Rhabdomyolysis: Genetic Traits That Elevate Risk

Rhabdomyolysis (rhabdo) is a potentially serious complication from overexertion. While people are starting to discover how serious this health condition can be, few are aware that certain genetic traits can raise the risk of getting rhabdo. In this podcast of Joe Cannon Health (episode 13) I'll summarize 5 genetic traits that can elevate someone's risk of developing this health issue. While some have heard of the sickle cell trait, there are other genetic traits most have not heard of

This episode is important for parents of kids who have these genetic traits as well as PE teachers and coaches of college-level student-athletes.

Episode Summary

The myth of the week: do you have to cleanse or detox your colon to lose weight

What is rhabdomyolysis?

1 Malignant hyperthermia

• what it is, how it happens and who gets it.
• how does it cause rhabdo?

2 Sickle Cell Trait

• What is sickle cell anemia, signs of the condition
• Sickle cell trait vs sickle cell anemia
• How many have this condition
• Exercise and sickle cell trait
• Sickle cell in the military and college athletes

3 McArdles disease

• What causes McArdles and what are the symptoms
• How to possibly recognize McArdles in kids

4 Duchenne's muscular dystrophy

• what is Duchenne's muscular dystrophy and how is it linked to rhabdomyolysis

5 Carnitine deficiency

• What does carnitine do and where do we get it from?
• Can carnitine supplements help rhabdomyolysis?

Quote of the week

References

1. Malignant hyperthermia
2. Malignant hyperthermia association of the united states
3. Malignant hyperthermia susceptibility in patients with exertional rhabdomyolysis: a retrospective cohort study and updated systematic review.
4. Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees
5. Exertional Rhabdomyolysis and Malignant Hyperthermia in a Patient with Ryanodine Receptor Type 1 Gene, L-type Calcium Channel α-1 Subunit Gene, and Calsequestrin-1 Gene Polymorphisms
6. Sickle Cell Anemia (mayo clinic)
7. What is Sickle Cell Trait (CDC)
8. SICKLE CELL ANEMIA IN THE WHITE RACEIMPROVEMENT IN TWO CASES FOLLOWING SPLENECTOMY (1937)
9. Sickle cell anemia in two White American children: essential laboratory criteria for diagnosis.
10. Sickle Cell Trait and Sudden Death
11. Drug and nutritional treatment for McArdle disease
12. Emotionally-intense situations can result in rhabdomyolysis in McArdle disease.
13. Glycogen storage disease type V 
14. Duchenne Muscular Dystrophy (DMD)
15. Primary carnitine deficiency in a 57-year-old patient with recurrent exertional rhabdomyolysis
16. NCAA Sickle Cell Trait For Coaches (PDF)
17. NCAA: Sickle Cell Trait
18. Information About McArdles Disease
19. Emotionally-intense situations can result in rhabdomyolysis in McArdle disease.
20. Protective effects of L-carnitine on myoglobinuric acute renal failure in rats.