHT® Age-Defying Supplement: Scientific Rationale for Boosting Workout and Post-Workout Recovery.” This paper (which can be found by doing an online search) is not a peer-reviewed clinical study. Rather, it discusses how the ingredients in EHT might reduce inflammation that occurs after intense exercise and improve recovery.

No doubt, there is human research on the vitamins/ minerals in the product. The EHT molecule also might hold promise in theory.

But, whether or not Neora EHT Brain Formula would benefit people who do CrossFit, Zumba, Tabata or any other exercise program is speculation until the research is published.

Is Neora EHT Brain Formula FDA Approved?

The FDA doesn't technically “approve” supplements. This is part of the US law that regulates supplements, called DSHEA, which is short for the Dietary Supplement Health and Education Act.  In the US, supplement companies do not have to tell the FDA that they are making a new supplement or get FDA approval before a supplement is marketed to the public.

Who Makes Neora EHT Brain Formula?

There are two different companies involved with this dietary supplement:

  1. Neora
  2. Signum Biosciences

Let's look briefly look at each company separately.

The Neora Company

According to the company website (Neora.com / formally Neurium), the company is a “relationship marketing company.” That means they offer a variety of products that are sold via distributors, called “Brand Partners.” In other words, Neora is a multi-level marketing company. There is nothing wrong with that. It's how they do business.

The address on file with the Better Business Bureau is 4201 Spring Valley Road, Farmers Branch, Texas 75244-3631. This is less than 3 miles from their previous home,  4006 Belt Line Road Addison, TX 75001.

While the company was not accredited by the Better Business Bureau; it did have an A+ rating when the BBB website was checked.

Signum Biosciences

Signum Biosciences is the biopharmaceutical company that discovered the EHT molecule. They are a privately held biotechnology company founded in 2002. This company is located at 11 Deerpark Dr Monmouth Jct, NJ 08852. The former company address was 133 Wall Street, Princeton, NJ 08540.

Their contact phone number is 732.329.6344. While not an accredited company, the BBB gives Signum an A+ rating.

Contact Neora

The company can be reached at these phone numbers:

Where Can You Buy Neora EHT Brain Formula

The supplement is not sold in stores like Target, Walmart, CVS, Walgreens, Costco, RiteAid, Sames Club, Kroger or Food Lion. To purchase any Neora supplement, most people go through a Neora Brand Ambassador. Another option is to purchase directly from Nora.com.

Here it is on Amazon too

How Much Does EHT Brain Formula Cost?

When I checked the company website, for a 1 month's supply (non-returning customer), the cost varried between$65 and $85 per month, depending on where you purchased it from and if you opted for autoshipments.

Yearly Cost

If buying directly from the Neora website or an annual cost of the Brain Formula is:

Monthly delievery: $65/month: $780

One-time purchase: $80/month: $960

How To Take Neora EHT Brain Formula

The company website says to take 1 tablet per day with food in the morning, preferably with some food that has healthy fats. This is likely to increase absorption. A box contains 30 tablets, which is a month's supply.

Neora EHT Brain Formula Side Effects

I believe the EHT Brain Formula supplement is safe for healthy people. I’m not aware of any side effects from the product at the time this review was created. There is also a lack of human research on this product as well. That said, here are a few things worth mentioning. Speak to your doctor if you think any of this applies to you. This list is not complete:

Neora EHT Brain Formula Pro and Con

Here is a quick rundown of what I liked and didn't like about this supplement. These are my opinions. Take them for what they are.

ProCon
Been around a long timeExpensive
Company is respectedNo human clinical proof

Does Neora EHT Work?

While preliminary research hints the EHT molecule, might have benefits, I think it's too soon to tell. This supplement has been out for a few years now, and the company has not published clinical studies to back up its claims. While the ingredients in Neora Brain Health Formula appear to make sense on paper, they need to be tested in people with clinical results published in medical journals. So, is it a scam? Many people say it's not. Many have said it's the real deal. Stay tuned for more research.

Here it is on Amazon
Any Questions or Comments?

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