You may have heard of Apidexin as weight loss supplement but does it work? Are there any Apidexin side effects? The bottle says Apidexin is “scientifically formulated” which makes you think they have tested it. One thing’s for sure, there are a lot of ingredients in Apidexin, some of which I've looked previously and others I’ve not. Another thing that caught my eye is that Apidexin isn’t cheap: one month cost $49.95 according to the product website. There are many Apidexin reviews on the web but a lot of them also sell supplements and say things that I just don’t agree with. What I’d like to do with this Apidexin review is take a look at each of its ingredients because that’s the best way to see if it really is worth your time and money.
Is Apidexin Supplement Or A Drug?
When I look at the Apidexin bottle, it reminds me of something I might get at a pharmacy. I'm guessing this is just cleaver marketing to give the impression that it is FDA approved or is some how like a 
Apidexin also sounds a lot like Apidex-P which is another name for Phentermine, a weight loss drug.
Let me be clear. Apidexin is not a drug or a hormone. Apidexin is a dietary supplement. It has no relationship to phentermine or any other weight loss drug.
There is research on many of its ingredients but there is no published clinical proof on Apidexin itself. This is true for most weight loss supplements. Keep this in mind as you read this review.
Apidexin Ingredients
Apidexin has the following ingredients according to the Apidexin.com website:
| 3 capsules contains | % Daily Value |
| Vitamin B12 900 micrograms | 15,000% |
| Chromax 60 micrograms | 50% |
| Proprietary blend of: | 1,111 mg |
| Coleus forskolin | |
| Irvinginia gabogenesis | |
| Razberi K | |
| Fucoxanthin 10% | |
| Guggul Ez-100 | |
| Lipolide-sc | |
| Thermodiamine | |
| Bioperine |
The Apidexin website also lists scientific studies as proof that these ingredients work. Where relevant, I’ll also address these studies. Let’s now look at the weight loss proof for each of the ingredients in Apidexin.
Vitamin B12
There is zero published peer reviewed clinical proof showing vitamin B12 causes weight loss. I have already reviewed vitamin B12 and weight loss as well as several other supplement that have B12 (Type vitamin B12 in the search box and they will show up). Most healthy people store several years’ of B12 in their body. If you store so much, why would you need more?
One reason that B12 might be used in weight loss supplements is because people think it gives them more energy. That's why its in energy drinks. But this isn’t true for most healthy people. For more on B12 also read my review of 5 Hour Energy.
Chromax
This is another name for chromium picolinate. Chromium is found in several supplements I've looked at previously including Avesil, Diab-X, Fat Stripper and Glucosulin. These other reviews give you many additional insights, but the bottom line is that chromium picolinate doesn't work.
Study comment. It’s interesting that on the Apidexin website that they mention “a recent study” about chromium and weight loss, but when you read the study, you see it was conducted in 1996 – hardly what I’d call “recent”.
The fact is that MANY studies have shown that chromium picolinate does not help weight loss. For example, here is a 2010 chromium weight loss study published in the Journal of Complementary and Alternative Medicine where 80 overweight people got 1000 micrograms of chromium picolinate (Apidexin has only 60 micrograms) for 6 months. The results: Chromium doesn't work.
There are so many nails in the “chromium picolinate doesn't help weight loss” coffin that I wonder why supplement companies keep putting in their products?
Coleus
This is also called Coleus forskohlii (and forskolin). I've already written a very in-depth Coleus forskohii review as it pertains to weight loss and included side effects also, so do read that for much more info. Basically, the research on coleus forskohii is interesting. There are some human studies showing it may work but I have questions about those studies that need to be addressed before I give it 2 thumbs up.
Study comment. I noticed that one of the coleus forskohii studies mentioned on the Apidexin website (Kreider et al 2002) is an “abstract”. Abstracts are summaries of studies. They may not be peer reviewed. As such I discount abstracts as “proof”.
Irvingia Gabonensis
This is the fancy name for African Mango. I’ve already covered African Mango in my Irvinginia gabonensis weight loss review. DO READ the comments in that review also as this are the most important part.
Ian, one of the readers of my site, has graciously undertaken the task of putting himself on Irvingia Gabonensis for several weeks and posted his weight loss results in the comments for everyone to see. Ian’s weight loss experiment speaks volumes to anyone who is thinking about using irvingia gabonensis for weight loss.
Study comment. On the Apidexin website, the studies used to support Irvingia Gabonensis are the same studies as that used to support Coleus forskohii. This makes no sense since both studies are of coleus forskohii. This is probably a mistake that occurred when the Apidexin website was created.
Razberi K
This is a compound found in raspberries. It is often called raspberry ketone and its chemical name is 4-(4-hydroxyphenyl) butan-2-one. I'm telling you the chemical name in case raspberry ketone supplements ever become popular (I predict they will ).
Update 3/7/12. I was right. Raspberry ketones have become VERY popular. I have written an entire review on raspberry ketones and weight loss so see that review for more info on this ingredient.
