You've seen the TV commercial for MyBiotin ProClinical featuring Dr. Bertha Baum and Olga Villaderdethat and became curious. Purity Products, the makers of the supplement say MyBiotin Pro Clinical grows thicker hair in as little as three weeks, improves skin hydration and reduces fine lines and wrinkles that you had just a few years ago. You wonder if all of these fantastic claims are really true. Well, are they? In this non-sponsored, honest review, discover the ingredients and research on My Biotin Pro Clinical; the cost, pitfalls, money-back guarantee, pros and cons, and how to get a refund if it doesn't work for you.
My Biotin Pro Clinical Ingredients
The Supplement Facts Label tells us that My Biotin is a clean supplement containing only three ingredients.
| Amount | Percent Daily Value | |
| Biotin (from magnesium Biotinate | 10,000 mcg | 33333% |
| MB40X (composed of Inositol-stabilized arginine silicate & magnesium biotinate) | 160 mg | N/A |
| Astaxanthin (AstaReal) | 4 mg | NA |
Notice both biotin and the MB40X ingredient contain magnesium biotinate. This common trait tells us magnesium biotinate is essential to My Biotin Pro Clinical. It's actually called “super biotin” in the TV commercial. Magnesium biotinate is a chelated form of the vitamin and is composed of 93% biotin. This form of biotin is also patented. The magnesium biotinate patent number is WO2018045244A1.
Other Ingredients
Vegetable cellulose (for the capsule), rice flour, vegetable magnesium stearate. These ingredients don't play an active role in the hair and wrinkle effects of the supplement.
My Biotin vs. My Biotin Pro Clinical
There are two versions of this supplement. Here is how they compare to each other:
| My Biotin (1 capsule) | My Biotin ProClinical 1 capsule) | |
| Biotin | 10,000 mcg | 10,000 mcg |
| MB40X | 160 mcg | 160 mg |
| Astaxanthin (AstaReal) | 4 mg |
As you can see, both supplements are almost identical to each other. The only difference is My Biotin ProClinical contains 4 mg of astaxanthin. While astaxanthin has benefits, if you are having trouble deciding which to purchase, go with the regular My Biotin supplement if it's less expensive. My Biotin ProClinical is part of Purity Product's “My Line” of supplements, including My Vitamin C and My Keratin.
What is MB40X – And Its Real Name?
MB40X is an invented abbreviation probably created for marketing purposes. MB40X refers to the combination of magnesium biotinate and inositol arginine silicate. Purity Products states this combination is 40 times (40X) more soluble than regular biotin (sometimes called D-biotin, vitamin B7, or vitamin H). The important thing to know is that the actual name of MB40X is Lustriva. This is the compound listed in the MyBiotin Certificate of Analysis and what was tested in the Clinical study summarized below.
Lustriva is a supplement ingredient from a company called Nutrition 21 (Nutrition21.com). Nutrition21 develops and supplies nutritional components to other companies – such as Purity Products. Nutrition21 also makes an extra effort by sponsoring many clinical research studies you will read about below. Nutrition 21 was a subsidiary of JDS Therapeutics, which sold it to another company called Everwell Health Holdings (also called Everwell Health or Everwell) in 2021.
Other supplements that contain the Lustriva ingredient include:
- Kallista Anti-Aging Complex Powder (160 mg of Lustriva)
- Nicole Wilkins nPower Collagen Plus (80 mg of Lustriva)
40X more Bio Soluble? What Does That Mean?
If you saw the MyBiotin TV commercial, you heard – over and over again – that the supplement is “40X more bio soluble” than regular biotin. Even some clinical studies mention this statistic. The word soluble means the ability to be dissolved. Bio-soluble refers to the capacity of a substance to be dissolved in a biological system – like you. The impression this gives is that bio-soluble means better absorbed by the body.
Some research suggests magnesium biotinate – the form of biotin used in MyBiotin – is better absorbed. But does that mean it works better than regular biotin seen in other supplements?
My Biotin Pro Clinical Ingredients Research
Here's a summary of the clinical investigations on the ingredients in MB40X (also called, Lustriva). MB40X is a combination of
- Magnesium biotinate
- Inositol-stabilized arginine silicate
Most of the research on these substances was conducted at Firat University in Elazig, Turkey, and supported by grants from JDS Therapeutics / Nutrition 21.
