Metformin is a popular diabetes drug but is can it also help us live longer? In episode 19 of Joe Cannon Health I review the life extension research on metformin to help you decide if its right for you. Is it the fountain of youth? Should non-diabetics be taking this drug? Does it raise NAD levels? Here you will learn what the research says and questions we still need to know the answer to. Does metformin have any side effects? What's the correct dosage to take? If this medication has longevity effects, how does it work? Are there any supplements that can act like Metformin? If you have any questions or comments, leave them below.
Episode Summary
- The myth of the week – does muscle turn to fat?
- What is metformin
- History of the drug and where was it discovered
- What is Glucophage
- Animal life extension research
- Human life extension research
- How does it slow aging?
- Epigenetic effects
- Microbiome effects
- Inhibition of MTOR
- Rapamycin, AMPK and MTOR
- How to naturally lower MTOR
- oxygen
- ketogenic diet
- leucine
- arginine
- animal protein
- Metformin side effects
- 7 Questions that still need to be answered
References
- Silicon Valley techies are turning to a cheap diabetes drug to help them live longer
- Metformin: historical overview
- Metformin as Anti-Aging Therapy: Is It for Everyone?
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
- Metformin slows down aging and extends life span of female SHR mice.
- Metformin improves healthspan and lifespan in mice.
- Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila.
- Metformin supplementation and life span in Fischer-344 rats.
- Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats
- Nutrient regulation of mTORC1 at a glance
- TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
- L-Arginine Enhances Protein Synthesis by Phosphorylating mTOR (Thr 2446) in a Nitric Oxide-Dependent Manner in C2C12 Cells
- Might a Vegan Diet Be Healthy, or Even Healthier?
- Metformin directly targets the H3K27me3 demethylase KDM6A/UTX.
- Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule
- Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
- Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis.
- Metformin in Longevity Study (MILES) ClinicalTrials.gov
- Targeting Aging with Metformin (TAME) ClinicalTrials.gov
- Ageing: A midlife longevity drug?
- Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults.
- Feature: The man who wants to beat back aging (Science.org)
- The pharmacogenetics of metformin.
- Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
- Metabolic adaptation of skeletal muscle to high altitude hypoxia: how new technologies could resolve the controversies
- The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway