Supplement Clarity

Alani Nu Balance Review: Safe For The Liver? Ingredients Breakdown

Joe Cannon

Updated August 17, 2025. Balance capsules from Alani Nutrition are said to help support hormonal balance, weight management, complexion, and fertility, as well as improve overall sleep and energy levels. Sounds great, but do they really work? Do they have any side effects? Do Alani Nu Balance supplements cause liver failure? In this review, you'll learn about the ingredients and clinical research on Balance hormonal support capsules. I'll also do a deep dive into the accusations of liver problems. If you know the research, you can better decide if they are right for you. For the record, I have no connection to this or any other supplement company.

Alani Nu Balance Research

No clinical research on the supplement could be located. As such, it's necessary to look at the research on the ingredients in Alani Nu Balance. Let's do that next.

 

Alani Nu Balance Ingredients

There are six ingredients in Alani Nu Balance supplements. A serving is 4 capsules. Four veggie capsules contain the following ingredients listed in order as they appear on the label:

Alani Nu Balance Ingredients

As can be seen, even though folic acid (folate) is listed first, the supplement is mostly composed of Myo-inositol (2 grams).

Other ingredients contained in the supplement include:

  1. Hypromellose (used to make the veggie capsule)
  2. Silica
  3. Vitamin C palmitate

These other ingredients play no role in how effective the supplement is.

Let's look at the relevant research on each of the ingredients next.

Folate

Folate is a B vitamin (vitamin B9). Folate is critical for pregnant women because it reduces birth defects (neural tube defects).  The vitamin can also reduce homocysteine which some think is related to heart disease. Folate does not appear to reduce miscarriage.

The supplement contains a specific type of folate called 5 methyltetrahydrofolic acid (5-MTHF) which is said to be the most biologically active form. Some people may not be able to make 5-MTHF. Thus, providing the vitamin in the 5-MTHF form can help those who can't activate the vitamin.

The Alani Nu Balance supplement label states 4 capsules provides 400 micrograms of folate. This is 100% of the non-pregnancy daily value for this vitamin. The label incorrectly states the supplement contains 200% DV.

Good food sources of folate include dark green leafy vegetables like spinach and kale, as well as fruits and vegetables in general. Nuts and grains and seafood also contain folate.

Folate is the natural form of the vitamin. Folic acid is the synthetic form. Supplements usually contain folic acid because it's better absorbed than the natural folate vitamin.

Chromium

The mineral chromium is known to help reduce blood sugar levels. As such, chromium may benefit women with PCOS – polycystic ovary syndrome. In theory, the blood sugar-lowering effects of chromium may benefit women at risk of gestational diabetes.

Most studies find chromium supplements do not help weight loss. That said, most research involves chromium picolinate. The Balance supplement contains chromium nicotinate. At least one study has noted chromium nicotinate may help weight loss.  Overall, more clinical studies find it does not work so it's up to the reader to decide for herself.

Chromium supplements do not build muscle or improve athletic performance, so they are of little value to women who exercise and not deficient in this mineral. Balance capsules contain a specific form of chromium called TRAACS nicotinate glycate chelate. What that? It's chromium which is bonded to the vitamin niacin (nicotinic acid). It's also called chromium nicotinate. This form of the mineral may be better absorbed the chromium alone.

Myo-Inositol

This is the most abundant ingredient in Balance capsules.  So, what is myo-inositol? Inositol is a compound we get from foods like nuts, beans, and citrus fruits. It looks like sugar, but it's not sugar. The prefix myo refers to muscle. Inositol is called myo-inositol because it was first isolated from muscle.

There are nine types of inositol. Myoinistol is the most abundant of those types. It's estimated Americans get about 1 gram a day from food although this may vary from person to person. Fruits, vegetables, and seeds are sources of natural inositol.

Inositol helps cells function by helping make up cell membranes. Inositol also helps cells communicate with each other, and the compound also appears to regulate endocrine function.

What are myoinositol benefits? It looks like sugar but ironically, studies find inositol supplements can help lower blood sugar. The supplement seems to benefit women with PCOS and metabolic syndrome (pre-diabetes).  Inositol also appears to help pregnancy-related diabetes, too (gestational diabetes).

Some researchers have noted that depressed people have lower levels of inositol in their blood.  As such, some speculate Myo-inositol may be a natural depression supplement. So far the evidence is murky.

Some call Inositol vitamin B8, but this is not true. Inositol is not a vitamin because we can not make it in the body.