Study 1
In this investigation, the ingredients in MyBiotin (magnesium biotinate and arginine silicate inositol complex) appeared to improve hair density in rats better than rats receiving no treatment.
Study 2
Researchers conducted this study showing that My Biotin's ingredients protect the skin of rats from UV radiation damage and improve the elasticity and appearance of rat skin in addition to reducing skin inflammation.
Study 3
A topical ointment using the arginine silicate inositol complex was shown to speed up the healing of skin wounds in rats.
Study 4
This interesting study sought to determine magnesium biotinate's impact on social behavior problems. Researchers noted that magnesium biotinate improved learning and behavior in rats. In addition, the magnesium-biotin combo reduced inflammation. It also increased the size and number of Purkinje fibers in the cerebellum area of the brain. Serotonin and dopamine, and antioxidant enzymes like glutathione, catalase, and superoxide dismutase were also increased.
Study 5
In this analysis, researchers revealed that magnesium biotinate was more effective than regular biotin at reducing blood lipid levels in rats.
Can Biotin Help Lower Blood Sugar Levels
Watch on my Youtube channel too
Can Biotin Help Multiple Sclerosis?
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What Is Inositol Stabilized Arginine Silicate?
As the name suggests, this is a combination of the amino acid arginine, the mineral silicon, and inositol, a type of sugar. It is a fundamental component of the MB40X compound. Arginine is well-known in the exercise world for its cardiovascular benefits. Silicon is also necessary for hair, skin, nails, and bone health, and some research suggests silicon may also increase the absorption of arginine.
Inositol stabilizes or preserves the arginine-silicate combo to make it more effective. In other supplements, the inositol-stabilized arginine silicate 
Study 1
In this investigation, 1500 mg was given to healthy men (aged 18-35 years) for between 3 and 14 days. Results showed that the arginine silicate inositol complex increased the speed the men could perform complex mental tasks. Keep in mind that the dosage used in this study was much more than found in My Biotin, which has 160 mg.
Study 2
In this experiment, 26 video gamers in their early 20s were given 1600 mg of the inositol, arginine, and silicon complex. They then played their favorite video game for one hour. Compared to those who took a placebo, those taking the supplement showed some improvements in short-term memory, concentration, reasoning, and reaction time.
Video Review
Click here to watch the video review of My Biotin on my Youtube channel.
What Does My Biotin Astaxanthin Do?
Astaxanthin appears to be used to help with the anti-wrinkle effects of MyBiotin. Astaxanthin is a type of carotenoid phytonutrient. Unlike other carotenoids, astaxanthin does not raise vitamin A levels. Despite this, astaxanthin is a powerful antioxidant being 40X as potent as beta-carotene. As a natural red pigment produced by bacteria and algae, astaxanthin provides color to foods like lobster, salmon, and Atlantic trout. Its most popular sources are krill and krill oil.
In the MyBiotin TV commercial, Dr. Baum states that astaxanthin allows you to “drench your skin from the inside out” and that it provides “70 times” greater skin hydration than a placebo. Dr. Baum explains that astaxanthin helps the body hold on to hyaluronic acid (HA). This substance helps the skin retain moisture.
Preliminary research appears to show astaxanthin reduces DNA damage to the skin. Inhibiting DNA damage would be expected to help skin stay healthy looking. In one study, women taking 6-12 mg of astaxanthin showed reduced inflammation. However, there were no changes to skin moisture or wrinkles. Wrinkles and hydration did not get worse, either.
A review of previous studies concluded that oral and topical astaxanthin might be effective at helping skin aging. However, the researchers also cautioned more research was needed. One possible alarming astaxanthin side effect is that the substance may change your urine color to red or orange. This outcome is harmless, however.
The astaxanthin used in the My Biotin formula is called “AstaReal.” AstaReal Inc, a subsidiary of Fuji Chemical Industries CO. in Japan, bills itself as “the worlds leading producer and innovator of natural astaxanthin.” The company extracts its sustainable astaxanthin from non-GMO freshwater green microalgae (Haematococcus pluvialis).
Astaxanthin Health Effects Video
Watch on my Youtube channel too.
