Supplement Clarity

Lipozene Review. Does It Work? Just The Facts

Updated 4/3/24. Have you seen the TV commercials for Lipozene featuring Holly Robinson Peete and Rodney Peete?  Maybe you've seen the commercials and wondered if Lipozene really worked. Lipozene has been around a long time and was actually one of the first supplements I looked at when this site was created. It was time to take a new look at this diet pill to see if anything had changed. In this review, we will look at the ingredients in Lipozene, its evidence, and side effects to help you see if this weight loss supplement is right for you.

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Lipozene Research

Does Lipozene have any clinical evidence proving it really works? Well, on the FAQ page of, there is a question titled “What were Lipozene's Clinical Study results?” The answer to that question makes reference to a company-sponsored study showing those taking the supplement for 8 weeks “lost 4.93 more pounds than the placebo group, and 3.86 lbs. of body fat!”


That's pretty impressive, but what they don't tell us is if the study was published in a medical journal. If it was, then we could see:

While I liked the study was done under “free-living conditions” where people did not change their eating or exercise habits, there is much we are not told about how this study was conducted.

To double-check, I searched both and for research. I simply went to those sites and entered “Lipozene.”

No relevant studies showed up.

This appears to show Lipozene -itself – has no peer-reviewed clinical evidence (the best kind of evidence). That said, this is not necessarily a deal-breaker because I'm very familiar with the key ingredient in Lipozene.

Let's look at that next.

Lipozene Ingredients

There is only 1 ingredient in this supplement. The label tells us that 2 capsules of Lipozene contain 1500 mg of an ingredient called:

This is the name of a large, purple-colored plant that is common to various parts of Asia. The root of the plant is often where the ingredients in supplements come from. Thus, another name for this on supplement labels is konjac root extract. Other names include glucomannan, devil's tongue and simply, konjac.

By whatever name you call it by, it's a water-soluble fiber that expands in size -like a sponge – when it comes in contact with a liquid. This ability to expand temporarily stretches the stomach, slowing gastric emptying (stomach emptying) and making our brain think that we are full.

This in turn, reduces our desire to eat. This is how Lipozene and other konjac fiber supplements work.

Other weight loss supplements containing this konjac root extract include:

See those reviews for more info on those products.

Other Ingredients In Lipozene

The Lipozene label also tells us it contains:

These other ingredients play no role in the weight loss effects of this supplement.

Konjac  Fiber Research

Glucomannan (konjac fiber)

This is the key ingredient in this supplement. There is research on konjac fiber as it pertains to weight loss. On the product package, it's called “Amorphophallus Konjac.” Remember the other name for this fiber is glucomannan. Let's summarize that research next.


In a 2015 study, 83 overweight men and women were given either konjac supplements or a placebo for 60 days. The amount of konjac used was 3000 mg (3 grams) a day. These researchers noted that the Konjac supplements caused significantly more weight and fat loss than those who took the placebo.


In a review of 9 previous studies, published in 2014, researchers concluded glucomannan (konjac) did not produce statistically significant weight loss benefits.


In this study glucomannan was given to 42 overweight men and women, along with a diet and exercise program. The study lasted 8 weeks.  These researchers used 3000 mg of glucomannan. They noted glucomannan promoted significant loses in body weight and fat compared to those who just worked out. Exercise also enhanced the effects of glucomannan.


A review article published in 2008 that included 14 studies concluded that glucomannan was effective at reducing body weight as well as cholesterol, triglycerides, and blood sugar levels.


In a review article from 2005, the researchers note that taking 2g – 4g per day of glucomannan produced significant weight loss in obese and overweight adults.

A fiber called PolyGlycopleX (PGX) is derived from glucomannan (konjac). In one small study, 5g of PGX fiber, given 2-3 times a day (10g-15g/day total)  to 29 overweight people for 14 weeks produced reductions in body weight and body fat.

In a 1984 study, 1000 mg (1g) of glucomannan fiber given 3 times a day (3g total) to 20 overweight people was shown to produce significant weight loss over a 2 month period.

To be fair, not all studies show it works. But, there are enough of them to think it might help some people.