Glutathione

Glutathione is a powerful antioxidant defense substance that we make. Some call glutathione the “master antioxidant” because of its found in all the cells of the body. It's technically a peptide-protein molecule made up of the amino acids, glutamic acid cysteine, and glycine. As an antioxidant, glutathione neutralizes free radicals which can damage cells and DNA.

The Balance supplement uses Setria glutathione. Setria is the trademarked name of the Kyowa supplement company (Kyowa-USA.com). The company has supported research on their supplement to show it has benefits. This is likely why other companies use the Setria brand.

The Alani Nutrition company says glutathione brightens complexion and reduces wrinkles. While some studies have looked into the skin anti-aging effects, more research is needed to know which people it would work best with.

Several before-and-after YouTube videos by women  do say their acne has improved, such as this video of a woman who used the supplement for 5 months.

The good news is it's not hard to raise your levels. Two inexpensive ways to boost glutathione production are exercise and taking N-acetyl cysteine supplements.

Here are 15 ways to raise glutathione naturally

Watch on YouTube 

Diindolylmethane

Diindolylmethane is often called “DIM.” You make DIM when you eat broccoli, cauliflower, brussels sprouts, and other cruciferous vegetables. Researchers are interested in DIM because it may help reduce cancer. It appears diindolylmethane can modulate estrogen levels. Because of this, some feel DIM may help reduce hormone-sensitive cancers like breast and endometrial cancer.

DIM may also help men with prostate cancer too. That said, the anti-cancer effects of DIM will require human clinical studies to know for sure. While obtaining DIM from food is safe, those with a history of cancer should talk to their doctor about diindolylmethane supplements.

Alpha-Lipoic Acid

Alpha-lipoic acid (ALA) is an antioxidant. The nutrient is found naturally in vegetables like broccoli and spinach as well as meats.  Because of its antioxidant properties, ALA may be used topically to reduce skin aging, although the reason it's said to be used in Balance capsules is to improve insulin sensitivity.

Various studies have noted alpha-lipoic acid can lower blood sugar levels in people with insulin resistance  (pre-diabetes). While studies tend to use more ALA than is found in Balance capsules, it's possible that ALA -combined with the other blood sugar-lowering ingredients – may work similarly. More research is needed.

Watch on YouTube 

Alpha-lipoic acid may also be used to help weight loss. Some studies note ALA may aid weight loss, but if it works, the effects may not be noticed by most people. There are better weight loss supplements out there.

Estrogen Modulating Ingredients

Here's a breakdown of the ingredients that may alter estrogen levels

Alani Nu Balance Blood Sugar-Lowering Ingredients

Here's a breakdown of Balance capsule ingredients that reduce blood sugar

Several people have reported that skin conditions like acne improved when taking Balance supplements. Some evidence suggests high blood sugar levels and insulin resistance are linked to acne. If this is true, then improving blood sugar control may help reduce acne breakouts. Given that 3 of the six ingredients in Balance capsules can modulate blood sugar, these ingredients may be responsible for the positive outcomes people are reporting.

Antioxidant Ingredients

Who Makes Alani Nu Balance?

The company is called Alani Nutrition LLC, and the website is AlaniNu.com. The address listed on the bottles of the Balance supplement is PO Box 35159, Louisville, KY 40232.  Since this is a PO Box, its possible the company has its supplements made by another organization. No other business address could be located. The website was registered in 2017 by an organization called “Onyx and Rose.”

The company had an A+ rating from the Better Business Bureau, although customers gave the company 1.45 out of 5 stars (based on 11 customer reviews). See the BBB file for updates and more information.

The BBB also mentions another company called 3DEnergyDrinks as a related business. That company also has an A+ BBB rating.

Alani Nutrition Questions and Answers

How much do Balance capsules cost?

One bottle is $49.99. If you purchase a subscription, bottles are $47.49. Not a significant savings in my opinion

Can you take Alani Nu Balance while on birth control pills?

There's no proof that the supplements interfere with birth control pills and increase the risk of pregnancy. Balance does not contain saw palmetto, which some women fear increases the risk of pregnancy.

See the Saw palmetto birth control pill review for more insights.

Can it help hair grow?

There's no evidence that Balance supplements regrow hair or improve hair thickness. If this happened to you, leave a comment below. For more insights on other supplements, see these reviews

How do you contact Alani Nutrition?