My Biotin Pro Clinical Clinical Research
As proof of its effectiveness, The Purity Products website mentions research showing that the active ingredients in MyBiotin increase hair thickness by 20% after three months of use. They say the active ingredients also reduced facial wrinkles more than the placebo after 3 months too. While there is indeed a clinical study, the researchers did not test MyBiotin Pro Clinical. Rather they examined the substance called Lustriva, which Purity Products calls MB40X. Lustriva and MB40X are the same thing but are simply referred to by different names. Purity Products calls it MB40X.
Here is a summary of the study, which is titled a randomized, double-blind evaluation of a novel biotin and silicon ingredient complex on the hair and skin of healthy women. The investigation was supported by JDS Therapeutics/Nutrition 21, the company that makes the Lustriva compound.
- The study involved 89 healthy women and lasted 3 months
- Their average age was 47, and about 96% of the women were Caucasian
The women were split up into three groups:
- Placebo group
- Low dose MB40X (Lustriva) group
- High dose MB40X (Lustriva) group
How much did they take?
- The low-dose group took 146.5 mg of inositol-stabilized arginine silicate with 3.5 mg of magnesium biotinate, 10 mg of silicon, and 3 mg of biotin.
- The high-dose group took 146.5 mg of inositol-stabilized arginine silicate with 11.7 mg of magnesium biotinate, 10 mg of silicon, and 10 mg of biotin.
Results:
- Both low-dose and high-dose Lustriva (MB40X) showed a significant reduction in facial wrinkles after 3 weeks. However, by the end of the study, only the high-dose group showed a significant decrease in wrinkle depth.
- The high-dose group showed significant improvements in skin texture (less roughness) after 3 weeks
- The high-dose Lustriva group (high dose MB40X) showed significant improvements in terminal hair and vellus and terminal hair percentages
- Neither supplement dosage appeared to have improved nail growth or strength
- Those taking the placebo saw no improvements in any parameter measured
Here is the before and after picture of one of the people who took part in the study:
Study problems
- The supplement combo was tested against a placebo only. How does MB40X compare to regular biotin?
- This investigation tested the ingredients in My Biotin – not My Biotin Pro Clinical (which also contains astaxanthin). This is an important consideration if you are unsure which version to purchase.
How To Buy My Biotin Pro Clinical and How Much Does It Cost?
One of the easiest ways to purchase this supplement is directly from the company at PurityProducts.com. Each bottle has 30 capsules, which is a one-month supply. Prices listed on the Purity Pride website are as follows:
| My Biotin | My Biotin ProClinical | |
| One bottle | $29.95 | $39.95 |
| Auto shipment subscription | $24.95 | $37.95 |
There is no cost for shipping, even if you purchase a single bottle. If you choose the auto-shipment option, you can have one to four bottles sent to you every one to four months. It's very flexible. Purchasing from Purity Products also earns you “PurityPoints” which you can use to bring down the cost of future purchases.
Yearly Cost of MyBiotin
If used as directed, a bottle will last you one month. Here is the annual cost of each supplement:
- My Biotin Price: $299.40 to $359.40
- My Biotin Pro Clinical price: $455.40 to $479.40
Where Can You Purchase My Biotin Pro Clinical?
This supplement is popular and can be purchased at many shops, including Walmart, CVS, and the Purity Products website (PurityProdcutsc.com). It can also be purchased on Amazon too.
Beware The Free Bottle Offered on TV
If you watched the MyBiotin TV commercial, you heard about the introductory bottle selling for $9.95 plus shipping and handling. The starter bottle is a full 30-day supply. If you try it yourself, remember that the introductory starter bottle will enter you into the auto-ship program. This means
Purity Products will send you more of their MyBiotin supplement every month so you do not run out of it. This is a good service, but be aware of it so you are not surprised by unexpected credit card charges. To order your starter bottle, call either of these customer service numbers:
- 800 699 3851 (the number listed in the TV commercial)
- 800-479-5944 (the number listed on PurityProducts.com)
Who Makes My Biotin Pro Clinical?
The company is called Purity Products, known in some circles as Water Pure, Inc. The Purity Products company address is 200 Terminal Drive, Plainview, NY 11803-2312. If you search for this address, you will see a large building with the sign “Purity Products Shipping and Receiving.” Purity Products sells many supplements, including Zorbz Liposomal Vitamin C, HA Joint Formula, Dr. Cannells's Advanced D, and The “Medicine Hunter,” Chris Kilham's Green Tea CR.