Glucomannan Review

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Lipozene Research Summary

Here is a quick summary of the research presented above.

Study YearType Of StudyStudy Results
201583 people/ 60days/ 3g usedKonjac works
2014Review paper of 9 previous studiesKonjac does not work
200742 people /8 weeks/3g usedKonjac works
2008Review paper of 14 previous studiesKonjac works
2005Review paperKonjac works
201029 people/ 8 weeks. 10-15g of PGX fiber usedKonjac PGX fiber works
198420 people/ 8 weeks, 3g usedKonjac works

As can be seen from the table above, if konjac root extract is going to help weight, it may take 2000 mg-3000 mg before benefits are observed.  Keep in mind that none of these studies used Lipozene itself. Instead, the research is on the active ingredient, which is called konjac (glucomannan)

Here is on Amazon


METABO UP Plus is the other supplement mentioned on the Lipozene website and in TV commercials. The name implies that this supplement is supposed to increase the metabolic rate. In fact, on the product website ( they say the supplement will “increase energy and boost metabolism.”

Increased metabolic rates might – in theory – burn more calories. The more calories we burn, could, in theory, contribute to weight loss.

METABO Up -which was the original product marketed – was replaced by Metabo Up PLUS. The METABO UP supplement contained these ingredients:

Metabo Up PLUS contains these ingredients in 2 tablets:

IngredientAmount Per ServingPercent Daily Value
Vitamin B 6600 micrograms30% DV
Vitamin B1215 micrograms215% DV
Blend Containing952 mg
Green tea extract (50% polyphenols)
Guarana seed extract (22% caffeine)
Oolong tea leaf
Kola nut extract (10% caffeine)
Platycodon root extract (10:1)

As can be seen, they added a couple of extra ingredients to Metabo UP PLUS.

Other ingredients also present in Metabo Up Plus are calcium carbonate, microcrystalline cellulose, stearic acid, silicon dioxide, Croscarmellose sodium, magnesium stearate, and pharmaceutical glaze.

We are told the total amount of ingredients in the proprietary blend adds up to 952 mg. What we can say about these ingredients?  The first 5 ingredients of the proprietary blend all contain caffeine. The caffeine-containing ingredients in Metabo Up Plus are as follows:

It turns out 2 capsules of MetaboUp PLUS has 120 mg of caffeine. This is why they say it boosts metabolism and gives you energy. It does it the same way any other caffeine product will.

As for Oolong tea. There is at least one study showing that oolong tea can help weight loss. This study used more oolong tea than Metabo UP has. I also saw Oolong when I reviewed Fit Tea (click to read review)

Here's Oolong Tea on Amazon

The last ingredient in the blend is Platycodon. This refers to the plant called Platycodon grandiflorum. The website says it can help to “breakdown stored fat.” That might be true in mice. But what about people? Let's wait for more research.

Bottom Line: MetaoUP PLUS is a caffeine supplement.

Is Lipozene + Metabo Up Better?

While I've seen them marketed together, I don't believe using both equals more weight loss. In other words, I don't think people have to take both supplements. After all, it's just a caffeine supplement. Since that's the case, wouldn't it be easier to just drink coffee or diet soda and get the same effect?

In the research summarized above, people only took the konjac fiber, which is the active ingredient of Lipozene. As such, that's all I think people need.

How Much Caffeine?

Lipozene has no caffeine.

Metabo Up Plus has 120 mg in 2 capsules. This is roughly about what is in a cup of coffee.

How To Take Lipozene?

It's recommended to take 1 or 2 capsules with 8 oz of water at least 30 minutes before eating.

Who Makes Lipozene?

The company is called the Obesity Research Institute LLC. Two addresses were found for the company

A previous company address is 4910 Longley Ln STE 101 Reno, NV 89502-7933.  Their phone number is: (800) 409-9768.   It's ironic that given the name “research” is in the name of the company, no published, peer-reviewed clinical research for Lipozene could be uncovered at the time this review was created.

The BBB had an NC rating for the Obesity Research Institute when this review was updated. Ratings sometimes change, so see the BBB website for updates and more information.