The customer service contact number is 502-689-5926. Customers can reach out via this email address: contact AT alaninu.com.

How to purchase Alani

The company makes many dietary supplements. They can all be purchased directly from the company website, AlaniNu.com. You can also find the supplement at GNC, Amazon and similar companies. Some social media influencers may promote these supplements too.

Money-Back guarantee

Supplements come with a 30-day money-back guarantee. If you opened the bottle, the company will refund you 50% of the price you paid. If you did not open the bottle, you will receive a 100% refund of the sales price. You need to email the company first to be issued a refund. See the company information section above for how to do this.

Alani Nu Balance Side Effects

Bottles of Alani Nu Balance warn people not to take if they are at risk of high blood pressure or are being treated for high blood pressure, have kidney or thyroid problems, being treated for psychiatric problems, anxiety, depression, have difficulty urinating, seizure issues, or have had a stroke.

They also state the supplement is not approved for men with prostate problems. The supplement are NOT intended for children.

Testimonials posted on Amazon include the following:

Additional considerations when taking Alani Nu Balance include:

Does Alani Nu Balance And Liver Failure?

In January 2020, the New York Post and other news outlets reported that a 23-year-old Emily Goss from Texas who required a liver transplant on Christmas Day 2019 after taking Alani Nutrition Balance supplements for several months.

Here's a video from news station KETK NBC:

This appears to be the first case attributed to the Balance supplement. As the New York Post reports, Alani Nutrition denies the claims and states they partner with a licensed pharmacist when creating supplements and that their products are made in a facility that follows good manufacturing procedures (GMP).

Some of the news reports I saw have called Alani Balance an herbal supplement. But none of the six ingredients in the supplement are herbals.

One way to try to figure this out is to go to the LiverTox website, which maintains a list of supplements that have been linked to liver damage. Searching LiverTox for the ingredients in Alani Nutrition Balance supplements:

  1. Folate
  2. Chromium
  3. Myoinositol
  4. Glutathione
  5. Diindolylmethane (DIM)
  6. Alpha Lipoic Acid (ALA)

None of the 6 listed ingredients in Alani Nu Balance appeared to be associated with liver damage.

Searching the National Library of Medicine for reports of hepatitis or liver failure revealed this:

Folic Acid

No reports of human liver damage caused by folic acid supplements could be located.

Chromium

Some reports link chromium polynicotinate to liver hepatitis but in the cases, people were often taking a multi-ingredient supplement and not chromium alone. This leaves open the question as to which ingredient was responsible for the liver toxicity. For what it's worth, there is not much chromium in Balance capsules (only 120 micrograms).

Myo-Inositol (Inositol)

Reports of human liver failure caused by inositol supplements could not be located.

Glutathione

No reports of human liver failure by glutathione supplements could be located.

Diindolylmethane (DIM)

DIM supplements don't seem to be related to human liver failure.

Alpha Lipoic Acid (ALA)

No reports of human liver failure by alpha-lipoic acid supplements could be located.

Summary: No good evidence for the ingredients in Alani Nu Balance causing liver damage in people could be found – at least from what I could tell. Leave a comment below if you found the evidence I missed.

Speculation: Other Causes of Liver Failure?

If the ingredients are not connected to liver damage, what could be the reason for what happened to the woman from Texas? We can only speculate. For those seeking answers, here is some speculation. Take it for what it is:

1 Could it be that the unique combination of ingredients in Alani Nu Balance is responsible? In other words, some or all of the ingredients combined with each other to cause the problem. At this time, I'm not aware of this combination of ingredients causing problems.

2 Could the ingredients contain adulterations – other compounds not listed on the label? Unfortunately, China and other countries make many dietary supplement ingredients (and medications). In the past, the FDA has recalled several prescription medications due to the presence of hazardous compounds.

3. Could the liver damage be due to a tainted batch of ingredients? The company states they work with a facility that follows good manufacturing practices. That's good. But what country do the ingredients come from?

 Is Alani Nu Balance Right For You?

Based on the listed ingredients, Alani Nu Balance looks like an expensive inositol supplement.  Myoinoisitol makes up most of the ingredients, and it's very affordable. Several of the ingredients lower blood sugar and this may help reduce acne too. There's no evidence that the supplement improves menopause symptoms or helps women get pregnant. When in doubt, investigate the health supplements you take, and if you have medical problems, talk to your doctor first.

Any Comments or Questions?

Exit mobile version