Purity Products Customer Service
- 800-256-6102 (24-hour order hotline)
- 888-769 7873
Customer service is available M-F, 9 am to 9 pm EST, and on Saturday from 9 am to 5 pm EST.
Who Is Dr. Bertha Baum
Dr. Baum is the medical expert featured in the TV commercial. She is a board-certified dermatologist & cosmetic surgeon based in Hallandale Beach, Florida. Her website is DrBaum.com. In addition, the TV commercial lists that she is also a spokesperson for Purity products.
Who Is Olga Villavdere
Olga Villaverde is the woman who interviews Dr. Baum during the My Biotin Pro Clinical TV commercial. Miss Villaverde is an on-air TV host and reporter associated 
Purity Products & The Better Business Bureau
The Better Business Bureau indicates the company has been in business since 1991. That's much longer than many other companies and is a good sign. The Better Business Bureau accredited the company and gave it an A+ rating. The company responds to customer complaints lodged with the BBB, which is also nice to see.
My Biotin Pro Clinical FAQ
How do you take it yourself?
Take one capsule only per day.
Does MyBiotin Contain Gluten?
The supplement is GFCO-certified gluten-free.
Is it vegan?
The supplement is vegan and organic.
Is it Kosher?
The company reports that MyBiotin is not Kosher certified.
What about Halal certification?
The company has gone the extra mile to ensure MyBiotin is ISA Halal certified.
Where is My Biotin made?
The supplement is “lab tested in the USA.” This may not mean the same as “made in the US” or “made in America.”
Will it return hair to its natural color?
This is a hair growth and wrinkle supplement, not a gray hair restoration supplement. There's no proof biotin or “super biotin” rejuvenates hair to its natural color.
Is it independently tested?
While the FDA does not routinely test dietary supplements, Purity Products indicates MyBiotin is NSF certified. NSF is a respected independent 3rd party company that tests nutritional supplements, ensuring they do not contain contaminants or ingredients not listed on the supplement facts label. In addition, you can download and read the Certificate of Analysis for My Biotin at the Purity Products website.
How does it work?
The mechanism is unclear; however, it's speculated that arginine improves blood flow to the skin and hair because of its ability to raise nitric oxide levels. Nitric oxide is a vasodilator. As such, it's able to relax muscles in the blood vessels and allow for greater blood flow. This may provide more significant amounts of oxygen and nutrients to hair and skin. In addition, hair contains protein, and magnesium is a mineral that aids with protein synthesis. It's noteworthy that many Americans do not consume adequate amounts of magnesium.
My Biotin Pro Clinical Customer Complaints
- The urine color changed to “electric orange.”
- Face broke out with small red bumps after using it.
- Did not notice any improvements.
- No change in the rate of hair falling out but improvements in nail growth.
My Biotin Money Back Guarantee and Refund Policy
All supplements purchased from PurityProducts.com come with a 60-day money-back guarantee. The 60 days begins when you receive the supplements, not when you order them. To get a refund, call the company's Customer Service department at 888-769-7873 to obtain a return authorization number and instructions on how to send your supplements back. Return the supplements to this address:
PURITY PRODUCTS
Returns Department
200 Terminal Drive
Plainview, New York 11803
Customer service is available M-F, 9 am to 9 am EST. If you request a refund on 12 or more bottles, the company will charge a 15% processing fee for unopened and perfectly-conditioned products. This only occurs if you are returning 12 bottles or more.
The Free Gift: Collagen Factor C
If you order My Biotin Pro Clinical as a free gift, you'll also receive the Collagen Factor-C supplement. Each capsule of Collagen Factor-C contains 500 mg of vitamin C, and 25 mc (1000 IU) of vitamin D. Here is the supplement Facts label:
| Amount | Percent Daily Value | |
| Vitamin C (ascorbic acid combined with lipid metabolite fatty acids | 500 mg | 556% |
| Vitamin D 3 (cholecalciferol) | 25 mcg (1000 IU) | 125% |
| Acerola extract (malpighia punicfolia) | 2.5 mg | |
| Citrus Bioflavonoid Complex (85mg Total Bioflavonoids including Hesperidin) | 170 mg | |
| Rose hips | 2.5 mg | |
| Rutin | 10 mg |
Overall, this looks like a vitamin C supplement with added ingredients. Unfortunately, this reporter is unaware if it works better than other vitamin C supplements.
