Supplement Clarity

Zicam Facts You Need To Know

I posted something about supplements on Facebook recently and somebody commented about a terrible experience they had with a supplement called Zicam, which is a popular over the counter cold remedy containing zinc.  In her comment, she said after  she using Zicam, she lost her sense of smell. She said it's unlikely she would ever get her sense of smell back again. I am familiar with this unfortunate side effect. Let's look at the evidence for zinc and the loss of smell.

Zinc Swabs In Your Nose?

If you have heard me lecture, you know I've been telling people to avoid over-the-counter zinc-based cold remedies that require people to insert an applicator into their nose.

I have been saying this because of reports that have arisen over the last 10 years alleging these products may lead to a loss in the sense of smell. In some instances, the loss of smell may be permanent.

Now, the Food and Drug Administration (FDA) confirms this in their June 16th 2009 Warning Letter to the makers of Zicam where they state they have received 130 complaints from people whose smell sense was either reduced or permanently lost. Some of these reports occurred after a single application. On the same day the FDA issued a public Safety Alert about Zicam.

Zicam is the product specifically mentioned in the FDA Warning Letter and public safety alert. Zicam has been around for years and even touted on Rush Limbaugh’s syndicated radio show in spite of prior case reports linking these products to loss of smell.
As reported in the Washington Post article about Zicam, In 2006, the maker of Zicam (Matrixx Initatives) agreed to pay 12 million dollars to settle 340 lawsuits stemming from people who had lost their sense of smell. In some instance, just one application of Zicam caused a loss of smell.

Can Zinc Reduce Colds/Flus?

Interest in zinc as a cold remedy has been around since the 1990s when studies found cold lozenges containing 13.3 mg of zinc gluconate appeared to reduce the duration and severity of colds when taken at first sign of symptoms. If you have ever used lozenges called Cold-EEZE® you have seen the actual studies listed on the package.
A common mantra in the supplement industry these days is “our product works faster”. As I understand it, this is the rationale behind Zicam. In other words, by exposing the nasal passages to zinc, you speed the absorption of zinc, which in turn makes you feel better faster.
The problem is that this is faulty reasoning because “works faster” does not always mean the same thing as “works better”.
In fact, that’s the question I always ask to the people who say stuff like this. In other words, I'll ask them if they can prove to me (through published, clinical studies on their product) that a faster delivery means a better result. Nobody has ever proven to my satisfaction the works faster argument. This is because “works faster” is just marketing hype to make people think that something works better.

The peer reviewed published clinical studies find that sucking on zinc throat lozenges might help reduce cold symptoms (by about 10% to 30%).

My litmus test for all supplements is “published peer reviewed research”. To their credit, Cold-EEZE® is the ONLY PRODUCT on the market that has this proof. As such, it’s the zinc-based product I would recommend to people as long as they don't take the lozenges all the time.

Side effects of zinc

Zinc is safe when consumed in food. While zinc, taken for a short period of time, at the early stages of infection might help colds / flus, taking this mineral all the time (to prevent getting sick) is not recommended. It's easy to get more than the RDA for zinc and this is where problems can occur. Too much zinc may also lower HDL (good cholesterol). This can accelerate the risk of heart disease.
Senior citizens are a group I'm always concerned about when it comes to zinc supplements because they usually have several health issues – including heart disease. In seniors, taking zinc supplements regularly might do much more harm than good. Generally, it's always best to get zinc from food rather than high potency zinc supplements.
What do you think?
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