The chemical structure of raspberry ketone is similar to synephrine and capsaicin, both of which are used in various weight loss supplements.
For more info on synepherine and capsaicin, read my review of Jillian Michaels Maximum Fat Strength Fat Burner. It’s an eye opener!
In one raspberry ketone weight loss study published in 2005, raspberry ketone appeared to:
- Reduce weight gain when mice that were fed a high fat diet
- Reduce body weight in lab mice
- Increase the release of fat from fat cells in lab mice
- Increase triglyceride levels (this may be due to the enhanced fat release from fat cells).
This is an interesting study even though it is a mouse study. Another study – again in mice – found that raspberry ketone increased adiponectin levels.
Remember that adiponectin is a fat cell hormone that helps break down fat (among other things). This is intriguing.
These were the only raspberry ketone weight loss studies I could locate. The results are interesting and I am looking forward to human studies.
Right now nobody knows if raspberry ketone works in humans as it seems to in mice. It might, but if it does, how much raspberry ketone works? Nobody knows this.
Fucoxanthin
What is fucoxanthin? This is a carotenoid (plant nutrient) found in some sea vegetables like seaweed.
There are a few studies that Fucoxanthin helps weight loss in lab animals. One study published in 2010 also noted that fucoxanthin helped weight loss in humans also. In this study particular study, overweight people used 2.4 mg of fucoxanthin. How much is in Apidexin? They don’t tell you.
The big problem with fucoxanthin has to do with its possible contamination with iodine. Remember, this stuff comes from seaweed – which has a lot of iodone. Too much iodine might disrupt how the thyroid gland works.
More iodine does not mean a faster metabolism. If it did, then people who eat a lot of fast food – which is often loaded with iodized salt – would be super skinny!
Guggul EZ
As I first reviewed in my book on supplements, guggul has been used for centuries in Aurvetic medicine. There are different types (categories) of guggul. The E and Z types seem to be most active. Guggul contains Guggulsterones which are said to be the things that “work the magic”.
When it comes to guggul weight loss research, there isn’t much good proof. One study published in the Journal of the American Medical Association in 2003, noted that guggul did not help weight loss. Researchers gave 103 people 3000 to 6000 mg guggul extract – which is far more than is in Apidexin.
As for guggul side effects, it may have some blood thinning effects and there is even a case report of liver failure after taking a supplement that contained guggul. Guggle was not the only ingredient in that supplement so it is unknown if guggul did this or not.
People with histories of some cancers should talk to their doctor before taking guggul supplements. I suspect guggul may also interact with cholesterol lowering drugs since it does appear to reduce cholesterol. Bottom line, guggul, like many herbs, has multiple effects in the body. Its weight loss proof however is pretty poor in my opinion.
Lipolide-sc
This is a trademarked name for clary sage also known as Sclareolide. I cannot locate any clary sage weight loss research. The company that makes this product (Integritynut.com) makes many statements about how this compound helps weight loss but gives no clinical proof to substantiate any of the claims.
One lab rat study hints that clary sage may have some antidepressant activity. That doesn't mean it is an antidepressant in people but, if it does, I wonder if there might be interactions with antidepressant medications? I don’t know the answer to this so run this past a doctor.
ThermoDiamine
Other names for Thermo-Diamine are evodiamine and evodia. These are the names used in scientific research of the herb. I do not recommend this evodia if you have any health issues.
According to some lab animal research some extracts of evodia may alter heart rate and blood pressure. The herb probably has many side effects that might vary according to what extract is being used.
Thermodiamine is a trademarked product of the company Integrity (Integritynut.com). On their website they list a Evodiamine weight loss study from 2001 where evodiamine caused weight loss. Here is the 2001 evodia weight loss study that Integrity references.
What they DO NOT tell you that this is a lab rat study. Because evodamine may thin the blood and have other effects, speak to a doctor before using.
Study comment. On the Apidexin website they list an evodamine weight loss study from 2008. It’s a study of evodiamine helping weight loss in mice.
Bioperine
This ingredient is said to enhance the absorption of the other ingredients which as the Apidexin website says, to “help you get better results for less money”.
Supplements Similar To Apidexin
While I wrote my review I noticed that there are supplements sold on Amazon that sound and look like Apidexin but are spelled differently. For example, here is a product called Abidexin on Amazon. The name and bottle are almost identical to Apidexin. Interestingly the websites for Apidexin (Apidexin.com) AND Abidexin (Abidexin.com) are almost identical. The ingredients in Apidexin and Abidexin are also the same also. I'm not sure if both products are by the same company or not?
Does It Work?
As far as I can tell Apidexin -itself – has no published peer reviewed clinical evidence to make me believe it helps people lose weight. This is one of the reasons that I personally would not recommend Apidexin. The product contains ingredient that I don't feel have enough research as well as ingredients that I don't think work at all. I recommend you avoid this product but if you want to see what others are saying, here is Apidexin on Amazon.