Calling Purity Products Customer Service
The customer service people are helpful and polite. They even called me back when they thought a previous call was disconnected – though I did not share my phone number with the company when I called. One customer service rep who this reporter spoke with asked many questions and offered supplement solutions without me initiating an interest. The rep offered discounts and even provided his phone extension in case I was interested in purchasing supplements in the future. It was all very polite, but I got the impression he wanted to make a sale. To be fair, other customer service reps I spoke with were not like this. On two different occasions, the representatives answered my questions and did not inquire or make supplement suggestions.
My Biotin Pro Clinical Adverse Reactions and Side Effects
This supplement is likely safe for most people. A toxicological study using rats found no harmful effects even when extremely high doses (39 grams of biotin for a 154 lb human) were used for three months. A toxicity study using the inositol arginine silicate complex showed no problems when men took 500 mg for two weeks. Similarly, the human trial involving 89 women who took the key ingredients in My Biotin for 3 months did not experience side effects either. While this is encouraging, there are some necessary things to know before taking this or any biotin supplement.
- Start with less for the first week. This will give your body time to adjust. If side effects do occur, taking less may also minimize them.
- Speak to your doctor if you take any medications or if you are pregnant or breastfeeding or take medications.
- Stop taking at least two weeks before surgery.
- Biotin is known to interfere with several laboratory tests, including but not limited to those for thyroid hormones, insulin, testosterone, growth hormone, and prostate PSA levels. Biotin supplements may make doctors think your levels are too low (such as for thyroid stimulating hormone) or too high (as in the case of testosterone). MyBiotin and Pro Clinical versions contain 10,000 mcg (10 mg) of biotin, which might interfere with these laboratory tests. Avoid taking biotin supplements for 3-4 days before having blood tests. Prior to blood tests, always inform your physician about the supplements you are taking.
- Astaxanthin may cause your urine and feces to appear orange or red. This is harmless.
My Biotin Pro Clinical vs. Nutrafol & Viviscal
The ingredients in the popular Nutrafol hair growth supplement differ from the Purity Products supplement. However, one similarity is that both contain biotin Four capsules of Nutrafol provide 3,000 mcg of vitamin B7. This is a lot less than My Biotin, which has 10,000 mcg.
Unlike Nutrafol, My Biotin does not contain saw palmetto, which some research indicates has hair growth-promoting effects. On the downside, some women feel saw palmetto is controversial, which may be why Purity Products did not include it in their formula. Another difference is the Nutrafol company makes no claims about improving fine lines and wrinkles on the face. Click here to see Nutrafol's before & after pictures.
Viviscal is another top-rated hair growth supplement. The company making this supplement makes no claims about reducing facial wrinkles. Viviscal has only 120 mcg of biotin, which is far less than either My Biotin or Nutrafol. That said, there are at least 5 clinical investigations indicating the effectiveness of Viviscal. This is more proof than its competitors. Ironically, even the Purity Products website references a study conducted on Viviscal! Another difference is that Viviscal costs less, which puts a smaller dent in your wallet.
My Biotin ProClincal Pros & Cons
These are the opinions of this reporter. Yours may be different.
| Pros | Cons |
| A human clinical study exists showing it works | Most studies conducted on animals |
| Sold by a well-known company | Not kosher |
| Vegan | Pricey |
| GMO-free | Bold claims |
| 3rd party NSF certification | Will take at least 3 months to notice a difference |
| Gluten-Free | |
| Organic | |
| Halal certified | |
| Customer service phone support | |
| Company has an A+ Better Business Bureau rating |
The Verdict: Does My Biotin Really Work?
The My Biotin supplement has at least one clinical investigation, which appears to show the ingredients in the supplement -what Purity Products calls MB40X – work as advertised. While the study seems to be well done, the results need to be verified by other researchers. That's how science works. Unfortunately, the researchers did not compare the MB40X compound to regular biotin to see if it was better. Despite what you saw in the TV commercial, the clinical study used the ingredients found in the regular MyBiotin supplement – not the Pro Clinical version. Consider this when making your purchase.