Contact Lipozene lists the following contact numbers:

I called both phone numbers, but I could NOT reach a human to speak with. The customer service number consisted of a bunch of automated responses based on what keypad number you push. When you call you may get hit with a “Congratulations” sales pitch where they offer to double the order.

Even calling the New Orders phone number consisted of the same long-winded sales pitch. I called several times and could never speak to a human.

Here it is on Amazon

Where To Buy Lipozene

This weight loss supplement is pretty mainstream, and it should be available at most retail stores like Walmart, CVS, GNC, Target, Costco, Acme Vitamin Shoppe, Walgreens, and RiteAid.

Lipozene Cost

A bottle of Lipozene costs $29.95. That's not too bad compared to other supplements which can cost much more. That said, if buying  Lipozene on a regular basis, the cost will add up.

If you order, I suggest you call the company rather than order from the website. If you do, ask if they will be adding the non-refundable fee of $1.35 to the order.

Also, check local stores as it may be on sale. This supplement is also sold online.

Returning Lipozene

If buying from the Lipozene website or from a TV commercial, all supplements come with a 30-day money-back guarantee. If ordering from the website/TV commercial make sure you ask if the 30 days begin when you order the product, when it's shipped or when you receive the product. This is important and could make the difference of them honoring the guarantee or not.
If you need to return Lipozene, the website has this statement:
Customers have a total of 30 days to return the Lipozene weight loss pills for a refund. Return authorization numbers must be received from Customer Service and written on the shipping box. Please contact Customer Service with any questions about Lipozene's weight loss guarantee at 1-888-220-8907.
All refunds are subject to a $1.35 processing fee that is non-refundable. This is true for both Lipozene and Metabo UP. If you can, call Lipozene Customer Service before returning any products. That way you will get the best advice on how to handle this situation.

Before returning it, you have to obtain a Return Authorization Number from the company.

You can obtain this by calling the company at 1-888-220-8907. This is important. Don't just send it back without the Return Authorization Number or the guarantee won't be authorized.

If you purchased from a local retail store, just return it there. I'm sure stores will honor returns/exchanges. The same thing goes for buying from eBay or Amazon too.


Lipozene vs. Konjac Fiber

Lipozene contains only 1 active ingredient – konjac fiber – also called glucomannan. The product does contain an amount similar to what research studies have found works, so that is good.

Because of this, I believe Lipozene and Konjac fiber would work equally. This is important because konjac fiber can be purchased by itself, as capsules or a fiber powder to mix into smoothies or water.

Heres Konjac on Amazon

Lipozene Pro & Con

Here is a quick overview of what I liked and didn't care for about this supplement:

What's GoodWhat's Not So Good
Buying 1 bottle is not too expensiveCan become expensive if used long term
Contains amounts of knojac used in researchAutoship program
Been around a long timeLack of clinical research on Lipozene itself
No stimulants in Lipozene (Metabo Up Plus has stimulants)Customer service difficult to get a hold of
$1.35 non refundable processing fee on returns

Lipozene Side Effects

Lipozene is safe for most healthy people. That said, here are some potential issues to keep in mind. See your doctor if you think any of this applies to you. This list is not complete.

Holly Robinson Peete Lipozene Commercial

Lipozene TV commercials currently feature actress Holly Robinson Peete and her husband, former football player, Rodney Peete. From some of the comments I've seen online, they have taken some heat for doing the commercial. I won't add to that because they are not the first -or last -celebrities to endorse weight loss supplements.

For example, Kirstie Alley and Octavia Spencer and Bob Harper and Chris Powell have all marketed weight loss supplements.

Lipozene is pretty tame compared to many other supplements I've seen – and its key ingredient has some evidence.

In the past, Lipozene TV commercials have featured Stacey Travis, an accomplished actress and has appeared in many movies and TV shows including Big Bang Theory, and Seinfeld.

Does Lipozene Work?

Lipozene contains a fiber called konjac (glucomannan), which some studies have shown may help people lose weight. Lipozen also contains the amount of konjac fiber that research has shown can work. As such, its quite possible this supplement may benefit some people.

Here it is on Amazon

Here it is on Ebay

What Do You Think?


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